JP2017520862A5 - - Google Patents
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- Publication number
- JP2017520862A5 JP2017520862A5 JP2017502928A JP2017502928A JP2017520862A5 JP 2017520862 A5 JP2017520862 A5 JP 2017520862A5 JP 2017502928 A JP2017502928 A JP 2017502928A JP 2017502928 A JP2017502928 A JP 2017502928A JP 2017520862 A5 JP2017520862 A5 JP 2017520862A5
- Authority
- JP
- Japan
- Prior art keywords
- transmembrane
- modified
- soluble
- water
- score
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461971388P | 2014-03-27 | 2014-03-27 | |
| US61/971,388 | 2014-03-27 | ||
| US201461993783P | 2014-05-15 | 2014-05-15 | |
| US61/993,783 | 2014-05-15 | ||
| US201562117550P | 2015-02-18 | 2015-02-18 | |
| US62/117,550 | 2015-02-18 | ||
| PCT/US2015/022780 WO2015148820A1 (en) | 2014-03-27 | 2015-03-26 | Water-soluble membrane proteins and methods for the preparation and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020070346A Division JP2020119589A (ja) | 2014-03-27 | 2020-04-09 | 水溶性膜タンパク質ならびにその調製および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017520862A JP2017520862A (ja) | 2017-07-27 |
| JP2017520862A5 true JP2017520862A5 (https=) | 2018-05-17 |
Family
ID=54196406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502928A Pending JP2017520862A (ja) | 2014-03-27 | 2015-03-26 | 水溶性膜タンパク質ならびにその調製および使用方法 |
| JP2020070346A Pending JP2020119589A (ja) | 2014-03-27 | 2020-04-09 | 水溶性膜タンパク質ならびにその調製および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020070346A Pending JP2020119589A (ja) | 2014-03-27 | 2020-04-09 | 水溶性膜タンパク質ならびにその調製および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20150370960A1 (https=) |
| EP (2) | EP3122767B1 (https=) |
| JP (2) | JP2017520862A (https=) |
| AU (2) | AU2015237137A1 (https=) |
| CA (1) | CA2978076A1 (https=) |
| SG (1) | SG11201607980UA (https=) |
| WO (1) | WO2015148820A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012220558A1 (en) | 2011-02-23 | 2013-08-22 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| HK1218858A1 (zh) | 2013-03-14 | 2017-03-17 | 麻省理工学院 | 用於长时间持续释放人类抗体的多层可注射自组装肽脚手架水凝胶 |
| WO2015149085A2 (en) * | 2014-03-27 | 2015-10-01 | Massachusetts Institute Of Technology | Warer-soluble trans-membrane proteins and methods for the preparation and use thereof |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
| US11293923B2 (en) * | 2017-09-01 | 2022-04-05 | Massachusetts Institute Of Technology | S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof |
| CN108250290B (zh) * | 2018-02-23 | 2024-03-12 | 上海捌加壹医药科技有限公司 | Ccr4的n端重组蛋白及其用途 |
| US11401320B2 (en) | 2020-03-31 | 2022-08-02 | Massachusetts Institute Of Technology | QTY FC fusion receptor proteins |
| CA3181741A1 (en) * | 2020-06-16 | 2021-12-23 | Jurgen Bernhagen | Chemokine-selective cxcr4 ectodomain-derived (poly)peptide |
| TW202216771A (zh) | 2020-06-26 | 2022-05-01 | 德商拜耳廠股份有限公司 | 用於治療應用之ccr8抗體 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065363A2 (en) * | 2003-01-21 | 2004-08-05 | The Trustees Of The University Of Pennsylvania | Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel kcsa |
| WO2007089899A2 (en) * | 2006-02-01 | 2007-08-09 | Oklahoma Medical Research Foundation | Water-soluble (g protein)-coupled receptor protein |
| JP5433894B2 (ja) * | 2009-01-16 | 2014-03-05 | 修己 池田 | 立体構造データ帰属方法、立体構造データ帰属プログラム及び立体構造データ帰属装置 |
| JP5509421B2 (ja) * | 2009-12-22 | 2014-06-04 | 独立行政法人産業技術総合研究所 | 可溶性予測装置および可溶性予測方法 |
| AU2012220558A1 (en) * | 2011-02-23 | 2013-08-22 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| US20130273585A1 (en) * | 2012-04-11 | 2013-10-17 | Gangagen, Inc. | Soluble cytoplasmic expression of heterologous proteins in escherichia coli |
| US9670264B2 (en) * | 2013-04-25 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Water soluble G-protein coupled receptor |
-
2015
- 2015-03-26 WO PCT/US2015/022780 patent/WO2015148820A1/en not_active Ceased
- 2015-03-26 JP JP2017502928A patent/JP2017520862A/ja active Pending
- 2015-03-26 US US14/669,753 patent/US20150370960A1/en not_active Abandoned
- 2015-05-27 SG SG11201607980UA patent/SG11201607980UA/en unknown
- 2015-05-27 EP EP15729292.1A patent/EP3122767B1/en active Active
- 2015-05-27 AU AU2015237137A patent/AU2015237137A1/en not_active Abandoned
- 2015-05-27 EP EP20184442.0A patent/EP3805260A1/en active Pending
- 2015-05-27 CA CA2978076A patent/CA2978076A1/en active Pending
-
2017
- 2017-04-28 US US15/581,495 patent/US20170344699A1/en not_active Abandoned
-
2019
- 2019-09-16 AU AU2019232778A patent/AU2019232778B2/en active Active
-
2020
- 2020-04-09 JP JP2020070346A patent/JP2020119589A/ja active Pending
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