JP2024024140A - Chemical liquid mixing device, chemical liquid injection system, and chemical liquid mixing method - Google Patents

Abstract

The present invention provides a chemical liquid mixing device, a chemical liquid injection system, and a chemical liquid mixing method that can uniformly and efficiently mix a plurality of types of chemical liquids at a desired concentration during injection. A chemical liquid mixing device according to the present invention includes a first container containing a first chemical liquid, a second container containing a second chemical liquid, and connected to the first container via a first flow path. a mixer that is connected to the second container via a second channel and mixes the first chemical solution and the second drug solution; and a third container that is connected to the mixer via a third channel. By making the inside of the third container a negative pressure with respect to the inside of the mixer, the first chemical solution is transferred from the first container and the second drug solution is transferred from the second container to the mixer. and the mixed liquid is introduced into the third container. [Selection diagram] Figure 5

Description

The present invention relates to a chemical liquid mixing device for mixing two types of chemical liquids, a chemical liquid injection system for injecting the mixed medical liquid, and a method for mixing chemical liquids.

Currently, medical fluoroscopic imaging devices include CT (Computed Tomography) scanners, MRI (Magnetic Resonance Imaging) devices, PET (Positron Emission Tomography) devices, ultrasound diagnostic devices, CT angiography devices, and MR angiography devices. equipment, angiography equipment, etc. There is a device. When using these devices, a mixture of multiple types of medicinal solutions with different specific gravity and viscosity is injected into the patient's body in order to obtain clear images. For example, when injecting a mixture of a contrast agent diluted with physiological saline, the contrast agent and physiological saline are mixed together, and then the mixture is injected into the patient's body.

Patent Document 1 discloses that a contrast medium container and a physiological saline container are connected to a syringe via a cock that switches the flow path, and a plunger inserted into the syringe and a flow path opening/closing means are operated to separate the contrast medium and physiological saline. It is described that the saline solution is sequentially introduced into the syringe to form a mixed solution. A mixture of the contrast agent and physiological saline mixed in the syringe is injected into the patient from the discharge port through the channel opening/closing means and through the indwelling needle punctured into the patient's blood vessel.

Special Publication No. 2008-047699

However, when a liquid mixture is prepared using the apparatus disclosed in Patent Document 1 and injected into a patient, there is a risk that the contrast medium and physiological saline may be injected without being mixed well. In other words, since the contrast agent and physiological saline have different specific gravity and viscosity, there is a risk that the contrast agent layer with a higher specific gravity and the physiological saline layer with a lower specific gravity may separate into two layers.

As a result, the two types of chemical liquids are mixed in a plane within the plane where the layer of the chemical liquid with high specific gravity and the layer of the chemical liquid with low specific gravity are in contact, that is, within the two-dimensional plane. However, since it is difficult to mix a contrast medium with a high viscosity and a saline solution with a low viscosity, there is a risk that the contrast medium and saline solution may be injected while being separated into two layers. Note that, hereinafter, in this specification, the above-mentioned planar mixing will be referred to as two-dimensional mixing.

If the drug solution is injected with the two layers separated in this way, the concentration of the injected contrast medium will vary depending on the location. As a result, there is a possibility that unevenness may occur in images captured by the fluoroscopic imaging device. Such image unevenness may make it difficult to identify a lesion, and may also prevent blood vessels from being clearly imaged.

In order to solve this problem, a method can be considered in which the contrast medium and physiological saline are mixed in advance. However, since the amount of contrast medium to be injected differs from patient to patient, in the pre-mixing method, it is necessary to mix the contrast medium and physiological saline independently each time an image is taken. Furthermore, there is a possibility that the mixed drug solution will be contaminated when the contrast agent and physiological saline are mixed.

In order to solve the above problem, the chemical liquid mixing device according to the present invention includes a first container that stores a first chemical liquid, a second container that stores a second chemical liquid, and a liquid mixture that connects the first container and the first flow path. a mixer that is connected to the second container via a second flow path and mixes the first chemical liquid and the second chemical liquid; and a mixer that is connected to the mixer via a third flow path. 3 containers, and by making the inside of the third container a negative pressure with respect to the inside of the mixer, the first chemical solution is removed from the first container and the second drug solution is removed from the second container. , the liquid mixture is simultaneously introduced into the mixer and mixed, and the mixed liquid is introduced into the third container.

Further, the drug solution injection system according to the present invention includes the drug solution mixing device according to the present invention, a head to which the syringe is attached, a controller connected to the head, and a drug solution injection system connected to the third container. It is characterized by having a mixed liquid injection path for injecting.

Further, in the method for mixing chemical solutions according to the present invention, a first container containing a first drug solution, a second container containing a second drug solution, and a first container connected to the first container and the second container, the first container being connected to the first container and the second container. A method for mixing a chemical liquid in a chemical liquid mixing device having a mixer for mixing a chemical liquid and the second chemical liquid, and a third container connected to the mixer, the inside of the third container being the inside of the mixer. By creating a negative pressure in It is characterized by being introduced into three containers.

According to the present invention, it is possible to uniformly and efficiently mix a plurality of types of drug solutions at a desired concentration during injection without performing the mixing operation as a separate and independent operation. Therefore, it is possible to prevent unevenness in images taken by the fluoroscopic imaging device.

FIG. 1 is a perspective view of a liquid drug injection system according to a first embodiment. FIG. 2 is a perspective view of a head connecting a mixing tube and a syringe of the chemical liquid injection system according to the first embodiment. FIG. 3 is a perspective view of a mixing tube. FIG. 2 is a perspective view of a mixer with tubes connected thereto. It is a perspective view of a mixer. FIG. 2 is a schematic diagram of a longitudinal section of a mixer with tubes connected thereto. FIG. 3 is a schematic diagram of a longitudinal section of the mixer. 7 is a sectional view taken along line VIII-VIII in FIG. 6. FIG. 8 is a sectional view taken along line IX-IX in FIG. 7. FIG. FIG. 3 is a conceptual diagram in a longitudinal cross section for explaining the flow within the mixer. FIG. 11 is a schematic cross-sectional view taken along the line XI-XI in FIG. 10 for explaining the flow within the mixer. FIG. 2 is a schematic longitudinal cross-sectional view of the mixer according to the first embodiment. FIG. 7 is a schematic longitudinal cross-sectional view of a mixer according to a second embodiment. It is a schematic diagram of the longitudinal cross section of the mixer based on 3rd Embodiment. It is a schematic diagram of the longitudinal cross section of the mixer based on 4th Embodiment. FIG. 3 is a perspective view of a liquid drug injection system according to a second embodiment. It is a perspective view of the head which connected the mixing tube and syringe of the chemical|medical solution injection system based on 2nd Example.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a chemical liquid mixing device, a chemical liquid injection system, and a chemical liquid mixing method according to the present invention will be described in detail with reference to the accompanying drawings. Note that the embodiments described below do not limit the configuration according to the claims of the present application. Although a plurality of features are described in this embodiment, not all of these features are essential, and a plurality of features may be arbitrarily combined. Furthermore, in the attached drawings, the device according to the present embodiment is drawn on a different scale from the actual size in order to make it easier to understand, and the same or similar components are given the same reference numbers and duplicates are used. The explanation will be omitted.

