JP2017538758A5 - - Google Patents
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- JP2017538758A5 JP2017538758A5 JP2017533218A JP2017533218A JP2017538758A5 JP 2017538758 A5 JP2017538758 A5 JP 2017538758A5 JP 2017533218 A JP2017533218 A JP 2017533218A JP 2017533218 A JP2017533218 A JP 2017533218A JP 2017538758 A5 JP2017538758 A5 JP 2017538758A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- grape
- composition according
- product
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 39
- 241000219095 Vitis Species 0.000 claims 30
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 30
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 30
- 235000014787 Vitis vinifera Nutrition 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 8
- 239000000284 extract Substances 0.000 claims 6
- 229940087559 grape seed Drugs 0.000 claims 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- 230000003627 anti-cholesterol Effects 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 235000013761 grape skin extract Nutrition 0.000 claims 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 claims 1
- 240000005528 Arctium lappa Species 0.000 claims 1
- 235000003130 Arctium lappa Nutrition 0.000 claims 1
- 235000008078 Arctium minus Nutrition 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- 102000016938 Catalase Human genes 0.000 claims 1
- 108010053835 Catalase Proteins 0.000 claims 1
- 241001233914 Chelidonium majus Species 0.000 claims 1
- 244000298479 Cichorium intybus Species 0.000 claims 1
- 235000007542 Cichorium intybus Nutrition 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- 244000163122 Curcuma domestica Species 0.000 claims 1
- 235000003392 Curcuma domestica Nutrition 0.000 claims 1
- 244000019459 Cynara cardunculus Species 0.000 claims 1
- 235000019106 Cynara scolymus Nutrition 0.000 claims 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 206010019708 Hepatic steatosis Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 229940122355 Insulin sensitizer Drugs 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- 244000131316 Panax pseudoginseng Species 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 244000046146 Pueraria lobata Species 0.000 claims 1
- 235000015422 Rumex crispus ssp. crispus Nutrition 0.000 claims 1
- 235000015426 Rumex crispus ssp. fauriei Nutrition 0.000 claims 1
- 244000207667 Rumex vesicarius Species 0.000 claims 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 claims 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 1
- 241000320380 Silybum Species 0.000 claims 1
- 235000010841 Silybum marianum Nutrition 0.000 claims 1
- 229940100389 Sulfonylurea Drugs 0.000 claims 1
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 1
- 108010012715 Superoxide dismutase Proteins 0.000 claims 1
- 240000001949 Taraxacum officinale Species 0.000 claims 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims 1
- 229940123464 Thiazolidinedione Drugs 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- 229960001570 ademetionine Drugs 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
- 235000016520 artichoke thistle Nutrition 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- 235000021466 carotenoid Nutrition 0.000 claims 1
- 150000001747 carotenoids Chemical class 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 235000003373 curcuma longa Nutrition 0.000 claims 1
- 238000001784 detoxification Methods 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 235000004626 essential fatty acids Nutrition 0.000 claims 1
- 239000000469 ethanolic extract Substances 0.000 claims 1
- 208000010706 fatty liver disease Diseases 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 1
- 229940038487 grape extract Drugs 0.000 claims 1
- 229940087603 grape seed extract Drugs 0.000 claims 1
- 235000002532 grape seed extract Nutrition 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 235000009200 high fat diet Nutrition 0.000 claims 1
- 230000003859 lipid peroxidation Effects 0.000 claims 1
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims 1
- 235000019136 lipoic acid Nutrition 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- 239000000401 methanolic extract Substances 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- ZXERDUOLZKYMJM-ZWECCWDJSA-N obeticholic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)CCC(O)=O)CC[C@H]21 ZXERDUOLZKYMJM-ZWECCWDJSA-N 0.000 claims 1
- 229960001601 obeticholic acid Drugs 0.000 claims 1
- 230000036542 oxidative stress Effects 0.000 claims 1
- 229960005095 pioglitazone Drugs 0.000 claims 1
- 229960002797 pitavastatin Drugs 0.000 claims 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 1
- 229960002965 pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 229960000672 rosuvastatin Drugs 0.000 claims 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
- 229960002855 simvastatin Drugs 0.000 claims 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 1
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 1
- 229960002663 thioctic acid Drugs 0.000 claims 1
- 235000013976 turmeric Nutrition 0.000 claims 1
