JP2018015537A - Clamp, medical tube and injection system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent such the problem that, when applied pressing force is released, blockage of the tube is automatically released and injection starts before opening of the tube.SOLUTION: A clamp 150 for blocking a tube includes: a fixing part 151 for fixing the tube; a movable part 155 having a projection part 154 projecting toward the fixing part 151 and displacing toward the fixing part 151 when being applied with pressing force; and a hinge part 156 connecting the movable part 155 to the fixing part 151. The hinge part 156 urges the movable part 155 in a direction of separating apart from the fixing part 151 when the pressing force is released.SELECTED DRAWING: Figure 4

Description

  The present invention relates to a clamp for closing a tube, and a medical tube and an injection system provided with the clamp.

  As medical fluoroscopic imaging apparatuses, for example, MRI (Magnetic Resonance Imaging) apparatus, CT (Computed Tomography) apparatus, Angio imaging apparatus, PET (Positron Emission Tomography) apparatus, SPECT (Single Photon Emission Computed Tomography) apparatus, CT Angio apparatus There are imaging devices such as MR angio devices, ultrasonic diagnostic devices, and blood vessel imaging devices. When a subject is imaged by these imaging devices, a plurality of types of drug solutions (for example, contrast medium and physiological saline) having different specific gravity or viscosity are mixed and injected into the body of the subject for the purpose of obtaining a clear image. There is a case.

  As a device for mixing chemical solutions, for example, a mixing device described in Patent Document 1 is known. The mixing device includes a swirl flow generation chamber for generating a swirl flow, a first inlet for introducing a contrast agent into the swirl flow generation chamber, and a first inlet for introducing physiological saline into the swirl flow generation chamber. 2 inflow ports, and a constriction chamber provided between the outflow port from which the mixed chemical solution flows out and the swirl flow generation chamber. And when bleeding the medical tube provided with this mixing device, the flow path in the medical tube may be closed.

  As a clamp for closing a tube, for example, in Patent Document 2, a main body and a sealing member are connected via a bending portion, and a locking mechanism is provided at an end of the main body and the sealing member opposite to the bending portion. There is disclosed a clamp provided. The tube is disposed in the clamp, and is closed by bending the curved portion and locking the ends of the main body and the sealing member. Thereafter, when the engagement between the ends is released, the ends are separated from each other by the biasing force generated by the bending portion, and the tube is opened.

JP 2011-217796 A JP 2009-273615 A

  In Patent Document 2, when the clamp is closed, it is locked by the locking mechanism, so that the tube is kept closed even when the pressing force is released. Therefore, the injection may be started by mistake before opening the closed tube. In this case, the drug solution is not injected into the subject when the tube is closed. However, since the imaging apparatus starts imaging in conjunction with the start of injection, the imaging apparatus performs useless imaging. Furthermore, when the piston of the syringe is pushed with the tube closed, a high pressure is applied to the syringe. Thereby, the syringe may be damaged.

  In order to solve the above-described problem, a clamp as an example of the present invention is a clamp that closes a tube, and includes a fixing portion that fixes the tube, a protruding portion that protrudes toward the fixing portion, and a pressing force. And a hinge part that connects the movable part and the fixed part, and the hinge part moves the movable part when the pressing force is released. The urging is performed in a direction away from the fixed portion.

  Moreover, the medical tube as another example of the present invention is a medical tube including a first tube and a clamp that closes the first tube, and the clamp fixes the first tube. A movable portion that displaces in a direction toward the fixed portion when a pressing force is applied, and a hinge portion that connects the movable portion and the fixed portion. The hinge part biases the movable part in a direction away from the fixed part when the pressing force is released.

  In addition, an injection system as another example of the present invention includes the medical tube and an injection device on which the first syringe and the second syringe are mounted.

  Accordingly, when the applied pressing force is released, the tube is automatically closed, so that it is possible to prevent the injection from being started before the tube is opened.

  Further features of the present invention will become apparent from the following description of embodiments, given by way of example with reference to the accompanying drawings.

1 is a schematic perspective view of an injection system. It is a schematic side view of the medical tube of 1st Embodiment of this invention. It is a schematic side view of a mixing device. It is a schematic perspective view of the clamp seen from the movable part side. It is a schematic side view of a clamp. It is a schematic perspective view of the clamp seen from the fixed part side. It is a schematic front view of a clamp. It is a schematic sectional drawing of the clamp at the time of cancellation | release of pressing force. It is a schematic sectional drawing of the clamp at the time of application of pressing force. It is the schematic of the medical tube of 2nd Embodiment of this invention. It is a schematic perspective view of the clamp seen from the movable part side. It is a schematic side view of a clamp. It is a schematic plan view of a clamp. It is a schematic bottom view of a clamp. It is the schematic rear view and schematic front view of a clamp. It is XVI-XVI sectional drawing of the clamp of FIG. It is a schematic side view which shows a use condition.

  Hereinafter, exemplary embodiments for carrying out the present invention will be described in detail with reference to the drawings. However, dimensions, materials, shapes, and relative positions of components described in the following embodiments are arbitrary, and can be changed according to the configuration of the apparatus to which the present invention is applied or various conditions. In addition, unless otherwise specified, the scope of the present invention is not limited to the embodiments specifically described below. In the present specification, “up and down” corresponds to an upward direction and a downward direction in the direction of gravity, respectively.

[First Embodiment]
FIG. 1 is a schematic perspective view of a chemical solution injection system 100 including a clamp 150 and a mixing device 110. As shown in FIG. 1, an injection system 100 for injecting a drug solution to a subject includes a first syringe 131 filled with a first drug solution (for example, a contrast agent) and a second syringe solution filled with a second drug solution (for example, physiological saline). An injection device 120 on which a syringe 132 is mounted is provided. The injection system 100 also includes a medical tube 140 connected to the first syringe 131 and the second syringe 132. Furthermore, the injection system 100 includes a first syringe 131 and a second syringe 132 attached to the injection device 120. The medical tube 140 is connected to the conduit portion at the distal end of the first syringe 131 and the conduit portion at the distal end of the second syringe 132.

  The injection device 120 includes an injection head 121 on which the first syringe 131 and the second syringe 132 are mounted, and a control device (not shown) that controls the injection head 121. The injection head 121 is wired to the control device via a metal cable and an optical cable. The control device and the injection head 121 may be wirelessly connected, for example, may be connected by a wireless method using a frequency band of 2.4 GHz to 5 GHz. In addition, a remote control device such as a hand switch can be wired or wirelessly connected to the injection head 121 or the control device. In addition, the power supply of the injection | pouring head 121 can be provided in the injection | pouring head 121 or a control apparatus. Further, a power source independent from the injection head 121 can be provided separately, and the power source can be replaced with a battery.