FIG. 1 shows a perspective view of a liquid drug injection system 100 according to a first embodiment of the present invention. This drug injection system 100 includes a drug solution injection device 200 (injector) for injecting a drug solution such as a contrast medium into a patient, a syringe 201 attached to the drug solution injection device 200, and a mixing tube 300 connected to the syringe 201. It is equipped with Further, a fluoroscopic imaging device (not shown) is connected to the main unit 212 of the liquid drug injection system 100, and various data are transmitted and received between the fluoroscopic imaging device and the liquid drug injection system 100 when injecting a drug solution and photographing an image. .

The chemical injection device 200 includes a head 210 to which a syringe 201 is attached, and a main unit 212 connected to the head 210 via a head cable 211. This main unit 212 is connected to a power source (not shown) via a power cable 218. Note that in FIG. 1, the syringe 201 is shown housed in a syringe protective case.

The syringe 201 is filled with a mixture of a contrast agent and physiological saline. The syringe (third container) 201 is connected via the mixer 1 to a first container 401 containing a contrast medium (first drug solution) 403 and a second container 402 containing physiological saline (second drug solution) 404. ing. The contrast agent 403 in the first container 401 and the physiological saline 404 in the second container 402 are mixed in the mixer 1 when being sucked into the syringe 201, and introduced into the syringe 201 as a mixed liquid. Details will be described later.

Specific examples of the contrast agent 403 include a contrast agent with an iodine concentration of 240 mg/mL (for example, a viscosity of 3.3 mPa·s at 37°C, a specific gravity of 1.268 to 1.296), a contrast agent with an iodine concentration of 300 mg/mL (for example, , a contrast agent with a viscosity of 6.1 mPa·s and a specific gravity of 1.335 to 1.371 at 37°C, and an iodine concentration of 350 mg/mL (for example, a contrast agent with a viscosity of 10.6 mPa·s and a specific gravity of 1.392 to 1.433 at 37°C). ) etc. Further, specific examples of the physiological saline 404 include physiological saline containing 180 mg of sodium chloride in 20 mL of physiological saline (for example, viscosity 0.9595 mPa·s at 20°C, specific gravity 1.004 to 1.006), etc. There is.

The head 210 is rotatably held at the top of a stand pole 217 on a movable stand base 216 placed on the floor. As a result, the head 210 is placed in an attitude in which the distal end side of the head 210 (the side to which the syringe 201 is attached) faces the floor, and an attitude in which the rear end side of the head 210 (the side to which the syringe 201 is not attached) faces the floor. Can rotate.

Console 213 includes a touch panel and is connected to hand switch 214 via a cable. Further, the console 213 functions as a controller, and is connected to the main unit 212 via a console cable 215, as well as to the head 210 via the main unit 212 and cables 215, 211. The main unit 212 is connected to the head 210 via a head cable 211. When injecting a medical solution into a patient, an operator operates a touch panel to input physical data of the patient such as injection speed, injection amount, injection time, weight, data on the type of medical solution, and the like.

Further, the console 213 stores in advance data on operation patterns (injection protocols), data on drug solutions, and the like. The console 213 then calculates optimal injection conditions according to the input data and pre-stored data. Thereafter, the console 213 determines the amount of drug solution to be injected into the patient and the injection protocol based on the calculated injection conditions.

After determining the amount of drug solution and the injection protocol, the console 213 displays predetermined data or graphs on the touch panel. The operator confirms the displayed data or graphs, and can start injection using the injection head, hand switch, or start button (including a physical button or touch panel) on the console. Note that when injection is started by pressing the button on the hand switch 214, the injection may be performed only while the button on the hand switch 214 is being pressed.

FIG. 2 shows a perspective view of the head 210 of the liquid medicine injector 200 of the liquid medicine injection system 100 and the mixing tube 300. The syringe 201 attached to the head 210 has conduit sections 202 and 203 at its tip. Note that in FIG. 2, the syringe 201 is shown housed in a syringe protective case.

The conduit section 202 communicates with the catheter 103 via a flexible tube (mixed liquid injection path) 105, a branch pipe (not shown), a catheter hub 104, and the like.

Conduit section 203 is connected to mixing tube 300 via flexible tube 106. The mixing tube 300 is connected to a first container 401 containing a contrast agent 403 and a second container 402 containing a physiological saline solution 404.

FIG. 3 shows a perspective view of a mixing tube 300. The mixing tube 300 includes a mixer 1, a first tube (first channel) 301, a second tube (second channel) 302, and a third tube (third channel) 303. The first tube 301 connects the first container 401 and the mixer 1, the second tube 302 connects the second container 402 and the mixer 1, and the third tube 303 connects the flexible tube 106 and the mixer 1. do. Then, a medical solution with a high specific gravity (contrast medium, first medical solution) passes through the first tube 301 , a medical solution with a small specific gravity (physiological saline, second medical solution) passes through the second tube 302 , and a third tube 303 . The mixed chemical solution (first mixed solution) passes through. Note that in this embodiment, the first tube 301, the second tube 302, and the third tube 303 are flexible tubes. However, these tubes may also be rigid tubes.

The first tube 301 has a first connection part 304 connected to a first container 401 containing a contrast agent 403. Further, the second tube 302 has a second connection portion 305 that is connected to a second container 402 containing physiological saline 404 . Further, the third tube 303 has a third connection portion 306 that is connected to the flexible tube 106. Note that the first connecting portion 304, the second connecting portion 305, and the third connecting portion 306 are connected by a method such as a screw connection or bonding.

Although a configuration has been illustrated in which the conduit portion 203 of the syringe 201 is connected to the mixing tube 300 via the flexible tube 106, the present invention is not limited to this configuration. The conduit portion 203 of the syringe 201 may be configured to be directly connected to the third connection portion 306 of the mixing tube 300. The conduit section 203 of the syringe 201 and the third connection section 306 of the mixing tube 300 may be connected to each other in a removable manner by, for example, a screw connection, or in a fixed connection by joining or the like. Good too.

Further, a check valve can be provided in the first tube 301 or the second tube 302. By providing the check valve, it is possible to prevent the mixed chemical liquid and the like from flowing back into the first container 401 and the second container 402 side. Further, the check valve may be provided in the third tube 303.

The syringe 201 includes a cylinder, a seal member (not shown) that slides within the cylinder, and a plunger (not shown) that is connected to the seal member and operates to move the seal member. The syringe 201 is fixed to the syringe protection case with the plunger attached. This syringe protection case is fixed to the head 210 by a syringe clamper.

Furthermore, the head 210 is provided with a syringe presser (not shown). This syringe presser engages with a locking portion of a plunger attached to the syringe 201 and operates to move the plunger in and out of the syringe. In addition, during drug suction, the contrast medium 403 from the first container 401 and the physiological saline 404 from the second container 402 are drawn through the flexible tube 106 connected to the conduit section 203 at the tip of the syringe 201 and the mixer 1. Fill the syringe 201. At this time, the syringe presser advances the plunger to the tip of the syringe in the axial direction of the syringe 201, and then retreats it to the rear end of the syringe.

When the inside of the syringe 201 is made negative pressure by the operation of the plunger, the contrast medium and physiological saline are sucked, flow into the mixer 1 of the mixing tube 300, and are mixed in the mixer 1. Thereafter, the mixed drug solution of contrast agent and physiological saline flows into the syringe 201 via the third tube 303 and the flexible tube 106.

When injecting a drug, a flexible tube 105 is attached to the conduit section 202 at the tip of the syringe 201 and communicated with the catheter 103 via a branch tube, catheter hub 104, etc. (not shown). The syringe presser then moves the plunger forward in the axial direction of the syringe 201. As a result, the mixed liquid in the syringe 201 is pushed out, and the medicinal liquid is injected into the patient's blood vessel via the catheter 103.

