JP2018062488A - グレリンシグナル増強剤およびグレリンシグナル増強用食品組成物 - Google Patents
グレリンシグナル増強剤およびグレリンシグナル増強用食品組成物 Download PDFInfo
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- JP2018062488A JP2018062488A JP2016202425A JP2016202425A JP2018062488A JP 2018062488 A JP2018062488 A JP 2018062488A JP 2016202425 A JP2016202425 A JP 2016202425A JP 2016202425 A JP2016202425 A JP 2016202425A JP 2018062488 A JP2018062488 A JP 2018062488A
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- ghrelin
- ginseng
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- signal
- enhancer
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Abstract
Description
オタネニンジンの根を乾燥させた人参生薬の刻み(クラシエ製薬)1.5kgを量り、15kgの温水を入れ、20分間かけて100℃に昇温し、100℃で60分間加熱還流抽出した後、100メッシュの篩いでろ過した。ろ液を減圧下で6倍濃縮した後、噴霧乾燥し、噴霧乾燥エキス210gを得た。
グレリン受容体(GHSR受容体)は、活性化されると細胞内のカルシウムイオン濃度を上昇させる。人参エキスおよび種々の化合物によるグレリンシグナルの増強作用を観察するために、以下のようにカルシウム流量アッセイを行った。
人参エキスを5μg/mL、30μg/mLまたは100μg/mL添加し、グレリン存在下でのグレリンシグナルの増強効果を調べた。図1は、人参エキスによるグレリンシグナル増強作用を示すグラフである。図1に示すように、人参エキスは、グレリン存在下で、用量依存的にグレリンシグナルを増強させた。
パナキサジオールを10μM、30μMまたは60μM添加し、グレリン存在下でのグレリンシグナルの増強効果を調べた。図2は、パナキサジオールによるグレリンシグナル増強作用を示すグラフである。図2に示すように、パナキサジオールは、グレリン存在下で、用量依存的にグレリンシグナルを増強させた。
プロトパナキサトリオールを60μM添加し、グレリン存在下でのグレリンシグナルの増強効果を調べた。図3は、プロトパナキサトリオールによるグレリンシグナル増強作用を示すグラフである。図3に示すように、プロトパナキサトリオールは、グレリン存在下でグレリンシグナルを増強させた。
パナキサトリオールを60μM添加し、グレリン存在下でのグレリンシグナルの増強効果を調べた。図4は、パナキサトリオールによるグレリンシグナル増強作用を示すグラフである。図4に示すように、パナキサトリオールは、グレリン存在下でグレリンシグナルを増強させた。
プロトパナキサジオールを60μM添加し、グレリン存在下でのグレリンシグナルの増強効果を調べた。図5は、プロトパナキサジオールによるグレリンシグナル増強作用を示すグラフである。図5に示すように、プロトパナキサジオールは、グレリン存在下でグレリンシグナルを増強させた。
したがって、図2〜図5に示すように、人参由来のダンマラン系トリテルペンにグレリンシグナル増強作用があることが示唆された。
Claims (5)
- 人参を有効成分として含有する、グレリンシグナル増強剤。
- 前記人参が、人参から抽出したエキスとして含有される、請求項1に記載のグレリンシグナル増強剤。
- ダンマラン系トリテルペンまたはその配糖体を有効成分として含有する、グレリンシグナル増強剤。
- 前記ダンマラン系トリテルペンまたはその配糖体が、パナキサジオール、プロトパナキサジオール、パナキサトリオールおよびプロトパナキサトリオールからなる群より選択される少なくとも1つまたはその配糖体を含む、請求項3に記載のグレリンシグナル増強剤。
- 人参を有効成分として含有する、グレリンシグナル増強用食品組成物。
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JP2021107358A (ja) * | 2019-12-27 | 2021-07-29 | クラシエ製薬株式会社 | グレリン受容体の活性化剤 |
WO2022225045A1 (ja) * | 2021-04-23 | 2022-10-27 | 東レ株式会社 | グレリン抵抗性を伴う悪液質の治療剤又は予防剤 |
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JOURNAL OF VASCULAR SURGERY, vol. 53, no. 1, JPN6019037088, 2011, pages 156 - 164, ISSN: 0004380050 * |
TETRAHEDRON LETTERS, JPN6020018739, 1965, pages 207 - 213, ISSN: 0004279917 * |
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Cited By (3)
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JP2021107358A (ja) * | 2019-12-27 | 2021-07-29 | クラシエ製薬株式会社 | グレリン受容体の活性化剤 |
JP7430442B2 (ja) | 2019-12-27 | 2024-02-13 | クラシエ株式会社 | グレリン受容体の活性化剤 |
WO2022225045A1 (ja) * | 2021-04-23 | 2022-10-27 | 東レ株式会社 | グレリン抵抗性を伴う悪液質の治療剤又は予防剤 |
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