JP2018100223A - Food composition for stress reduction - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a food composition that is taken as food and drink and the like and exhibits a stress reduction effect.SOLUTION: This invention relates to a food composition for stress reduction that contains at least one of vanillin and borneol as an active ingredient.SELECTED DRAWING: None

Description

  The present invention relates to a food composition for reducing stress, and relates to a food composition containing at least one of vanillin and borneol as an active ingredient.

  Today is an era of stress overload. Excessive stress affects a wide range of the immune system, nervous system, digestive system or circulatory system, and as a result, causes a wide variety of diseases, thereby reducing the quality of life.

  Stress-related symptoms caused by stress include opportunistic infections due to decreased immunity in the immune system, neurosis such as depression in the nervous system, gastric / duodenal ulcer or irritable bowel in the digestive system Examples of syndrome and circulatory system include hypertension or ischemic heart disease.

  Reducing the cause of stress is the fundamental solution for preventing or ameliorating these diseases, but this is currently difficult, and a technology that can easily reduce stress on a daily basis is desired. It is rare.

  Therefore, an object of this invention is to provide the food composition which can exhibit the effect which reduces stress by ingesting daily as food-drinks etc. easily.

  As a result of intensive studies in order to solve the above problems, the present inventors have found that the above problems can be solved by the following food composition for stress reduction and the like, and have completed the present invention.

That is, the present invention is as follows.
[1] A food composition for stress reduction containing at least one of vanillin and borneol as an active ingredient.
[2] The food composition for stress reduction according to [1], wherein the content of vanillin is 40 to 400 wt ppb.
[3] The stress-reducing food composition according to [1] or [2], wherein the borneol content is 4 to 40 wt ppb.
[4] The food composition for stress reduction according to any one of [1] to [3], which is a beverage.
[5] A stress reducing agent containing at least one of vanillin and borneol as an active ingredient.

  The stress-reducing food composition of the present invention contains at least one of vanillin and borneol as an active ingredient, thereby having a relaxation promoting action, a sedative action, an anxiolytic action, and an autonomic nerve regulating action, and taking this Therefore, stress can be reduced.

FIG. 1A and FIG. 1B are diagrams showing the results of evaluating the amount of activity. 2A and 2B are diagrams showing the results of measuring heart rate variability. FIG. FIG. 3A and FIG. 3C are diagrams showing the staying time in the light box. Moreover, FIG. 3B and FIG. 3D are figures which show the frequency | count of invasion to a bright box.

  The food composition for stress reduction of the present invention (hereinafter also referred to as the food composition of the present invention) is characterized by containing at least one of vanillin and borneol as an active ingredient.

  The vanillin used in the present invention may be a synthetic product, but natural vanilla extract or natural vanilla extracted by an extraction method in which a component that dissolves in a solvent is dissolved from a natural vanillin-containing plant. It may be purified from the extract. Moreover, what removed the other volatile component of the vanillin which inhibits a stress reduction effect from a natural vanilla extract may be used.

  In the present specification, “natural vanilla extract” is an extract obtained by pressing various kinds of solvents as an extraction solvent to a vanilla bean that has been subjected to a curing treatment, and by pressing and extracting from the extracted liquid or the vanilla beans that have undergone a curing treatment. Refers to liquid.

  In addition, “natural vanilla” is a vanilla bean itself, which is a fruit of the orchidaceae vanilla genus, or a single physical, chemical or biological processing (including curing) on vanilla beans, What is combined with each processing, each processing is performed alone or in combination, multiple times, or vanilla beans themselves and those processed vanilla beans are subjected to extraction processing, the resulting residue, Refers to the residue produced as a result of reprocessing the obtained extract.

  The content of vanillin as an active ingredient in the food composition of the present invention is preferably 40 wt ppb or more, more preferably 100 wt ppb or more, and further preferably 200 wt ppb. Moreover, it is preferable that it is 400 weight ppb or less, More preferably, it is 350 weight ppb or less, More preferably, it is 300 weight ppb or less. By setting the vanillin content in the above range, a sufficient stress reduction effect can be obtained.

  Borneol used in the present invention may be a synthetic material, but is obtained by distilling with water vapor from a resin or trunk of a tree or a trunk of an evergreen tree belonging to Dypterocarpacae. It may be a purified product.

