JP2017523178A5 - - Google Patents
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- JP2017523178A5 JP2017523178A5 JP2017504104A JP2017504104A JP2017523178A5 JP 2017523178 A5 JP2017523178 A5 JP 2017523178A5 JP 2017504104 A JP2017504104 A JP 2017504104A JP 2017504104 A JP2017504104 A JP 2017504104A JP 2017523178 A5 JP2017523178 A5 JP 2017523178A5
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- JP
- Japan
- Prior art keywords
- composition
- mds
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- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(C1[C@@](CC2)O[C@@]2C1C(N1CC*CC1)=O)=O Chemical compound *C(C1[C@@](CC2)O[C@@]2C1C(N1CC*CC1)=O)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028729P | 2014-07-24 | 2014-07-24 | |
| US62/028,729 | 2014-07-24 | ||
| US201462029327P | 2014-07-25 | 2014-07-25 | |
| US62/029,327 | 2014-07-25 | ||
| PCT/US2015/041714 WO2016014783A1 (en) | 2014-07-24 | 2015-07-23 | Protein phosphatase 2a inhibitors for treating myelodysplastic syndromes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018232414A Division JP6862404B2 (ja) | 2014-07-24 | 2018-12-12 | 骨髄異形成症候群を治療するためのタンパク質ホスファターゼ２ａ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523178A JP2017523178A (ja) | 2017-08-17 |
| JP2017523178A5 true JP2017523178A5 (enExample) | 2018-08-30 |
| JP6453441B2 JP6453441B2 (ja) | 2019-01-16 |
Family
ID=55163749
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504104A Expired - Fee Related JP6453441B2 (ja) | 2014-07-24 | 2015-07-23 | 骨髄異形成症候群を治療するためのタンパク質ホスファターゼ２ａ阻害剤 |
| JP2018232414A Expired - Fee Related JP6862404B2 (ja) | 2014-07-24 | 2018-12-12 | 骨髄異形成症候群を治療するためのタンパク質ホスファターゼ２ａ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018232414A Expired - Fee Related JP6862404B2 (ja) | 2014-07-24 | 2018-12-12 | 骨髄異形成症候群を治療するためのタンパク質ホスファターゼ２ａ阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20170209434A1 (enExample) |
| EP (1) | EP3171870B1 (enExample) |
| JP (2) | JP6453441B2 (enExample) |
| CN (1) | CN106572989B (enExample) |
| WO (2) | WO2016014783A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| CA2877167A1 (en) | 2012-06-29 | 2014-01-03 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes |
| CA2909160C (en) | 2013-04-09 | 2021-05-25 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
| CN106572989B (zh) | 2014-07-24 | 2021-08-27 | H·李·莫菲特癌症中心与研究所公司 | 用于治疗骨髓增生异常综合征的蛋白磷酸酶2a抑制剂 |
| WO2016134257A1 (en) | 2015-02-19 | 2016-08-25 | Lixter Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders |
| CN107708686B (zh) | 2015-05-15 | 2021-02-19 | 莱克斯特生物技术公司 | 氧杂二环庚烷前药 |
| US20190111053A1 (en) | 2016-01-27 | 2019-04-18 | Lixte Biotechnology, Inc. | Clinical regimen for treating myelodysplastic syndrome with phosphatase inhibitor |
| WO2018107004A1 (en) | 2016-12-08 | 2018-06-14 | Lixte Biotechnology, Inc. | Oxabicycloheptanes for modulation of immune response |
| CN113694071B (zh) * | 2021-08-31 | 2025-08-15 | 上海交通大学医学院附属瑞金医院 | 清除和/或溶解衰老细胞和/或抑制细胞衰老的化合物用于治疗精神障碍 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404716B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US7189740B2 (en) * | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| US7879569B2 (en) | 2004-11-09 | 2011-02-01 | The Trustees Of The University Of Pennsylvania | Methods for diagnosis of myelodysplastic syndromes (MDS) |
| WO2007092414A2 (en) | 2006-02-06 | 2007-08-16 | Lixte Biotechnology Holdings, Inc. | Use of phosphatases to treat tumors overexpressing n-cor |
| TWI449524B (zh) * | 2006-09-07 | 2014-08-21 | Stemline Therapeutics Inc | 以斑螫酸酐（ｃａｎｔｈａｒｉｄｉｎ）及斑螫酸酐類似物進行之癌症治療 |
| BRPI0806365B8 (pt) | 2007-02-06 | 2021-05-25 | Lixte Biotechnology Holdings Inc | composto, uso do composto, composição farmacêutica e uso da composição farmacêutica |
