JP2017528164A5 - - Google Patents
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- JP2017528164A5 JP2017528164A5 JP2017533744A JP2017533744A JP2017528164A5 JP 2017528164 A5 JP2017528164 A5 JP 2017528164A5 JP 2017533744 A JP2017533744 A JP 2017533744A JP 2017533744 A JP2017533744 A JP 2017533744A JP 2017528164 A5 JP2017528164 A5 JP 2017528164A5
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- 238000012360 testing method Methods 0.000 claims description 153
- 239000000090 biomarker Substances 0.000 claims description 129
- 239000000523 sample Substances 0.000 claims description 113
- 238000000034 method Methods 0.000 claims description 103
- 230000000750 progressive effect Effects 0.000 claims description 80
- 239000013074 reference sample Substances 0.000 claims description 75
- 239000003795 chemical substances by application Substances 0.000 claims description 46
- 101000744900 Homo sapiens Zinc finger homeobox protein 3 Proteins 0.000 claims description 38
- 102100039966 Zinc finger homeobox protein 3 Human genes 0.000 claims description 38
- 238000001514 detection method Methods 0.000 claims description 38
- 101000830742 Homo sapiens Tryptophan 5-hydroxylase 1 Proteins 0.000 claims description 37
- 102100024971 Tryptophan 5-hydroxylase 1 Human genes 0.000 claims description 37
- 102100034330 Chromaffin granule amine transporter Human genes 0.000 claims description 34
- 108091006772 SLC18A1 Proteins 0.000 claims description 34
- 101000579354 Homo sapiens PHD finger protein 21A Proteins 0.000 claims description 29
- 102100028222 PHD finger protein 21A Human genes 0.000 claims description 29
- 102100030708 GTPase KRas Human genes 0.000 claims description 28
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 claims description 28
- 101000973960 Homo sapiens Nucleolar protein 3 Proteins 0.000 claims description 27
- 101000974015 Homo sapiens Nucleosome assembly protein 1-like 1 Proteins 0.000 claims description 27
- 102100022400 Nucleolar protein 3 Human genes 0.000 claims description 27
- 102100022389 Nucleosome assembly protein 1-like 1 Human genes 0.000 claims description 27
- 101000967216 Homo sapiens Eosinophil cationic protein Proteins 0.000 claims description 26
- 101000712530 Homo sapiens RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 claims description 26
- 101000771237 Homo sapiens Serine/threonine-protein kinase A-Raf Proteins 0.000 claims description 26
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 claims description 26
- 102100029437 Serine/threonine-protein kinase A-Raf Human genes 0.000 claims description 26
- 101000992748 Homo sapiens Mortality factor 4-like protein 2 Proteins 0.000 claims description 25
- 101000829153 Homo sapiens Somatostatin receptor type 5 Proteins 0.000 claims description 25
- 102100031304 Mortality factor 4-like protein 2 Human genes 0.000 claims description 25
- 102100029329 Somatostatin receptor type 1 Human genes 0.000 claims description 25
- 102100023801 Somatostatin receptor type 4 Human genes 0.000 claims description 25
- 102100023806 Somatostatin receptor type 5 Human genes 0.000 claims description 25
- 108010064556 somatostatin receptor subtype-4 Proteins 0.000 claims description 25
- 108010082379 somatostatin receptor type 1 Proteins 0.000 claims description 25
- 101001094820 Homo sapiens Paraneoplastic antigen Ma2 Proteins 0.000 claims description 23
- 101000727979 Homo sapiens Remodeling and spacing factor 1 Proteins 0.000 claims description 23
- 102100035467 Paraneoplastic antigen Ma2 Human genes 0.000 claims description 23
- 102100029771 Remodeling and spacing factor 1 Human genes 0.000 claims description 23
- 101000687634 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Proteins 0.000 claims description 22
- 101000829138 Homo sapiens Somatostatin receptor type 3 Proteins 0.000 claims description 22
