JP2017516842A5 - - Google Patents
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- Publication number
- JP2017516842A5 JP2017516842A5 JP2017503776A JP2017503776A JP2017516842A5 JP 2017516842 A5 JP2017516842 A5 JP 2017516842A5 JP 2017503776 A JP2017503776 A JP 2017503776A JP 2017503776 A JP2017503776 A JP 2017503776A JP 2017516842 A5 JP2017516842 A5 JP 2017516842A5
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- JP
- Japan
- Prior art keywords
- compound
- compound according
- activity
- cell
- furthermore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 230000000694 effects Effects 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 101000980354 Homo sapiens Protein Mdm4 Proteins 0.000 claims 3
- 102100024314 Protein Mdm4 Human genes 0.000 claims 3
- 102100032257 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 2
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972514P | 2014-03-31 | 2014-03-31 | |
| US61/972,514 | 2014-03-31 | ||
| PCT/US2015/023462 WO2015153535A1 (en) | 2014-03-31 | 2015-03-31 | Novel hdmx inhibitors and their use for cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516842A JP2017516842A (ja) | 2017-06-22 |
| JP2017516842A5 true JP2017516842A5 (OSRAM) | 2018-05-17 |
| JP6483804B2 JP6483804B2 (ja) | 2019-03-13 |
Family
ID=54241190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503776A Expired - Fee Related JP6483804B2 (ja) | 2014-03-31 | 2015-03-31 | 新規なｈｄｍｘ阻害剤およびガン治療のためのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10183912B2 (OSRAM) |
| EP (1) | EP3125891A4 (OSRAM) |
| JP (1) | JP6483804B2 (OSRAM) |
| CA (1) | CA2944462A1 (OSRAM) |
| WO (1) | WO2015153535A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016075333A1 (en) * | 2014-11-14 | 2016-05-19 | Vib Vzw | Direct and selective inhibition of mdm4 for treatment of cancer |
| IL255290B2 (en) | 2015-04-27 | 2024-01-01 | Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct | Substances that bind to EGF1 and their use in the treatment of inflammatory diseases and tumors |
| AU2018364990B2 (en) * | 2017-11-09 | 2023-08-24 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Compounds for inhibiting Ly6K and methods of using same |
| CN119241434A (zh) * | 2021-12-25 | 2025-01-03 | 珞达生物医药(苏州)有限公司 | 固有免疫激活药物及其用途 |
| CN114805205A (zh) * | 2022-04-27 | 2022-07-29 | 郑州大学 | 一种吖啶类化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA805652B (en) * | 1979-09-14 | 1981-09-30 | New Zealand Dev Finance | Compounds having antitumour properties |
| US5939428A (en) * | 1996-06-20 | 1999-08-17 | National Health Research Institutes | Alkyl N- 3-(acridin-9-yl)amino-5-hydroxymethyl! phenylcarbamates |
| FI20000480A0 (fi) * | 2000-03-01 | 2000-03-01 | Orion Yhtymae Oyj | Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina |
| US7232663B2 (en) * | 2005-07-13 | 2007-06-19 | The University Of Wyoming | Assays employing novel substrates for measuring P450-mediated N-dealkylation |
| WO2008010984A2 (en) * | 2006-07-17 | 2008-01-24 | The Trustees Of The University Of Pennsylvania | Acridine activation of p53 and uses thereof |
| WO2008033466A2 (en) | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
| US20120220537A1 (en) * | 2009-11-01 | 2012-08-30 | Ariel-University Research And Development Company Ltd. | 9-aminoacridine derivatives, their preparation and uses |
-
2015
- 2015-03-31 JP JP2017503776A patent/JP6483804B2/ja not_active Expired - Fee Related
- 2015-03-31 CA CA2944462A patent/CA2944462A1/en not_active Abandoned
- 2015-03-31 US US15/300,871 patent/US10183912B2/en not_active Expired - Fee Related
- 2015-03-31 WO PCT/US2015/023462 patent/WO2015153535A1/en not_active Ceased
- 2015-03-31 EP EP15772336.2A patent/EP3125891A4/en not_active Withdrawn
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