CA2949754A1 - Use of aminoglycoside analogs in the treatment of rett syndrome - Google Patents

Use of aminoglycoside analogs in the treatment of rett syndrome Download PDF

Info

Publication number
CA2949754A1
CA2949754A1 CA2949754A CA2949754A CA2949754A1 CA 2949754 A1 CA2949754 A1 CA 2949754A1 CA 2949754 A CA2949754 A CA 2949754A CA 2949754 A CA2949754 A CA 2949754A CA 2949754 A1 CA2949754 A1 CA 2949754A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
mecp2
rett syndrome
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2949754A
Other languages
English (en)
French (fr)
Inventor
Timor Baasov
Shmuel Tuvia
Dori Pelled
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eloxx Pharmaceuticals Ltd
Original Assignee
Eloxx Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eloxx Pharmaceuticals Ltd filed Critical Eloxx Pharmaceuticals Ltd
Publication of CA2949754A1 publication Critical patent/CA2949754A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2949754A 2014-06-05 2015-06-04 Use of aminoglycoside analogs in the treatment of rett syndrome Abandoned CA2949754A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462008028P 2014-06-05 2014-06-05
US62/008,028 2014-06-05
PCT/IL2015/050573 WO2015186134A1 (en) 2014-06-05 2015-06-04 Use of aminoglycoside analogs in the treatment of rett syndrome

Publications (1)

Publication Number Publication Date
CA2949754A1 true CA2949754A1 (en) 2015-12-10

Family

ID=53525222

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2949754A Abandoned CA2949754A1 (en) 2014-06-05 2015-06-04 Use of aminoglycoside analogs in the treatment of rett syndrome

Country Status (6)

Country Link
US (2) US20170360817A1 (enExample)
EP (1) EP3151840A1 (enExample)
JP (1) JP2017516835A (enExample)
CA (1) CA2949754A1 (enExample)
IL (1) IL249402A0 (enExample)
WO (1) WO2015186134A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2640734T (lt) 2010-11-18 2018-02-12 Technion Research & Development Foundation Ltd. Aminoglikozidai ir jų panaudojimas genetinių susirgimų gydymui
EP3151840A1 (en) 2014-06-05 2017-04-12 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome
WO2017037718A1 (en) 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
CA2996763A1 (en) * 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
WO2017037717A1 (en) 2015-09-02 2017-03-09 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
AU2018235441C1 (en) * 2017-03-15 2024-10-24 Eloxx Pharmaceuticals Ltd. Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5960712A (ja) 1982-09-30 1984-04-06 Toshiba Corp デ−タ判別装置
JP5830213B2 (ja) * 2004-02-17 2015-12-09 ザ ホスピタル フォー シック チルドレン Ｍｅｃｐ２ｅ１遺伝子
DK2390255T3 (en) * 2006-04-03 2016-11-07 Technion Res & Dev Foundation Novel aminoglycosides and uses thereof in the treatment of genetic disorders
LT2640734T (lt) 2010-11-18 2018-02-12 Technion Research & Development Foundation Ltd. Aminoglikozidai ir jų panaudojimas genetinių susirgimų gydymui
EP3151840A1 (en) 2014-06-05 2017-04-12 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome

Also Published As

Publication number Publication date
US20190183915A1 (en) 2019-06-20
US20170360817A1 (en) 2017-12-21
IL249402A0 (en) 2017-02-28
WO2015186134A1 (en) 2015-12-10
US10576095B2 (en) 2020-03-03
EP3151840A1 (en) 2017-04-12
JP2017516835A (ja) 2017-06-22

Similar Documents

Publication Publication Date Title
US10576095B2 (en) Use of aminoglycoside analogs in the treatment of Rett syndrome
RU2677276C2 (ru) Способы лечения рака
US20210292316A1 (en) Compounds for the treatment of cancer
Dileep et al. Synthesis of novel tetrazole containing hybrid ciprofloxacin and pipemidic acid analogues and preliminary biological evaluation of their antibacterial and antiproliferative activity
US20070112049A1 (en) Small Molecule Inhibitors of Botulinum Neurotoxins
US20200123127A1 (en) Removal of senescence-associated macrophages
WO2022095972A1 (zh) 异喹啉类化合物在治疗肿瘤中的应用
US10722515B2 (en) Dual CLK/CDK1 inhibitors for cancer treatment
US20210220380A1 (en) Aminoglycoside derivatives and uses thereof in treating genetic disorders
CN114796254A (zh) 多杀菌素衍生物作为精氨酸代琥珀酸合成酶激活剂及其应用
JP6343034B2 (ja) ナフチリジンジオン誘導体
JP2019206553A (ja) 神経系の障害の処置のためのパントテン酸誘導体
US20220281803A1 (en) Molecular design of new antibiotics and antibiotic adjuvants against mcr strains
JP2015534990A (ja) 誤制御されたｅＩＦ４Ｅに関連する疾患又は障害を治療又は予防するための組成物及び方法
US10934326B2 (en) Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability
Tengler et al. Synthesis and Biological Evaluation of 2‐Hydroxy‐3‐[(2‐aryloxyethyl) amino] propyl 4‐[(Alkoxycarbonyl) amino] benzoates
US20230312597A1 (en) Novel compounds with antibacterial and anti viral activities
US20110263574A1 (en) Pirenzepine as otoprotective agent
US20190127313A1 (en) Antimicrobial agents
US20230151021A1 (en) Compounds and Compositions for Treating Hematologic Malignancies
Buchkevych et al. Synthesis of New 6, 7 (N, O)-Heterocyclic 1, 4-Naphthoquinones
US20170100374A1 (en) Potentiator-corrector combinations useful in the treatment of cystic fibrosis
WO2013192301A1 (en) Imidazo bicyclic imminium compounds as antitumor agents
US20210393677A1 (en) Compounds for modulation and as functional replacement of alphaketoglutaric acid (2og)-dependent oxygenases
Malhotra et al. Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211123