JP2017518101A5 - - Google Patents
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- Publication number
- JP2017518101A5 JP2017518101A5 JP2016569438A JP2016569438A JP2017518101A5 JP 2017518101 A5 JP2017518101 A5 JP 2017518101A5 JP 2016569438 A JP2016569438 A JP 2016569438A JP 2016569438 A JP2016569438 A JP 2016569438A JP 2017518101 A5 JP2017518101 A5 JP 2017518101A5
- Authority
- JP
- Japan
- Prior art keywords
- wound dressing
- wound
- hydrogel
- hyaluronic acid
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010052428 Wound Diseases 0.000 claims 18
- 208000027418 Wounds and injury Diseases 0.000 claims 18
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 9
- 229920002674 hyaluronan Polymers 0.000 claims 9
- 229960003160 hyaluronic acid Drugs 0.000 claims 9
- 239000000017 hydrogel Substances 0.000 claims 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000000835 fiber Substances 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 240000002657 Thymus vulgaris Species 0.000 claims 2
- 235000007303 Thymus vulgaris Nutrition 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims 2
- 210000000416 exudates and transudate Anatomy 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 235000002020 sage Nutrition 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000001585 thymus vulgaris Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 230000029663 wound healing Effects 0.000 claims 2
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- MWIXENPCUPDSOS-QMMMGPOBSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanehydrazide Chemical compound NNC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWIXENPCUPDSOS-QMMMGPOBSA-N 0.000 claims 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 1
- 235000012097 Eugenia cumini Nutrition 0.000 claims 1
- 244000060474 Eugenia jambolana Species 0.000 claims 1
- 239000005770 Eugenol Substances 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims 1
- 241001529742 Rosmarinus Species 0.000 claims 1
- 240000007164 Salvia officinalis Species 0.000 claims 1
- 235000002912 Salvia officinalis Nutrition 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 229960004365 benzoic acid Drugs 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 229960002217 eugenol Drugs 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 229960003943 hypromellose Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 235000017807 phytochemicals Nutrition 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- 229930000223 plant secondary metabolite Natural products 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA2014/04120 | 2014-06-05 | ||
| ZA201404120 | 2014-06-05 | ||
| PCT/IB2015/054262 WO2015186101A1 (en) | 2014-06-05 | 2015-06-05 | Wound dressing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518101A JP2017518101A (ja) | 2017-07-06 |
| JP2017518101A5 true JP2017518101A5 (cg-RX-API-DMAC7.html) | 2018-07-12 |
| JP6506311B2 JP6506311B2 (ja) | 2019-04-24 |
Family
ID=53476941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569438A Active JP6506311B2 (ja) | 2014-06-05 | 2015-06-05 | 創傷被覆材 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10080816B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3151872B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6506311B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107106720B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015186101A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019014236A2 (pt) | 2017-01-23 | 2020-03-17 | Afyx Therapeutics A/S | Método para a fabricação de um produto de duas camadas à base de fibras eletrofiadas |
| JP7353980B2 (ja) * | 2017-01-23 | 2023-10-02 | アフリックス セラピューティクス アー／エス | 高含量の生体接着物質を有する電界紡糸繊維を調製する方法 |
| US11980700B2 (en) | 2017-03-08 | 2024-05-14 | Alafair Biosciences, Inc. | Hydrogel medium for the storage and preservation of tissue |