| WO2009020565A1 (en) | 2007-08-03 | 2009-02-12 | Lixte Biotechnology, Inc. | Use of phosphates to treat neuroblastomas and medullogastomas |
| WO2009045440A1 (en) | 2007-10-01 | 2009-04-09 | Lixte Biotechnology Holdings, Inc. | Hdac inhibitors |
| US8058268B2 (en) | 2008-08-01 | 2011-11-15 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| CA2730428A1 (en) | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase |
| US8227473B2 (en) | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| US20120135522A1 (en) | 2009-06-18 | 2012-05-31 | Kovach John S | Methods of modulating cell regulation by inhibiting p53 |
| WO2011094683A2 (en) * | 2010-01-29 | 2011-08-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of identifying myelodysplastic syndromes |
| US20140235649A1 (en) | 2011-05-24 | 2014-08-21 | Lixte Biotechnology, Inc. | Use of phosphatase inhibitors or histone deacetylase inhibitors to treat diseases characterized by loss of protein function |
| WO2013056211A2 (en) * | 2011-10-13 | 2013-04-18 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Telomerase reverse transcriptase deficience as diagnostic marker of myelodysplastic syndrome |
| US20150174123A1 (en) | 2012-06-29 | 2015-06-25 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes for the treatment of reperfusion injury |
| CA2877167A1 (en) | 2012-06-29 | 2014-01-03 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes for the treatment of diabetes |
| US9738933B2 (en) * | 2012-12-05 | 2017-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | RNF41 as a biomarker predicting response to lenalidomide in non-del(5q) MDS |
| WO2014137741A1 (en) | 2013-03-05 | 2014-09-12 | Lixte Biotechnology, Inc. | Hdac inhibitors for treating traumatic brain injury |
| US20160009727A1 (en) | 2013-03-15 | 2016-01-14 | Lixte Biotechnology, Inc. | Sanguinarine analog pp2c inhibitors for cancer treatment |
| CA2909160C (en) | 2013-04-09 | 2021-05-25 | Lixte Biotechnology, Inc. | Formulations of oxabicycloheptanes and oxabicycloheptenes |
| EP3068398A4 (en) | 2013-11-15 | 2017-11-15 | Lixte Biotechnology, Inc. | Protein phosphatase inhibitors that cross the blood brain barrier |
| WO2015196073A1 (en) | 2014-06-20 | 2015-12-23 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes for the treatment of ovarian cancer |
| CN106572989B (zh) | 2014-07-24 | 2021-08-27 | H·李·莫菲特癌症中心与研究所公司 | 用于治疗骨髓增生异常综合征的蛋白磷酸酶2a抑制剂 |
| CA2960989A1 (en) | 2014-09-12 | 2016-03-17 | Lixte Biotechnology, Inc. | Human dosing of phosphatase inhibitor |
| US9994584B2 (en) | 2014-10-15 | 2018-06-12 | Lixte Biotechnology, Inc. | Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid |
| WO2016134257A1 (en) | 2015-02-19 | 2016-08-25 | Lixter Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders |
| CN107708686B (zh) | 2015-05-15 | 2021-02-19 | 莱克斯特生物技术公司 | 氧杂二环庚烷前药 |
-
2015
- 2015-07-23 CN CN201580041767.1A patent/CN106572989B/zh not_active Expired - Fee Related
- 2015-07-23 US US15/328,838 patent/US20170209434A1/en not_active Abandoned
- 2015-07-23 JP JP2017504104A patent/JP6453441B2/ja not_active Expired - Fee Related
- 2015-07-23 WO PCT/US2015/041714 patent/WO2016014783A1/en not_active Ceased
- 2015-07-23 US US15/328,235 patent/US10071094B2/en active Active
- 2015-07-23 WO PCT/US2015/041709 patent/WO2016014778A1/en not_active Ceased
- 2015-07-23 EP EP15825076.1A patent/EP3171870B1/en not_active Not-in-force
-
2018
- 2018-08-20 US US16/105,479 patent/US10434100B2/en active Active
- 2018-12-12 JP JP2018232414A patent/JP6862404B2/ja not_active Expired - Fee Related
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