JP2017528446A5 - - Google Patents
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- Publication number
- JP2017528446A5 JP2017528446A5 JP2017508663A JP2017508663A JP2017528446A5 JP 2017528446 A5 JP2017528446 A5 JP 2017528446A5 JP 2017508663 A JP2017508663 A JP 2017508663A JP 2017508663 A JP2017508663 A JP 2017508663A JP 2017528446 A5 JP2017528446 A5 JP 2017528446A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- dlbcl
- compound
- diazepin
- thieno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 35
- 229940124597 therapeutic agent Drugs 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 14
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 12
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 12
- 239000007962 solid dispersion Substances 0.000 claims 8
- 210000003719 b-lymphocyte Anatomy 0.000 claims 6
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 4
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- GNMUEVRJHCWKTO-FQEVSTJZSA-N 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- Chemical compound C([C@@H]1N=C(C2=C(N3C(C)=NN=C31)SC(=C2C)C)C=1C=CC(Cl)=CC=1)C(=O)NC1=CC=C(O)C=C1 GNMUEVRJHCWKTO-FQEVSTJZSA-N 0.000 claims 2
- 230000004163 JAK-STAT signaling pathway Effects 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108020000411 Toll-like receptor Proteins 0.000 claims 2
- 102000002689 Toll-like receptor Human genes 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- -1 compound acetamide dihydrate Chemical class 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 229940124291 BTK inhibitor Drugs 0.000 claims 1
- 108700003785 Baculoviral IAP Repeat-Containing 3 Proteins 0.000 claims 1
- 102100021662 Baculoviral IAP repeat-containing protein 3 Human genes 0.000 claims 1
- 101150104237 Birc3 gene Proteins 0.000 claims 1
- 229940126161 DNA alkylating agent Drugs 0.000 claims 1
- 239000012624 DNA alkylating agent Substances 0.000 claims 1
- 229940126190 DNA methyltransferase inhibitor Drugs 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 102000006947 Histones Human genes 0.000 claims 1
- 108010033040 Histones Proteins 0.000 claims 1
- 101001011441 Homo sapiens Interferon regulatory factor 4 Proteins 0.000 claims 1
- 101000852483 Homo sapiens Interleukin-1 receptor-associated kinase 1 Proteins 0.000 claims 1
- 101000669406 Homo sapiens Toll-like receptor 6 Proteins 0.000 claims 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 1
- 102100030126 Interferon regulatory factor 4 Human genes 0.000 claims 1
- 102100036342 Interleukin-1 receptor-associated kinase 1 Human genes 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 101150039798 MYC gene Proteins 0.000 claims 1
- 101150053046 MYD88 gene Proteins 0.000 claims 1
- 102100024134 Myeloid differentiation primary response protein MyD88 Human genes 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- 101100379220 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) API2 gene Proteins 0.000 claims 1
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 claims 1
- 102100039387 Toll-like receptor 6 Human genes 0.000 claims 1
- 108010047933 Tumor Necrosis Factor alpha-Induced Protein 3 Proteins 0.000 claims 1
- 102100024596 Tumor necrosis factor alpha-induced protein 3 Human genes 0.000 claims 1
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 claims 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 229960002707 bendamustine Drugs 0.000 claims 1
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 1
- 229960003603 decitabine Drugs 0.000 claims 1
