JP2017537968A - トリオキサカルシンｄｃ４５−ａ２の全合成及びトリオキサカルシン類似体の調製 - Google Patents

トリオキサカルシンｄｃ４５−ａ２の全合成及びトリオキサカルシン類似体の調製 Download PDF

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Publication number
JP2017537968A
JP2017537968A JP2017532666A JP2017532666A JP2017537968A JP 2017537968 A JP2017537968 A JP 2017537968A JP 2017532666 A JP2017532666 A JP 2017532666A JP 2017532666 A JP2017532666 A JP 2017532666A JP 2017537968 A JP2017537968 A JP 2017537968A
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substituted
alkoxy
hydrogen
compound
hydroxy
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JP2017532666A
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Japanese (ja)
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JP2017537968A5 (https=
Inventor
キリアコス シー． ニコラウ
キリアコス シー． ニコラウ
クワン カイ
クワン カイ
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William Marsh Rice University
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William Marsh Rice University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2017532666A 2014-12-19 2015-12-18 トリオキサカルシンｄｃ４５−ａ２の全合成及びトリオキサカルシン類似体の調製 Withdrawn JP2017537968A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094662P 2014-12-19 2014-12-19
US62/094,662 2014-12-19
US201562186128P 2015-06-29 2015-06-29
US62/186,128 2015-06-29
PCT/US2015/066703 WO2016100833A2 (en) 2014-12-19 2015-12-18 Total synthesis of trioxacarcin dc-45-a2 and preparation of trioxacarcin analogs

Publications (2)

Publication Number Publication Date
JP2017537968A true JP2017537968A (ja) 2017-12-21
JP2017537968A5 JP2017537968A5 (https=) 2019-01-31

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ID=56127867

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017532666A Withdrawn JP2017537968A (ja) 2014-12-19 2015-12-18 トリオキサカルシンｄｃ４５−ａ２の全合成及びトリオキサカルシン類似体の調製

Country Status (23)

Country Link
US (1) US10899773B2 (https=)
EP (1) EP3233877A4 (https=)
JP (1) JP2017537968A (https=)
KR (1) KR20170122718A (https=)
CN (1) CN107250144A (https=)
AU (1) AU2015364347A1 (https=)
BR (1) BR112017013194A2 (https=)
CA (1) CA2970955A1 (https=)
CL (1) CL2017001599A1 (https=)
CO (1) CO2017007074A2 (https=)
CR (1) CR20170331A (https=)
DO (1) DOP2017000144A (https=)
EA (1) EA201791388A1 (https=)
EC (1) ECSP17046657A (https=)
GT (1) GT201700139A (https=)
HK (1) HK1243422A1 (https=)
IL (1) IL252947A0 (https=)
MA (1) MA41216A (https=)
MX (1) MX2017008162A (https=)
PE (1) PE20171787A1 (https=)
PH (1) PH12017501147A1 (https=)
SG (1) SG11201704935XA (https=)
WO (1) WO2016100833A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210230178A1 (en) * 2017-08-17 2021-07-29 William Marsh Rice University Trioxacarcin analogs and dimers as potent anticancer agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815995A (ja) 1981-07-22 1983-01-29 Kyowa Hakko Kogyo Co Ltd Ｄｃ−４５−ａ↓１およびｄｃ−４５−ａ↓２ならびにそれらの製造法
EP0157203A3 (en) 1984-04-04 1986-10-01 American Cyanamid Company Antitumor agents ll-d49194 alpha 1, ll-d49194 beta, ll-d49194 beta 2, ll-d49194 upsilon, ll-d49194 delta, ll-d49194 epsilon, ll-d49194 zeta, and ll-d49194 eta
JPS63135389A (ja) 1986-11-26 1988-06-07 Kyowa Hakko Kogyo Co Ltd Ｄｃ−４５類の誘導体
EP2550285B1 (en) 2010-03-22 2017-07-19 President and Fellows of Harvard College Trioxacarcins and uses thereof
JP6408478B2 (ja) 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ トリオキサカルシン、トリオキサカルシン−抗体複合体、およびその用途

Also Published As

Publication number Publication date
EP3233877A2 (en) 2017-10-25
WO2016100833A3 (en) 2017-01-05
GT201700139A (es) 2018-10-24
AU2015364347A1 (en) 2017-07-13
BR112017013194A2 (pt) 2018-01-02
HK1243422A1 (zh) 2018-07-13
US20190023717A1 (en) 2019-01-24
CA2970955A1 (en) 2016-06-23
US10899773B2 (en) 2021-01-26
DOP2017000144A (es) 2017-09-29
WO2016100833A2 (en) 2016-06-23
IL252947A0 (en) 2017-08-31
KR20170122718A (ko) 2017-11-06
EP3233877A4 (en) 2018-10-17
CO2017007074A2 (es) 2017-10-20
CR20170331A (es) 2017-11-17
MX2017008162A (es) 2018-03-06
PH12017501147A1 (en) 2018-03-05
PE20171787A1 (es) 2017-12-28
ECSP17046657A (es) 2019-03-29
EA201791388A1 (ru) 2017-11-30
MA41216A (fr) 2017-10-24
CL2017001599A1 (es) 2018-11-09
CN107250144A (zh) 2017-10-13
SG11201704935XA (en) 2017-07-28

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