JP2017530964A5 - - Google Patents
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- JP2017530964A5 JP2017530964A5 JP2017514844A JP2017514844A JP2017530964A5 JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5 JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- chch
- pharmaceutical composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051760P | 2014-09-17 | 2014-09-17 | |
| US62/051,760 | 2014-09-17 | ||
| PCT/US2015/050275 WO2016044331A1 (en) | 2014-09-17 | 2015-09-15 | Bicyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530964A JP2017530964A (ja) | 2017-10-19 |
| JP2017530964A5 true JP2017530964A5 (index.php) | 2018-11-01 |
| JP6833677B2 JP6833677B2 (ja) | 2021-02-24 |
Family
ID=55454101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514844A Expired - Fee Related JP6833677B2 (ja) | 2014-09-17 | 2015-09-15 | 二環式化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10308609B2 (index.php) |
| EP (1) | EP3193855B1 (index.php) |
| JP (1) | JP6833677B2 (index.php) |
| KR (1) | KR20170048588A (index.php) |
| CN (1) | CN106999451B (index.php) |
| AR (1) | AR101905A1 (index.php) |
| CA (1) | CA2961605C (index.php) |
| TW (1) | TWI686376B (index.php) |
| WO (1) | WO2016044331A1 (index.php) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI630194B (zh) | 2013-03-14 | 2018-07-21 | 凱立拉製藥公司 | 雙環止痛化合物 |
| EP3080072A4 (en) | 2013-12-12 | 2017-07-19 | Kalyra Pharmaceuticals, inc. | Bicyclic alkyl compounds and synthesis |
| WO2015134710A1 (en) | 2014-03-07 | 2015-09-11 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
| US10308609B2 (en) | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| HRP20190853T1 (hr) | 2015-07-06 | 2019-06-28 | Gilead Sciences, Inc. | Cot modulatori i postupci za njihovu upotrebu |
| WO2018213140A1 (en) * | 2017-05-15 | 2018-11-22 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
| MX2020001352A (es) * | 2017-08-09 | 2020-03-20 | Denali Therapeutics Inc | Compuestos, composiciones y metodos. |
| CN111201245B (zh) | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| EP3665142A4 (en) * | 2017-09-11 | 2021-04-28 | Recurium IP Holdings, LLC | CONTINUOUS CURRENT PROCESS FOR THE PRODUCTION OF BICYCLIC CONNECTIONS |
| BR112020014160A2 (pt) * | 2018-01-10 | 2020-12-08 | Recurium Ip Holdings, Llc | Compostos de benzamida |
| WO2019204180A1 (en) * | 2018-04-19 | 2019-10-24 | Merck Sharp & Dohme Corp. | Novel [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| EP3810116B1 (en) * | 2018-05-31 | 2023-11-15 | Merck Sharp & Dohme LLC | Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| US12091392B2 (en) | 2019-02-13 | 2024-09-17 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CA3129609A1 (en) | 2019-02-13 | 2020-08-20 | Denali Therapeutics Inc. | Eukaryotic initiation factor 2b modulators |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
| IL291665B2 (en) * | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| WO2021108198A1 (en) | 2019-11-26 | 2021-06-03 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| US11655237B2 (en) | 2020-03-30 | 2023-05-23 | Gilead Sciences, Inc. | Solid forms of a Cot inhibitor compound |
| AU2021245924B2 (en) | 2020-04-02 | 2024-02-29 | Gilead Sciences, Inc. | Process for preparing a Cot inhibitor compound |
| CN114349774B (zh) * | 2021-12-23 | 2024-06-04 | 凯美克(上海)医药科技有限公司 | 一种双环[1.1.1]戊基角位硼酸酯类化合物的制备方法 |
| CN115010593B (zh) * | 2022-07-15 | 2023-08-25 | 上海毕得医药科技股份有限公司 | 一种3-甲基双环[1.1.1]戊烷-1-羧酸的合成方法 |
| CN116082201B (zh) * | 2023-02-22 | 2024-06-21 | 浙江工业大学 | 一种氯代双环［1.1.1］戊胺衍生物的合成方法 |
| WO2026004939A1 (ja) * | 2024-06-28 | 2026-01-02 | キッセイ薬品工業株式会社 | ジ置換ビシクロ［１．１．１］ペンタン化合物 |
Family Cites Families (49)
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| IL54795A (en) | 1978-05-26 | 1980-10-26 | Yeda Res & Dev | Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types |
| KR900701960A (ko) | 1988-06-03 | 1990-12-05 | 한스 마크 | [1,1,1]프로펠란을 기본으로하는 화합물 및 제조방법 |
| AU626949B2 (en) | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| AU4743890A (en) | 1988-12-06 | 1990-06-26 | Upjohn Company, The | Antibacterial quinolone compounds |
| DE69919142T2 (de) | 1998-03-17 | 2005-01-20 | Pfizer Products Inc., Groton | Bicyclo [2.2.1] heptane und verwandte verbindungen |
| AU3898000A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of neuropathic pain or fibromyalgia |
| DE10025946A1 (de) | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
| CA2409927A1 (en) | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| CA2529674A1 (en) | 2003-07-28 | 2005-02-03 | Merz Pharma Gmbh & Co. Kgaa | The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity |
| AU2004309164B2 (en) * | 2003-12-22 | 2007-11-15 | Pfizer Inc. | Triazole derivatives as vasopressin antagonists |