  The injection head 121 is mounted on a movable caster stand 122 placed on the floor, and is rotatably held on the upper part of the caster stand 122. Thereby, the attitude | position which orient | assigns the front end side (the side in which the 1st syringe 131 and the 2nd syringe 132 are mounted | worn) of the injection head 121 to a floor surface, and the rear end side (the 1st syringe 131 and the 2nd syringe 132) of the injection head 121. The injection head 121 can be rotated to a posture in which the side on which the is not attached is directed to the floor surface. In addition, it replaces with the caster stand 122, a ceiling suspension member is provided, and the injection | pouring head 121 can also be suspended from a ceiling via this ceiling suspension member.

  The injection head 121 is provided with a plurality of operation buttons 123 such as a forward button, an acceleration button, a backward button, a check button, and a start button. The user can manually operate the injection head 121 by operating the operation button 123. Specifically, the pressing portion of the injection head 121 moves forward while the user presses the forward button, and the pressing portion moves backward while the user presses the backward button. When the user presses the check button, the injection head 121 stands by in a state where injection is possible. Thereafter, when the user presses the start button, the injection head 121 advances the pressing portion and starts the injection of the chemical solution. Further, since the operation buttons are also displayed on the touch panel of the control device, the user can also inject the injection head 121 by operating the touch panel.

  Moreover, the injection head 121 has a drive mechanism (not shown). For example, the drive mechanism includes a transmission mechanism connected to the shaft of the motor, a screw shaft connected to the transmission mechanism, a feed screw nut attached to the screw shaft, and an actuator connected to the feed screw nut. The transmission mechanism includes a pinion gear connected to the shaft and a screw gear connected to the screw shaft. The transmission mechanism transmits the rotation from the motor to the screw shaft. Thereby, the rotation of the shaft of the motor is transmitted to the screw shaft via the pinion gear and the screw gear. Therefore, the screw shaft rotates in accordance with the transmitted rotation, and the feed screw nut slides in the forward direction or the reverse direction as the screw shaft rotates. As the feed screw nut slides, the pressing portion moves forward or backward.

  The injection head 121 is provided with two syringe receivers, and the first syringe 131 and the second syringe 132 are mounted on the syringe receiver. The first syringe 131 is filled with a first chemical solution (for example, contrast agent) having a large specific gravity, and the second syringe 132 is filled with a second chemical solution (for example, physiological saline) having a specific gravity smaller than that of the first chemical solution. Yes. Specific examples of the contrast agent include a contrast agent having an iodine concentration of 240 mg / mL (for example, a viscosity of 3.3 Pa · s at 37 ° C. and a specific gravity of 1.268 to 1.296), and a contrast agent having an iodine concentration of 300 mg / mL (for example, a viscosity of 6.1 at 37 ° C. mPa · s, specific gravity of 1.335 to 1.371), and a contrast agent having an iodine concentration of 350 mg / mL (for example, a viscosity of 10.6 mPa · s at 37 ° C. and a specific gravity of 1.392 to 1.433). A specific example of physiological saline is a physiological saline containing 180 mg of sodium chloride in 20 mL of physiological saline (for example, viscosity 0.9595 mPa · s at 20 ° C., specific gravity 1.004 to 1.006).

  Each of the first syringe 131 and the second syringe 132 is provided with a piston that can slide within the syringe. Then, when the motor rotates forward with the rear end of the piston in contact with the pressing portion, the pressing portion pushes the piston in the forward direction. When the piston moves forward, the drug solution in the syringe is pushed out and injected into the body of the subject through the medical tube 140 connected to the tip of the syringe. On the other hand, when the motor reverses, the pressing portion pulls the piston in the backward direction.

  The first syringe 131 and the second syringe 132 may be either a syringe filled with a chemical solution or an empty syringe not filled with a chemical solution. A syringe filled with a chemical solution includes a prefilled syringe prefilled with a chemical solution, a syringe obtained by manually filling an empty syringe with a chemical solution, and a user emptying with a suction device or a filling device. The syringe obtained by filling the syringe with a chemical solution is included. Further, when an empty syringe is mounted on the injection head 121, the user can fill the syringe with the chemical solution using the injection head 121, a suction device or a filling device.

  The first syringe 131 and the second syringe 132 can be provided with a data carrier such as an RFID (Radio Frequency Identifier) or a barcode. In this data carrier, for example, information on the filled chemical solution is recorded. The injection device 120 can read information recorded from the data carrier through the injection head 121 and control the injection pressure of the chemical solution. For example, the control device calculates the optimum injection amount per body weight based on the read information on the chemical solution (iodine amount, gadolinium content, sodium gadoxetate content, etc.) and displays it on the touch panel of the control device.

[Medical tube]
FIG. 2 is a schematic side view of the medical tube 140 including the clamp 150 along the longitudinal direction. As shown in FIG. 2, the medical tube 140 includes a flexible first tube 148 connected to the first syringe 131 filled with the first chemical solution via the one-way valve 141 and the first female connector 149, And a clamp 150 for closing the first tube 148. The clamp 150 crushes the first tube 148 and closes the flow path of the first chemical liquid flowing through the inside. The one-way valve 141 is connected to the first syringe 131 and prevents the chemical liquid from flowing back to the first syringe 131. Further, a first female connector 149 is joined to the one-way valve 141.

  The medical tube 140 includes a flexible second tube 143 that is connected to the second syringe 132 filled with the second chemical solution via the second female connector 142. The second female connector 142 is connected to the second syringe 132. Furthermore, the medical tube 140 includes a mixing device 110 for mixing the first chemical solution and the second chemical solution, and a flexible third tube 144 that communicates with the outlet 119 (FIG. 3) of the mixing device 110. I have.

  The medical tube 140 includes a male rotary lock connector 145 connected to the tip of the third tube 144. A removable liquid pool cap 147 is attached to the male rotary lock connector 145. The liquid reservoir cap 147 is used when the medical tube 140 is vented, and is removed when the chemical liquid is injected. A removable cap 146 is attached to the one-way valve 141 and the second female connector 142. The cap 146 is removed when the chemical solution is injected.

  The first tube 148 is joined to the first female connector 149 and the joint 160 of the mixing device 110. The second tube 143 is joined to the second female connector 142 and the conduit portion 115 of the mixing device 110. Further, the third tube 144 is joined to the conduit portion 116 of the mixing device 110. These flexible tubes can be formed from polyvinyl chloride and are joined together by, for example, solvent bonding. Note that the second tube 143 and the third tube 144 may be rigid tubes.

