JP2017528114A5 - - Google Patents
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- JP2017528114A5 JP2017528114A5 JP2016574232A JP2016574232A JP2017528114A5 JP 2017528114 A5 JP2017528114 A5 JP 2017528114A5 JP 2016574232 A JP2016574232 A JP 2016574232A JP 2016574232 A JP2016574232 A JP 2016574232A JP 2017528114 A5 JP2017528114 A5 JP 2017528114A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- cells
- population
- antigen
- passaged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 77
- 201000011510 cancer Diseases 0.000 claims 36
- 238000000034 method Methods 0.000 claims 33
- 210000004027 cell Anatomy 0.000 claims 30
- 210000004881 tumor cell Anatomy 0.000 claims 30
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 210000000130 stem cell Anatomy 0.000 claims 20
- 238000001727 in vivo Methods 0.000 claims 18
- 239000002771 cell marker Substances 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 8
- 102000004669 Protein-Lysine 6-Oxidase Human genes 0.000 claims 6
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 claims 6
- 201000008271 Atypical teratoid rhabdoid tumor Diseases 0.000 claims 5
- 102000052030 Aldehyde Dehydrogenase 1 Family Human genes 0.000 claims 4
- 101710196131 Aldehyde dehydrogenase 1 Proteins 0.000 claims 4
- 101001009683 Homo sapiens Neuronal membrane glycoprotein M6-a Proteins 0.000 claims 4
- 102100030394 Neuronal membrane glycoprotein M6-a Human genes 0.000 claims 4
- 102100027980 Semaphorin-3C Human genes 0.000 claims 4
- 101710199433 Semaphorin-3C Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 claims 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 claims 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 206010051810 Angiomyolipoma Diseases 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 201000008199 Pleuropulmonary blastoma Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- AGSPXMVUFBBBMO-UHFFFAOYSA-N beta-aminopropionitrile Chemical compound NCCC#N AGSPXMVUFBBBMO-UHFFFAOYSA-N 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000006285 cell suspension Substances 0.000 claims 1
- 208000012191 childhood neoplasm Diseases 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462016773P | 2014-06-25 | 2014-06-25 | |
| US62/016,773 | 2014-06-25 | ||
| PCT/IL2015/050663 WO2015198334A2 (en) | 2014-06-25 | 2015-06-25 | Identification of cancer stem cells and use of same for diagnosis and treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528114A JP2017528114A (ja) | 2017-09-28 |
| JP2017528114A5 true JP2017528114A5 (enExample) | 2018-08-09 |
| JP6587288B2 JP6587288B2 (ja) | 2019-10-09 |
Family
ID=53674236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574232A Expired - Fee Related JP6587288B2 (ja) | 2014-06-25 | 2015-06-25 | がん幹細胞の同定ならびに診断および処置のためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10883994B2 (enExample) |
| EP (1) | EP3161480B1 (enExample) |
| JP (1) | JP6587288B2 (enExample) |
| KR (1) | KR20170041192A (enExample) |
| CN (1) | CN106537148B (enExample) |
| AU (1) | AU2015278659A1 (enExample) |
| CA (1) | CA2953663A1 (enExample) |
| ES (1) | ES2791199T3 (enExample) |
| IL (1) | IL249741B (enExample) |
| SG (1) | SG11201610630RA (enExample) |
| WO (1) | WO2015198334A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2791199T3 (es) | 2014-06-25 | 2020-11-03 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Identificación de marcadores de células madre cancerosas y uso de los mismos para diagnóstico y tratamiento |
| WO2017153475A1 (en) * | 2016-03-09 | 2017-09-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Total cellular iron as a marker of cancer stem cells and uses thereof |