Note that the mixing tube 300 is equipped with a backflow prevention mechanism, such as a check valve, for preventing flow from the syringe 201 side to the first container 401 side and the second container 402 side. This backflow prevention mechanism prevents the liquid mixture in the syringe 201 from flowing into the first container 401, the second container 402, or the mixer 1 even if the inside of the syringe 201 is pressurized by the operation of the plunger.

Note that the conduit portion 203 of the syringe 201 may be equipped with a backflow prevention mechanism, such as a check valve, for preventing flow from the syringe 201 toward the mixing tube 300 side. This backflow prevention mechanism prevents the mixed liquid in the syringe 201 from flowing into the mixing tube 300 even if the inside of the syringe 201 is pressurized by the operation of the plunger.

Further, the conduit portion 202 at the tip of the syringe 201 and/or the flexible tube 105 are equipped with a backflow prevention mechanism, such as a check valve, to prevent the flow toward the syringe 201 side. It's okay. This backflow prevention mechanism prevents the flow from the flexible tube 105 attached to the conduit section 202 at the tip of the syringe 201 to the syringe 201 even if the inside of the syringe 201 becomes a negative pressure state due to the operation of the plunger. There isn't. That is, when the contrast medium and physiological saline are sucked into the syringe 201 and mixed, air, liquid medicine, patient's blood, etc. can be prevented from being sucked into the syringe 201 from the catheter 103 side and flowing into the syringe 201.

Note that, before injection of the chemical solution, priming is performed for the purpose of removing air. There are several methods for this priming, and the inside of the mixing tube 300 is filled with physiological saline, a contrast agent, or a mixed solution. Specifically, the inside of the syringe 201 is made negative pressure by the operation of the plunger, and the contrast agent 403 is sucked out from the first container 401 and the physiological saline 404 from the second container 402. As a result, the first tube 301 is filled with a contrast agent, the second tube 302 is filled with physiological saline, and the mixer 1 and third tube 303 are filled with a mixture of physiological saline and contrast agent.

Furthermore, when the backward movement of the plunger is continued to create a negative pressure in the syringe 201, the liquid mixture flows into the syringe 201 through the third tube 303. As a result, the entire flow path within the mixing tube 300 is filled with the chemical solution, and air is removed.

Next, the head 210 is rotated so that the rear end side of the head 210 (the side to which the syringe 201 is not attached) faces the floor. In this posture, the plunger is operated to pressurize the inside of the syringe 201. Since the air inside the syringe 201 gathers in the upper part of the distal end of the syringe 201, the flexible tube 105 is connected to the gas vent passage (not shown) provided at that position and the conduit part at the distal end of the syringe 201. The air inside the syringe 201 is discharged to the outside of the syringe 201 through. For example, priming for the purpose of air removal is performed in this way.

As the mixer 1, a mixer such as a T-shaped joint, a Y-shaped joint, or a static mixer can be used. The chemical liquid mixing device of this embodiment employs a mixer that achieves mixing of chemical liquids using a spiral flow described later.

4 and 5 show perspective views of a mixer 1 according to the invention. FIG. 4 shows the mixer 1 to which the first tube 301, the second tube 302, and the third tube 303 are connected, and FIG. 5 shows the mixer 1 to which these tubes are not connected.

The mixer 1 of this embodiment includes a first chamber that is a swirling flow generation chamber 2 that generates a swirling flow, and a second chamber that is a constricted chamber 3 that concentrates the swirling flow in the axial direction. The swirling flow generation chamber 2 of this embodiment has a cylindrical outer shape and a cylindrical internal space. Further, the constricted chamber 3 of this embodiment has a funnel-shaped outer shape and a conical inner space coaxial with the inner space of the swirling flow generation chamber 2 .

Note that the shape of the inner surface of the cylindrical outer shape of the swirling flow generation chamber 2 in a cross section perpendicular to the axis can be various shapes such as a circle, an ellipse, and other curved lines. Further, the swirling flow generation chamber 2 may be configured to have a constricted shape in which the inner diameter becomes smaller as it approaches the constricted chamber 3. In this case, the inner surface of the swirling flow generation chamber 2 and the inner surface of the constriction chamber 3 can be configured with surfaces that connect at the same inclination with respect to the symmetry axis of the conical space that the swirling flow generation chamber 2 has. Further, the swirling flow generation chamber 2 is arranged such that the inclination of the inner surface of the constriction chamber 3 with respect to the symmetry axis of the swirling flow generation chamber 2 is larger than the inclination of the inner surface of the swirling flow generation chamber 2 with respect to the symmetry axis of the swirling flow generation chamber 2. A constriction shape can be constructed.

In FIG. 5, the flow direction A of the mixed chemical solution is indicated by an arrow. A cylindrical first conduit section 4 connected to the first tube 301 is provided at a position on the upstream side in the flow direction A from the center of the swirling flow generation chamber 2 so as to extend along the flow direction A. It is being Similarly, a cylindrical second conduit portion 5 connected to the second tube 302 is also provided at a position upstream from the center of the swirling flow generation chamber 2 . Furthermore, a cylindrical third conduit portion 6 connected to the third tube 303 is provided at a position downstream from the center of the constriction chamber 3 in the flow direction A.

The first conduit portion 4 into which the chemical liquid with a high specific gravity flows communicates with the first inlet 14 (FIG. 7) of the swirling flow generation chamber 2. Therefore, the first conduit portion 4 is provided at the center of the front outer end surface 11A of the swirling flow generation chamber 2 on the upstream side in the flow direction A. Further, the third conduit section 6 through which the mixed chemical solution flows out is arranged such that the center line of the third conduit section 6 and the center line of the first conduit section 4 coincide, that is, so that the two are coaxial. It is provided at the end of the outlet 16.

On the other hand, the second conduit portion 5 into which the chemical liquid with low specific gravity flows communicates with the second inlet 15 of the swirling flow generation chamber 2 . Therefore, the second conduit portion 5 is provided on the external curved side surface of the swirl flow generation chamber 2, and extends in the tangential direction of the circumference of the swirl flow generation chamber 2, which has a circular cross section. In other words, the second conduit portion 5 of this embodiment is provided at a position shifted toward the peripheral edge of the swirling flow generating chamber 2 from the central axis of the cylindrical space that the swirling flow generating chamber 2 has. As a result, a swirling flow of the chemical liquid having a low specific gravity flowing from the second conduit portion 5 is generated.

In this embodiment, the contrast medium flows in from the first conduit section 4, and the physiological saline flows in from the second conduit section 5. Then, in the swirling flow generation chamber 2 and the constriction chamber 3, the contrast agent and physiological saline are mixed. Thereafter, the mixed drug solution of contrast agent and physiological saline flows out from the third conduit section 6.

Note that, as long as a vortex is generated within the swirling flow generation chamber 2, the dimensions may be such that an appropriate volume is formed from the second conduit portion 5 to the constriction chamber 3. Therefore, if there is sufficient volume from the second conduit section 5 to the constriction chamber 3, the second conduit section 5 may be provided near the center of the swirling flow generation chamber 2. However, even in this case, the second conduit portion 5 is provided on the side surface of the swirl flow generation chamber 2 and extends in the tangential direction of the circumference of the swirl flow generation chamber 2 .