  The contrast agent pushed out from the first syringe 131 flows into the swirl flow generation chamber 112 of the mixing device 110 through the one-way valve 141, the first female connector 149, and the first tube 148. Further, the physiological saline pushed out from the second syringe 132 flows into the swirl flow generation chamber 112 through the second female connector 142 and the second tube 143. The contrast agent and the physiological saline are mixed in the swirl flow generation chamber 112 and the constriction chamber 113. Thereafter, the mixed drug solution of the contrast medium and physiological saline flows out from the outlet 119 to the third tube 144.

  For example, the mixing device 110, the first female connector 149, the second female connector 142, and the male rotary lock connector 145 can be formed from polycarbonate. Also, the cap 146 can be formed from polyethylene, while the valve 141 can be formed from polycarbonate and silicone rubber.

[Mixing device]
FIG. 3 is a schematic side view of the mixing device 110 along the longitudinal direction. In FIG. 3, the internal shape of the mixing device 110 is indicated by a dotted line.

  As shown in FIG. 3, the mixing device 110 includes a swirl flow generation chamber 112 for generating a swirl flow, a first inlet 117 for introducing the first chemical liquid into the swirl flow generation chamber 112, and a second chemical liquid. Between the swirl flow generating chamber 112 and the outflow port 119, the second inflow port 118 for introducing the swirl flow generating chamber 112, the outflow port 119 through which the mixed chemical liquid of the first chemical solution and the second chemical solution flows out, And a constriction chamber 113 having a space continuously constricted toward the outflow port 119. The mixing device 110 extends from the side surface of the swirl flow generation chamber 112 and is connected to the conduit portion 115 to which the second tube 143 is connected. The mixing device 110 is located on the downstream side of the constriction chamber 113 in the flow direction of the mixed drug solution and is third. A conduit portion 116 to which the tube 144 is joined is provided.

  The swirl flow generation chamber 112 has a substantially cylindrical outer shape and a curved inner surface that forms a substantially cylindrical inner space for concentrating the swirl flow in the axial direction. The swirl flow generation chamber 112 communicates with the constriction chamber 113 and has a joint 160 that joins the downstream end of the first tube 148 in the flow direction of the chemical solution. The joint 160 constitutes an upstream end face of the swirl flow generation chamber 112 in the chemical flow direction, and a first inlet 117 is formed in the joint 160. Further, the swirl flow generation chamber 112 is formed with a second inlet 118 that communicates with the second tube 143 inserted into the conduit portion 115. In addition, the cross-sectional shape in the short direction of the swirl flow generation chamber 112 may be formed from a circle, an ellipse, or other curves.

  The constriction chamber 113 is provided between the swirl flow generation chamber 112 and the outflow port 119 and is continuously narrowed in an axial symmetry toward the outflow port 119. That is, the constriction chamber 113 has a substantially funnel-shaped outer shape and a substantially truncated cone inner space coaxial with the inner space of the swirl flow generation chamber 112. Further, the constriction chamber 113 communicates with the outflow port 119 and has an inclined inner surface facing the outflow port 119 so as to form a funnel-shaped space. Thereby, the swirl flow generated in the swirl flow generation chamber 112 is concentrated in the direction of the central axis of the vortex. The inner shape of the constriction chamber 113 may be a shape that narrows toward the conduit portion 116 and may be formed from a moderately stepped inner surface.

  The conduit portion 115 has a substantially cylindrical shape and communicates with the second inlet 118 of the swirl flow generation chamber 112. The second inlet 118 opens in a curved shape along the shape of the curved inner surface of the swirling flow generation chamber 112. The conduit portion 115 is provided on a curved side surface outside the swirl flow generation chamber 112 and extends in the tangential direction of the circumference of the swirl flow generation chamber 112. That is, the conduit part 115 is provided at a position shifted from the central axis of the cylindrical space of the swirling flow generation chamber 112 to the peripheral side of the swirling flow generation chamber 112. As a result, a swirling flow of the chemical solution flowing in from the conduit portion 115 is generated in the swirling flow generating chamber 112.

  The conduit portion 116 has a substantially cylindrical shape, and the center line of the conduit portion 116 coincides with the center line of the first inflow port 117. That is, the first inlet 117, the swirl flow generation chamber 112, the constriction chamber 113, the outlet 119, and the conduit portion 116 are coaxial. Since each component part is arrange | positioned so that it may have a coaxial, the isotropy of the vortex which generate | occur | produces in the mixing device 110 can be improved. That is, vortices can be uniformly generated in the space without stagnation, and the mixing efficiency can be improved.

  The joint 160 of the swirl flow generation chamber 112 has a substantially cylindrical receiving portion 161 that receives the end of the first tube 148. The first tube 148 inserted into the joint 160 communicates with the swirl flow generation chamber 112 via the first inflow port 117. As a result, the chemical liquid having a large specific gravity that has passed through the first inlet 117 is introduced into the swirl flow generation chamber 112 in a direction parallel to the central axis of the swirling flow of the chemical liquid having a small specific gravity. That is, the chemical solution having a large specific gravity is introduced in a direction parallel to the central axis of the cylindrical space included in the swirl flow generation chamber 112.

[Mixed liquid]
When mixing a chemical solution, a high specific gravity chemical solution (contrast agent) from the first syringe 131 flows into the swirl flow generation chamber 112 from the first inlet 117 via the first tube 148. When the contrast agent flows into the swirl flow generation chamber 112, it becomes a jet flow. The momentum of the jet flow is diffused in the outer circumferential direction of the swirl flow generation chamber 112. That is, the contrast agent flow is diffused in the outer circumferential direction of the swirl flow generation chamber 112.

  Further, the chemical solution (physiological saline) having a small specific gravity from the second syringe 132 flows into the swirl flow generation chamber 112 from the second inlet 118 through the second tube 143. The physiological saline is guided from the second inlet 118 to the curved inner surface of the swirling flow generation chamber 112 and swirls along the curved inner surface. Then, the swirling flow of the physiological saline is guided to the constriction chamber 113 and concentrated in the central axis direction of the swirling flow (axial centering). Such a vortex is known as a Rankine vortex, and the inertial force of the swirling flow can be concentrated in the vicinity of the rotation axis of the vortex.

  In the swirl flow generation chamber 112, the jet flow of the contrast medium collides with the swirl flow of the physiological saline. Then, the swirling flow starts to form a swirling motion so as to involve the jet flow from the surroundings. Thereafter, the peak of the swirl strength of the swirl flow transitions from the outer peripheral side of the swirl flow generation chamber 112 so as to approach the central axis of the mixing device 110 as it goes toward the tip of the constriction chamber 113. Then, the jet flow is induced and caught in the vortex center of the swirl flow in which the swirl strength is focused in this way.