- 102100024837 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Human genes 0.000 claims description 22
- 102100023803 Somatostatin receptor type 3 Human genes 0.000 claims description 22
- 102100039676 Frizzled-7 Human genes 0.000 claims description 21
- 101000885797 Homo sapiens Frizzled-7 Proteins 0.000 claims description 21
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 claims description 19
- 102100031168 CCN family member 2 Human genes 0.000 claims description 19
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 19
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 claims description 19
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims description 19
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 19
- 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 claims description 19
- 101000652369 Homo sapiens Spermatogenesis-associated protein 7 Proteins 0.000 claims description 19
- 102100034836 Proliferation marker protein Ki-67 Human genes 0.000 claims description 19
- 108091006775 SLC18A2 Proteins 0.000 claims description 19
- 102100030257 Spermatogenesis-associated protein 7 Human genes 0.000 claims description 19
- 102100034333 Synaptic vesicular amine transporter Human genes 0.000 claims description 19
- 101000798124 Homo sapiens Multifunctional methyltransferase subunit TRM112-like protein Proteins 0.000 claims description 18
- 102100032242 Multifunctional methyltransferase subunit TRM112-like protein Human genes 0.000 claims description 18
- 238000003745 diagnosis Methods 0.000 claims description 18
- 101000976379 Homo sapiens ZZ-type zinc finger-containing protein 3 Proteins 0.000 claims description 16
- 102100023893 ZZ-type zinc finger-containing protein 3 Human genes 0.000 claims description 16
- 239000002299 complementary DNA Substances 0.000 claims description 14
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 13
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 13
- 102100026246 E3 ubiquitin-protein ligase NRDP1 Human genes 0.000 claims description 12
- 101000692706 Homo sapiens E3 ubiquitin-protein ligase NRDP1 Proteins 0.000 claims description 12
- 101000835705 Homo sapiens Tectonin beta-propeller repeat-containing protein 2 Proteins 0.000 claims description 12
- 102100026312 Tectonin beta-propeller repeat-containing protein 2 Human genes 0.000 claims description 12
- 102100036184 5'-3' exonuclease PLD3 Human genes 0.000 claims description 11
- 101001074389 Homo sapiens 5'-3' exonuclease PLD3 Proteins 0.000 claims description 11
- 238000001356 surgical procedure Methods 0.000 claims description 11
- 238000002560 therapeutic procedure Methods 0.000 claims description 11
- 102100022614 COMM domain-containing protein 9 Human genes 0.000 claims description 10
- 101000899981 Homo sapiens COMM domain-containing protein 9 Proteins 0.000 claims description 10
- 101000982889 Homo sapiens Ornithine decarboxylase antizyme 2 Proteins 0.000 claims description 9
- 101000981502 Homo sapiens Pantothenate kinase 2, mitochondrial Proteins 0.000 claims description 9
- 101000807961 Homo sapiens V-type proton ATPase subunit H Proteins 0.000 claims description 9
- 102100027035 Ornithine decarboxylase antizyme 2 Human genes 0.000 claims description 9
- 102100024127 Pantothenate kinase 2, mitochondrial Human genes 0.000 claims description 9
- 102100039006 V-type proton ATPase subunit H Human genes 0.000 claims description 9
- 102100028698 Glycosyltransferase 8 domain-containing protein 1 Human genes 0.000 claims description 8
- 101001058421 Homo sapiens Glycosyltransferase 8 domain-containing protein 1 Proteins 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 230000004044 response Effects 0.000 claims description 8
- 230000004614 tumor growth Effects 0.000 claims description 8
- 101000611427 Homo sapiens Polyglutamine-binding protein 1 Proteins 0.000 claims description 7
