SG11201607980UA - Water-soluble trans-membrane proteins and methods for the preparation and use thereof - Google Patents

Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Info

Publication number
SG11201607980UA
SG11201607980UA SG11201607980UA SG11201607980UA SG11201607980UA SG 11201607980U A SG11201607980U A SG 11201607980UA SG 11201607980U A SG11201607980U A SG 11201607980UA SG 11201607980U A SG11201607980U A SG 11201607980UA SG 11201607980U A SG11201607980U A SG 11201607980UA
Authority
SG
Singapore
Prior art keywords
preparation
methods
water
membrane proteins
soluble trans
Prior art date
Application number
SG11201607980UA
Other languages
English (en)
Inventor
Shuguang Zhang
Fei Tao
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority claimed from PCT/US2015/032722 external-priority patent/WO2015149085A2/en
Publication of SG11201607980UA publication Critical patent/SG11201607980UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physiology (AREA)
  • Computing Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201607980UA 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof SG11201607980UA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461971388P 2014-03-27 2014-03-27
US201461993783P 2014-05-15 2014-05-15
US201562117550P 2015-02-18 2015-02-18
PCT/US2015/022780 WO2015148820A1 (en) 2014-03-27 2015-03-26 Water-soluble membrane proteins and methods for the preparation and use thereof
US14/669,753 US20150370960A1 (en) 2014-03-27 2015-03-26 Water-soluble membrane proteins and methods for the preparation and use thereof
PCT/US2015/032722 WO2015149085A2 (en) 2014-03-27 2015-05-27 Warer-soluble trans-membrane proteins and methods for the preparation and use thereof

Publications (1)

Publication Number Publication Date
SG11201607980UA true SG11201607980UA (en) 2016-10-28

Family

ID=54196406

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201607980UA SG11201607980UA (en) 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Country Status (7)

Country Link
US (2) US20150370960A1 (https=)
EP (2) EP3122767B1 (https=)
JP (2) JP2017520862A (https=)
AU (2) AU2015237137A1 (https=)
CA (1) CA2978076A1 (https=)
SG (1) SG11201607980UA (https=)
WO (1) WO2015148820A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012220558A1 (en) 2011-02-23 2013-08-22 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
HK1218858A1 (zh) 2013-03-14 2017-03-17 麻省理工学院 用於长时间持续释放人类抗体的多层可注射自组装肽脚手架水凝胶
WO2015149085A2 (en) * 2014-03-27 2015-10-01 Massachusetts Institute Of Technology Warer-soluble trans-membrane proteins and methods for the preparation and use thereof
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof
US11293923B2 (en) * 2017-09-01 2022-04-05 Massachusetts Institute Of Technology S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof
CN108250290B (zh) * 2018-02-23 2024-03-12 上海捌加壹医药科技有限公司 Ccr4的n端重组蛋白及其用途
US11401320B2 (en) 2020-03-31 2022-08-02 Massachusetts Institute Of Technology QTY FC fusion receptor proteins
CA3181741A1 (en) * 2020-06-16 2021-12-23 Jurgen Bernhagen Chemokine-selective cxcr4 ectodomain-derived (poly)peptide
TW202216771A (zh) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004065363A2 (en) * 2003-01-21 2004-08-05 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel kcsa
WO2007089899A2 (en) * 2006-02-01 2007-08-09 Oklahoma Medical Research Foundation Water-soluble (g protein)-coupled receptor protein
JP5433894B2 (ja) * 2009-01-16 2014-03-05 修己 池田 立体構造データ帰属方法、立体構造データ帰属プログラム及び立体構造データ帰属装置
JP5509421B2 (ja) * 2009-12-22 2014-06-04 独立行政法人産業技術総合研究所 可溶性予測装置および可溶性予測方法
AU2012220558A1 (en) * 2011-02-23 2013-08-22 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
US20130273585A1 (en) * 2012-04-11 2013-10-17 Gangagen, Inc. Soluble cytoplasmic expression of heterologous proteins in escherichia coli
US9670264B2 (en) * 2013-04-25 2017-06-06 The Trustees Of The University Of Pennsylvania Water soluble G-protein coupled receptor

Also Published As

Publication number Publication date
AU2015237137A1 (en) 2016-10-27
WO2015148820A1 (en) 2015-10-01
AU2019232778A1 (en) 2019-10-03
US20170344699A1 (en) 2017-11-30
JP2017520862A (ja) 2017-07-27
US20150370960A1 (en) 2015-12-24
EP3122767A2 (en) 2017-02-01
JP2020119589A (ja) 2020-08-06
EP3805260A1 (en) 2021-04-14
CA2978076A1 (en) 2015-10-01
AU2019232778B2 (en) 2021-09-09
EP3122767B1 (en) 2020-07-08

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