  According to the mixing device 110, a strong rotational force is applied to the contrast agent, which is a highly viscous fluid, and a centrifugal force is generated. As a result, the contrast agent is scattered in the outer peripheral direction of the swirl flow generation chamber 112. This flow structure is constructed continuously during the injection process, resulting in turbulence of the entire flow field in the mixing device 110. That is, the mixed liquid of the contrast medium and the physiological saline is guided into the constriction chamber 113 that is continuously constricted toward the outflow port 119, so that two fluids having different vectors actively collide with each other. . Thereby, the contrast agent can be wound around the center of the vortex and continuously scattered in the outer peripheral direction of the swirl flow generation chamber 112.

  As a result, the entire flow field is turbulent and the contrast agent and saline are mixed efficiently. Thereafter, the flow of the mixed drug solution of the contrast medium and physiological saline is rectified in the stenosis chamber 113. Then, the rectified mixed chemical liquid flows out from the outflow port 119 to the third tube 144.

[Clamp]
Subsequently, the clamp 150 will be described with reference to FIGS. 4 to 9. 4 to 8 show the clamp 150 in a state where the pressing force is released. 4 is a schematic perspective view of the clamp 150 as viewed from above, and FIG. 5 is a schematic side view of the clamp 150 along the longitudinal direction. FIG. 6 is a schematic perspective view of the clamp 150 as viewed from below.

  As shown in FIG. 4, the clamp 150 that closes the first tube 148 includes a fixing portion 151 (fixing hole 152) that fixes the first tube 148. The clamp 150 includes a movable portion 155 having a protruding portion 154 that protrudes toward the fixed portion 151. Further, the clamp 150 includes a hinge portion 156 that connects the movable portion 155 and the fixed portion 151. Such a clamp 150 can be formed by molding a resin (for example, polypropylene, nylon, or polyacetal).

  The fixing portion 151 has a pair of fixing holes 152 facing each other. As shown in FIG. 5, each of the pair of fixing holes 152 has an insertion port 158 into which the first tube 148 is inserted. The insertion port 158 has a width D2 narrower than the diameter D1 of the fixing hole 152. In other words, the length of the opening width of the insertion port 158 along the longitudinal direction of the clamp 150 is shorter than the length of the widest portion of the fixing hole 152 along the longitudinal direction.

  Therefore, when the first tube 148 is inserted into the fixing hole 152 and the clamp 150 is attached to the first tube 148, both ends of the insertion port 158 overlap the first tube 148. This prevents the clamp 150 from falling off the first tube 148. Note that the first tube 148 contacts both ends of the fixing hole 152 at the time of insertion. However, since the first tube 148 is crushed during insertion and returns to its original shape after insertion, both ends of the insertion port 158 do not hinder insertion of the first tube 148.

  Moreover, the fixing | fixed part 151 has a taper shape, and height is low as it goes to the edge part on the opposite side to the hinge part 156 from the fixing hole 152. As shown in FIG. Thus, when the pressing force is released, the distal end portion of the movable portion 155 is greatly separated from the fixed portion 151, so that the first tube 148 can be easily taken out.

  As shown in FIG. 6, the fixing portion 151 has an opening 153 located between the pair of fixing holes 152. The opening 153 communicates with the pair of fixing holes 152 and penetrates the fixing portion 151. The opening 153 is provided at a position facing the protruding portion 154 and has a larger size than the protruding portion 154. When the movable portion 155 is displaced, the protruding portion 154 is inserted into the opening 153.

  The movable portion 155 is displaced in the direction indicated by the arrow R toward the fixed portion 151 when a pressing force is applied. Then, as the movable portion 155 is displaced, the protruding portion 154 is received in the opening 153. As shown in FIG. 4, the movable portion 155 has a protrusion 157 provided on the outer surface of the movable portion 155 opposite to the protruding portion 154. The protrusion 157 has a substantially semi-cylindrical shape and extends in the width direction orthogonal to the longitudinal direction of the movable portion 155. Further, the protrusion 157 functions as a finger slip stopper when the user applies a pressing force to the movable portion 155. The number of protrusions 157 is not limited to three, and may be at least more than three.

  The protruding portion 154 of the movable portion 155 has a substantially triangular prism shape and extends in the longitudinal direction of the movable portion 155. Further, the height of the protrusion 154 is set so that the end of the protrusion 154 on the hinge part 156 side is not inserted into the opening 153 when the flow path is closed. Note that the protruding portion 154 may have other shapes such as a prismatic shape and a semi-cylindrical shape.

  The protrusion part 154 has a taper shape, and the width | variety becomes narrow as it goes to the fixing | fixed part 151 (FIG. 7). In addition, the tip of the protrusion 154 is rounded so as not to damage the first tube 148. Further, the protruding portion 154 is located at a position where it protrudes from the opening 153 when the pressing force is released. Therefore, the elasticity of the hinge portion 156 is set such that the protruding portion 154 is separated from the opening 153 by a predetermined distance when the pressing force is released. Thereby, when fixing the 1st tube 148, the protrusion part 154 does not inhibit the approach of the 1st tube 148.

  Subsequently, the clamp 150 will be described with reference to FIGS. 7 is a schematic front view of the clamp 150 viewed from the side opposite to the hinge portion 156, and FIG. 8 is a schematic cross-sectional view of the central portion of the clamp 150 along the line VIII-VIII in FIG. FIG. 9 shows a cross section corresponding to FIG. 8, and is a schematic cross section of the clamp 150 when a pressing force is applied. Moreover, in FIG. 9, the crushed 1st tube 148 is typically illustrated. Therefore, in FIG. 9, the first tube 148 is shown as if it is separated from the fixing hole 152. However, the actual first tube 148 is only slightly displaced downward from the fixing hole 152.

  The hinge portion 156 is a so-called living hinge, and is located between the fixed portion 151 and the movable portion 155 as shown in FIG. The hinge portion 156 is provided across the width direction orthogonal to the longitudinal direction of the fixed portion 151 and the movable portion 155. Further, the hinge portion 156 is thinner than the movable portion 155 so as to be easily deformed. The hinge portion 156 has a curved cross-sectional shape, and deforms when the user applies a pressing force to the movable portion 155. Specifically, the hinge portion 156 is deformed as the movable portion 155 approaches the fixed portion 151.

  As shown in FIG. 8, the opening area of the edge portion of the opening 153 opposite to the movable portion 155 side is widened so as to spread outward. Further, the pair of fixing holes 152 are opposed to the back side portion of the protruding portion 154, that is, the portion closer to the hinge portion 156 than the center. Thereby, since the distance between the fixing hole 152 and the protrusion part 154 becomes short, a flow path can be closed quickly.

  When a pressing force is applied to the movable portion 155 shown in FIG. 8 in the direction toward the fixed portion 151, the movable portion 155 moves until it comes into contact with the fixed portion 151 as shown in FIG. For example, the user can apply a pressing force by pressing the protrusion 157 of the movable portion 155 with a finger. The movable part 155 pushed down with the finger moves toward the fixed part 151. At this time, the hinge portion 156 is deformed with the movement of the movable portion 155. Then, the protruding portion 154 of the movable portion 155 abuts against the first tube 148 and is crushed. When crushed by the projecting portion 154, the first tube 148 is deformed and the space (flow path) through which the chemical solution flows is closed.