6 and 7 show schematic longitudinal cross-sections of the mixer 1 according to the invention. Specifically, FIGS. 6 and 7 include the center lines of the first conduit section 4, the swirling flow generation chamber 2, the constriction chamber 3, and the third conduit section 6, and are parallel to the axial direction of the second conduit section 5. It is a schematic diagram of a cross section. Furthermore, portions that do not appear in the cross section along the center line are also shown by dotted lines for convenience. Note that FIG. 6 shows the mixer 1 to which the first tube 301, the second tube 302, and the third tube 303 are connected, and FIG. 7 shows the mixer 1 to which these tubes are not connected.

The swirling flow generation chamber 2 has a curved inner surface 17 that is a cylindrical inner surface that forms a columnar space. The second inlet 15 is configured such that the axis of the second inlet 15 is perpendicular to the axis of the swirl flow generation chamber 2, and the cylinder forming the flow path of the second inflow port 15 and the swirl flow generation chamber The two curved cylindrical inner surfaces 17 are configured to have a common tangential plane. Thereby, the chemical liquid flowing in from the second inlet 15 generates a swirling flow. Further, the constricted chamber 3 is provided between the swirling flow generation chamber 2 and the outlet 16 and has a constricted shape that is continuously narrowed toward the outlet 16. Furthermore, the constriction chamber 3 has an inner surface 18 that is inclined toward the outlet 16 so as to form a funnel-shaped space, and communicates with the swirling flow generation chamber 2 . As a result, the generated swirling flow is concentrated in the direction of the center axis of the vortex.

Further, the first conduit portion 4 into which the contrast medium flows is communicated with the swirling flow generation chamber 2 via the first inlet 14 . Thereby, the chemical liquid having a high specific gravity that has passed through the first inlet can be introduced into the swirling flow generation chamber 2 in a direction parallel to the central axis of the swirling flow of the chemical liquid having a low specific gravity. That is, the chemical liquid having a high specific gravity is introduced in a direction parallel to the central axis of the cylindrical space that the swirling flow generation chamber 2 has. Further, the second conduit portion 5 into which the physiological saline flows is in communication with the swirling flow generation chamber 2 via the second inlet 15 . Thereby, physiological saline can be introduced into the swirl flow generation chamber 2 so that a swirl flow is generated in the swirl flow generation chamber 2.

Further, the second conduit portion 5 extends in a direction perpendicular to the central axis of the swirling flow generation chamber 2 . Further, the swirling flow generation chamber 2 communicates with the large-diameter opening 12 of the constriction chamber 3 at a boundary C indicated by a dotted line in the figure. Further, the constricted chamber 3 communicates with an outflow port 16 via a small-diameter opening 13 . Note that in this embodiment, the second conduit portion 5 extends within a plane perpendicular to the symmetry axis of the swirling flow generation chamber 2. However, the second conduit portion 5 can also extend obliquely with respect to a plane perpendicular to the symmetry axis of the swirling flow generation chamber 2 .

In this embodiment, the center line of the first inlet 14, the center axis of the swirling flow generation chamber 2, the center axis of the constriction chamber 3, and the center line of the outlet 16 are all straight lines indicated by dotted lines in the figure. B (center line of mixer 1). By arranging the constituent parts so as to have coaxes in this manner, the isotropy of the vortex generated within the mixer 1 can be enhanced. In other words, the vortex can be generated uniformly within the space without stagnation, and the mixing efficiency can be improved.

The first tube 301 is joined within the first receiving portion 21 formed inside the first conduit portion 4 . Further, the third tube 303 is joined within the third receiving portion 23 formed inside the third conduit portion 6. Note that the first tube 301 and the third tube 303 may be threadedly connected to the first receiving part 21 and the third receiving part 23.

By the way, if the flow rate of the chemical liquid with low specific gravity is slow, there is a possibility that the inertial force of the swirling flow will be attenuated due to the flow colliding with the chemical liquid with high specific gravity that stagnates and remains in the mixer 1 at the start of injection. When the inertial force is attenuated, the swirling strength becomes insufficient, making it impossible to generate a vortex in a short period of time. Alternatively, it takes a long time to grow the generated vortex until the flow velocity of the vortex becomes sufficiently high. Therefore, the mixing efficiency of the chemical solution decreases.

Therefore, in this embodiment, the inner diameter of the second inlet 15 indicated by the dotted line in the figure is made narrower than the inner diameter of the first inlet 14. That is, the second inlet 15 into which the chemical liquid with a low specific gravity flows is narrower than the first inlet port 14 into which the chemical liquid with a high specific gravity flows. Specifically, the inner diameter of the second inlet 15 is approximately two-thirds to one-third the inner diameter of the first inlet 14. For example, when the first inlet 14 has an inner diameter of 1.5 mm, the second inlet 15 has an inner diameter of 1 mm to 0.5 mm.

As a result, when injecting a chemical liquid at a predetermined pressure, the flow rate of a chemical liquid with a low specific gravity flowing in from the second inlet 15 having a small cross-sectional area is lower than that of a chemical liquid having a high specific gravity flowing in from the first inlet 14 having a large cross-sectional area. faster than the flow velocity. However, the present invention is not limited to a configuration in which the flow rate of the chemical liquid with a lower specific gravity is made faster than the flow rate of the chemical liquid with a higher specific gravity, and the flow rates of both can be made to be the same speed. In this case, for example, the inner diameter of the second inlet 15 is the same as the inner diameter of the first inlet 14.

In this example, the inner diameter of the swirling flow generation chamber 2 and the inner diameter of the large-diameter opening 12 of the constriction chamber 3 are 7.5 mm, and the inner diameter of the small-diameter side opening 13 and the outflow port 16 of the constriction chamber 3 is 1.5 mm. It is 5mm. Further, the inclined inner surface 18 of the constriction chamber 3 is inclined by 15 degrees with respect to the central axis of the constriction chamber 3. Furthermore, in the flow direction A parallel to the central axis of the swirling flow generating chamber 2, which is indicated by an arrow in FIG. It is.

Note that these dimensions are just examples, and the dimensions of the mixer 1 according to the present invention are not limited to these. For example, the inclined inner surface 18 of the constriction chamber 3 may be configured such that the internal space of the constriction chamber 3 narrows in an axially symmetrical manner as it approaches the outlet 16. Further, it is more preferable that the angle at the boundary C between the swirling flow generation chamber 2 and the constriction chamber 3 changes gradually. This is because if there is a part with a large angle change, that is, a corner, a resistance force will be generated at that part.

In the chemical liquid mixing and injection device of this embodiment, by creating a negative pressure in the syringe 201, the medical liquid flows into the mixer 1 from the first container 401 and the second container 402. Therefore, the flow rate of the chemical solution in the first container 401 and the second container 402 flowing into the mixer 1 is determined by the diameter of the first inlet 14, the diameter of the second inlet 15, and the pressure difference before and after the first inlet 14. , the pressure difference before and after the second inlet 15, the temperature, the viscosity of each chemical solution, etc. In order to mix two liquids as a mixed chemical solution with a constant concentration distribution, it is necessary to maintain a constant flow rate balance of the chemical solutions from the first container 401 and the second container 402. Therefore, in order to maintain a constant flow rate balance of the medicinal solutions from the first container 401 and the second container 402, the temperature, the viscosity of each medicinal solution, the level of negative pressure inside the applied syringe 201, etc. are taken into consideration. A first inlet 14 and a second inlet 15 are designed. Parameters related to the design of the first inlet 14 and the second inlet 15 include the opening diameter and the cross-sectional shape of the orifice including the flow direction.

In addition to the design of the first inlet 14 and the second inlet 15, a mechanism (flow rate adjustment mechanism) for adjusting the opening area of the chemical liquid flow path is provided in at least one of the first tube 301 and the second tube 302. It may be made to have. In the examples shown in FIGS. 1 to 3, the flow rate adjustment mechanism 307 is arranged in the second tube 302, which is the flow path for the physiological saline 404.

