JP2017516835A - レット症候群治療におけるアミノグリコシド類縁体の使用 - Google Patents

レット症候群治療におけるアミノグリコシド類縁体の使用 Download PDF

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JP2017516835A
JP2017516835A JP2016571284A JP2016571284A JP2017516835A JP 2017516835 A JP2017516835 A JP 2017516835A JP 2016571284 A JP2016571284 A JP 2016571284A JP 2016571284 A JP2016571284 A JP 2016571284A JP 2017516835 A JP2017516835 A JP 2017516835A
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Prior art keywords
compound
alkyl
mecp2
rett syndrome
configuration
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JP2016571284A
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Japanese (ja)
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JP2017516835A5 (cg-RX-API-DMAC7.html
Inventor
バーソブ，ティモール
トゥヴィア，シュムエル
ペッレド，ドリ
Original Assignee
エロックス ファーマシューティカルズ リミテッド
エロックス ファーマシューティカルズ リミテッド
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Publication of JP2017516835A publication Critical patent/JP2017516835A/ja
Publication of JP2017516835A5 publication Critical patent/JP2017516835A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016571284A 2014-06-05 2015-06-04 レット症候群治療におけるアミノグリコシド類縁体の使用 Pending JP2017516835A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462008028P 2014-06-05 2014-06-05
US62/008,028 2014-06-05
PCT/IL2015/050573 WO2015186134A1 (en) 2014-06-05 2015-06-04 Use of aminoglycoside analogs in the treatment of rett syndrome

Publications (2)

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JP2017516835A true JP2017516835A (ja) 2017-06-22
JP2017516835A5 JP2017516835A5 (cg-RX-API-DMAC7.html) 2018-04-26

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JP2016571284A Pending JP2017516835A (ja) 2014-06-05 2015-06-04 レット症候群治療におけるアミノグリコシド類縁体の使用

Country Status (6)

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US (2) US20170360817A1 (cg-RX-API-DMAC7.html)
EP (1) EP3151840A1 (cg-RX-API-DMAC7.html)
JP (1) JP2017516835A (cg-RX-API-DMAC7.html)
CA (1) CA2949754A1 (cg-RX-API-DMAC7.html)
IL (1) IL249402A0 (cg-RX-API-DMAC7.html)
WO (1) WO2015186134A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2640734T3 (en) 2010-11-18 2018-01-22 Technion Res & Dev Foundation AMINOGLYCOSIDES AND ITS APPLICATIONS FOR TREATMENT OF GENETIC DISORDERS
EP3151840A1 (en) 2014-06-05 2017-04-12 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome
IL257820B (en) * 2015-09-02 2022-09-01 Eloxx Pharmaceuticals Ltd Aminoglycoside derivatives and uses thereof in treating genetic disorders
EP3350194A4 (en) 2015-09-02 2019-04-24 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
EP3344640A4 (en) 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
BR112019018834A2 (pt) 2017-03-15 2020-04-14 Eloxx Pharmaceuticals Ltd preparação em grande escala de aminoglicosídeos de pseudotrissacarídeos e de seus intermediários

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113841A2 (en) * 2006-04-03 2007-10-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
JP2013542981A (ja) * 2010-11-18 2013-11-28 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド アミノグリコシドおよび遺伝性障害の処置におけるその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5960712A (ja) 1982-09-30 1984-04-06 Toshiba Corp デ−タ判別装置
CA2554380C (en) * 2004-02-17 2015-05-19 The Hospital For Sick Children Mecp2e1 gene
EP3151840A1 (en) 2014-06-05 2017-04-12 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007113841A2 (en) * 2006-04-03 2007-10-11 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
JP2013542981A (ja) * 2010-11-18 2013-11-28 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド アミノグリコシドおよび遺伝性障害の処置におけるその使用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 50, JPN7019000573, 19 November 2013 (2013-11-19), pages 805 - 816, ISSN: 0003986177 *
JEYAKUMAR KANDASAMY; DANA ATIA-GLIKIN; VALERY BELAKHOV; TIMOR BAASOV: "REPAIRING FAULTY GENES BY AMINOGLYCOSIDES: IDENTIFICATION OF NEW PHARMACOPHORE WITH 以下備考", MEDCHEMCOMM, vol. VOL:2, NR:3, JPN5017004368, 2011, GB, pages 165 - 171, ISSN: 0003986176 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, JPN6019006793, 2012, pages 10630 - 10643, ISSN: 0003986175 *
JOURNAL OF MOLECULAR MEDICINE, vol. 89, JPN6019006791, 2011, pages 389 - 398, ISSN: 0003986174 *
PEDIATRIC RESEARCH, vol. 65, JPN7019000572, 2009, pages 520 - 523, ISSN: 0003986173 *
PLOS ONE, vol. 6, JPN6019006789, 2011, pages 20733, ISSN: 0004143265 *

Also Published As

Publication number Publication date
US20170360817A1 (en) 2017-12-21
WO2015186134A1 (en) 2015-12-10
CA2949754A1 (en) 2015-12-10
IL249402A0 (en) 2017-02-28
US20190183915A1 (en) 2019-06-20
EP3151840A1 (en) 2017-04-12
US10576095B2 (en) 2020-03-03

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