JP2017517538A5 - - Google Patents

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Publication number
JP2017517538A5
JP2017517538A5 JP2016572302A JP2016572302A JP2017517538A5 JP 2017517538 A5 JP2017517538 A5 JP 2017517538A5 JP 2016572302 A JP2016572302 A JP 2016572302A JP 2016572302 A JP2016572302 A JP 2016572302A JP 2017517538 A5 JP2017517538 A5 JP 2017517538A5
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JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
ring
pyridazin
imidazo
Prior art date
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Granted
Application number
JP2016572302A
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English (en)
Japanese (ja)
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JP6491679B2 (ja
JP2017517538A (ja
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Publication date
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Priority claimed from PCT/IB2015/054200 external-priority patent/WO2015189744A1/en
Publication of JP2017517538A publication Critical patent/JP2017517538A/ja
Publication of JP2017517538A5 publication Critical patent/JP2017517538A5/ja
Application granted granted Critical
Publication of JP6491679B2 publication Critical patent/JP6491679B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016572302A 2014-06-12 2015-06-03 Gabaa受容体活性のモジュレーターとしてのイミダゾピリダジン誘導体 Active JP6491679B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011137P 2014-06-12 2014-06-12
US62/011,137 2014-06-12
PCT/IB2015/054200 WO2015189744A1 (en) 2014-06-12 2015-06-03 Imidazopyridazine derivatives as modulators of the gabaa receptor activity.

Publications (3)

Publication Number Publication Date
JP2017517538A JP2017517538A (ja) 2017-06-29
JP2017517538A5 true JP2017517538A5 (US07585860-20090908-C00112.png) 2018-07-12
JP6491679B2 JP6491679B2 (ja) 2019-03-27

Family

ID=53434408

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016572302A Active JP6491679B2 (ja) 2014-06-12 2015-06-03 Gabaa受容体活性のモジュレーターとしてのイミダゾピリダジン誘導体

Country Status (6)

Country Link
US (1) US9802945B2 (US07585860-20090908-C00112.png)
EP (1) EP3154979B1 (US07585860-20090908-C00112.png)
JP (1) JP6491679B2 (US07585860-20090908-C00112.png)
CA (1) CA2951497C (US07585860-20090908-C00112.png)
ES (1) ES2664810T3 (US07585860-20090908-C00112.png)
WO (1) WO2015189744A1 (US07585860-20090908-C00112.png)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3324961A4 (en) 2015-07-17 2019-03-13 Ovid Therapeutics, Inc. METHOD FOR TREATING DEVELOPMENT DISORDERS WITH GABOXADOL
EP3386983A1 (en) 2015-12-10 2018-10-17 Pfizer Limited 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
WO2018003691A1 (ja) * 2016-06-28 2018-01-04 東レ株式会社 エポキシ樹脂組成物、プリプレグおよび繊維強化複合材料
EP3481387A4 (en) * 2016-08-11 2020-04-08 Ovid Therapeutics Inc METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
JP2020529440A (ja) 2017-08-04 2020-10-08 オービッド・セラピューティクス・インコーポレイテッドOvid Therapeutics Inc. 糖尿病および関連する状態の処置におけるガボキサドールの使用
EP3982937A4 (en) * 2019-07-15 2022-08-10 Ovid Therapeutics Inc. PHARMACEUTICAL FORMULATIONS WITH GABOXADOL FOR THERAPEUTIC TREATMENT
US20220387429A1 (en) * 2019-10-21 2022-12-08 Sk Biopharmaceuticals Co., Ltd. Use of imidazopyrimidine or imidazotriazine compound for prevention, alleviation, or treatment of developmental disability
CN114981266A (zh) * 2019-10-22 2022-08-30 纽罗塞克医疗公司 Gabaa正向变构调节剂化合物、其制备方法和用途
WO2021081357A1 (en) * 2019-10-23 2021-04-29 Neurocycle Therapeutics, Inc. Treatment of epileptic conditions with gabaa receptor modulators
CN116693555A (zh) * 2022-02-25 2023-09-05 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
WO2023213198A1 (zh) * 2022-05-04 2023-11-09 华东师范大学 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂
CN117069725A (zh) * 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB9921150D0 (en) * 1999-09-07 1999-11-10 Merck Sharp & Dohme Therapeutic agents
AU1253002A (en) 2000-11-10 2002-05-21 Merck Sharp & Dohme Imidazo-triazine derivatives as ligands for gaba receptors
GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
EP1838152A2 (en) * 2005-01-21 2007-10-03 Neurogen Corporation Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives
EP1995241B1 (en) 2007-03-23 2010-03-17 ICAgen, Inc. Inhibitors of ion channels
RS53941B1 (en) 2009-01-12 2015-08-31 Pfizer Limited SULFONAMID DERIVATIVES
SG175090A1 (en) 2009-05-07 2011-11-28 Astrazeneca Ab Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора

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