  When opening the flow path, the user releases the pressing force (releases the finger from the movable portion 155). When the pressing force is released, the hinge portion 156 biases the movable portion 155 in a direction away from the fixed portion 151. Thereby, the movable part 155 moves in the direction away from the fixed part 151 by the elasticity of the hinge part 156. When the pressing force is released, the hinge portion 156 biases the movable portion 155 until the entire protruding portion 154 comes out of the opening 153. As a result, when the movable portion 155 returns to the original position shown in FIG. 8, the protruding portion 154 is separated from the first tube 148. For this reason, the first tube 148 returns to its original shape, and a space in which the chemical solution flows in the tube is created (the flow path is opened).

[Preparation of chemical injection]
Next, preparation for injecting a chemical solution will be described with reference to FIG. 2 which is a schematic side view of the medical tube 140. First, the user removes the medical tube 140 from the sterilization bag and removes the cap 146. Then, the user connects the first syringe 131 filled with the contrast agent to the one-way valve 141. Similarly, the user connects the second syringe 132 filled with physiological saline to the second female connector 142.

  Next, the user performs priming for the purpose of bleeding. First, the user pushes the piston of the first syringe 131 to push out the contrast agent, and fills the first tube 148 with the contrast agent. Next, the piston of the second syringe 132 is pushed to push out the physiological saline, and the inside of the second tube 143, the mixing device 110, and the third tube 144 is filled with the physiological saline. At this time, since the one-way valve 141 is provided, the chemical solution does not flow backward to the first syringe 131 side.

  Thereby, the inside of the medical tube 140 is filled with the chemical solution. Excess chemical liquid is discharged from the male rotary lock connector 145 and stored in the liquid storage cap 147. Thereafter, the user visually looks for bubbles in the medical tube 140, and removes the liquid reservoir cap 147 when it is determined that air bleeding has been completed. Then, the user mounts the first syringe 131 and the second syringe 132 on the injection device 120. Note that when bleeding air, the physiological saline solution may be extruded into the mixing device 110 after the physiological saline solution is pushed out first, or the physiological saline solution and the contrast agent may be introduced into the mixing device 110 at the same time. .

  Subsequently, the user connects the male rotary lock connector 145 to an imaging catheter or an indwelling needle already placed in the body of the subject. Here, in order to confirm reverse blood, a pressing force is applied to the clamp 150 to close the flow path in the first tube 148. Then, the piston of the second syringe 132 is slightly pulled back while closing the flow path. When reverse blood can be confirmed, the user releases the pressing force applied to the clamp 150. Thereby, the first tube 148 is automatically opened.

  The first tube 148 is closed when the reverse blood is confirmed because when the piston of the second syringe 132 is pulled, the piston of the first syringe 131 connected to the second syringe 132 through the mixing device 110 moves forward. This is to prevent it. This is because when the piston of the first syringe 131 moves forward, the contrast agent is pushed out and consumed.

[Infusion of chemicals]
Next, the injection of the chemical solution will be described with reference to FIG. First, after mounting the first syringe 131 and the second syringe 132 on the injection device 120, the user turns on the power of the injection device 120. Then, the user operates the operation button 123 of the injection device 120 or the operation button displayed on the touch panel to input data necessary for creating the injection protocol to the control device. For example, the necessary data includes physical data of the subject such as body weight, height, body surface area, heart rate, and cardiac output, and data on the type of drug solution. Note that the user may turn on the power of the injection device 120 before mounting the syringe. Further, the injection protocol, the chemical solution data, and the like can be input to the control device from an external storage medium.

  The control device stores in advance a basic injection protocol such as an injection speed, an injection amount, an injection time, and an injection maximum pressure (injection pressure limit value), and data of a chemical solution. And a control apparatus determines the individual injection | pouring protocol suitable for an individual test subject according to the input data and the data memorize | stored previously. In addition, the control device displays predetermined data such as the injection speed, the injection amount, and the injection time on the touch panel. The user confirms the contents of the determined injection protocol and changes the contents if necessary. The injection protocol, drug solution data, and the like can be input to the control device from an external device such as an imaging device. The injection protocol may be locked with a password so that a third party cannot change it.

  The control device may display the injection protocol on an external device such as a portable display or a tablet computer. These devices are wirelessly connected to the injection head 121 or the control device of the injection device 120 according to a standard such as Bluetooth (registered trademark) or Wi-Fi, and can be used as a head display of the injection head 121.

  When the user confirms the injection protocol, the user presses the check button from among the operation buttons 123. Thereby, injection device 120 stands by in the state where injection is possible. Thereafter, the user starts injection by pressing the start button in the operation button 123 or the start button of the remote control device. Then, the injection device 120 automatically injects the chemical solution according to the injection protocol. Further, after or simultaneously with the injection of the chemical solution, the imaging device performs imaging of the subject. When the injection device 120 has a head display, the user can also start injection by pressing a start button displayed on the head display.

  According to the first embodiment described above, since the closing of the tube is automatically released when the pressing force applied to the movable portion 155 is released, the injection is prevented from starting before the tube is opened. it can. Further, according to the mixing device 110, the contrast agent, which is a fluid having a large specific gravity and a high viscosity, can be turbulent and efficiently mixed in the three-dimensional direction in the mixing device 110. As a result, the mixing efficiency can be significantly improved.

  Further, according to the mixing device 110, even with a small amount of contrast medium and physiological saline, a vortex can be generated in several tens of milliseconds. Therefore, the contrast agent and the physiological saline can be mixed in a short time, and a small amount of the contrast agent and the physiological saline can be reliably mixed. As a result, it is possible to suppress the occurrence of image unevenness.

[Second Embodiment]
The second embodiment will be described with reference to FIGS. 10 to 16. In the description of the second embodiment, differences from the first embodiment will be described, and description of the components described in the first embodiment will be omitted. Except where specifically described, the constituent elements having the same reference numerals perform substantially the same operations and functions, and the effects thereof are also substantially the same.

[Medical tube]
FIG. 10 is a schematic view along the longitudinal direction of the medical tube 140 including the clamp 250. In FIG. 10, the medical tube 140 includes a clamp 250 that closes the first tube 148. The clamp 250 crushes the first tube 148 and closes the flow path of the first chemical liquid that flows inside the first tube 148. The medical tube 140 including the clamp 250 of the second embodiment can be connected to the chemical solution injection system 100 of FIG.

