JP2017537062A5 - - Google Patents
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- Publication number
- JP2017537062A5 JP2017537062A5 JP2017519672A JP2017519672A JP2017537062A5 JP 2017537062 A5 JP2017537062 A5 JP 2017537062A5 JP 2017519672 A JP2017519672 A JP 2017519672A JP 2017519672 A JP2017519672 A JP 2017519672A JP 2017537062 A5 JP2017537062 A5 JP 2017537062A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- group
- protein
- polyethylene glycol
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003153 chemical reaction reagent Substances 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 13
- 125000003827 glycol group Chemical group 0.000 claims 13
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 235000018102 proteins Nutrition 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000000032 diagnostic agent Substances 0.000 claims 4
- 229940039227 diagnostic agent Drugs 0.000 claims 4
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 101800001442 Peptide pr Proteins 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000468 ketone group Chemical group 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1418986.4 | 2014-10-24 | ||
| GB1418984.9 | 2014-10-24 | ||
| GBGB1418986.4A GB201418986D0 (en) | 2014-10-24 | 2014-10-24 | Novel conjugates and novel conjugating reagents |
| GB1418989.8 | 2014-10-24 | ||
| GB1418984.9A GB2531715A (en) | 2014-10-24 | 2014-10-24 | Novel drug conjugates |
| GBGB1418989.8A GB201418989D0 (en) | 2014-10-24 | 2014-10-24 | Novel conjugation process and reagents |
| PCT/GB2015/052953 WO2016063006A1 (en) | 2014-10-24 | 2015-10-08 | Conjugates and conjugating reagents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537062A JP2017537062A (ja) | 2017-12-14 |
| JP2017537062A5 true JP2017537062A5 (show.php) | 2018-11-22 |
| JP6612860B2 JP6612860B2 (ja) | 2019-11-27 |
Family
ID=54337308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519672A Active JP6612860B2 (ja) | 2014-10-24 | 2015-10-08 | コンジュゲート及びコンジュゲート試薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20170290925A1 (show.php) |
| EP (1) | EP3220956B1 (show.php) |
| JP (1) | JP6612860B2 (show.php) |
| KR (1) | KR102513926B1 (show.php) |
| CN (1) | CN107073131B (show.php) |
| AU (1) | AU2015334717B2 (show.php) |
| BR (1) | BR112017005760A2 (show.php) |
| CA (1) | CA2963043A1 (show.php) |
| ES (1) | ES2960741T3 (show.php) |
| IL (1) | IL250644B (show.php) |
| MX (1) | MX2017005199A (show.php) |
| RU (1) | RU2017108448A (show.php) |
| SG (1) | SG11201701342XA (show.php) |
| WO (1) | WO2016063006A1 (show.php) |
| ZA (1) | ZA201701337B (show.php) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
| WO2017122019A1 (en) | 2016-01-12 | 2017-07-20 | Crescendo Biologics Limited | Immunoconjugates that bind prostate specific membrane antigen (psma) |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| US11273224B2 (en) | 2016-04-14 | 2022-03-15 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-CH2—CH2—O-) units in a ring |
| GB201608936D0 (en) * | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| EP4282434A3 (en) | 2016-06-06 | 2024-03-06 | Abzena (UK) Limited | Antibodies, uses thereof and conjugates thereof |
| GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| GB201615725D0 (en) | 2016-09-15 | 2016-11-02 | Polytherics Ltd | Novel cytotoxic agents and conjugates thereof |
| CN110475802B (zh) | 2017-03-30 | 2022-03-08 | 日油株式会社 | 异双官能性单分散聚乙二醇以及使用该异双官能性单分散聚乙二醇的缀合物 |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| CN111836846B (zh) | 2018-03-13 | 2023-06-13 | 日油株式会社 | 在主链和侧链具有单分散聚乙二醇的异双官能性化合物 |