  The content of borneol as an active ingredient in the food composition of the present invention is preferably 4 wt ppb or more, more preferably 10 wt ppb or more, and further preferably 20 wt ppb. Moreover, it is preferable that it is 40 weight ppb or less, More preferably, it is 35 weight ppb or less, More preferably, it is 30 weight ppb or less. By making the content of borneol within the above range, a sufficient stress reduction effect can be obtained.

  The food composition of the present invention can be provided as a form of food or drink. In the food and drink, the active ingredients can be blended as they are or in the form of agents containing them. As a form of food-drinks, it can shape | mold arbitrarily, for example in the shape of a granule, a granular form, a paste form, a gel form, solid form, or a liquid.

  In addition to the above active ingredients, the food and drink may contain other ingredients such as nutritional supplements. Examples of such components include vitamins, minerals, various plants and extracts thereof, purified products and fractions, microorganisms and growth factors and microorganism products thereof, dietary fibers and enzyme degradation products thereof, animal bodies and the like. Examples include extracts, purified products, degradation products and products, various oligosaccharides, lipids, various proteins, and protein degradation products.

  In addition, various known substances that are recognized to be contained in foods and drinks, such as binders, disintegrants, lubricants, coating agents, thickeners, dispersants, reabsorption accelerators, flavoring agents, buffering agents. And excipients such as surfactants, solubilizers, preservatives, emulsifiers, tonicity agents, stabilizers or pH adjusters.

  Specific examples of food and drink include, for example, juices, soft drinks, milk drinks, tea drinks, functional drinks, nutritional supplement drinks and non-alcoholic beer drinks; alcohol drinks such as beer and sparkling liquor; soup and miso soup Liquid foods and drinks such as soups; Carbohydrate-containing foods and drinks such as rice, rice cakes, noodles, breads and pasta; Western confectionery such as cookies and cakes; Japanese confectionery such as buns and sheepskin; Gummies and tablets Candy, gums, chocolates and various confectionery such as frozen confectionery or ice confectionery such as jelly, yogurt and pudding; processed products using eggs and processed products of seafood or livestock meat; seasonings; However, it is not limited to these. Among these, beverages are particularly preferable.

  In addition, foods and drinks include foods classified as beauty foods / health foods, functional labeling foods, foods for specified health use, dietary supplements, foods with a disease risk reduction label, or foods for the sick. Is done. Examples of the functional display and the disease risk reduction display include a display indicating that the stress-related symptoms are for prevention, improvement, suppression, and / or alleviation.

  The food composition of the present invention is preferably taken at least once, preferably several times after a certain period, before or during a period of increased mental stress or mental pressure. More preferably, it is taken at least once before a stress factor occurs. It may also be taken immediately before a mentally harsh situation.

  Stress factors include, for example, exams, driving, presentations, stressful sporting events, business meetings, repetitive work, intellectual labor, mental instability in menopause, and premenstrual mental instability.

  The amount of intake when the food composition of the present invention is taken orally by mammals including humans varies depending on the age of the mammal, the level of stress factors, the degree of sensitivity to stress, etc., and is generally defined. Although it is not possible, 300 to 3000 ng is preferable as the amount of vanillin per kg body weight per day, and 30 to 300 ng is preferable as the amount of borneol.

  By ingesting the food composition of the present invention as described above, a relaxation promoting action, a sedative action, an anxiolytic action and an autonomic nerve regulating action can be obtained, and stress can be reduced. In addition, as a result of reducing stress by the food composition of the present invention, prevention or improvement of various diseases caused by stress can be expected.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these Examples at all.

Example 1: Sedative effect (evaluation of activity)
The effect of vanillin and borneol on the activity of mice was evaluated by the activity of infrared rays. A group of 6 or more ICR mice (male) grouped according to body weight (8 animals / group) was used as a test animal.

  Vanillin (manufactured by Nacalai Tesque Co., Ltd., administered doses are 0.0004 mg / kg, 0.004 mg / kg, 0.04 mg / kg, 0.4 mg / kg or 4 mg / kg bw) or borneol (Tokyo Chemical Industry Co., Ltd.) Company-manufactured, 0.000004 mg / kg, 0.00004 mg / kg, 0.0004 mg / kg, 0.004 mg / kg or 0.04 mg / kg bw) dissolved in 0.5% aqueous carboxymethylcellulose solution The test product was orally administered to the test animals (administration volume 10 ml / kg bw), and the amount of activity was measured for 6.5 hours after administration.