- -1 Ki67 Proteins 0.000 claims description 7
- 102100040748 Polyglutamine-binding protein 1 Human genes 0.000 claims description 7
- 230000001613 neoplastic effect Effects 0.000 claims description 5
- 238000012935 Averaging Methods 0.000 claims description 4
- 101000829127 Homo sapiens Somatostatin receptor type 2 Proteins 0.000 claims description 4
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 4
- 102100023802 Somatostatin receptor type 2 Human genes 0.000 claims description 4
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 239000002853 nucleic acid probe Substances 0.000 claims description 4
- 102000014187 peptide receptors Human genes 0.000 claims description 4
- 108010011903 peptide receptors Proteins 0.000 claims description 4
- 102000005157 Somatostatin Human genes 0.000 claims description 3
- 108010056088 Somatostatin Proteins 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims description 3
- 229960000553 somatostatin Drugs 0.000 claims description 3
- 101000667104 Homo sapiens Vacuolar protein sorting-associated protein 13C Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102100039112 Vacuolar protein sorting-associated protein 13C Human genes 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000009826 neoplastic cell growth Effects 0.000 claims description 2
- 230000000955 neuroendocrine Effects 0.000 claims description 2
- 230000000306 recurrent effect Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 102100026611 Alpha-1,2-mannosyltransferase ALG9 Human genes 0.000 claims 19
- 101000717828 Homo sapiens Alpha-1,2-mannosyltransferase ALG9 Proteins 0.000 claims 19
- 102100040428 Chitobiosyldiphosphodolichol beta-mannosyltransferase Human genes 0.000 claims 2
- 101000891557 Homo sapiens Chitobiosyldiphosphodolichol beta-mannosyltransferase Proteins 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000010801 machine learning Methods 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 238000012706 support-vector machine Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 102100037140 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Human genes 0.000 description 6
- 101000740545 Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Proteins 0.000 description 6
- 101000771662 Homo sapiens WD repeat and FYVE domain-containing protein 3 Proteins 0.000 description 6
- 102100029465 WD repeat and FYVE domain-containing protein 3 Human genes 0.000 description 6
- 239000003550 marker Substances 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050465P | 2014-09-15 | 2014-09-15 | |
| US62/050,465 | 2014-09-15 | ||
| PCT/US2015/050274 WO2016044330A1 (en) | 2014-09-15 | 2015-09-15 | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020175701A Division JP7157788B2 (ja) | 2014-09-15 | 2020-10-20 | 膵・消化管神経内分泌新生物の診断のための組成物、方法およびキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528164A JP2017528164A (ja) | 2017-09-28 |
| JP2017528164A5 true JP2017528164A5 (https=) | 2018-10-18 |
| JP6782700B2 JP6782700B2 (ja) | 2020-11-11 |
Family
ID=54207775
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533744A Active JP6782700B2 (ja) | 2014-09-15 | 2015-09-15 | 膵・消化管神経内分泌新生物の診断のための組成物、方法およびキット |
| JP2020175701A Active JP7157788B2 (ja) | 2014-09-15 | 2020-10-20 | 膵・消化管神経内分泌新生物の診断のための組成物、方法およびキット |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020175701A Active JP7157788B2 (ja) | 2014-09-15 | 2020-10-20 | 膵・消化管神経内分泌新生物の診断のための組成物、方法およびキット |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10407730B2 (https=) |
| EP (2) | EP3194618B1 (https=) |
| JP (2) | JP6782700B2 (https=) |
| KR (2) | KR102762958B1 (https=) |
| CN (1) | CN107208132A (https=) |
| AU (3) | AU2015317893B2 (https=) |
| CA (1) | CA2959670C (https=) |
| DK (2) | DK3929303T3 (https=) |
| ES (2) | ES2881474T3 (https=) |
| IL (2) | IL250867B (https=) |
