JP2017520531A5 - - Google Patents
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- Publication number
- JP2017520531A5 JP2017520531A5 JP2016568950A JP2016568950A JP2017520531A5 JP 2017520531 A5 JP2017520531 A5 JP 2017520531A5 JP 2016568950 A JP2016568950 A JP 2016568950A JP 2016568950 A JP2016568950 A JP 2016568950A JP 2017520531 A5 JP2017520531 A5 JP 2017520531A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- antibody
- hydrophobic interaction
- interaction chromatography
- ultrafiltration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 41
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 41
- 238000000034 method Methods 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 10
- 238000004191 hydrophobic interaction chromatography Methods 0.000 claims 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 238000000108 ultra-filtration Methods 0.000 claims 7
- 230000009261 transgenic effect Effects 0.000 claims 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 210000002919 epithelial cell Anatomy 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 210000005075 mammary gland Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 102000003838 Sialyltransferases Human genes 0.000 claims 1
- 108090000141 Sialyltransferases Proteins 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 238000001641 gel filtration chromatography Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 229920000620 organic polymer Polymers 0.000 claims 1
- 239000002952 polymeric resin Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462006584P | 2014-06-02 | 2014-06-02 | |
| US62/006,584 | 2014-06-02 | ||
| PCT/IB2015/001643 WO2015186004A2 (en) | 2014-06-02 | 2015-06-02 | Production of fc fragments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017520531A JP2017520531A (ja) | 2017-07-27 |
| JP2017520531A5 true JP2017520531A5 (enExample) | 2018-07-12 |
Family
ID=54337822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568950A Pending JP2017520531A (ja) | 2014-06-02 | 2015-06-02 | Ｆｃ断片の産生 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20170129966A1 (enExample) |
| EP (1) | EP3149030A2 (enExample) |
| JP (1) | JP2017520531A (enExample) |
| KR (1) | KR20170040132A (enExample) |
| CN (1) | CN106573973A (enExample) |
| AR (1) | AR100716A1 (enExample) |
| AU (1) | AU2015270152A1 (enExample) |
| BR (1) | BR112016028182A2 (enExample) |
| CA (1) | CA2950241A1 (enExample) |
| IL (1) | IL249274A0 (enExample) |
| MX (1) | MX2016015893A (enExample) |
| WO (1) | WO2015186004A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011350895B2 (en) | 2010-12-30 | 2015-05-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Glycols as pathogen inactivating agents |
| BR112015019348A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária |
| EP3594230A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| MX384222B (es) | 2013-07-05 | 2025-03-14 | Lab Francais Du Fractionnement | Matriz de cromatografia de afinidad. |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| US11618769B2 (en) | 2017-11-14 | 2023-04-04 | Bio-Sourcing S.A. | Antibody purification |
| FR3075200B1 (fr) * | 2017-12-15 | 2022-12-23 | Lab Francais Du Fractionnement | Variants avec fragment fc ayant une affinite augmentee pour fcrn et une affinite augmentee pour au moins un recepteur du fragment fc |
| WO2019116096A1 (en) * | 2017-12-15 | 2019-06-20 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Production of fc fragments |
| CN119881293A (zh) | 2018-03-21 | 2025-04-25 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| CN110669134A (zh) * | 2019-10-15 | 2020-01-10 | 广东菲鹏生物有限公司 | IgM-FC片段、IgM-FC抗体及制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5827690A (en) * | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| EP0690452A3 (en) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Electrically erasable memory and method of erasure |
| US5843705A (en) | 1995-02-21 | 1998-12-01 | Genzyme Transgenic Corporation | Transgenically produced antithrombin III |
| US6268487B1 (en) * | 1996-05-13 | 2001-07-31 | Genzyme Transgenics Corporation | Purification of biologically active peptides from milk |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| TW200740839A (en) * | 2005-06-17 | 2007-11-01 | Wyeth Corp | Methods of purifying Fc region containing proteins |
| EP2815768A3 (en) * | 2006-04-05 | 2015-01-14 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| EP2662449B1 (en) | 2007-05-30 | 2017-02-15 | Postech Academy-Industry- Foundation | Immunoglobulin fusion proteins |
| US20080311119A1 (en) * | 2007-06-14 | 2008-12-18 | Biogen Idec Ma Inc. | Antibody formulations |
| RU2012133148A (ru) | 2010-01-11 | 2014-02-20 | Хилор Лтд. | Способ лечения воспалительного заболевания и расстройства |
| CN104168913A (zh) * | 2011-08-10 | 2014-11-26 | 法国化学与生物科技实验室 | 高半乳糖基化抗体 |
| GB201115665D0 (en) | 2011-09-09 | 2011-10-26 | Univ Leuven Kath | Autoimmune and inflammatory disorder therapy |
-
2015
- 2015-06-02 JP JP2016568950A patent/JP2017520531A/ja active Pending
- 2015-06-02 MX MX2016015893A patent/MX2016015893A/es unknown
- 2015-06-02 US US15/315,809 patent/US20170129966A1/en not_active Abandoned
- 2015-06-02 WO PCT/IB2015/001643 patent/WO2015186004A2/en not_active Ceased
- 2015-06-02 EP EP15784149.5A patent/EP3149030A2/en not_active Withdrawn
- 2015-06-02 AU AU2015270152A patent/AU2015270152A1/en not_active Abandoned
- 2015-06-02 BR BR112016028182A patent/BR112016028182A2/pt not_active Application Discontinuation
- 2015-06-02 CN CN201580029461.4A patent/CN106573973A/zh active Pending
- 2015-06-02 CA CA2950241A patent/CA2950241A1/en not_active Abandoned
- 2015-06-02 KR KR1020167036698A patent/KR20170040132A/ko not_active Withdrawn
- 2015-06-02 AR ARP150101747A patent/AR100716A1/es unknown
-
2016
- 2016-11-29 IL IL249274A patent/IL249274A0/en unknown
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