JP2017516835A - レット症候群治療におけるアミノグリコシド類縁体の使用 - Google Patents

レット症候群治療におけるアミノグリコシド類縁体の使用 Download PDF

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JP2017516835A
JP2017516835A JP2016571284A JP2016571284A JP2017516835A JP 2017516835 A JP2017516835 A JP 2017516835A JP 2016571284 A JP2016571284 A JP 2016571284A JP 2016571284 A JP2016571284 A JP 2016571284A JP 2017516835 A JP2017516835 A JP 2017516835A
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compound
alkyl
mecp2
rett syndrome
configuration
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JP2017516835A5 (enExample
Inventor
バーソブ，ティモール
トゥヴィア，シュムエル
ペッレド，ドリ
Original Assignee
エロックス ファーマシューティカルズ リミテッド
エロックス ファーマシューティカルズ リミテッド
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Publication of JP2017516835A publication Critical patent/JP2017516835A/ja
Publication of JP2017516835A5 publication Critical patent/JP2017516835A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016571284A 2014-06-05 2015-06-04 レット症候群治療におけるアミノグリコシド類縁体の使用 Pending JP2017516835A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462008028P 2014-06-05 2014-06-05
US62/008,028 2014-06-05
PCT/IL2015/050573 WO2015186134A1 (en) 2014-06-05 2015-06-04 Use of aminoglycoside analogs in the treatment of rett syndrome

Publications (2)

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JP2017516835A true JP2017516835A (ja) 2017-06-22
JP2017516835A5 JP2017516835A5 (enExample) 2018-04-26

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JP2016571284A Pending JP2017516835A (ja) 2014-06-05 2015-06-04 レット症候群治療におけるアミノグリコシド類縁体の使用

Country Status (6)

Country Link
US (2) US20170360817A1 (enExample)
EP (1) EP3151840A1 (enExample)
JP (1) JP2017516835A (enExample)
CA (1) CA2949754A1 (enExample)
IL (1) IL249402A0 (enExample)
WO (1) WO2015186134A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2640734T1 (en) 2010-11-18 2018-02-28 Technion Research & Development Foundation Ltd. Aminoglycosides and their uses in the treatment of genetic disorders
JP2017516835A (ja) 2014-06-05 2017-06-22 エロックス ファーマシューティカルズ リミテッド レット症候群治療におけるアミノグリコシド類縁体の使用
EP3344641A4 (en) * 2015-09-02 2019-09-18 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
US11306115B2 (en) 2015-09-02 2022-04-19 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3350194A4 (en) 2015-09-02 2019-04-24 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
CN117466958A (zh) * 2017-03-15 2024-01-30 Eloxx制药有限公司 假三糖氨基糖苷及其中间体的大规模制备

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113841A2 (en) * 2006-04-03 2007-10-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
JP2013542981A (ja) * 2010-11-18 2013-11-28 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド アミノグリコシドおよび遺伝性障害の処置におけるその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5960712A (ja) 1982-09-30 1984-04-06 Toshiba Corp デ−タ判別装置
WO2005078099A1 (en) * 2004-02-17 2005-08-25 The Hospital For Sick Children Mecp2e1 gene
JP2017516835A (ja) 2014-06-05 2017-06-22 エロックス ファーマシューティカルズ リミテッド レット症候群治療におけるアミノグリコシド類縁体の使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113841A2 (en) * 2006-04-03 2007-10-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
JP2013542981A (ja) * 2010-11-18 2013-11-28 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド アミノグリコシドおよび遺伝性障害の処置におけるその使用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 50, JPN7019000573, 19 November 2013 (2013-11-19), pages 805 - 816, ISSN: 0003986177 *
JEYAKUMAR KANDASAMY; DANA ATIA-GLIKIN; VALERY BELAKHOV; TIMOR BAASOV: "REPAIRING FAULTY GENES BY AMINOGLYCOSIDES: IDENTIFICATION OF NEW PHARMACOPHORE WITH 以下備考", MEDCHEMCOMM, vol. VOL:2, NR:3, JPN5017004368, 2011, GB, pages 165 - 171, ISSN: 0003986176 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, JPN6019006793, 2012, pages 10630 - 10643, ISSN: 0003986175 *
JOURNAL OF MOLECULAR MEDICINE, vol. 89, JPN6019006791, 2011, pages 389 - 398, ISSN: 0003986174 *
PEDIATRIC RESEARCH, vol. 65, JPN7019000572, 2009, pages 520 - 523, ISSN: 0003986173 *
PLOS ONE, vol. 6, JPN6019006789, 2011, pages 20733, ISSN: 0004143265 *

Also Published As

Publication number Publication date
WO2015186134A1 (en) 2015-12-10
US20170360817A1 (en) 2017-12-21
EP3151840A1 (en) 2017-04-12
US20190183915A1 (en) 2019-06-20
CA2949754A1 (en) 2015-12-10
IL249402A0 (en) 2017-02-28
US10576095B2 (en) 2020-03-03

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