JP2017520862A - 水溶性膜タンパク質ならびにその調製および使用方法 - Google Patents

水溶性膜タンパク質ならびにその調製および使用方法 Download PDF

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JP2017520862A
JP2017520862A JP2017502928A JP2017502928A JP2017520862A JP 2017520862 A JP2017520862 A JP 2017520862A JP 2017502928 A JP2017502928 A JP 2017502928A JP 2017502928 A JP2017502928 A JP 2017502928A JP 2017520862 A JP2017520862 A JP 2017520862A
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protein
transmembrane
amino acid
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JP2017520862A5 (https=
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チャン，シュウガン
タオ，フェイ
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physiology (AREA)
  • Computing Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017502928A 2014-03-27 2015-03-26 水溶性膜タンパク質ならびにその調製および使用方法 Pending JP2017520862A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461971388P 2014-03-27 2014-03-27
US61/971,388 2014-03-27
US201461993783P 2014-05-15 2014-05-15
US61/993,783 2014-05-15
US201562117550P 2015-02-18 2015-02-18
US62/117,550 2015-02-18
PCT/US2015/022780 WO2015148820A1 (en) 2014-03-27 2015-03-26 Water-soluble membrane proteins and methods for the preparation and use thereof

Related Child Applications (1)

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JP2020070346A Division JP2020119589A (ja) 2014-03-27 2020-04-09 水溶性膜タンパク質ならびにその調製および使用方法

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JP2017520862A true JP2017520862A (ja) 2017-07-27
JP2017520862A5 JP2017520862A5 (https=) 2018-05-17

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JP2017502928A Pending JP2017520862A (ja) 2014-03-27 2015-03-26 水溶性膜タンパク質ならびにその調製および使用方法
JP2020070346A Pending JP2020119589A (ja) 2014-03-27 2020-04-09 水溶性膜タンパク質ならびにその調製および使用方法

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US (2) US20150370960A1 (https=)
EP (2) EP3122767B1 (https=)
JP (2) JP2017520862A (https=)
AU (2) AU2015237137A1 (https=)
CA (1) CA2978076A1 (https=)
SG (1) SG11201607980UA (https=)
WO (1) WO2015148820A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012220558A1 (en) 2011-02-23 2013-08-22 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
HK1218858A1 (zh) 2013-03-14 2017-03-17 麻省理工学院 用於长时间持续释放人类抗体的多层可注射自组装肽脚手架水凝胶
WO2015149085A2 (en) * 2014-03-27 2015-10-01 Massachusetts Institute Of Technology Warer-soluble trans-membrane proteins and methods for the preparation and use thereof
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof
US11293923B2 (en) * 2017-09-01 2022-04-05 Massachusetts Institute Of Technology S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof
CN108250290B (zh) * 2018-02-23 2024-03-12 上海捌加壹医药科技有限公司 Ccr4的n端重组蛋白及其用途
US11401320B2 (en) 2020-03-31 2022-08-02 Massachusetts Institute Of Technology QTY FC fusion receptor proteins
CA3181741A1 (en) * 2020-06-16 2021-12-23 Jurgen Bernhagen Chemokine-selective cxcr4 ectodomain-derived (poly)peptide
TW202216771A (zh) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040215400A1 (en) * 2003-01-21 2004-10-28 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
JP2010165216A (ja) * 2009-01-16 2010-07-29 National Institute Of Advanced Industrial Science & Technology 立体構造データ帰属方法、立体構造データ帰属プログラム及び立体構造データ帰属装置
JP2011133962A (ja) * 2009-12-22 2011-07-07 National Institute Of Advanced Industrial Science & Technology 可溶性予測装置および可溶性予測方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089899A2 (en) * 2006-02-01 2007-08-09 Oklahoma Medical Research Foundation Water-soluble (g protein)-coupled receptor protein
AU2012220558A1 (en) * 2011-02-23 2013-08-22 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
US20130273585A1 (en) * 2012-04-11 2013-10-17 Gangagen, Inc. Soluble cytoplasmic expression of heterologous proteins in escherichia coli
US9670264B2 (en) * 2013-04-25 2017-06-06 The Trustees Of The University Of Pennsylvania Water soluble G-protein coupled receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040215400A1 (en) * 2003-01-21 2004-10-28 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
JP2010165216A (ja) * 2009-01-16 2010-07-29 National Institute Of Advanced Industrial Science & Technology 立体構造データ帰属方法、立体構造データ帰属プログラム及び立体構造データ帰属装置
JP2011133962A (ja) * 2009-12-22 2011-07-07 National Institute Of Advanced Industrial Science & Technology 可溶性予測装置および可溶性予測方法

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Publication number Publication date
SG11201607980UA (en) 2016-10-28
AU2015237137A1 (en) 2016-10-27
WO2015148820A1 (en) 2015-10-01
AU2019232778A1 (en) 2019-10-03
US20170344699A1 (en) 2017-11-30
US20150370960A1 (en) 2015-12-24
EP3122767A2 (en) 2017-02-01
JP2020119589A (ja) 2020-08-06
EP3805260A1 (en) 2021-04-14
CA2978076A1 (en) 2015-10-01
AU2019232778B2 (en) 2021-09-09
EP3122767B1 (en) 2020-07-08

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