According to the configuration of the present invention, the contrast medium 403 and physiological saline 404 are introduced into the mixer 1, mixed, and inserted into the syringe 201 in order to introduce the mixed solution (mixed drug solution) into the syringe 201. The head 210 controls the operation of the plunger. Therefore, compared to a method in which the contrast medium 403 and physiological saline 404 are prepared in syringes and the driving of the plungers of the two syringes is synchronously controlled, the mixing method of the present invention efficiently mixes the drug solution with simpler control. Can be mixed.

Further, the inner surface of the mixer 1 according to the present invention can be subjected to a hydrophilic treatment. By performing the hydrophilic treatment, it is possible to prevent air bubbles from adhering to the inner surface of the mixer 1 when air is removed. Examples of methods for this hydrophilic treatment include plasma treatment, ozone treatment, corona discharge treatment, glow discharge treatment, and ultraviolet irradiation treatment. In addition, when performing the hydrophilic treatment, the treatment is performed on at least one surface of the curved inner surface 17 of the swirling flow generation chamber 2, the front inner end surface 11B of the swirling flow generation chamber 2, or the inclined inner surface 18 of the constriction chamber 3. Ru.

8 and 9 are schematic diagrams in a cross section that is perpendicular to the central axis D of the swirling flow generation chamber 2 and includes the axis of the second conduit portion 5. FIG. Note that FIG. 8 shows the mixer 1 to which the second tube 302 is connected, and FIG. 9 shows the mixer 1 to which the second tube 302 is not connected.

The second tube 302 into which physiological saline flows is joined within the second receiving portion 22 formed inside the second conduit portion 5. Further, the second conduit portion 5 extends parallel to a tangent to the inner circumferential circle in a cross section perpendicular to the axis of the swirling flow generation chamber 2 . The second conduit portion 5 is provided so as to be continuous from the curved side surface of the outer periphery of the swirling flow generation chamber 2 . Therefore, the second inlet 15 opens in a curved shape along the shape of the curved inner surface 17 of the swirling flow generation chamber 2 . Note that the second tube 302 may be threadedly connected to the second receiving portion 22.

Mixing using the swirling flow generated in the mixer 1 according to the present invention will be described with reference to FIGS. 10 and 11. In addition, hereinafter, in this specification, the process of mixing by the swirling flow generated in the mixer 1 will be referred to as a spiral flow. In FIGS. 10 and 11, the flow of the contrast agent, which is a medical solution with a high specific gravity, is shown by a solid line arrow, and the flow of physiological saline, which is a medical solution with a low specific gravity, is shown by a dotted line arrow. The dotted circle in FIG. 11 schematically shows the position of the central axis D of the swirling flow generation chamber 2.

The contrast agent flowing into the mixer 1 from the first container 401 via the first tube 301 becomes a jet flow shown by arrow E when it flows into the swirling flow generation chamber 2 from the first inlet 14 having a small inner diameter. The momentum of the jet flow is then diffused in the outer circumferential direction of the swirling flow generation chamber 2 as shown by arrow F. That is, the flow of the contrast agent becomes a flow that is diffused in the outer circumferential direction of the swirling flow generation chamber 2.

On the other hand, the physiological saline flowing into the mixer 1 from the second container 402 via the second tube 302 is guided from the second inlet 15 to the curved inner surface 17 of the swirl flow generation chamber 2, as shown by arrow G. A swirling flow swirls along the curved inner surface 17. The swirling flow of physiological saline is then guided into the constriction chamber 3 and concentrated in the direction of the central axis of the swirling flow (axial centering). Such a vortex is known as a Rankine vortex, and can concentrate the inertial force of the swirling flow near the rotation axis of the vortex.

As shown in FIG. 10, in the swirling flow generation chamber 2, the contrast agent jet collides with the swirling flow of physiological saline. Then, the swirling flow starts to form a swirling motion so as to involve the jet flow from its surroundings. Thereafter, the peak of the swirling strength of the swirling flow transitions from the outer circumferential side of the swirling flow generating chamber 2 toward the central axis of the mixer 1 as it moves toward the constricted chamber 3 . Then, the jet flow is guided and drawn into the vortex center of the swirling flow where the swirling strength is focused in this way.

This applies a strong rotational force to the contrast medium, which is a highly viscous fluid, and thus generates centrifugal force. As a result, the contrast agent scatters toward the outer circumference of the swirling flow generation chamber 2. This flow structure is constructed continuously during the injection process, resulting in a turbulent flow throughout the flow field within the mixer 1. Thereafter, the flow of the mixed drug solution of contrast agent and physiological saline is rectified in the constriction chamber 3. Then, the rectified mixed chemical solution flows out from the outlet 16 to the third tube 303.

In other words, the mixed chemical solution of contrast agent and physiological saline is guided into the constriction chamber 3 that is continuously constricted toward the outlet 16, so that the two fluids with different vectors actively collide. . Thereby, the contrast agent can be drawn into the center of the vortex and continuously scattered toward the outer circumferential direction of the swirling flow generation chamber 2. As a result, the entire flow field becomes turbulent and the contrast agent and saline are mixed efficiently.

In this way, by introducing the jet of contrast agent in a direction parallel to the axis of rotation of the swirling flow of physiological saline, the swirling flow and the jet actively collide. Thereby, the contrast agent, which is a fluid with a large specific gravity and high viscosity, can be made into a turbulent flow and mixed efficiently in three-dimensional directions within the mixer 1. As a result, mixing efficiency is significantly improved compared to two-dimensional mixing. Note that in this specification, such three-dimensional mixing will be referred to as three-dimensional mixing.

Furthermore, even with a small amount of contrast medium and saline, a vortex can be generated in several tens of milliseconds. Therefore, according to the spiral flow using the mixer 1 of the present invention, it becomes possible to mix the contrast medium and physiological saline in a short time, and also to reliably mix a small amount of the contrast medium and physiological saline. be able to. As a result, it is possible to prevent the occurrence of image unevenness.

Furthermore, the mixer 1 of the present invention can exhibit higher mixing efficiency than a T-shaped joint under a wide range of conditions in which the total flow rate of contrast medium and saline is 0.6 to 10 mL/sec. Furthermore, high mixing efficiency can be achieved even under conditions where the flow rate of the contrast medium is higher than the flow rate of physiological saline, for example, when the flow rate of the contrast medium is four times that of physiological saline.

In the case of spiral flow using the mixer 1 according to the present invention, the contrast agent and physiological saline are almost completely mixed in several tens of milliseconds by three-dimensional mixing. Therefore, the mixed chemical solution flowing out from the outlet 16 is not separated into two layers.

By using the chemical liquid mixing device of the present invention, chemical liquids can be mixed with high efficiency.

Next, referring to FIG. 12, a first embodiment of the present invention will be described. Note that the same reference numerals are used for the same components as in the above embodiment, and explanations thereof will be omitted.

In the embodiment shown in FIG. 7, the curved inner surface 17 of the swirl flow generation chamber 2 and the inner end surface 11B on the first inlet 14 side constitute a corner 30. Air bubbles tend to adhere to such corners. Furthermore, if the angle change at the corner is large, the resistance will also be large. Therefore, in the first embodiment shown in FIG. 12, a tapered portion 31 is formed between the curved inner surface 17 of the swirling flow generation chamber 2 and the inner end surface 11B on the first inlet 14 side. This makes it difficult for air bubbles to adhere to the inner surface of the swirling flow generation chamber 2, and also makes it possible to reduce resistance.