  The clamp 250 is attached in advance to the first tube 148 so that the open end side of the clamp 250 faces the first syringe 131 side, that is, the first female connector 149 side. In other words, the clamp 250 is attached to the first tube 148 such that the hinge portion 256 (FIG. 11) faces the mixing device 110 side. In the attached state, the first tube 148 is inserted into the pair of fixing holes 252 (FIG. 11) of the clamp 250. The protrusion 254 (FIG. 11) of the clamp 250 extends in a direction intersecting the first tube 148.

[Clamp]
The clamp 250 will be described with reference to FIGS. 11 to 17. This clamp is used to sandwich a flexible medical tube and block the flow of liquid in the tube at the sandwiched portion. 11 to 16 show the clamp 250 in a state where the pressing force is released. FIG. 11 is a schematic perspective view of the clamp 250 as viewed from above. FIG. 12 is a schematic side view of the clamp 250 along the longitudinal direction, and the left and right side views are symmetrical. 13 is a schematic plan view of the clamp 250 as viewed from above, and FIG. 14 is a schematic bottom view of the clamp 250 as viewed from below. 15A is a schematic front view of the clamp 250, and FIG. 15B is a schematic rear view of the clamp 250. FIG. 16 is a schematic cross-sectional view when the clamp 250 is cut in the longitudinal direction along the line XVI-XVI in FIG. 13. FIG. 17 is a schematic side view showing a use state in which a pressing force is applied.

  As shown in FIG. 11, the clamp 250 includes a fixing portion 251 (first fixing hole 252 </ b> A) that fixes the first tube 148. That is, when inserted into the first fixing hole 252A, the first tube 148 is fixed to the fixing portion 251 at the insertion portion of the first tube 148. The clamp 250 includes a movable portion 255 having a protruding portion 254 protruding inside the clamp 250 so as to protrude toward the fixed portion 251. Further, the clamp 250 includes a hinge portion 256 that connects the movable portion 255 and the fixed portion 251. Such a clamp 250 can be formed by molding a resin (for example, polypropylene, nylon, or polyacetal).

  The fixed portion 251 is provided with a stopper 259 with which the bottom surface S of the movable portion 255 abuts. The movable portion 255 is displaced toward the fixed portion 251 by the applied pressing force until it comes into contact with the stopper 259. In a state where the movable portion 255 and the stopper 259 are in contact with each other, the first tube 148 is crushed between the protruding portion 254 and the fixed portion 251 (concave portion 253), and the internal flow path is closed. The user can perceive by hand that the movable part 255 and the stopper 259 are in contact with each other, or can visually recognize them with the eyes. Further, the user can perceive the click sound generated when the movable portion 255 and the stopper 259 come into contact with each other. Thereby, the user can confirm that the internal flow path of the 1st tube 148 was closed.

  The displacement of the movable part 255 is completed when the movable part 255 comes into contact with the stopper 259. Therefore, it is possible to prevent the user from applying an excessive force, so that damage to the first tube 148 can be suppressed. Furthermore, the bottom surface S of the movable part 255 and the top surface T of the stopper 259 are both substantially planar. Therefore, force is applied to the stopper 259 in the extending direction of the stopper 259 from the movable portion 255 (direction perpendicular to the top surface T). Thereby, it can prevent that force is applied from the direction inclined with respect to the stopper 259, and can suppress that the stopper 259 inclines with a pressing force.

  The fixing portion 251 has a first fixing hole 252A formed in the stopper 259, and the hinge portion 256 has a second fixing hole 252B. The first fixing hole 252A and the second fixing hole 252B face each other. As shown in the rear view of FIG. 15A and the front view of FIG. 15B, the second fixing hole 252B is narrower in width in the width direction perpendicular to the longitudinal direction of the clamp 250 than the first fixing hole 252A. That is, the second fixing hole 252B has a substantially elliptical shape. The second fixing hole 252B is narrower than the first fixing hole 252A in the width direction (extending direction of the protruding portion 254). Therefore, when the clamp 250 is observed from the front side (FIG. 15B), the outline of the second fixing hole 252B can be visually recognized through the first fixing hole 252A.

  The inner diameter of the first fixing hole 252A has substantially the same length as the outer diameter of the first tube 148. The width of the second fixing hole 252B is shorter than the outer diameter of the first tube 148. Therefore, due to the elasticity of the first tube 148, the outer surface of the first tube 148 and the inner peripheral surface of the second fixing hole 252B are in close contact with each other. Thereby, even if force is applied in the direction in which the clamp 250 rotates with respect to the first tube 148 (the direction in which the clamp 250 rotates around the central axis of the first tube 148), the clamp 250 can be prevented from rotating.

  As shown in FIG. 15A, the inner peripheral surface of the second fixing hole 252B is tapered from the inside to the outside of the clamp 250. That is, the inner peripheral surface of the second fixing hole 252 </ b> B has a shape that gradually narrows in the insertion direction of the first tube 148. Accordingly, when the clamp 250 is attached to the medical tube 140, the first tube 148 can be easily inserted into the second fixing hole 252B.

  Returning to FIG. 11, the fixing portion 251 has a concave portion 253 facing the protruding portion 254 between the hinge portion 256 and the stopper 259. In other words, the recess 253 is located between the first fixing hole 252A and the second fixing hole 252B. The recess 253 has a shape that is substantially complementary to the tip of the protrusion 254. Then, when a pressing force is applied to the movable portion 255 and the movable portion 255 and the stopper 259 are in contact with each other, the first tube 148 is pushed into the concave portion 253. That is, the protrusion 254 deforms the first tube 148 and pushes the deformed portion into the recess 253. The first tube 148 is easily deformed because the deformed portion is pushed into the recess 253. Thereby, the 1st tube 148 can be crushed with small force, and an internal channel can be closed.

  As shown in FIG. 12, the heights of the edge E1 and the edge E2 of the recess 253 are set to be substantially the same height from the bottom of the recess 253. That is, the height of both edge portions E1 and E2 of the recess 253 is from the tip of the protruding portion 254 to both edge portions E1 and E2 in a state where the movable portion 255 and the stopper 259 are in contact with each other with a pressing force applied. The distance is set to match. Therefore, in the part corresponding to the edge part E2, the thickness of the fixing | fixed part 251 is thicker than the part corresponding to the edge part E1. With this height setting, the first tube 148 can be uniformly deformed with respect to the recess 253.

  The tip of the fixed portion 251 is curved in a direction away from the movable portion 255. Further, the tip of the movable portion 255 is curved in a direction away from the fixed portion 251. Further, a plurality of first protrusions 257A (FIG. 13) are disposed on the upper surface of the movable portion 255, and a plurality of second protrusions 257B (FIG. 14) are disposed on the lower surface of the fixed portion 251. That is, the movable part 255 has a first protrusion 257A provided on the outer surface opposite to the protruding part 254. In addition, the fixing portion 251 has a second protrusion 257B provided on the outer surface opposite to the concave portion 253. The first protrusions 257A and the second protrusions 257B have a substantially hemispherical shape and are arranged in a matrix. With these configurations, the user's finger is caught by the fixed portion 251 and the movable portion 255, so that an anti-slip effect is exhibited. Note that the number of the first protrusions 257A and the second protrusions 257B is not limited to nine, and may be at least more than nine.