- 229940040064 ubiquinol Drugs 0.000 claims 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 claims 1
- 229940035936 ubiquinone Drugs 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- 235000019156 vitamin B Nutrition 0.000 claims 1
- 239000011720 vitamin B Substances 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 229940045997 vitamin a Drugs 0.000 claims 1
- 239000001717 vitis vinifera seed extract Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021017048A JP7461901B2 (ja) | 2014-12-20 | 2021-02-05 | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094963P | 2014-12-20 | 2014-12-20 | |
| US62/094,963 | 2014-12-20 | ||
| PCT/US2015/066585 WO2016100774A1 (en) | 2014-12-20 | 2015-12-18 | Grape products for nonalcoholic fatty liver disease and other uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021017048A Division JP7461901B2 (ja) | 2014-12-20 | 2021-02-05 | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538758A JP2017538758A (ja) | 2017-12-28 |
| JP2017538758A5 true JP2017538758A5 (https=) | 2019-01-31 |
| JP7319761B2 JP7319761B2 (ja) | 2023-08-02 |
Family
ID=56127659
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533218A Active JP7319761B2 (ja) | 2014-12-20 | 2015-12-18 | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
| JP2021017048A Active JP7461901B2 (ja) | 2014-12-20 | 2021-02-05 | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021017048A Active JP7461901B2 (ja) | 2014-12-20 | 2021-02-05 | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10130671B2 (https=) |
| EP (1) | EP3233101A4 (https=) |
| JP (2) | JP7319761B2 (https=) |
| KR (2) | KR20240059654A (https=) |
| AU (1) | AU2015364473B2 (https=) |
| CA (1) | CA2971716A1 (https=) |
| IL (1) | IL252992B (https=) |
| WO (1) | WO2016100774A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7319761B2 (ja) * | 2014-12-20 | 2023-08-02 | ソノマシューティカルズ・エルエルシー | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
| WO2020138557A1 (ko) * | 2018-12-28 | 2020-07-02 | 경상대학교병원 | 지방간 예방 또는 치료용 약학적 조성물 및 건강기능식품 |
| JP2021073987A (ja) * | 2019-11-12 | 2021-05-20 | 禅インターナショナル株式会社 | 栄養組成物 |
| CN111826437B (zh) * | 2020-07-24 | 2023-09-29 | 中南大学湘雅二医院 | 检测cyp46a1基因表达的产品在制备诊断非酒精性脂肪性肝病工具中的应用 |
| CA3229785A1 (en) | 2020-10-16 | 2022-04-21 | Sonomaceuticals, Llc | Food compositions incorporating agricultural marc, and methods of producing thereof |
| KR102573089B1 (ko) | 2020-11-27 | 2023-09-01 | 한양대학교 산학협력단 | 비 알콜성 지방간 치료제에 대한 감수성 예측을 위한 바이오 마커 및 이의 용도 |
| KR20240046107A (ko) * | 2021-02-01 | 2024-04-08 | 알드바크 테라퓨틱스 인크. | 지방간 질환의 예방, 진행 예방 및 치료에서 사용하기 위한 데나토늄 염 |
| TR2023010537A2 (tr) * | 2023-08-28 | 2023-11-21 | Bursa Uludag Ueniversitesi | Buzağılarda Oksidatif Stresin Azaltılması İçin Üzüm Çekirdeği Ekstraktı Kullanımı |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH692837A5 (it) * | 1997-07-02 | 2002-11-29 | Lisapharma Spa | Composizione farmaceutica per uso alimentare, dietetico o medicinale adatta a migliorare l'assorbimento orale dei polifenoli e particolarmente del resveratrolo presenti nell'uva e nei suoi p |
| BRPI0821985A2 (pt) * | 2008-01-10 | 2015-06-23 | Evonik Roehm Gmbh | Preparacao farmacêutica ou nutracêutica revestida tendo liberação de substância ativa controlada |
| AU2009322474A1 (en) * | 2008-12-01 | 2011-07-21 | Lifespan Extension Llc | Methods and compositions for altering health, wellbeing, and lifespan |
| US8609156B2 (en) | 2009-10-05 | 2013-12-17 | Protanza Corporation | Compositions and methods of treatment that include plant extracts |
| JP2012187050A (ja) * | 2011-03-10 | 2012-10-04 | Manns Wine Co Ltd | ワイン風飲料及びこれを含有する飲食品 |
| BR112014026926B1 (pt) * | 2012-04-30 | 2021-03-09 | Sonomaceuticals, Llc | uso de uma quantidade eficaz de farinha de semente de uva chardonnay e composição compreendendo a mesma |
| US20150258032A1 (en) * | 2014-03-17 | 2015-09-17 | Kenneth Dale Lightburn | Compositions of Antioxidants and Oil for an antioxidant paste or supplement or liquid or frozen product |
| JP7319761B2 (ja) * | 2014-12-20 | 2023-08-02 | ソノマシューティカルズ・エルエルシー | 非アルコール性脂肪肝疾患および他の使用のためのブドウ生成物 |
-
2015
- 2015-12-18 JP JP2017533218A patent/JP7319761B2/ja active Active
- 2015-12-18 CA CA2971716A patent/CA2971716A1/en active Pending
- 2015-12-18 US US15/537,661 patent/US10130671B2/en active Active
- 2015-12-18 KR KR1020247014115A patent/KR20240059654A/ko not_active Ceased
- 2015-12-18 AU AU2015364473A patent/AU2015364473B2/en active Active
- 2015-12-18 WO PCT/US2015/066585 patent/WO2016100774A1/en not_active Ceased
- 2015-12-18 KR KR1020177018456A patent/KR20170095271A/ko not_active Ceased
- 2015-12-18 EP EP15871145.7A patent/EP3233101A4/en not_active Withdrawn
-
2017
- 2017-06-18 IL IL252992A patent/IL252992B/en unknown
-
2018
- 2018-10-15 US US16/159,922 patent/US10894073B2/en active Active
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2021
- 2021-01-18 US US17/151,544 patent/US11547736B2/en active Active
- 2021-02-05 JP JP2021017048A patent/JP7461901B2/ja active Active
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2022
- 2022-12-08 US US18/063,281 patent/US20230293622A1/en active Pending
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