| WO2019014389A1 (en) * | 2017-07-11 | 2019-01-17 | The Regents Of The University Of California | ANTIMICROBIAL AGENTS BASED ON STIMULI-SENSITIVE POLYSACCHARIDES |
| US12251492B2 (en) * | 2018-04-09 | 2025-03-18 | Luna Labs Usa, Llc | Nanofiber-reinforced hydrogel medical dressings |
| CN108926732A (zh) * | 2018-09-11 | 2018-12-04 | 佛山科学技术学院 | 一种适用于糖尿病足护理的载药缓释水凝胶敷料 |
| CN109908398A (zh) * | 2019-02-22 | 2019-06-21 | 宁波大学 | 一种抗菌水凝胶型皮肤敷料的制备方法 |
| US20220133546A1 (en) * | 2019-06-20 | 2022-05-05 | Kci Licensing, Inc. | Peel And Place Dressing For Negative-Pressure Therapy |
| CN111053942A (zh) * | 2019-12-26 | 2020-04-24 | 东华大学 | 一种甲壳素百里香精油凝胶及其制备方法 |
| CN111643724B (zh) * | 2020-07-01 | 2022-01-28 | 南京大学 | 一种载有噬菌体和酸性成纤维细胞生长因子的水凝胶伤口敷料的制备方法及其应用 |
| CN116171170A (zh) * | 2020-07-29 | 2023-05-26 | 伊莱克斯宾有限公司 | 纤维复合材料 |
| CN112480435B (zh) * | 2020-12-02 | 2022-07-05 | 福建师范大学 | 一种可注射抗菌水凝胶材料及其制备方法 |
| CN113425893A (zh) * | 2021-07-26 | 2021-09-24 | 郑州大学 | 一种载药水凝胶的制备方法及其应用 |
| CN114767923B (zh) * | 2022-03-24 | 2023-07-11 | 金发科技股份有限公司 | 一种复合水凝胶载银长效抗菌敷料及其制备方法和应用 |
| US20240148934A1 (en) * | 2022-11-08 | 2024-05-09 | Bone Pharm, Llc | Lyophilized hydrogel wound dressing |
| CN116650402B (zh) * | 2023-05-09 | 2024-02-06 | 首都医科大学附属北京儿童医院 | 一种促进创面修复的纳米凝胶及其制备方法 |
| WO2025065065A1 (en) * | 2023-09-30 | 2025-04-03 | Encap Hive Pty Ltd | Nanofibrous dermal mat, transdermal patches, dressings and dermatological products including same |
| CN118320166B (zh) * | 2024-04-12 | 2024-10-29 | 四川大学 | 创面敷料及其制备方法 |
| CN119326712B (zh) * | 2024-12-20 | 2025-03-21 | 皖南医学院第一附属医院（皖南医学院弋矶山医院） | 一种糖尿病足外用敷料及其制备方法 |
| CN120550184B (zh) * | 2025-07-29 | 2025-10-28 | 北京化工大学 | 一种时序递送药物的水凝胶微球系统及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3104043B2 (ja) * | 1992-02-19 | 2000-10-30 | 科学技術振興事業団 | 不均質構造薬物放出デバイス |
| SE9602200D0 (sv) * | 1996-06-03 | 1996-06-03 | Astra Ab | Wound dressing |
| US6624138B1 (en) | 2001-09-27 | 2003-09-23 | Gp Medical | Drug-loaded biological material chemically treated with genipin |
| DE10014557A1 (de) * | 2000-03-23 | 2001-10-04 | Lohmann Therapie Syst Lts | Wundauflage mit verminderter Verwachsungstendenz |
| US7687681B2 (en) * | 2000-05-26 | 2010-03-30 | Kimberly-Clark Worldwide, Inc. | Menses specific absorbent systems |
| US7019191B2 (en) * | 2003-03-25 | 2006-03-28 | Ethicon, Inc. | Hemostatic wound dressings and methods of making same |
| US7674837B2 (en) * | 2003-09-08 | 2010-03-09 | Fmc Biopolymer As | Gelled biopolymer based foam |
| WO2007120818A2 (en) * | 2006-04-12 | 2007-10-25 | Massachusetts Institute Of Technology | Compositions and methods for inhibiting adhesions |
| EP2121026B1 (en) * | 2006-12-11 | 2017-06-28 | CHIT2GEL Ltd. | Novel injectable chitosan mixtures forming hydrogels |
| KR100937625B1 (ko) * | 2007-08-10 | 2010-01-20 | 주식회사 제닉 | 가용성 웹 공극필름 및 이의 제조방법 |
| KR101062068B1 (ko) * | 2008-12-01 | 2011-09-02 | 포항공과대학교 산학협력단 | 유착방지용 조성물 |
| US8716219B2 (en) * | 2009-07-07 | 2014-05-06 | Sabanci University | Crosslinked protein nanocrystals, crosslinked protein nanoaggregates and method of preparation thereof |
| CN101638830B (zh) * | 2009-08-25 | 2011-06-15 | 江南大学 | 一种纳米纤维膜的制备方法 |
| AU2011287215B2 (en) * | 2010-08-05 | 2015-09-10 | Lifebond Ltd. | Dry composition wound dressings and adhesives |
| US20120070401A1 (en) * | 2010-09-21 | 2012-03-22 | Jinzhong Zhang | Composition and Method for Promoting Wound Healing |
| WO2012070027A1 (en) * | 2010-11-26 | 2012-05-31 | University Of The Witwatersrand, Johannesburg | A drug delivery device |
| SG10201701773UA (en) * | 2012-09-06 | 2017-04-27 | Univ Nanyang Tech | Hyaluronic Acid-Based Drug Delivery Systems |
-
2015
- 2015-06-05 EP EP15730855.2A patent/EP3151872B1/en active Active
- 2015-06-05 WO PCT/IB2015/054262 patent/WO2015186101A1/en not_active Ceased
- 2015-06-05 US US15/314,136 patent/US10080816B2/en active Active
- 2015-06-05 CN CN201580029997.6A patent/CN107106720B/zh active Active
- 2015-06-05 JP JP2016569438A patent/JP6506311B2/ja active Active