  The protruding portion 254 of the movable portion 255 is located between the hinge portion 256 and the stopper 259. The protruding portion 254 has a substantially triangular prism shape and extends in a direction (width direction) orthogonal to the longitudinal direction of the movable portion 255. Further, the height of the protruding portion 254 is set so that the distal end of the protruding portion 254 is not inserted into the recessed portion 253 in a state where a pressing force is applied to the movable portion 255 and the movable portion 255 and the stopper 259 are in contact with each other. ing. Note that the protruding portion 254 may have other shapes such as a prismatic shape and a semi-cylindrical shape.

  As shown in FIG. 16, which is a cross-sectional view along the longitudinal direction, the protruding portion 254 has a tapered shape, and the width becomes narrower toward the fixing portion 251. Further, the tip of the protrusion 254 is rounded so as not to damage the first tube 148. Furthermore, the tip of the protruding portion 254 is in a position in contact with a virtual line L that connects the center of the first fixing hole 252A and the center of the second fixing hole 252B when the pressing force is released. Therefore, the first tube 148 is inserted so as to contact the protruding portion 254 and push up the movable portion 255. When the pressing force is released and the movable portion 255 returns to the original position, the protruding portion 254 comes into contact with the first tube 148.

  As indicated by an arrow R, the movable portion 255 is displaced toward the fixed portion 251 when a pressing force is applied. As the movable portion 255 is displaced, the protrusion 254 approaches the recess 253. That is, when a pressing force is applied to the movable portion 255 in the direction toward the fixed portion 251, the movable portion 255 moves until it comes into contact with the stopper 259. For example, the user can apply a pressing force by pressing the first protrusion 257A of the movable portion 255 with a finger. The movable part 255 pushed down with the finger moves toward the fixed part 251. At this time, the hinge portion 256 is deformed with the movement of the movable portion 255.

  Next, the clamp 250 when a pressing force is applied will be described with reference to FIG. In FIG. 17, the crushed first tube 148 is schematically illustrated.

  In a state where the movable portion 255 is in contact with the stopper 259, the protruding portion 254 deforms and crushes the first tube 148. When crushed by the protruding portion 254, the internal flow path of the first tube 148 is closed. When opening the flow path, the user releases the pressing force (releases the finger from the movable portion 255). When the pressing force is released, the hinge portion 256 biases the movable portion 255 in a direction away from the fixed portion 251. As a result, the movable portion 255 moves away from the fixed portion 251 due to the elasticity of the hinge portion 256. When the pressing force is released, the hinge portion 256 urges the movable portion 255 so that the movable portion 255 is separated from the stopper 259. Then, the first tube 148 returns to its original shape, and the internal flow path of the first tube 148 is opened.

  The hinge portion 256 is a so-called living hinge and is located between the fixed portion 251 and the movable portion 255. In addition, the hinge portion 256 is provided across the width direction orthogonal to the longitudinal directions of the fixed portion 251 and the movable portion 255. Further, the hinge portion 256 has a curved cross-sectional shape, and is deformed when the user applies a pressing force to the movable portion 255. Specifically, the hinge portion 256 is deformed as the movable portion 255 approaches the fixed portion 251.

  According to the second embodiment described above, since the closing of the tube is automatically released when the pressing force applied to the movable portion 255 is released, the injection is prevented from starting before the tube is opened. it can. Furthermore, according to the second embodiment, the recessed portion 253 is formed in the fixed portion 251. Thereby, since the clamp 250 can be reduced in size compared with opening, the length of the 1st tube 148 can be shortened more. Therefore, the amount of contrast agent remaining in the first tube 148 can be reduced.

  Further, as shown in FIG. 16, since the upper surface of the movable portion 255 is recessed and the lower surface of the fixed portion 251 is curved, the user's finger is likely to be in close contact with the movable portion 255 and the fixed portion 251. Therefore, even when the user grips the clamp 250 from the first syringe 131 side (upstream side) or when the user grips the clamp 250 from the mixing device 110 side (downstream side), it is easy to apply a force to the clamp 250. In addition, also when using the clamp 250 of 2nd Embodiment, air bleeding, a reverse blood check, and injection | pouring of a chemical | medical solution are performed similarly to 1st Embodiment.

  In addition, it can replace with manual air bleeding and can also perform air bleeding automatically using the injection apparatus 120 or according to a user's operation. Specifically, the first syringe 131 and the second syringe 132 are mounted on the injection device 120, and the rear end side of the injection head 121 faces the floor surface. Next, the medical tube 140 is connected to the first syringe 131 and the second syringe 132. Then, the chemical liquid can be pushed out and air can be removed while the injection head 121 is kept perpendicular to the direction of gravity. Moreover, the chemical | medical solution to mix is not limited to a contrast agent and physiological saline. For example, one of the two types of liquid may be a mixed chemical solution of contrast medium and physiological saline, and the other may be physiological saline. In this case, the first syringe 131 is filled with a mixed drug solution (contrast medium and physiological saline) having a specific gravity and viscosity higher than that of physiological saline. The second syringe 132 is filled with physiological saline.

[Deformation]
The present invention has been described above with reference to each embodiment. However, the present invention is not limited to the above embodiment. Inventions modified within the scope not departing from the present invention and inventions equivalent to the present invention are also included in the present invention. Moreover, each embodiment and each modification can be combined suitably in the range which is not contrary to this invention.

  For example, a tapered portion can be formed between the inner surface of the swirl flow generation chamber 112 and the inner end surface of the swirl flow generation chamber 112 on the first inlet 117 side. In addition, a gentle curved surface can be provided at the boundary between the swirl flow generation chamber 112 and the constriction chamber 113 so that the inner surface of the constriction chamber 113 has a streamline shape. This makes it difficult for bubbles to adhere to the inner surface of the mixing device 110 and reduces the resistance.

  Further, a gentle curved surface can be formed on the outer surface of the mixing device 110, particularly on the boundary between the swirl flow generation chamber 112 and the constriction chamber 113. Further, the swirl flow generation chamber 112, the constriction chamber 113, and the conduit portion 116 have a common substantially cylindrical outer shape so that the swirl flow generation chamber 112, the constriction chamber 113, and the conduit portion 116 have a common curved side surface. It can be configured as follows. Thereby, when manufacturing with a metal mold | die, the shape of a metal mold | die can be simplified. Further, when manufacturing by cutting the base material, the amount of cutting can be reduced.