  The amount of activity was counted by counting the number of activities per hour by sensing the body temperature (far infrared rays) of the mouse with the lens of the device using a sensor for simple measurement of spontaneous momentum (manufactured by Neuroscience Co., Ltd.). The results are shown in FIGS. 1A and 1B.

  As shown in FIG. 1A, the mice received vanillin 0.004-0.04 mg / kg b. w. A decrease in activity was observed when a single dose was administered. Extrapolating this dose to humans (60 kg) in terms of body surface area results in 20-200 μg, and if added to a 500 mL beverage, the final concentration will be 40-400 wt ppb.

  In addition, as shown in FIG. 1B, Borneol was added to the mouse at 0.0004 to 0.004 mg / kg b. w. A decrease in activity was observed when a single dose was administered. Extrapolating this dose to humans (60 kg) in terms of body surface area yields 2-20 μg, and if added to a 500 mL beverage, the final concentration is 4-40 ppb.

Example 2: Stress reduction effect (measurement of heart rate variability)
The effects of vanillin and borneol on autonomic nerves were evaluated by heart rate variability. Wistar rats (male) 6 weeks of age or older were grouped (7-8 animals / group) according to body weight, and used as test animals.

  Heart rate measurement was started 60 minutes before oral administration, and vanillin (Nacalai Tesque, Inc., dose: 0.004 mg / kg bw) or borneol (Tokyo Kasei Kogyo, dose: 0. 0004 mg / kg bw) dissolved in 0.5% carboxymethylcellulose aqueous solution was orally administered to the test animals (dosing volume 10 ml / kg bw), and the heart rate was measured for 120 minutes. LF / HF, which is an index of autonomic nerve activity, was calculated from heart rate variability measured using a heart rate measuring telemetry device (manufactured by DSI), and the autonomic nerve activity was evaluated. The results are shown in FIGS. 2A and 2B.

  As shown in FIG. 2A and FIG. 2B respectively, when a single dose of vanillin (0.004 mg / kg bw) or borneol (0.0004 mg / kg bw) was administered to a rat, It was confirmed that LF / HF remained low. Extrapolating this dose to humans (60 kg) in terms of body surface area yields 40 μg for vanillin and 4 μg for borneol.

Example 3: Anti-anxiety effect (evaluation by light and dark box)
The anti-anxiety effect of vanillin and borneol was evaluated by a test that evaluates the state of anxiety with a light and dark box. Ddy mice (male) 5 weeks of age or older grouped according to body weight (7-8 mice / group) were used as test animals.

  60 minutes before the test, vanillin (manufactured by Nacalai Tesque, Inc., administered dose is 0.0004 mg / kg, 0.004 mg / kg or 0.4 mg / kg bw) or borneol (manufactured by Tokyo Chemical Industry Co., Ltd., A dose of 0.0004 mg / kg, 0.004 mg / kg or 0.4 mg / kg bw) dissolved in 0.5% aqueous carboxymethylcellulose solution was orally administered to the test animals (dosing volume 10 ml / kg). kg bw). The test was conducted for 5 minutes by placing a mouse in a device in which a light box and a dark box were connected, and using the number of times of intrusion into the light box and the staying time in the light box as indicators. The results are shown in FIGS. 3A to 3D.

  As shown in FIG. 3A to FIG. 3D, the anxiolytic effect was confirmed when vanillin and borneol were both administered at a dose of 0.0004 to 0.004 mg / kg in mice. Extrapolating this dose to humans (60 kg) in terms of body surface area yields 2-20 μg.

  The food composition of the present invention has a relaxation promoting action, a sedative action, an anxiolytic action and an autonomic nerve regulating action, and has the effect of reducing stress by ingesting this. From this feature, the food composition of the present invention is expected to be used as a new food or drink for preventing, improving, suppressing and / or alleviating stress-related symptoms.

Claims (5)

  A food composition for stress reduction comprising at least one of vanillin and borneol as an active ingredient.   The food composition for stress reduction according to claim 1, wherein the content of vanillin is 40 to 400 wt ppb.   The stress-reducing food composition according to claim 1 or 2, wherein the content of borneol is 4 to 40 wt ppb.   It is a drink, The food composition for stress reduction of any one of Claims 1-3.   A stress reducing agent comprising at least one of vanillin and borneol as an active ingredient.

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