JP2017526924A5 - - Google Patents
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- Publication number
- JP2017526924A5 JP2017526924A5 JP2017511945A JP2017511945A JP2017526924A5 JP 2017526924 A5 JP2017526924 A5 JP 2017526924A5 JP 2017511945 A JP2017511945 A JP 2017511945A JP 2017511945 A JP2017511945 A JP 2017511945A JP 2017526924 A5 JP2017526924 A5 JP 2017526924A5
- Authority
- JP
- Japan
- Prior art keywords
- nep
- vitro
- vitro method
- soluble
- test sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 238000000338 in vitro Methods 0.000 claims 12
- 102000003729 Neprilysin Human genes 0.000 claims 11
- 108090000028 Neprilysin Proteins 0.000 claims 11
- 206010019280 Heart failures Diseases 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 2
- 230000007211 cardiovascular event Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 238000010837 poor prognosis Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14182846.7A EP2990800A1 (en) | 2014-08-29 | 2014-08-29 | Neprilysin as heartfailure (HF) prognostic marker |
| EP14182846.7 | 2014-08-29 | ||
| PCT/EP2015/068729 WO2016030209A1 (en) | 2014-08-29 | 2015-08-14 | Neprilysin as heart failure prognostic marker |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526924A JP2017526924A (ja) | 2017-09-14 |
| JP2017526924A5 true JP2017526924A5 (enExample) | 2018-09-20 |
| JP6661216B2 JP6661216B2 (ja) | 2020-03-11 |
Family
ID=51421966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511945A Expired - Fee Related JP6661216B2 (ja) | 2014-08-29 | 2015-08-14 | 心不全予後マーカーとしてのネプリライシン |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10203341B2 (enExample) |
| EP (2) | EP2990800A1 (enExample) |
| JP (1) | JP6661216B2 (enExample) |
| CN (1) | CN107076758B (enExample) |
| AU (1) | AU2015309112A1 (enExample) |
| CA (1) | CA2959094A1 (enExample) |
| ES (1) | ES2734876T3 (enExample) |
| MX (1) | MX2017002453A (enExample) |
| RU (1) | RU2017109086A (enExample) |
| SG (1) | SG11201701393YA (enExample) |
| WO (1) | WO2016030209A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4056585A4 (en) * | 2019-11-06 | 2024-03-13 | National University Corporation Kagawa University | HEART FAILURE MARKER |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329648B (en) * | 2001-09-03 | 2010-09-01 | Intreat Pty Ltd | Diagnosis and treatment of cancers and other conditions |
| US10324093B2 (en) * | 2009-11-07 | 2019-06-18 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP2360280A1 (en) * | 2010-02-24 | 2011-08-24 | Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol | Genetic marker for the diagnosis of dementia with Lewy bodies |
| CN103403554A (zh) * | 2011-02-03 | 2013-11-20 | 雅培制药有限公司 | 慢性心力衰竭的预后和诊断方法 |
| JP5945063B2 (ja) * | 2012-04-12 | 2016-07-05 | ベー．エル．アー．ハー．エム．エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 慢性心不全が疑われる患者における有害事象の予後 |
| SI2887961T1 (sl) * | 2012-08-24 | 2021-08-31 | Novartis Ag | Zaviralci NEP za zdravljenje bolezni, značilnih po atrialni širitvi ali preoblikovanju |
| US20140206632A1 (en) | 2013-01-22 | 2014-07-24 | Singulex, Inc. | Endothelin in the Diagnosis of Cardiac Disease |
| SI2956464T1 (en) * | 2013-02-14 | 2018-08-31 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors (neutral endopeptidases) |
| CN105008337B (zh) * | 2013-02-14 | 2017-08-04 | 诺华股份有限公司 | 具有改善的体内功效的作为nep抑制剂的取代的联苯基丁酸衍生物 |
-
2014
- 2014-08-29 EP EP14182846.7A patent/EP2990800A1/en not_active Withdrawn
-
2015
- 2015-08-14 CA CA2959094A patent/CA2959094A1/en not_active Abandoned
- 2015-08-14 AU AU2015309112A patent/AU2015309112A1/en not_active Abandoned
- 2015-08-14 JP JP2017511945A patent/JP6661216B2/ja not_active Expired - Fee Related
- 2015-08-14 MX MX2017002453A patent/MX2017002453A/es unknown
- 2015-08-14 WO PCT/EP2015/068729 patent/WO2016030209A1/en not_active Ceased
- 2015-08-14 EP EP15750737.7A patent/EP3186639B1/en not_active Not-in-force
- 2015-08-14 CN CN201580050585.0A patent/CN107076758B/zh not_active Expired - Fee Related
- 2015-08-14 SG SG11201701393YA patent/SG11201701393YA/en unknown
- 2015-08-14 US US15/506,665 patent/US10203341B2/en not_active Expired - Fee Related
- 2015-08-14 RU RU2017109086A patent/RU2017109086A/ru not_active Application Discontinuation
- 2015-08-14 ES ES15750737T patent/ES2734876T3/es active Active
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