CA2949754A1 - Use of aminoglycoside analogs in the treatment of rett syndrome - Google Patents
Use of aminoglycoside analogs in the treatment of rett syndrome Download PDFInfo
- Publication number
- CA2949754A1 CA2949754A1 CA2949754A CA2949754A CA2949754A1 CA 2949754 A1 CA2949754 A1 CA 2949754A1 CA 2949754 A CA2949754 A CA 2949754A CA 2949754 A CA2949754 A CA 2949754A CA 2949754 A1 CA2949754 A1 CA 2949754A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- alkyl
- mecp2
- rett syndrome
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462008028P | 2014-06-05 | 2014-06-05 | |
| US62/008,028 | 2014-06-05 | ||
| PCT/IL2015/050573 WO2015186134A1 (en) | 2014-06-05 | 2015-06-04 | Use of aminoglycoside analogs in the treatment of rett syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2949754A1 true CA2949754A1 (en) | 2015-12-10 |
Family
ID=53525222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2949754A Abandoned CA2949754A1 (en) | 2014-06-05 | 2015-06-04 | Use of aminoglycoside analogs in the treatment of rett syndrome |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170360817A1 (enExample) |
| EP (1) | EP3151840A1 (enExample) |
| JP (1) | JP2017516835A (enExample) |
| CA (1) | CA2949754A1 (enExample) |
| IL (1) | IL249402A0 (enExample) |
| WO (1) | WO2015186134A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2640734B1 (en) | 2010-11-18 | 2017-10-18 | Technion Research & Development Foundation Ltd. | Aminoglycosides and uses thereof in treating genetic disorders |
| CA2949754A1 (en) | 2014-06-05 | 2015-12-10 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
| CA2996763A1 (en) | 2015-09-02 | 2017-03-09 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US11306115B2 (en) | 2015-09-02 | 2022-04-19 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| EP3350194A4 (en) | 2015-09-02 | 2019-04-24 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| CA3055883A1 (en) * | 2017-03-15 | 2018-09-20 | Eloxx Pharmaceuticals Ltd. | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof |
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| JPS5960712A (ja) | 1982-09-30 | 1984-04-06 | Toshiba Corp | デ−タ判別装置 |
| WO2005078099A1 (en) * | 2004-02-17 | 2005-08-25 | The Hospital For Sick Children | Mecp2e1 gene |
| JP5345928B2 (ja) * | 2006-04-03 | 2013-11-20 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | 新規なアミノグリコシド類および遺伝子疾患の治療におけるその使用 |
| EP2640734B1 (en) * | 2010-11-18 | 2017-10-18 | Technion Research & Development Foundation Ltd. | Aminoglycosides and uses thereof in treating genetic disorders |
| CA2949754A1 (en) | 2014-06-05 | 2015-12-10 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
-
2015
- 2015-06-04 CA CA2949754A patent/CA2949754A1/en not_active Abandoned
- 2015-06-04 JP JP2016571284A patent/JP2017516835A/ja active Pending
- 2015-06-04 EP EP15735743.5A patent/EP3151840A1/en not_active Withdrawn
- 2015-06-04 WO PCT/IL2015/050573 patent/WO2015186134A1/en not_active Ceased
- 2015-06-04 US US15/316,209 patent/US20170360817A1/en not_active Abandoned
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2016
- 2016-12-05 IL IL249402A patent/IL249402A0/en unknown
-
2019
- 2019-01-28 US US16/258,735 patent/US10576095B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL249402A0 (en) | 2017-02-28 |
| US10576095B2 (en) | 2020-03-03 |
| EP3151840A1 (en) | 2017-04-12 |
| WO2015186134A1 (en) | 2015-12-10 |
| JP2017516835A (ja) | 2017-06-22 |
| US20170360817A1 (en) | 2017-12-21 |
| US20190183915A1 (en) | 2019-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |
|
| FZDE | Discontinued |
Effective date: 20211123 |