JP2017533922A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017533922A5 JP2017533922A5 JP2017525115A JP2017525115A JP2017533922A5 JP 2017533922 A5 JP2017533922 A5 JP 2017533922A5 JP 2017525115 A JP2017525115 A JP 2017525115A JP 2017525115 A JP2017525115 A JP 2017525115A JP 2017533922 A5 JP2017533922 A5 JP 2017533922A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 38
- 229910052739 hydrogen Inorganic materials 0.000 claims 32
- 239000001257 hydrogen Substances 0.000 claims 32
- 150000002431 hydrogen Chemical class 0.000 claims 32
- 229910052736 halogen Inorganic materials 0.000 claims 22
- 150000002367 halogens Chemical class 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 12
- 125000004452 carbocyclyl group Chemical group 0.000 claims 11
- 239000003112 inhibitor Substances 0.000 claims 11
- 125000002252 acyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 102100029895 Bromodomain-containing protein 4 Human genes 0.000 claims 6
- 101710126815 Bromodomain-containing protein 4 Proteins 0.000 claims 6
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 claims 5
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000000816 peptidomimetic Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 150000003384 small molecules Chemical group 0.000 claims 3
- UMZWNADQRDCKII-UHFFFAOYSA-N 2-[5-(5-bromo-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]butanedioic acid Chemical compound OC(=O)CC(C(O)=O)n1c(O)c(sc1=S)C1=c2cc(Br)ccc2=NC1=O UMZWNADQRDCKII-UHFFFAOYSA-N 0.000 claims 2
- 229940096923 Bcl6 inhibitor Drugs 0.000 claims 2
- 101100381525 Mus musculus Bcl6 gene Proteins 0.000 claims 2
- 102000013538 Proto-Oncogene Proteins c-bcl-6 Human genes 0.000 claims 2
- 108010090920 Proto-Oncogene Proteins c-bcl-6 Proteins 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 238000011316 allogeneic transplantation Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 230000004199 lung function Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076358P | 2014-11-06 | 2014-11-06 | |
| US62/076,358 | 2014-11-06 | ||
| PCT/US2015/059551 WO2016073903A1 (en) | 2014-11-06 | 2015-11-06 | Use of compositions modulating chromatin structure for graft versus host disease (gvhd) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017533922A JP2017533922A (ja) | 2017-11-16 |
| JP2017533922A5 true JP2017533922A5 (https=) | 2018-12-13 |
Family
ID=55909890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525115A Pending JP2017533922A (ja) | 2014-11-06 | 2015-11-06 | 移植片対宿主病（ｇｖｈｄ）のためのクロマチン構造を調節する組成物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20190000860A1 (https=) |
| EP (1) | EP3215160A4 (https=) |
| JP (1) | JP2017533922A (https=) |
| KR (1) | KR20170098808A (https=) |
| CN (1) | CN107249593A (https=) |
| AU (1) | AU2015342895A1 (https=) |
| BR (1) | BR112017009440A2 (https=) |
| CA (1) | CA2966336A1 (https=) |
| WO (1) | WO2016073903A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016029492A2 (pt) | 2014-06-17 | 2017-10-17 | Eisai R&D Man Co Ltd | método para tratamento de linfoma não hodgkin |
| EP3885343A1 (en) | 2014-11-06 | 2021-09-29 | Dana-Farber Cancer Institute, Inc. | Indole compounds as ezh2 inhibitors and uses thereof |
| AU2016275051A1 (en) | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| AU2017252460B2 (en) | 2016-04-22 | 2021-11-18 | Dana-Farber Cancer Institute, Inc. | EZH2 inhibitors and uses thereof |
| JP7125353B2 (ja) | 2017-01-19 | 2022-08-24 | 第一三共株式会社 | Ｈｔｌｖ－１関連脊髄症を治療することに用いるための医薬組成物 |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CN108685880A (zh) * | 2018-04-16 | 2018-10-23 | 广东省人民医院(广东省医学科学院) | Bcl-6小分子抑制剂用于制备预防或治疗cGVHD的药物 |
| CA3104209A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| JP2022514353A (ja) * | 2018-12-21 | 2022-02-10 | ザ ウォルター アンド イライザ ホール インスティテュート オブ メディカル リサーチ | 炎症の治療方法 |
| US12421228B2 (en) | 2019-04-22 | 2025-09-23 | Mirati Therapeutics, Inc. | Naphthyridine derivatives as PRC2 inhibitors |
| US12252493B2 (en) | 2019-06-05 | 2025-03-18 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer |
| CN112341390B (zh) * | 2019-08-07 | 2022-08-23 | 四川大学 | 用于制备靶向组蛋白甲基转移酶ezh2共价抑制剂的化合物及其制备方法和用途 |