| EP3789401A1 (en) | 2019-09-03 | 2021-03-10 | Gamamabs Pharma | Amhrii-binding antibody drug conjugates and their use thereof in the treatment of cancers |
| US20230258651A1 (en) * | 2020-04-29 | 2023-08-17 | Araclon Biotech, S.L | Methods for quantification of amyloid beta peptides in plasma by mass spectrometry |
| GB2594753B (en) | 2020-05-27 | 2022-05-18 | Spirea Ltd | Antibody-drug conjugates |
| US20250041439A1 (en) | 2021-09-21 | 2025-02-06 | Spirea Limited | Antibody-drug conjugates |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| WO1999045964A1 (en) * | 1998-03-12 | 1999-09-16 | Shearwater Polymers, Incorporated | Poly(ethylene glycol) derivatives with proximal reactive groups |
| KR100511749B1 (ko) * | 2001-11-06 | 2005-09-02 | 선바이오(주) | 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체 |
| ZA200603619B (en) * | 2003-11-06 | 2008-10-29 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| JP2009509918A (ja) * | 2005-08-05 | 2009-03-12 | シンタルガ・ビーブイ | トリアゾール含有放出可能なリンカー、これらの共役体、および製造方法 |
| US20070141134A1 (en) * | 2005-12-16 | 2007-06-21 | Kosak Matthew K | Shielded micelles for polynucleotide delivery |
| KR20090057383A (ko) * | 2006-09-15 | 2009-06-05 | 엔존 파마슈티컬즈, 인코포레이티드 | 다기능성 링커를 포함하는 표적화된 고분자 전구약물 |
| WO2008098930A1 (en) * | 2007-02-14 | 2008-08-21 | Biocompatibes Uk Limited | Derivatisation of biological molecules |
| GB0922354D0 (en) * | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
| CN104906592B (zh) * | 2011-02-25 | 2017-11-03 | 广州南沙龙沙有限公司 | 用于蛋白质药物偶联物的支链联接体 |
| EP2678037B1 (en) * | 2011-02-25 | 2014-12-03 | Lonza Ltd | Branched linker for protein drug conjugates |
| GB201210770D0 (en) * | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| US9650331B2 (en) * | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| RU2015101333A (ru) * | 2012-06-19 | 2016-08-10 | Политерикс Лимитед | Новый способ получения конъюгатов антител и новые конъюгаты антител |
| SG11201501618WA (en) * | 2012-10-24 | 2015-04-29 | Polytherics Ltd | Drug-protein conjugates |
| NO2789793T3 (show.php) * | 2012-10-24 | 2018-01-27 | ||
| SI3057585T1 (sl) * | 2013-10-15 | 2020-12-31 | Seagen Inc. | Pegilirani linkerji zdravila za izboljšano farmakokinetiko konjugata ligand-zdravilo |
-
2015
- 2015-10-08 ES ES15782051T patent/ES2960741T3/es active Active
- 2015-10-08 AU AU2015334717A patent/AU2015334717B2/en active Active
- 2015-10-08 WO PCT/GB2015/052953 patent/WO2016063006A1/en not_active Ceased
- 2015-10-08 CN CN201580057559.0A patent/CN107073131B/zh active Active
- 2015-10-08 CA CA2963043A patent/CA2963043A1/en not_active Abandoned
- 2015-10-08 SG SG11201701342XA patent/SG11201701342XA/en unknown
- 2015-10-08 EP EP15782051.5A patent/EP3220956B1/en active Active
- 2015-10-08 RU RU2017108448A patent/RU2017108448A/ru unknown
- 2015-10-08 JP JP2017519672A patent/JP6612860B2/ja active Active
- 2015-10-08 KR KR1020177010432A patent/KR102513926B1/ko active Active
- 2015-10-08 MX MX2017005199A patent/MX2017005199A/es unknown
- 2015-10-08 BR BR112017005760A patent/BR112017005760A2/pt not_active Application Discontinuation
- 2015-10-08 US US15/517,969 patent/US20170290925A1/en not_active Abandoned
-
2017
- 2017-02-16 IL IL250644A patent/IL250644B/en active IP Right Grant
- 2017-02-22 ZA ZA2017/01337A patent/ZA201701337B/en unknown
-
2020
- 2020-03-03 US US16/807,298 patent/US20200268885A1/en active Pending
-
2024
- 2024-03-19 US US18/609,210 patent/US20240293549A1/en active Pending
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