JP2017523214A - ヘテロ環キナーゼ阻害剤 - Google Patents

ヘテロ環キナーゼ阻害剤 Download PDF

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Publication number
JP2017523214A
JP2017523214A JP2017506378A JP2017506378A JP2017523214A JP 2017523214 A JP2017523214 A JP 2017523214A JP 2017506378 A JP2017506378 A JP 2017506378A JP 2017506378 A JP2017506378 A JP 2017506378A JP 2017523214 A JP2017523214 A JP 2017523214A
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JP
Japan
Prior art keywords
benzo
imidazol
amine
pyridin
mmol
Prior art date
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Pending
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JP2017506378A
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English (en)
Japanese (ja)
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JP2017523214A5 (enExample
Inventor
キャロリン・ダイアン・ジアーバ
ジョアン・ジェイ・ブロンソン
ジョン・イー・マコー
ビレシュワル・ダスグプタ
スシール・ジェタナンド・ナラ
ビベカナンダ・エム・ブルドゥラ
パン・センリアン
リチャード・エイ・ハーツ
ラムクマール・ラジャマニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2017523214A publication Critical patent/JP2017523214A/ja
Publication of JP2017523214A5 publication Critical patent/JP2017523214A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017506378A 2014-08-05 2015-07-27 ヘテロ環キナーゼ阻害剤 Pending JP2017523214A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462033425P 2014-08-05 2014-08-05
US62/033,425 2014-08-05
PCT/US2015/042165 WO2016022312A1 (en) 2014-08-05 2015-07-27 Heterocyclic kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2017523214A true JP2017523214A (ja) 2017-08-17
JP2017523214A5 JP2017523214A5 (enExample) 2018-03-29

Family

ID=53784009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017506378A Pending JP2017523214A (ja) 2014-08-05 2015-07-27 ヘテロ環キナーゼ阻害剤

Country Status (5)

Country Link
US (1) US10035777B2 (enExample)
EP (1) EP3177604A1 (enExample)
JP (1) JP2017523214A (enExample)
CN (1) CN107108552A (enExample)
WO (1) WO2016022312A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021510707A (ja) * 2018-01-15 2021-04-30 ユーシービー バイオファルマ エスアールエル Ｉｌ−１７モジュレータとしての縮合イミダゾール誘導体
JP2022548568A (ja) * 2019-09-11 2022-11-21 プレリュード・セラピューティクス・インコーポレイテッド Ｃｄｋ阻害剤及び医薬品としてのそれらの使用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3019475A1 (en) 2013-07-08 2016-05-18 Bristol-Myers Squibb Company Aryl amide kinase inhibitors
ES2678877T3 (es) 2013-10-11 2018-08-20 Bristol-Myers Squibb Company Inhibidores de pirrolotriazina quinasa
EA202090306A1 (ru) * 2017-07-21 2020-06-25 Кадмон Корпорейшн, Ллк ИНГИБИТОРЫ Rho-АССОЦИИРОВАННОЙ, СОДЕРЖАЩЕЙ СУПЕРСПИРАЛЬ ПРОТЕИНКИНАЗЫ
KR102595520B1 (ko) 2018-07-05 2023-10-30 엘지디스플레이 주식회사 헤테로아릴기를 가진 벤즈아졸 유도체 및 이를 포함하는 유기전계발광소자
WO2020021015A1 (en) * 2018-07-26 2020-01-30 Esteve Pharmaceuticals, S.A. New imidazopyridine derivatives for treating pain and pain related conditions
CN115884810B (zh) 2020-04-30 2025-01-17 詹森药业有限公司 作为il-17调节剂的咪唑并哒嗪
WO2022152852A1 (en) * 2021-01-15 2022-07-21 Glaxosmithkline Intellectual Property Development Limited Antagonists of mrgx2

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH04253966A (ja) * 1990-07-23 1992-09-09 Dr Karl Thomae Gmbh ベンゾイミダゾール、これらの化合物を含む製薬組成物
EP0543263A2 (de) * 1991-11-16 1993-05-26 Dr. Karl Thomae GmbH Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CN101798300A (zh) * 2010-02-23 2010-08-11 陈志龙 N-苯基吲哚甲基取代的双苯并咪唑衍生物及其降压等应用
JP2016520062A (ja) * 2013-05-09 2016-07-11 ギリアード サイエンシーズ， インコーポレイテッド ブロモドメイン阻害剤としてのベンゾイミダゾール誘導体

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JPH1036361A (ja) 1996-07-25 1998-02-10 Fuji Photo Film Co Ltd ベンゾチアゾール化合物の製造方法
US20040224952A1 (en) 2003-05-07 2004-11-11 Cowart Marlon D. Fused bicyclic-substituted amines as histamine-3 receptor ligands
WO2010024903A1 (en) 2008-08-29 2010-03-04 Yangbo Feng BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS
KR20120093066A (ko) * 2009-05-29 2012-08-22 스미또모 가가꾸 가부시키가이샤 신경영양인자의 활성이 관여하는 질환의 치료 또는 예방제
WO2013042137A1 (en) * 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
HUE036040T2 (hu) 2012-03-09 2018-06-28 Lexicon Pharmaceuticals Inc Adaptor-asszociált kináz 1 gátlása fájdalom kezelésére

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04253966A (ja) * 1990-07-23 1992-09-09 Dr Karl Thomae Gmbh ベンゾイミダゾール、これらの化合物を含む製薬組成物
EP0543263A2 (de) * 1991-11-16 1993-05-26 Dr. Karl Thomae GmbH Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
CN101798300A (zh) * 2010-02-23 2010-08-11 陈志龙 N-苯基吲哚甲基取代的双苯并咪唑衍生物及其降压等应用
JP2016520062A (ja) * 2013-05-09 2016-07-11 ギリアード サイエンシーズ， インコーポレイテッド ブロモドメイン阻害剤としてのベンゾイミダゾール誘導体

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021510707A (ja) * 2018-01-15 2021-04-30 ユーシービー バイオファルマ エスアールエル Ｉｌ−１７モジュレータとしての縮合イミダゾール誘導体
JP7271557B2 (ja) 2018-01-15 2023-05-11 ユーシービー バイオファルマ エスアールエル Ｉｌ－１７モジュレータとしての縮合イミダゾール誘導体
JP2022548568A (ja) * 2019-09-11 2022-11-21 プレリュード・セラピューティクス・インコーポレイテッド Ｃｄｋ阻害剤及び医薬品としてのそれらの使用
JP7763489B2 (ja) 2019-09-11 2025-11-04 プレリュード・セラピューティクス・インコーポレイテッド Ｃｄｋ阻害剤及び医薬品としてのそれらの使用

Also Published As

Publication number Publication date
WO2016022312A1 (en) 2016-02-11
CN107108552A (zh) 2017-08-29
US20170260145A1 (en) 2017-09-14
US10035777B2 (en) 2018-07-31
EP3177604A1 (en) 2017-06-14

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