| WO2021175432A1 (en) | 2020-03-04 | 2021-09-10 | Boehringer Ingelheim International Gmbh | Method for administration of an anti cancer agent |
| TW202400140A (zh) | 2022-04-27 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合 |
| IL317937A (en) * | 2022-08-09 | 2025-02-01 | Dana Farber Cancer Inst Inc | Macrocyclic BCL6 joints |
| WO2024211684A1 (en) * | 2023-04-06 | 2024-10-10 | Halda Therapeutics Opco, Inc. | Heterobifunctional compounds and methods of treating disease |
| TW202543650A (zh) | 2024-03-08 | 2025-11-16 | 美商海爾達醫療運營公司 | 異雙官能化合物及其在治療疾病中之用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552083B1 (en) * | 1999-07-16 | 2003-04-22 | Kissei Pharmaceutical Co., Ltd. | Agents inhibiting chronic rejection reactions after organ transplantation |
| US8338464B2 (en) * | 2006-11-30 | 2012-12-25 | Albert Einstein College Of Medicine Of Yeshiva University | Small molecule inhibitors of BCL6 |
| KR20080107050A (ko) * | 2007-06-05 | 2008-12-10 | 울산대학교 산학협력단 | 항-ｃｄ１３７ 단일클론 항체를 포함하는 만성이식편대숙주 질환의 예방 또는 치료용 약학적 조성물 |
| JP5889875B2 (ja) * | 2010-05-07 | 2016-03-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | アザインダゾール |
| US20120014979A1 (en) * | 2010-07-16 | 2012-01-19 | Alexander Dent | Use of bcl6 inhibitors for treating autoimmune diseases |
| ES2951688T3 (es) * | 2011-02-28 | 2023-10-24 | Epizyme Inc | Compuestos de heteroarilo biciclico fusionados en 6,5 sustituidos |
| EP2755962B1 (en) * | 2011-09-13 | 2017-03-01 | Glaxosmithkline LLC | Azaindazoles |
| BR112014010803A2 (pt) * | 2011-11-04 | 2017-04-25 | Glaxosmithkline Intellectual Property (No 2) Ltd | método de tratamento |
| WO2013067302A1 (en) * | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
| US20130280332A1 (en) * | 2012-02-17 | 2013-10-24 | Nexbio, Inc. | Methods, Compounds and Compositions for Treatment of Influenza and Parainfluenza Patients |
| WO2014155301A1 (en) * | 2013-03-26 | 2014-10-02 | Piramal Enterprises Limited | Substituted bicyclic compounds as inhibitors of ezh2 |
-
2015
- 2015-11-06 EP EP15856340.3A patent/EP3215160A4/en not_active Withdrawn
- 2015-11-06 AU AU2015342895A patent/AU2015342895A1/en not_active Abandoned
- 2015-11-06 CA CA2966336A patent/CA2966336A1/en not_active Abandoned
- 2015-11-06 WO PCT/US2015/059551 patent/WO2016073903A1/en not_active Ceased
- 2015-11-06 CN CN201580066388.8A patent/CN107249593A/zh active Pending
- 2015-11-06 BR BR112017009440A patent/BR112017009440A2/pt not_active Application Discontinuation
- 2015-11-06 JP JP2017525115A patent/JP2017533922A/ja active Pending
- 2015-11-06 KR KR1020177014969A patent/KR20170098808A/ko not_active Withdrawn
- 2015-11-06 US US15/524,707 patent/US20190000860A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017533922A5 (https=) | ||
| US11149043B2 (en) | Prodrug modulators of the integrated stress pathway | |
| US10246406B2 (en) | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof | |
| ES2877629T3 (es) | Administración de profármacos activados por hipoxia y agentes antiangiogénicos para el tratamiento del cáncer | |
| JP2017511360A5 (https=) | ||
| JP2016516074A5 (https=) | ||
| BR112020013247A2 (pt) | amidas heterocíclicas como inibidores de quinase | |
| JP2017537886A5 (https=) | ||
| JP4779298B2 (ja) | 抗腫瘍剤 | |
| CN105579439B (zh) | 辐射减轻性药物制剂 | |
| TW201716059A (zh) | 新穎方法 | |
| CO2022008616A2 (es) | Composición farmacéutica oral que comprende compuesto de carbamato y método de preparación para la misma | |
| US11168071B2 (en) | Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use | |
| RU2008112181A (ru) | Применение конденсированных производных имидазола для лечения заболеваний, опосредованных рецептором ccr3 | |
| JP6509244B2 (ja) | 水晶体硬化抑制剤 | |
| JP2011506393A5 (https=) | ||
| US20220287993A1 (en) | Pharmaceutical composition comprising hdac inhibitor and anti-pd1 antibody or anti pd-l1 antibody | |
| WO2018158175A1 (en) | Combination of bub1 inhibitors | |
| US20210308138A1 (en) | Tissue transglutaminase modulators for medicinal use | |
| WO2022016231A1 (en) | Methods of treatment | |
| EP4633679A1 (en) | Peptide drug conjugates | |
| WO2021048418A1 (en) | Combination therapies comprising bortezomib for the treatment of cholangiocarcinoma | |
| US20140163053A1 (en) | Use of Tetrahydropyrimidines |