- 239000003968 dna methyltransferase inhibitor Substances 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- 229960004942 lenalidomide Drugs 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 1
- 108091028159 miR-92a-1 stem-loop Proteins 0.000 claims 1
- 108091086713 miR-96 stem-loop Proteins 0.000 claims 1
- 108091028482 miR-96-1 stem-loop Proteins 0.000 claims 1
- 108091090007 miR-96-2 stem-loop Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 1
- 229960003452 romidepsin Drugs 0.000 claims 1
- OHRURASPPZQGQM-UHFFFAOYSA-N romidepsin Natural products O1C(=O)C(C(C)C)NC(=O)C(=CC)NC(=O)C2CSSCCC=CC1CC(=O)NC(C(C)C)C(=O)N2 OHRURASPPZQGQM-UHFFFAOYSA-N 0.000 claims 1
- 108010091666 romidepsin Proteins 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462039072P | 2014-08-19 | 2014-08-19 | |
| US62/039,072 | 2014-08-19 | ||
| US201462086609P | 2014-12-02 | 2014-12-02 | |
| US62/086,609 | 2014-12-02 | ||
| PCT/EP2015/069092 WO2016026912A1 (en) | 2014-08-19 | 2015-08-19 | Methods of treating lymphoma using thienotriazolodiazepine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528446A JP2017528446A (ja) | 2017-09-28 |
| JP2017528446A5 true JP2017528446A5 (https=) | 2018-09-27 |
Family
ID=53900822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017508663A Pending JP2017528446A (ja) | 2014-08-19 | 2015-08-19 | チエノトリアゾロジアゼピン化合物を用いるリンパ腫の治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9968620B2 (https=) |
| EP (1) | EP3182976A1 (https=) |
| JP (1) | JP2017528446A (https=) |
| KR (1) | KR20170037670A (https=) |
| CN (1) | CN107073011A (https=) |
| WO (1) | WO2016026912A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108057036B (zh) * | 2016-11-07 | 2023-06-13 | 正大天晴药业集团股份有限公司 | 一种egfr抑制剂的固体药物组合物 |
| WO2022261204A1 (en) | 2021-06-08 | 2022-12-15 | The Regents Of The University Of California | Anticancer compounds |
| WO2025120552A1 (ko) * | 2023-12-07 | 2025-06-12 | 제이더블유중외제약 주식회사 | 헤테로사이클 유도체 함유 고체분산체, 이의 제조 방법, 이를 포함하는 약학적 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001095912A1 (fr) * | 2000-06-16 | 2001-12-20 | Mitsubishi Pharma Corporation | Compositions permettant de reguler la plage et/ou la vitesse de liberation du ph |
| KR101600634B1 (ko) * | 2007-12-28 | 2016-03-07 | 미쓰비시 타나베 파마 코퍼레이션 | 항암제 |
| AU2013283378B2 (en) * | 2012-06-25 | 2017-07-13 | Oncoethix Gmbh | Method of treating lymphoma using thienotriazolodiazepine compounds |
| JP2015531365A (ja) * | 2012-09-28 | 2015-11-02 | オンコエシックス エスエー | チエノトリアゾロジアゼピン化合物を含む医薬製剤 |
| WO2015018520A1 (en) | 2013-08-06 | 2015-02-12 | Oncoethix Sa | A bet-brd inhibitor represents a novel agent for alk positive anaplastic large cell lymphoma |
| JP2016529246A (ja) | 2013-08-06 | 2016-09-23 | オンコエシックス ゲーエムベーハー | Ｂｅｔブロモドメイン阻害剤を用いるびまん性大細胞型ｂ細胞性リンパ腫（ｄｌｂｃｌ）の治療方法 |
| US20170095484A1 (en) * | 2014-05-02 | 2017-04-06 | Oncoethix Gmbh | Method of treating resistant non-hodgkin lymphoma, medulloblastoma, and/or alk+non-small cell lung cancer using thienotriazolodiazepine compounds |
-
2015
- 2015-08-19 KR KR1020177007302A patent/KR20170037670A/ko not_active Withdrawn
- 2015-08-19 US US15/504,722 patent/US9968620B2/en not_active Expired - Fee Related
- 2015-08-19 WO PCT/EP2015/069092 patent/WO2016026912A1/en not_active Ceased
- 2015-08-19 EP EP15753363.9A patent/EP3182976A1/en not_active Withdrawn
- 2015-08-19 CN CN201580045068.4A patent/CN107073011A/zh active Pending
- 2015-08-19 JP JP2017508663A patent/JP2017528446A/ja active Pending
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