A second embodiment of the present invention will be described with reference to FIG. Note that the same reference numerals are used for the same components as in the above embodiment, and explanations thereof will be omitted.

In the embodiment shown in FIG. 7, a corner 32 exists at the boundary C between the swirling flow generation chamber 2 and the constriction chamber 3. Therefore, in the second embodiment, the inner surface of the constriction chamber 3 has a streamlined shape, and a gently curved surface 33 is provided at the boundary between the swirling flow generation chamber 2 and the constriction chamber 3. Further, a curved portion 34 is formed at the boundary between the curved inner surface 17 of the swirling flow generation chamber 2 and the inner end surface 11B on the first inlet 14 side. This makes it difficult for air bubbles to adhere and reduces resistance. In the second embodiment shown in FIG. 13, the boundary between the swirling flow generation chamber 2 and the constriction chamber 3 outside the mixer 1 is also formed by a gently curved surface. However, the external boundary between the swirling flow generation chamber 2 and the constriction chamber 3 may be formed by a corner, as in the above embodiment.

A third embodiment of the present invention will be described with reference to FIG. Note that the same reference numerals are used for the same components as in the above embodiment, and explanations thereof will be omitted.

In the embodiment shown in FIG. 7, the constriction chamber 3 has a funnel-shaped outer shape, and the swirling flow generating chamber 2 has a cylindrical outer shape. However, when the external shapes are different in this way, when manufacturing the mixer 1 using a mold, it is necessary to prepare a mold with a complicated shape, which increases the manufacturing cost. Further, when manufacturing the mixer 1 by cutting the base material, the amount of the base material to be scraped increases and the manufacturing time becomes longer.

Therefore, in the third embodiment shown in FIG. 14, the external curved side surface of the swirling flow generation chamber 2 is extended to the constriction chamber 3 and the third conduit portion 6. That is, the swirling flow generation chamber 2, the constriction chamber 3, and the third conduit section 6 have a common curved side surface 35, and the swirling flow generation chamber 2, the constriction chamber 3, and the third conduit section 6 have a cylindrical outer shape. It consists of Thereby, when manufacturing with a mold, the shape of the mold can be simplified. Furthermore, when manufacturing by cutting the base material, the amount of cutting can be reduced.

Note that the mixing tube 300 according to the present invention includes an optical sensor, an ultrasonic sensor, a static A capacitance sensor or the like may also be provided. For example, when an air detector is disposed outside the mixer 1, an attachment part for attaching the air detector can be formed on the outer surface of the mixer 1.

A fourth embodiment of the present invention will be described with reference to FIG. 15. Note that the same reference numerals are used for the same components as in the above embodiment, and explanations thereof will be omitted.

In the embodiment shown in FIG. 7, the swirling flow generation chamber 2, the constriction chamber 3, the first conduit section 4, the second conduit section 5, and the third conduit section 6 are integrally constructed of the same member. However, the first inlet 14, the second inlet 15, and the outlet 16, which have smaller inner diameters than the swirling flow generation chamber 2 and the constriction chamber 3, have higher strength than the swirling flow generation chamber 2 and the constriction chamber 3. required. Therefore, in the fourth embodiment shown in FIG. 15, a first conduit section 4 having a first inlet 14, a second conduit section 5 having a second inlet 15, and a third conduit section 6 having an outlet 16 are used. , the swirling flow generating chamber 2 and the constriction chamber 3 are composed of members 36, 37, and 38 separate from each other.

That is, the first conduit section 4 is constituted by another member 36, the second conduit section 5 is constituted by another member 37, and the third conduit section 6 is constituted by another member 38. Thereby, the first conduit section 4, the second conduit section 5, and the third conduit section 6 can be formed of a material with higher strength than the swirling flow generation chamber 2 and the constriction chamber 3. Note that the first conduit section 4, the second conduit section 5, and the third conduit section 6 can be connected to the swirling flow generation chamber 2 and the constriction chamber 3 by a method such as joining or screw connection.

Note that various modifications can be made to the mixer 1 within the scope of the present invention. For example, the inner diameter of the outlet port 16 can be made larger than that of the first inlet port 14 in order to reduce the resistance to the mixed chemical solution flowing out. Furthermore, in order to ensure sufficient volume, the length of the swirling flow generating chamber 2 in the direction along the central axis of the swirling flow generating chamber 2 can be made longer than the length of the constricted chamber 3.

Furthermore, in the above embodiment, a case was described in which two types of chemical solutions, a contrast medium and physiological saline, were mixed. However, one of the two types of chemical solutions is used as a contrast agent with a first concentration filled in the first container 401, and the other of the two types of drug solutions is used as a contrast agent with a second concentration different from the first concentration filled in the second container 402. It may also be used as a contrast agent. In that case, the specific gravity and viscosity of the contrast agent at the first concentration are greater than the specific gravity and viscosity of the contrast agent at the second concentration.

FIG. 16 shows a perspective view of a chemical liquid injection system 101 according to Example 2 of the present invention.
The chemical liquid injector 250 of the chemical liquid injection system 101 of the second embodiment is different from the first example in that the head 260 is configured to be able to drive the second syringe 205 in addition to the first syringe 201. The first syringe 201 has the same configuration as in Example 1, in which the contrast medium and saline are introduced into the mixer 1 and mixed by driving a plunger (not shown) to produce a mixed solution (first mixed solution). Therefore, detailed explanation thereof will be omitted. The second syringe 205 is filled with a medical solution (third medical solution) such as physiological saline.

Moreover, a plunger (not shown) is attached to both the first syringe 201 and the second syringe 205. The first syringe 201 and the second syringe 205 are fixed to the syringe protection case with the plunger attached. This syringe protection case is fixed to the head 260 by a syringe clamper.

Furthermore, the head 260 is provided with two syringe pressers (not shown). This syringe presser engages with locking portions of plungers attached to the first syringe 201 and the second syringe 205, and operates to move the plungers in and out of the respective syringes. Note that suction of the medicinal liquid into the first syringe 201 is performed as described in Example 1, so a description thereof will be omitted here.

To aspirate the drug into the second syringe 205, a filling suction tube (not shown) is attached to the conduit portion 206 at the tip, and the drug (in this case, physiological saline) is filled from the drug bag through the suction tube. At this time, the syringe presser advances the plunger to the tip of the syringe in the axial direction of the second syringe 205, and then retreats it to the rear end of the syringe.

When injecting a drug solution, a mixing tube 310 is attached to the conduit portions 202 and 206 at the tips of the first syringe 201 and the second syringe 205. Then, each syringe presser advances each plunger in the axial direction of the first syringe 201 and the second syringe 205. As a result, the mixture of contrast agent and physiological saline in the first syringe 201 and the physiological saline in the second syringe 205 are pushed out. Note that the two syringe pressers can be driven separately or simultaneously.

The extruded mixed liquid and physiological saline flow into the mixer (second mixer) 110 of the mixing tube 310 and are mixed in this mixer 110. Thereafter, the mixed drug solution and the physiological saline mixed drug solution (second mixed solution) mixed in the mixer 110 are injected into the patient's blood vessel via the catheter 103.

Note that, before injection of the chemical solution, priming is performed for the purpose of removing air. There are several methods for this priming, and the inside of the mixing tube 310 is filled with either a mixture of contrast agent and physiological saline, or a medical solution of physiological saline. Specifically, first, the mixed liquid is extruded from the first syringe 201, and the fourth tube 111 up to the mixer 110 is filled with the mixed liquid.