  Further, the swirl flow generation chamber 112 can also be configured to have a constriction shape that narrows as it approaches the constriction chamber 113. For example, the inner surface of the swirl flow generation chamber 112 and the inner surface of the constriction chamber 113 can be configured by a single surface that is inclined at the same inclination with respect to the central axis of the conical space that the swirl flow generation chamber 112 has. Further, the swirl flow generation chamber 112 is set so that the inclination of the inner surface of the constriction chamber 113 with respect to the central axis of the swirl flow generation chamber 112 is larger than the inclination of the inner surface of the swirl flow generation chamber 112 with respect to the central axis of the swirl flow generation chamber 112. A narrowed shape can be formed.

  Further, the swirl flow generation chamber 112, the constriction chamber 113, the joint portion 160, the conduit portion 115, and the conduit portion 116 may be integrally molded by the same member. Furthermore, the swirl flow generation chamber 112, the constriction chamber 113, the conduit portion 115, and the conduit portion 116 may be formed separately and joined together to form an integrated mixing device 110.

  Further, the inner diameter of the outlet 119 can be made larger than that of the first inlet 117. Furthermore, in the first and second embodiments, the length of the swirl flow generation chamber 112 in the direction along the center line C is shorter than the length of the constriction chamber 113. However, the swirl flow generation chamber 112 can be made longer than the constriction chamber 113 in order to ensure a sufficient volume.

  Further, the inner surface of the mixing device 110 can be subjected to a hydrophilic treatment. By performing the hydrophilic treatment, it is possible to prevent bubbles from adhering to the inner surface of the mixing device 110 when performing air bleeding. Examples of the hydrophilic treatment method include plasma treatment, ozone treatment, corona discharge treatment, glow discharge treatment, and ultraviolet irradiation treatment.

  In the medical tube 140 of FIG. 2, the length of the first tube 148 may be substantially the same as the width of the clamp 150. Accordingly, when the pistons of the first syringe 131 and the second syringe 132 are directed downward in the direction of gravity, the swirling flow generation chamber 112 can be held by the rigidity of the clamp 150 so that the conduit portion 116 faces upward. Therefore, when the air is released, the chemical liquid flows also to the corner on the joint 160 side by gravity, so that the air bubbles remaining in the corner can be washed away and discharged from the mixing device 110. Furthermore, when the conduit portion 116 of the mixing device 110 filled with the chemical solution is directed upward, the air in the first tube 148 and the mixing device 110 can be discharged from the outlet 119 by buoyancy. For example, the user can encourage the discharge of air by buoyancy by applying an impact to the mixing device 110 with a finger. The same applies to the medical tube 140 of FIG.

  Further, a three-way cock may be provided in place of the one-way valve 141, and a one-way valve or a three-way cock may be joined to the second female connector 142. One valve or a three-way stopcock may be provided on both the first tube 148 and the second tube 143, and one valve or a three-way stopcock may be provided on one of the first tube 148 and the second tube 143.

  110: mixing device, 112: swirl flow generation chamber, 113: constriction chamber, 117: first inlet, 118: second inlet, 119: outlet, 140: medical tube, 143: second tube, 144: Third tube, 148: first tube, 150: clamp, 151: fixed part, 152: fixed hole, 153: opening, 154: projecting part, 155: movable part, 156: hinge part, 158: insertion port, 250: Clamp, 251: fixed portion, 252A: first fixed hole, 252B: second fixed hole, 253: recessed portion, 254: protruding portion, 255: movable portion, 256: hinge portion, 259: stopper, bottom surface: S, top surface : T, E1: Edge, E2: Edge

Claims (17)

A clamp for closing the tube,
A fixing portion for fixing the tube;
A movable portion that has a protruding portion that protrudes toward the fixed portion, and that is displaced toward the fixed portion when a pressing force is applied;
A hinge portion connecting the movable portion and the fixed portion;
The hinge part is a clamp that urges the movable part in a direction away from the fixed part when the pressing force is released.   The clamp according to claim 1, wherein a stopper with which the movable part abuts is disposed on the fixed part.   The clamp according to claim 2, wherein a bottom surface of the movable part and a top surface of the stopper are planar. The fixing portion has a first fixing hole formed in the stopper,
The clamp according to claim 2 or 3, wherein the hinge portion has a second fixing hole.   The clamp according to claim 4, wherein the second fixing hole is narrower than the first fixing hole in a width direction of the clamp.   The clamp according to any one of claims 2 to 5, wherein the protruding portion is located between the hinge portion and the stopper.   The said fixing | fixed part is a clamp of Claim 6 which has the recessed part facing the said protrusion part between the said hinge part and the said stopper.   The height of both edges of the recess is set so that the distance from the tip of the protrusion to the edges coincides with each other in a state where the pressing force is applied. Clamp.   The clamp according to any one of claims 1 to 8, wherein a tip of the fixed portion is curved in a direction away from the movable portion. The fixing portion has a pair of fixing holes,
Each of the pair of fixing holes has an insertion port into which the tube is inserted,
The clamp according to claim 1, wherein the insertion port is narrower than a diameter of the fixing hole. The fixing portion has a pair of fixing holes,
The clamp according to claim 1, wherein the fixing portion has an opening into which the protruding portion is inserted between the pair of fixing holes.   The clamp according to claim 11, wherein when the pressing force is released, the hinge portion biases the movable portion until the entire protruding portion comes out of the opening.   The clamp according to any one of claims 1 to 12, wherein the projecting portion has a tapered shape, and the width becomes narrower toward the fixed portion.   The clamp according to any one of claims 10 to 13, wherein the fixing portion has a tapered shape, and the height thereof decreases toward an end portion opposite to the hinge portion. A medical tube comprising a first tube and a clamp for closing the first tube,
The clamp includes a fixed portion that fixes the first tube, a protruding portion that protrudes toward the fixed portion, a movable portion that is displaced in a direction toward the fixed portion when a pressing force is applied, and the movable portion And a hinge part for connecting the fixed part,
The hinge part is a medical tube that urges the movable part in a direction away from the fixed part when the pressing force is released. A swirl flow generation chamber for generating a swirl flow, a first inlet for introducing a first chemical into the swirl flow generation chamber, and a second flow for introducing a second chemical into the swirl flow generation chamber Provided between an inlet, an outlet from which the mixed chemical of the first chemical and the second chemical flows, and the swirl flow generation chamber and the outlet, and continuously narrows toward the outlet. A mixing device having a constricted chamber with a
A second tube communicating with the second inlet;
The medical tube according to claim 15, further comprising a third tube communicating with the outflow port.   An injection system comprising the medical tube according to claim 15 and an injection device on which the first syringe and the second syringe are mounted.

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