JP2017520527A5 - - Google Patents
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- JP2017520527A5 JP2017520527A5 JP2016567824A JP2016567824A JP2017520527A5 JP 2017520527 A5 JP2017520527 A5 JP 2017520527A5 JP 2016567824 A JP2016567824 A JP 2016567824A JP 2016567824 A JP2016567824 A JP 2016567824A JP 2017520527 A5 JP2017520527 A5 JP 2017520527A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- subject
- compound
- diabetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000010837 Diabetic eye disease Diseases 0.000 claims 3
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 201000011190 diabetic macular edema Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- LUUMLYXKTPBTQR-UHFFFAOYSA-N 4-chloro-n-[5-methyl-2-(7h-pyrrolo[2,3-d]pyrimidine-4-carbonyl)pyridin-3-yl]-3-(trifluoromethyl)benzenesulfonamide Chemical compound C=1C(C)=CN=C(C(=O)C=2C=3C=CNC=3N=CN=2)C=1NS(=O)(=O)C1=CC=C(Cl)C(C(F)(F)F)=C1 LUUMLYXKTPBTQR-UHFFFAOYSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 1
- 101150052909 CCL2 gene Proteins 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 101100495315 Dictyostelium discoideum cdk5 gene Proteins 0.000 claims 1
- 101100399297 Dictyostelium discoideum limE gene Proteins 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 101150050263 ICAM1 gene Proteins 0.000 claims 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 1
- 102000000536 PPAR gamma Human genes 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 101150097457 Vcam1 gene Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 230000004900 autophagic degradation Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000004637 cellular stress Effects 0.000 claims 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 1
- 229960002286 clodronic acid Drugs 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 101150006779 crp gene Proteins 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical compound Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 230000003345 hyperglycaemic effect Effects 0.000 claims 1
- NBGMRMDAEWWFIR-UHFFFAOYSA-N imidazole-2-thione Chemical compound S=C1N=CC=N1 NBGMRMDAEWWFIR-UHFFFAOYSA-N 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- PWDYHMBTPGXCSN-VCBMUGGBSA-N n,n'-bis[3,5-bis[(e)-n-(diaminomethylideneamino)-c-methylcarbonimidoyl]phenyl]decanediamide Chemical compound NC(N)=N/N=C(\C)C1=CC(C(=N/N=C(N)N)/C)=CC(NC(=O)CCCCCCCCC(=O)NC=2C=C(C=C(C=2)C(\C)=N\N=C(N)N)C(\C)=N\N=C(N)N)=C1 PWDYHMBTPGXCSN-VCBMUGGBSA-N 0.000 claims 1
- IBPXYDUJQWENPM-PKTZIBPZSA-N n-[2-[[(1r,2s)-2-[(4-methylsulfanylbenzoyl)amino]cyclohexyl]amino]-2-oxoethyl]-2-(propan-2-ylcarbamoylamino)-5-(trifluoromethyl)benzamide Chemical compound C1=CC(SC)=CC=C1C(=O)N[C@@H]1[C@H](NC(=O)CNC(=O)C=2C(=CC=C(C=2)C(F)(F)F)NC(=O)NC(C)C)CCCC1 IBPXYDUJQWENPM-PKTZIBPZSA-N 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 239000002461 renin inhibitor Substances 0.000 claims 1
- 229940086526 renin-inhibitors Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950011005 semapimod Drugs 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461993915P | 2014-05-15 | 2014-05-15 | |
| US61/993,915 | 2014-05-15 | ||
| US201462064344P | 2014-10-15 | 2014-10-15 | |
| US62/064,344 | 2014-10-15 | ||
| US201462076162P | 2014-11-06 | 2014-11-06 | |
| US62/076,162 | 2014-11-06 | ||
| US201562157773P | 2015-05-06 | 2015-05-06 | |
| US62/157,773 | 2015-05-06 | ||
| PCT/IB2015/053609 WO2015173786A1 (en) | 2014-05-15 | 2015-05-15 | Compositions and methods for treating and diagnosing ocular disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520527A JP2017520527A (ja) | 2017-07-27 |
| JP2017520527A5 true JP2017520527A5 (cg-RX-API-DMAC7.html) | 2018-06-28 |
| JP6625064B2 JP6625064B2 (ja) | 2019-12-25 |
Family
ID=54479391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567824A Active JP6625064B2 (ja) | 2014-05-15 | 2015-05-15 | 眼障害を治療かつ診断するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20170079955A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3142664B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6625064B2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3142664T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2789849T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE049518T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015173786A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP7088454B2 (ja) | 2015-12-30 | 2022-06-21 | コディアック サイエンシーズ インコーポレイテッド | 抗体および抗体複合体 |
| CA3040419A1 (en) * | 2016-10-13 | 2018-04-19 | Translatum Medicus, Inc. | Systems and methods for detection of ocular disease |
| WO2018119202A1 (en) * | 2016-12-23 | 2018-06-28 | StemBios Technologies, Inc. | Use of somatic stem cells for increasing level of peroxisome proliferator-activated receptor gamma |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| RU2683758C1 (ru) * | 2018-06-27 | 2019-04-01 | Федеральное государственное учреждение "Федеральный исследовательский центр "Информатика и управление" Российской академии наук" (ФИЦ ИУ РАН) | Автоматизированная система анализа ангиографических изображений глазного дна человека |
| EP3706136A1 (en) * | 2019-03-05 | 2020-09-09 | Novartis AG | Computerized systems for prediction of geographic atrophy progression using deep learning applied to clinical imaging |
| EP3990433A4 (en) | 2019-06-25 | 2023-07-26 | Translatum Medicus Inc. | METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| RU196414U1 (ru) * | 2019-12-23 | 2020-02-28 | Федеральное государственное учреждение "Федеральный исследовательский центр "Информатика и управление" Российской Академии Наук" | Анализатор ангиографических изображений глазного дна человека |
| GB202001336D0 (en) * | 2020-01-31 | 2020-03-18 | Imp College Innovations Ltd | Methods for measuring gut permeability and gastric emptying rate |
| WO2023200766A1 (en) * | 2022-04-14 | 2023-10-19 | Belite Bio, Inc | Methods, compositions and systems for evaluation of visual function |
| EP4662203A1 (en) * | 2023-02-10 | 2025-12-17 | Translatum Medicus Inc. | Bindarit conjugates, compositions and methods for treating ocular diseases or disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| WO2005108431A1 (en) * | 2004-05-04 | 2005-11-17 | University Of Kentucky Research Foundation | Methods and compositions for the treatment of ocular neovascularization |
| ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
| US8835481B2 (en) * | 2008-03-07 | 2014-09-16 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40 |
| EP2844250B1 (en) * | 2012-05-01 | 2017-11-08 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
-
2015
- 2015-05-15 ES ES15792756T patent/ES2789849T3/es active Active
- 2015-05-15 DK DK15792756.7T patent/DK3142664T3/da active
- 2015-05-15 JP JP2016567824A patent/JP6625064B2/ja active Active
- 2015-05-15 US US15/311,083 patent/US20170079955A1/en not_active Abandoned
- 2015-05-15 EP EP15792756.7A patent/EP3142664B1/en active Active
- 2015-05-15 HU HUE15792756A patent/HUE049518T2/hu unknown
- 2015-05-15 WO PCT/IB2015/053609 patent/WO2015173786A1/en not_active Ceased
-
2018
- 2018-05-30 US US15/993,183 patent/US20180338952A1/en not_active Abandoned
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