Next, physiological saline is pushed out from the second syringe 205 to fill the fifth tube 112, mixer 110, sixth tube 113, and from the sixth tube 113 to the catheter 103 with physiological saline. As a result, the mixing tube 310 and the entire medical liquid circuit from the mixing tube 310 to the catheter 103 are filled with the medical liquid, and air is removed.

Alternatively, there is also a method of first extruding the mixed liquid from the first syringe 201, then extruding the physiological saline from the second syringe 205, and then simultaneously extruding the medical solution from the first syringe 201 and the second syringe 205. Furthermore, there is a method of first extruding physiological saline from the second syringe 205 and then extruding the mixed liquid from the first syringe 201 to fill the entire medicinal liquid circuit with the medicinal liquid.

In addition to these methods, there is also a method of first extruding the physiological saline from the second syringe 205, then extruding the mixed liquid from the first syringe 201, and then extruding the medical solution from the first syringe 201 and the second syringe 205 at the same time. In addition, there is also a method of simultaneously extruding the medical liquid from the first syringe 201 and the second syringe 205 from the beginning to fill the entire medical liquid circuit with the medical liquid.

Note that, as in the first embodiment, the mixing tube 300 is equipped with a check valve, for example, to prevent the flow from the first syringe 201 side to the first container 401 side and the second container 402 side. Equipped with a backflow prevention mechanism. Due to this backflow prevention mechanism, even if the inside of the first syringe 201 becomes pressurized due to the operation of the plunger, the liquid mixture inside the first syringe 201 will not flow into the first container 401, the second container 402, or the mixer 1. Never.

Note that the conduit portion 203 of the first syringe 201 may be equipped with a backflow prevention mechanism, such as a check valve, to prevent the flow from the first syringe 201 to the mixing tube 300 side. . This backflow prevention mechanism prevents the liquid mixture in the first syringe 201 from flowing into the mixing tube 300 even if the inside of the first syringe 201 is pressurized by the operation of the plunger.

In addition, the conduit portion 202 at the tip of the first syringe 201, the conduit portion 206 at the tip of the second syringe 205, and the mixing tube 310 are provided with a A backflow prevention mechanism, such as a check valve, may be provided. Note that the backflow prevention mechanism (check valve) of the second syringe 205 has a configuration in which it is removed (does not function) when suctioning into the second syringe 205 and is attached (functions) after suctioning into the second syringe 205. It's good to have.

This backflow prevention mechanism prevents the flow from the mixing tube 310 side to the first syringe 201 side and the second syringe 205 side even if the inside of the first syringe 201 and the second syringe 205 become negative pressure due to the operation of the plunger. It will never occur. That is, when the contrast medium and saline are sucked into the first syringe 201 and mixed, air, liquid medicine, patient's blood, etc. are drawn into the first syringe 201 and the second syringe 205 from the catheter 103 and mixing tube 310 side. It can be prevented from being sucked into and flowing into.

Although a configuration has been illustrated in which the conduit portion 203 of the first syringe 201 is connected to the mixing tube 300 via the flexible tube 106, the present invention is not limited to this configuration. The conduit section 203 of the first syringe 201 may be directly connected to the third connection section 306 of the mixing tube 300. The connection between the conduit part 203 of the first syringe 201 and the third connection part 306 of the mixing tube 300 may be made detachable by a method such as a screw connection, or may be fixedly connected by joining or the like. It may also be a configuration.

As the mixer 110 of the mixing tube 310, it is preferable to use the mixer that achieves mixing of the chemical liquid by spiral flow, as described in Example 1 with reference to FIGS. 4 to 15.

The mixer 110 is disposed vertically or tilted so that the outflow port 16 is located below the first inflow port 14 . In addition, when arranged in this way, the central axes of the first inlet 14, the swirling flow generation chamber 2, and the constriction chamber 3 become parallel to the direction of gravity or are inclined toward the direction of gravity. In other words, the central axes of the first inlet 14, the swirling flow generation chamber 2, and the constriction chamber 3 are perpendicular to the floor surface or are inclined. That is, the flow direction A (FIG. 7) of the mixed chemical solution is oriented in the direction of gravity.

In this way, by directing the flow direction A of the mixed chemical in the mixer 110 toward the direction of gravity, the axial symmetry of the mixed chemical in the mixer 110 increases. Therefore, even when the influence of the specific gravity of the chemical liquids to be mixed is large, effective mixing of the chemical liquids can be achieved. In other words, even if the difference in specific gravity of the chemicals to be mixed is large, or if the influence of specific gravity is relatively strong due to the small inertia of the chemicals to be mixed (low rotation speed), effective mixing of the chemicals can be achieved. is achieved.

As a configuration for arranging the mixer 110 in this manner, a configuration in which the mixer 110 is fixed to the chemical liquid injection device 250 in parallel to the direction of gravity can be considered. Alternatively, a configuration may be considered in which a relay table is disposed between the drug solution injector 250 and the patient, and the mixer 110 is fixed on the relay table in parallel to the direction of gravity. Furthermore, a configuration can be considered in which the fourth tube 111 and the fifth tube 112 are made of rigid tubes bent toward the floor surface, and the mixer 110 is held parallel to the direction of gravity. In addition to these, the fourth tube 111 and the fifth tube 112 may be made sufficiently long so that the mixing tube 310 hangs down from the chemical liquid injector 250 toward the floor, and the mixer 110 is held parallel to the direction of gravity. Conceivable.

In the configuration of the second embodiment, before being injected into the patient, the drug solution is necessarily mixed with high efficiency in the mixer 110 using the spiral flow of the mixing tube 310.

According to the configuration of the chemical liquid injection system 101 of the second embodiment, the contrast medium can be diluted and mixed with physiological saline in two stages by the mixer 1 and the mixer 110 by driving and controlling the two plunger devices. That is, in a one-stage mixing process, the chemical liquid can be mixed more efficiently and with a simpler configuration, and a uniformly mixed mixed chemical liquid can be obtained.

Further, for contrast agent amounts (concentrations) that differ from patient to patient, appropriate mixing and injection of the contrast agent and physiological saline can be performed continuously immediately before injection without having to be performed independently. Therefore, it is possible to reduce the risk of contamination of the mixed chemical solution due to pre-mixing.

In the above-mentioned Example 2, the contrast medium and physiological saline are mixed in the mixer 1 to produce the first mixed drug solution, and the first mixed drug solution and physiological saline are mixed in the mixer 110 to produce the second mixed solution. The configuration is illustrated in which a medical solution is prepared and a second mixed medical solution is injected into the patient. However, the present invention is not limited to this configuration. A contrast agent (first chemical solution) and physiological saline (second chemical solution) are mixed in the mixer 1 to create a first mixed drug solution, and a mixer 110 mixes the first mixed drug solution and a third drug solution that is not physiological saline. It is also possible to create a third mixed drug solution by mixing the two, and inject the third mixed drug solution into the patient. As a result, by making it possible to continuously mix different medicinal solutions and inject them into a patient, it is possible to mix the medicinal solutions without contamination, even if the medicinal solutions have restrictions on the mixing order.

In Example 2, the second syringe 205 is filled with physiological saline or the like (third drug solution), but the second syringe 205 is also filled with the same mixed drug solution as the first syringe 201. A configuration that allows suction and mixing may be applied. With this configuration, it is possible to continuously mix and inject up to four types of drug solutions on-site, and it is possible to achieve the effect of increasing the degree of freedom in mixing drug solutions. In this case, the backflow prevention mechanism of the second syringe 205 can be configured to be always attached (functioning) similarly to the backflow prevention mechanism of the first syringe 201.