| GB0329693D0 (en) * | 2003-12-22 | 2004-01-28 | Pfizer Ltd | Compounds useful in therapy |
| WO2006024018A2 (en) | 2004-08-24 | 2006-03-02 | Neuromolecular Pharmaceuticals, Inc. | Compositions for treating nociceptive pain |
| US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
| JP2008120797A (ja) | 2006-10-19 | 2008-05-29 | Dainippon Sumitomo Pharma Co Ltd | Ｎ−置換フェニルアセトアミド誘導体からなる医薬 |
| CA2673922C (en) | 2006-12-27 | 2015-09-29 | Sanofi-Aventis | Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives |
| DE602008005715D1 (de) | 2007-02-06 | 2011-05-05 | Pfizer | 2-amino-5,7-dihydro-6h-pyrroloä3,4-düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs |
| EP2217597B1 (en) | 2007-10-01 | 2011-03-30 | Comentis, Inc. | Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
| TW201010997A (en) * | 2008-06-18 | 2010-03-16 | Pfizer Ltd | Nicotinamide derivatives |
| NZ598269A (en) | 2009-09-18 | 2014-12-24 | Zalicus Pharmaceuticals Ltd | Aryl sulphone derivatives as calcium channel blockers |
| CA2804147A1 (en) | 2010-06-30 | 2012-01-05 | Upsher-Smith Laboratories, Inc. | Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid |
| PE20140245A1 (es) | 2010-10-08 | 2014-03-30 | Abbvie Inc | Compuesto de furo[3,2-d]pirimidina |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| JP5595616B2 (ja) * | 2011-04-05 | 2014-09-24 | ファイザー・リミテッド | トロポミオシン関連キナーゼ阻害薬としてのピロロ［２，３−ｄ］ピリミジン誘導体 |
| HUE064883T2 (hu) | 2011-04-22 | 2024-04-28 | Signal Pharm Llc | Szubsztituált diaminokarboxamid- és diaminokarbonitril-pirimidinek, azok készítményei és azokkal történõ kezelési eljárások |
| PL2699576T3 (pl) | 2011-04-22 | 2016-05-31 | Pfizer | Pochodne pirazolospiroketonu do zastosowania jako inhibitory karboksylazy acetylo-COA |
| UA114606C2 (uk) | 2011-08-12 | 2017-07-10 | Ніссан Кемікал Індастріз, Лтд. | Трициклічні гетероциклічні сполуки та інгібітори jak |
| US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9493481B2 (en) * | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
| CA2870240A1 (en) | 2012-04-27 | 2013-10-31 | Nippon Zoki Pharmaceutical Co., Ltd. | Analgesic |
| CN107982531A (zh) | 2012-10-30 | 2018-05-04 | 吉利德科学公司 | 与赖氨酰氧化酶样蛋白2 (loxl2)相关的治疗和诊断方法 |
| TWI630194B (zh) | 2013-03-14 | 2018-07-21 | 凱立拉製藥公司 | 雙環止痛化合物 |
| WO2014169226A2 (en) | 2013-04-12 | 2014-10-16 | Philadelphia Health & Education Corporation D/B/A Drexel University Of Medicine | Methods of diagnosing and treating chronic pain |
| CA2914525C (en) * | 2013-06-28 | 2021-07-27 | Evotec International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| EP3060550B1 (en) | 2013-10-21 | 2019-05-15 | Merck Patent GmbH | Heteroaryl compounds as btk inhibitors and uses thereof |
| CN103588672A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 一种治疗癌性疼痛的药物 |
| CN103588668A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 化合物 |
| EP3080072A4 (en) | 2013-12-12 | 2017-07-19 | Kalyra Pharmaceuticals, inc. | Bicyclic alkyl compounds and synthesis |
| TW201609671A (zh) | 2013-12-20 | 2016-03-16 | 標誌製藥公司 | 經取代之二胺基嘧啶基化合物、其組合物及使用其之治療方法 |
| WO2015134710A1 (en) | 2014-03-07 | 2015-09-11 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
| AU2015244171A1 (en) | 2014-04-11 | 2016-11-03 | The University Of North Carolina At Chapel Hill | MerTK-specific pyrimidine compounds |
| WO2015159175A1 (en) | 2014-04-15 | 2015-10-22 | Pfizer Inc. | Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety |
| US10004732B2 (en) | 2014-04-24 | 2018-06-26 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| EP3174859B1 (en) | 2014-07-31 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists |
| US10308609B2 (en) | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| BR112017021194A2 (pt) * | 2015-04-03 | 2019-01-08 | Kalyra Pharmaceuticals Inc | compostos espirocíclicos |
| US20190060257A1 (en) | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
-
2015
- 2015-09-15 US US14/855,102 patent/US10308609B2/en active Active
- 2015-09-15 CA CA2961605A patent/CA2961605C/en active Active
- 2015-09-15 EP EP15842230.3A patent/EP3193855B1/en active Active
- 2015-09-15 CN CN201580061363.9A patent/CN106999451B/zh not_active Expired - Fee Related
- 2015-09-15 JP JP2017514844A patent/JP6833677B2/ja not_active Expired - Fee Related
- 2015-09-15 KR KR1020177009800A patent/KR20170048588A/ko not_active Ceased
- 2015-09-15 WO PCT/US2015/050275 patent/WO2016044331A1/en not_active Ceased
- 2015-09-16 TW TW104130651A patent/TWI686376B/zh not_active IP Right Cessation
- 2015-09-17 AR ARP150102980A patent/AR101905A1/es not_active Application Discontinuation
-
2019
- 2019-04-09 US US16/379,487 patent/US10975035B2/en not_active Expired - Fee Related
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