JP2017532369A5 - - Google Patents
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- Publication number
- JP2017532369A5 JP2017532369A5 JP2017530955A JP2017530955A JP2017532369A5 JP 2017532369 A5 JP2017532369 A5 JP 2017532369A5 JP 2017530955 A JP2017530955 A JP 2017530955A JP 2017530955 A JP2017530955 A JP 2017530955A JP 2017532369 A5 JP2017532369 A5 JP 2017532369A5
- Authority
- JP
- Japan
- Prior art keywords
- oral
- bromelain
- formulation
- diarrhea
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001465754 Metazoa Species 0.000 claims description 34
- 108010004032 Bromelains Proteins 0.000 claims description 19
- 239000004365 Protease Substances 0.000 claims description 19
- 235000019835 bromelain Nutrition 0.000 claims description 19
- 241000251468 Actinopterygii Species 0.000 claims description 16
- 230000000369 enteropathogenic effect Effects 0.000 claims description 16
- 244000005700 microbiome Species 0.000 claims description 16
- 238000009472 formulation Methods 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 241000282414 Homo sapiens Species 0.000 claims description 11
- 230000001142 anti-diarrhea Effects 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 9
- 206010012735 Diarrhoea Diseases 0.000 claims description 8
- 239000002738 chelating agent Substances 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000006186 oral dosage form Substances 0.000 claims description 5
- 241000282412 Homo Species 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 239000000787 lecithin Substances 0.000 claims description 3
- 235000010445 lecithin Nutrition 0.000 claims description 3
- 229940067606 lecithin Drugs 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000013361 beverage Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462041175P | 2014-08-25 | 2014-08-25 | |
| US62/041,175 | 2014-08-25 | ||
| PCT/US2015/046509 WO2016032944A1 (en) | 2014-08-25 | 2015-08-24 | Anti-diarrhea formulation which avoids antimicrobial resistance |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532369A JP2017532369A (ja) | 2017-11-02 |
| JP2017532369A5 true JP2017532369A5 (enExample) | 2018-09-27 |
| JP6920199B2 JP6920199B2 (ja) | 2021-08-18 |
Family
ID=55400400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017530955A Expired - Fee Related JP6920199B2 (ja) | 2014-08-25 | 2015-08-24 | 抗微生物剤耐性を回避する抗下痢製剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20170239334A1 (enExample) |
| EP (1) | EP3193629B1 (enExample) |
| JP (1) | JP6920199B2 (enExample) |
| KR (1) | KR102382930B1 (enExample) |
| CN (2) | CN114711336A (enExample) |
| AU (2) | AU2015306904A1 (enExample) |
| CA (1) | CA2959361A1 (enExample) |
| DK (1) | DK3193629T3 (enExample) |
| ES (1) | ES2938347T3 (enExample) |
| PH (1) | PH12017500338B1 (enExample) |
| WO (1) | WO2016032944A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4041285B1 (en) * | 2019-10-11 | 2024-09-18 | Anatara Lifesciences Limited | Gastrointestinal health composition |
| CA3171034A1 (en) * | 2020-03-12 | 2021-09-16 | Suzette Pereira | Methods of treating diarrhea or inflammatory conditions of the gut |
| CN112618579B (zh) * | 2020-12-24 | 2022-02-15 | 南京农业大学 | 一种防治仔猪腹泻复合益生菌制剂和制备方法及应用 |
| WO2022175262A1 (en) * | 2021-02-16 | 2022-08-25 | Dsm Ip Assets B.V. | Methods for reducing pathogenic e coli by selective feed additive intervention comprising enzymes such as muramidase |
| PL246387B1 (pl) * | 2022-08-16 | 2025-01-20 | Nutropharma Spolka Z Ograniczona Odpowiedzialnoscia | Kompozycja doustna i jej zastosowanie |
| KR102592953B1 (ko) * | 2023-01-30 | 2023-10-20 | 박예성 | 휴지기 없이 급여 가능한 반려동물용 영양제 제조공법 |
| CN116889261B (zh) * | 2023-07-22 | 2025-07-04 | 广东加大实业有限公司 | 一种防治腹泻乳猪饲料及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2798248B2 (ja) * | 1986-08-28 | 1998-09-17 | コーテックス リミテッド | 生物学的活性物質の動物の腸管部位へのデリバリーに有効なマイクロ顆粒状製剤 |
| EP0596962A4 (en) * | 1991-07-24 | 1997-01-15 | Enzacor Pty Ltd | Therapeutic compositions and methods. |
| US6054261A (en) * | 1998-05-20 | 2000-04-25 | Q-Pharma, Inc. | Coenzyme Q10 compositions for organ protection during perfusion |
| US6080403A (en) * | 1998-06-18 | 2000-06-27 | Star-Kist Foods, Inc. | Protease containing hairball remedy and use thereof |
| ES2302913T3 (es) * | 2002-02-14 | 2008-08-01 | Dsm Ip Assets B.V. | Formulaciones a base de coenzima q-10. |
| CN1548154A (zh) * | 2003-05-22 | 2004-11-24 | 维奥（四川）生物技术有限公司 | 用于治疗哺乳动物腹泻的菠萝蛋白酶微胶囊化药物组合物 |
| US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
| WO2008049437A1 (en) * | 2006-10-26 | 2008-05-02 | Biofiber-Damino A/S | Composition comprising lignin and antidi arrheal component |
| WO2009009879A1 (en) * | 2007-07-13 | 2009-01-22 | Aquience Inc. | Beverage composition for non-human animals |
| AT506095A1 (de) * | 2007-12-03 | 2009-06-15 | Volopharm Gmbh | Verwendung von proteasen |
| EP3064217B1 (en) * | 2009-01-06 | 2018-04-18 | Galenagen, LLC | Compositions comprising protease, amylase and lipase for use in the treatment of staphylococcus aureus infections |
-
2015
- 2015-08-24 US US15/505,904 patent/US20170239334A1/en not_active Abandoned
- 2015-08-24 CN CN202111584816.XA patent/CN114711336A/zh active Pending
- 2015-08-24 KR KR1020177008106A patent/KR102382930B1/ko active Active
- 2015-08-24 EP EP15836374.7A patent/EP3193629B1/en active Active
- 2015-08-24 ES ES15836374T patent/ES2938347T3/es active Active
- 2015-08-24 WO PCT/US2015/046509 patent/WO2016032944A1/en not_active Ceased
- 2015-08-24 JP JP2017530955A patent/JP6920199B2/ja not_active Expired - Fee Related
- 2015-08-24 CA CA2959361A patent/CA2959361A1/en not_active Abandoned
- 2015-08-24 DK DK15836374.7T patent/DK3193629T3/da active
- 2015-08-24 CN CN201580045389.4A patent/CN106998749A/zh active Pending
- 2015-08-24 PH PH1/2017/500338A patent/PH12017500338B1/en unknown
- 2015-08-24 AU AU2015306904A patent/AU2015306904A1/en not_active Abandoned
-
2019
- 2019-06-26 AU AU2019204496A patent/AU2019204496B2/en not_active Ceased
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