| CN108967358A (zh) * | 2018-05-31 | 2018-12-11 | 上海交通大学医学院附属瑞金医院 | 一种斑马鱼fl肿瘤模型的构建方法及其应用 |
| KR20200109544A (ko) * | 2019-03-13 | 2020-09-23 | 울산대학교 산학협력단 | 공통 유전자 추출에 의한 다중 암 분류 방법 |
| KR102400464B1 (ko) * | 2020-07-28 | 2022-05-19 | 부산대학교 산학협력단 | 암 줄기세포 검출용 바이오 마커 조성물 |
| CN114624304B (zh) * | 2021-12-09 | 2023-09-19 | 重庆医科大学国际体外诊断研究院 | 基于铈银纳米花和分支DNAzyme步行器的miRNA电化学传感器 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4289747A (en) | 1978-12-26 | 1981-09-15 | E-Y Laboratories, Inc. | Immunological determination using lectin |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5204096A (en) | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5171578A (en) | 1985-06-26 | 1992-12-15 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
| US5258499A (en) | 1988-05-16 | 1993-11-02 | Vestar, Inc. | Liposome targeting using receptor specific ligands |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US5935850A (en) | 1996-09-30 | 1999-08-10 | The Research Foundation Of State University Of New York | Model for cell migration and use thereof |
| US6037137A (en) | 1997-02-20 | 2000-03-14 | Oncoimmunin, Inc. | Fluorogenic peptides for the detection of protease activity |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| TW200422749A (en) | 2003-04-22 | 2004-11-01 | Adv Lcd Tech Dev Ct Co Ltd | Crystallization apparatus, crystallization method, phase modulation element, device and display apparatus |
| US20070021365A1 (en) * | 2005-06-21 | 2007-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto |
| CN101855339A (zh) | 2007-01-22 | 2010-10-06 | 雷文生物技术公司 | 人类癌症干细胞 |
| EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
| CA2715036A1 (en) * | 2008-03-14 | 2009-09-17 | Retrotope, Inc. | Therapies for cancer using isotopically substituted lysine |
| EP2263072A1 (en) | 2008-03-26 | 2010-12-22 | Veritide Limited | An analysis system |
| WO2010009121A2 (en) * | 2008-07-15 | 2010-01-21 | University Of Florida Research Foundation, Inc. | Colon stem cells associated with colitis and colorectal cancer and methods of use |
| WO2010097793A2 (en) | 2009-02-26 | 2010-09-02 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Isolated populations of renal stem cells and methods of isolating and using same |
| WO2010110346A1 (ja) * | 2009-03-24 | 2010-09-30 | 独立行政法人理化学研究所 | 白血病幹細胞マーカー |
| WO2012031280A2 (en) | 2010-09-03 | 2012-03-08 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
| EP2772268B8 (en) * | 2011-10-28 | 2020-01-08 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| ES2791199T3 (es) | 2014-06-25 | 2020-11-03 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Identificación de marcadores de células madre cancerosas y uso de los mismos para diagnóstico y tratamiento |
-
2015
- 2015-06-25 ES ES15739030T patent/ES2791199T3/es active Active
- 2015-06-25 CA CA2953663A patent/CA2953663A1/en not_active Abandoned
- 2015-06-25 WO PCT/IL2015/050663 patent/WO2015198334A2/en not_active Ceased
- 2015-06-25 JP JP2016574232A patent/JP6587288B2/ja not_active Expired - Fee Related
- 2015-06-25 AU AU2015278659A patent/AU2015278659A1/en not_active Abandoned
- 2015-06-25 EP EP15739030.3A patent/EP3161480B1/en active Active
- 2015-06-25 KR KR1020177001924A patent/KR20170041192A/ko not_active Withdrawn
- 2015-06-25 US US15/320,847 patent/US10883994B2/en active Active
- 2015-06-25 SG SG11201610630RA patent/SG11201610630RA/en unknown
- 2015-06-25 CN CN201580037960.8A patent/CN106537148B/zh not_active Expired - Fee Related
-
2016
- 2016-12-22 IL IL249741A patent/IL249741B/en active IP Right Grant
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