JP2018058822A - ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 - Google Patents

ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 Download PDF

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JP2018058822A
JP2018058822A JP2017147506A JP2017147506A JP2018058822A JP 2018058822 A JP2018058822 A JP 2018058822A JP 2017147506 A JP2017147506 A JP 2017147506A JP 2017147506 A JP2017147506 A JP 2017147506A JP 2018058822 A JP2018058822 A JP 2018058822A
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Japan
Prior art keywords
alkyl
antibody
mmol
cancer
methyl
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JP2018058822A5 (https=
Inventor
ジョージ ダッシン ラッセル
George Dushin Russell
ジョージ ダッシン ラッセル
エー． アブラミテ ジョゼフ
A Abramite Joseph
エー． アブラミテ ジョゼフ
エム， カサヴァント ジェフリー
M Casavant Jeffrey
エム， カサヴァント ジェフリー
チェ イエ
Ye Che
チェ イエ
フレデリック フィルツェン ゲイリー
Frederick Filzen Gary
フレデリック フィルツェン ゲイリー
フラナガン マーク
Edward Flanagan Mark
フラナガン マーク
マシュー ギルバート アダム
Matthew Gilbert Adam
マシュー ギルバート アダム
モイネ ルディヴィン
Moine Ludivine
モイネ ルディヴィン
ジョン オドネル クリストファー
Christopher John O'donnell
ジョン オドネル クリストファー
アール． ロバーツ リー
R Roberts Lee
アール． ロバーツ リー
スター ジェレミー
Starr Jeremy
スター ジェレミー
エヌ．トゥミー ローレンス
N Tumey Lawrence
エヌ．トゥミー ローレンス
ピー． ウッチェロ ダニエル
P Uccello Daniel
ピー． ウッチェロ ダニエル
ヤング ジェニファー
Young Jennifer
ヤング ジェニファー
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Pfizer Inc
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Pfizer Inc
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Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JP2018058822A publication Critical patent/JP2018058822A/ja
Publication of JP2018058822A5 publication Critical patent/JP2018058822A5/ja
Priority to JP2022102984A priority Critical patent/JP7555998B2/ja
Priority to JP2024157625A priority patent/JP2024174998A/ja
Withdrawn legal-status Critical Current

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Pharmacology & Pharmacy (AREA)
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  • Cell Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017147506A 2016-08-03 2017-07-31 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用 Withdrawn JP2018058822A (ja)

Priority Applications (2)

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JP2022102984A JP7555998B2 (ja) 2016-08-03 2022-06-27 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用
JP2024157625A JP2024174998A (ja) 2016-08-03 2024-09-11 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用

Applications Claiming Priority (4)

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US201662370270P 2016-08-03 2016-08-03
US62/370,270 2016-08-03
US201762530554P 2017-07-10 2017-07-10
US62/530,554 2017-07-10

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JP2018058822A5 JP2018058822A5 (https=) 2020-08-13

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JP2017147506A Withdrawn JP2018058822A (ja) 2016-08-03 2017-07-31 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用
JP2022102984A Active JP7555998B2 (ja) 2016-08-03 2022-06-27 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用
JP2024157625A Withdrawn JP2024174998A (ja) 2016-08-03 2024-09-11 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用

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JP2024157625A Withdrawn JP2024174998A (ja) 2016-08-03 2024-09-11 ヘテロアリールスルホンをベースとするコンジュゲーションハンドル、これらの調製のための方法、および抗体薬物コンジュゲートの合成におけるこれらの使用

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US (1) US11712480B2 (https=)
EP (1) EP3493853A1 (https=)
JP (3) JP2018058822A (https=)
CA (1) CA3032559C (https=)
WO (1) WO2018025168A1 (https=)

Cited By (1)

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WO2023068325A1 (ja) * 2021-10-20 2023-04-27 国立研究開発法人産業技術総合研究所 抗ガン剤、抗ガン剤のプロドラッグ、体外でガン細胞を死滅させる方法、ガンの治療方法、及びガンの治療装置

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JP2015502397A (ja) 2011-12-23 2015-01-22 ファイザー・インク 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
EP3725798B1 (en) * 2017-12-15 2026-03-04 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Bioactive conjugate, preparation method therefor and use thereof
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