In Example 2, in a two-syringe drug injection device including a first syringe 201 filled with a mixed drug solution and a second syringe 205 filled with physiological saline, a suction-type drug solution mixing mechanism is installed in the system of the first syringe 201. An example of a configuration in which this is introduced is shown. However, the present invention is not limited thereto, and may be applied to a drug solution (mixing) injection device including three or more syringes. That is, in a drug solution (mixing) injection device including three or more syringes, the suction type drug solution mixing mechanism of the present invention may be applied to a mixed drug solution introduced into each of one or more syringe systems.

Although the present invention has been explained using the above-described examples and embodiments, the present invention is not limited to the configurations of the above-described examples and embodiments. The present invention also includes modifications of the constituent elements of the present invention and structures equivalent to the constituent elements of the present invention within the scope of the invention described in the claims. Further, the above-described examples and embodiments can be combined as appropriate without substantially changing the content of the present invention.

1: Mixer, 2: Swirling flow generation chamber, 3: Constriction chamber, 14: First inlet, 15: Second inlet, 16: Outlet, 100: Chemical injection system, 300: Mixing tube

Claims (20)

a first container containing a first chemical solution;
a second container containing a second chemical solution;
a mixer that is connected to the first container via a first flow path and connected to the second container via a second flow path, and mixes the first chemical liquid and the second chemical liquid;
a third container connected to the mixer via a third flow path;
has
By making the inside of the third container a negative pressure with respect to the inside of the mixer, the first chemical liquid from the first container and the second chemical liquid from the second container flow simultaneously into the mixer. A chemical liquid mixing device characterized in that the liquid mixture is introduced into the third container. The third container is a syringe that includes a cylinder, a seal member that slides within the cylinder, and a plunger that is connected to the seal member and operates to move the seal member,
2. The chemical liquid mixing device according to claim 1, wherein the inside of the third container is made to have a negative pressure with respect to the inside of the mixer by moving the sealing member with the plunger. The mixer is
a swirling flow generation chamber for generating swirling flow;
a first inlet connected to the first flow path and for introducing the first chemical into the swirling flow generation chamber in a direction parallel to the central axis of the swirling flow;
The second chemical solution is connected to the second flow path and is connected to the swirling flow generation chamber so that a swirling flow of the second chemical solution having a specific gravity smaller than the specific gravity of the first chemical solution is generated in the swirling flow generation chamber. a second inlet for introducing the
an outlet connected to the third flow path, through which a mixed chemical solution of the first chemical solution and the second chemical solution flows out;
a constriction chamber provided between the swirling flow generation chamber and the outlet and having a space that is continuously narrowed toward the outlet;
The chemical liquid mixing device according to claim 1, characterized in that: The swirling flow generation chamber has a cylindrical space,
The liquid medicine mixing device according to claim 3, wherein the narrowed chamber has a conical space. The first inlet is formed at a front end face of the swirling flow generation chamber,
The chemical liquid mixing device according to claim 3, wherein the second inlet is formed on a side surface of the swirling flow generation chamber. The chemical liquid mixing device according to claim 3, wherein an inner diameter of the second inlet is smaller than an inner diameter of the first inlet. The chemical liquid mixing device according to claim 3, wherein a tapered portion is formed inside the swirling flow generation chamber at a boundary between a front inner end surface of the swirling flow generation chamber and an inner surface of the swirling flow generation chamber. The chemical liquid mixing device according to claim 3, wherein a curved portion is formed inside the swirling flow generation chamber at a boundary between a front inner end surface of the swirling flow generation chamber and an inner surface of the swirling flow generation chamber. 4. The chemical liquid mixing device according to claim 3, wherein the inner surface of the constricted chamber has a streamlined shape. The chemical liquid mixing device according to claim 1, further comprising a mechanism for preventing flow from the third container to the mixer. The chemical liquid mixing device according to claim 1, further comprising a mechanism for preventing flow from the mixer to the first container. The chemical liquid mixing device according to claim 1, further comprising a mechanism for preventing flow from the mixer to the second container. The drug solution mixing device according to claim 1, wherein the first drug solution is a contrast agent and the second drug solution is physiological saline. The chemical liquid mixing device according to claim 1, wherein the first chemical liquid is a contrast agent with a first concentration, and the second medical liquid is a contrast medium with a second concentration different from the first concentration. A chemical liquid mixing device according to claim 2;
a head to which the syringe is attached;
a controller connected to the head;
A liquid medicine injection system, characterized in that it has a mixed liquid injection path connected to the third container and for injecting a liquid medicine into a patient. a first container containing a first chemical solution;
a second container containing a second chemical solution;
a first mixer connected to the first container and the second container and mixing the first medical solution and the second medical solution;
a first syringe connected to the first mixer;
a second syringe containing a third drug solution;
a second mixer connected to the first syringe and the second syringe;
a controller that controls driving of the first syringe and the second syringe;
A chemical liquid injection system having:
The second mixer is
a swirling flow generation chamber for generating swirling flow;
a first inlet connected to the first syringe and for introducing the first mixed liquid into the swirling flow generation chamber in a direction parallel to the central axis of the swirling flow;
The third chemical solution is connected to the second syringe and is supplied to the swirling flow generation chamber such that a swirling flow of the third drug solution having a specific gravity smaller than the specific gravity of the first mixed liquid is generated in the swirling flow generation chamber. a second inlet for introducing the
an outlet connected to the third flow path and through which a second mixed liquid of the first mixed liquid and the third chemical liquid flows out;
a constriction chamber provided between the swirling flow generation chamber and the outlet and having a space that is continuously narrowed toward the outlet;
The controller controls the first medical solution from the first container and the second medical solution from the second container by making the inside of the first syringe a negative pressure with respect to the inside of the first mixer. The mixed first mixed liquid is introduced into the first syringe, and the first mixed liquid is introduced into the first syringe and the third liquid is mixed with the second mixed liquid from the first syringe. A chemical liquid injection system characterized in that the liquid medicine is mixed by flowing into two mixers, and the mixed liquid mixture is caused to flow out from the outlet. 17. The drug solution injection system according to claim 16, wherein the first drug solution is a contrast agent, and the second drug solution and the third drug solution are physiological saline. a first container containing a first chemical solution, a second container containing a second drug solution, and a mixer connected to the first container and the second container and mixing the first drug solution and the second drug solution; , a method for mixing a chemical liquid in a chemical liquid mixing device having a third container connected to the mixer,
By making the inside of the third container a negative pressure with respect to the inside of the mixer, the first chemical liquid from the first container and the second chemical liquid from the second container flow simultaneously into the mixer. A method for mixing chemical liquids, characterized in that the mixed liquid mixture is introduced into the third container. In the mixer, a swirling flow of the second chemical solution is generated, and the first chemical solution is introduced in a direction parallel to the central axis of the swirling flow, into a space that is continuously narrowed toward an outlet. By guiding the first chemical liquid and the second chemical liquid, causing the first chemical liquid and the second chemical liquid to collide,
19. The method for mixing chemical liquids according to claim 18, wherein the mixed chemical liquid of the first chemical liquid and the second chemical liquid is caused to flow out from the outlet and guided to the third container. The method for mixing medical solutions according to claim 18 or 19, wherein the first medical solution is a contrast agent and the second medical solution is physiological saline.

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