| MX (2) | MX386919B (https=) |
| PL (2) | PL3929303T3 (https=) |
| WO (1) | WO2016044330A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3194618B1 (en) | 2014-09-15 | 2021-04-21 | Clifton Life Sciences LLC | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm |
| KR102763004B1 (ko) * | 2017-05-25 | 2025-02-04 | 리퀴드 바이옵시 리서치 엘엘씨 | 흑색종의 검출 방법 |
| KR20250123230A (ko) * | 2017-11-30 | 2025-08-14 | 리퀴드 바이옵시 리서치 엘엘씨 | 유전자 발현 검정을 이용한 펩티드 수용체 방사선요법의 예측 |
| CN108048564B (zh) * | 2018-02-09 | 2021-03-05 | 中国科学院昆明动物研究所 | 人glt8d1基因的新用途 |
| WO2020027732A1 (en) * | 2018-07-30 | 2020-02-06 | Agency For Science, Technology And Research | Method and system for assessing fibrosis in a tissue sample |
| MX2022004372A (es) | 2019-10-10 | 2022-07-27 | Liquid Biopsy Res Llc | Composiciones, métodos y kits para la estabilización de muestras biológicas y de arn. |
| FR3110764B1 (fr) * | 2020-05-20 | 2024-05-10 | Quantum Surgical | Méthode de prédiction de la récidive d’une lésion par analyse d’images |
| CN113215255B (zh) * | 2021-04-26 | 2022-04-05 | 山东天川精准医疗科技有限公司 | 用于肝癌早期诊断或预后的生物标记物及其用途 |
| US20260021141A1 (en) * | 2022-07-15 | 2026-01-22 | Emendobio Inc. | Strategies For Knock-Ins At APLP2 Safe Harbor Sites |
| KR20250080875A (ko) * | 2022-09-30 | 2025-06-05 | 리퀴드 바이옵시 리서치 엘엘씨 | 타액에서 신경내분비암을 검출하는 방법 |
| CN117292755B (zh) * | 2023-08-09 | 2026-02-06 | 郑州大学 | 多模态临界边生物标志物识别方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005020795A2 (en) | 2003-08-25 | 2005-03-10 | The Johns Hopkins University | Method of diagnosis and treatment of pancreatic endocrine neoplasms based on differntial gene expression analysis |
| CA2727082C (en) * | 2008-06-12 | 2019-02-26 | Syntaxin Limited | Fusion proteins for use in suppression of acromegaly |
| WO2012119013A1 (en) * | 2011-03-01 | 2012-09-07 | Yale University | PREDICTING GASTROENTEROPANCREATIC NEUROENDOCRINE NEOPLASMS (GEP-NENs) |
| EP3194618B1 (en) | 2014-09-15 | 2021-04-21 | Clifton Life Sciences LLC | Compositions, methods and kits for diagnosis of a gastroenteropancreatic neuroendocrine neoplasm |
-
2015
- 2015-09-15 EP EP15771837.0A patent/EP3194618B1/en active Active
- 2015-09-15 CN CN201580061761.0A patent/CN107208132A/zh active Pending
- 2015-09-15 US US14/855,229 patent/US10407730B2/en active Active
- 2015-09-15 MX MX2017003370A patent/MX386919B/es unknown
- 2015-09-15 ES ES15771837T patent/ES2881474T3/es active Active
- 2015-09-15 EP EP21169154.8A patent/EP3929303B1/en active Active
- 2015-09-15 CA CA2959670A patent/CA2959670C/en active Active
- 2015-09-15 PL PL21169154.8T patent/PL3929303T3/pl unknown
- 2015-09-15 PL PL15771837T patent/PL3194618T3/pl unknown
- 2015-09-15 KR KR1020177010086A patent/KR102762958B1/ko active Active
- 2015-09-15 JP JP2017533744A patent/JP6782700B2/ja active Active
- 2015-09-15 AU AU2015317893A patent/AU2015317893B2/en active Active
- 2015-09-15 ES ES21169154T patent/ES3013599T3/es active Active
- 2015-09-15 DK DK21169154.8T patent/DK3929303T3/da active
- 2015-09-15 WO PCT/US2015/050274 patent/WO2016044330A1/en not_active Ceased
- 2015-09-15 KR KR1020257003150A patent/KR20250021631A/ko active Pending
- 2015-09-15 DK DK15771837.0T patent/DK3194618T3/da active
-
2017
- 2017-03-01 IL IL250867A patent/IL250867B/en active IP Right Grant
- 2017-03-14 MX MX2021012347A patent/MX2021012347A/es unknown
-
2019
- 2019-08-01 US US16/528,864 patent/US11168372B2/en active Active
-
2020
- 2020-10-20 JP JP2020175701A patent/JP7157788B2/ja active Active
-
2021
- 2021-03-09 IL IL281355A patent/IL281355B/en unknown
- 2021-08-06 AU AU2021212151A patent/AU2021212151B2/en active Active
- 2021-11-08 US US17/521,205 patent/US12258633B2/en active Active
-
2023
- 2023-11-03 AU AU2023258444A patent/AU2023258444A1/en active Pending
-
2025
- 2025-03-05 US US19/071,035 patent/US20260043085A1/en active Pending
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