JP2017515847A - がんの治療のための腫瘍溶解性ウイルスおよびオーロラキナーゼ阻害薬 - Google Patents

がんの治療のための腫瘍溶解性ウイルスおよびオーロラキナーゼ阻害薬 Download PDF

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JP2017515847A
JP2017515847A JP2016567517A JP2016567517A JP2017515847A JP 2017515847 A JP2017515847 A JP 2017515847A JP 2016567517 A JP2016567517 A JP 2016567517A JP 2016567517 A JP2016567517 A JP 2016567517A JP 2017515847 A JP2017515847 A JP 2017515847A
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oncolytic
virus
hsv1716
aurora
mln8237
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JP2017515847A5 (enExample
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コナー，ジョー
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ウイルツ・バイオロジクス・リミテッド
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Publication of JP2017515847A5 publication Critical patent/JP2017515847A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/765—Reovirus; Rotavirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016567517A 2014-05-12 2015-05-07 がんの治療のための腫瘍溶解性ウイルスおよびオーロラキナーゼ阻害薬 Pending JP2017515847A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1408297.8A GB201408297D0 (en) 2014-05-12 2014-05-12 Treatment of cancer
GB1408297.8 2014-05-12
PCT/GB2015/051347 WO2015173544A1 (en) 2014-05-12 2015-05-07 Oncolytic virus and aurora kinase inhibitor for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2017515847A true JP2017515847A (ja) 2017-06-15
JP2017515847A5 JP2017515847A5 (enExample) 2018-06-14

Family

ID=51032548

Family Applications (1)

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JP2016567517A Pending JP2017515847A (ja) 2014-05-12 2015-05-07 がんの治療のための腫瘍溶解性ウイルスおよびオーロラキナーゼ阻害薬

Country Status (6)

Country Link
US (1) US20170071991A1 (enExample)
EP (1) EP3142677A1 (enExample)
JP (1) JP2017515847A (enExample)
CN (1) CN106535940A (enExample)
GB (1) GB201408297D0 (enExample)
WO (1) WO2015173544A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102780496B1 (ko) * 2016-07-29 2025-03-11 오하이오 스테이트 이노베이션 파운데이션 종양용해성 바이러스에 의한 PTEN-Long의 발현
US11357776B2 (en) 2016-10-28 2022-06-14 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and an aurora kinase inhibitor and methods of use thereof
JP2020501589A (ja) * 2016-12-23 2020-01-23 ウイルツ・バイオロジクス・リミテッド がんの治療
CN109576231B (zh) * 2017-09-28 2022-03-25 北京康万达医药科技有限公司 分离的重组溶瘤腺病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
CN109985239B (zh) * 2017-12-29 2024-10-18 广州威溶特医药科技有限公司 极光激酶抑制剂和甲病毒在制备抗肿瘤药物的应用
CN116004567A (zh) * 2022-12-07 2023-04-25 北京大学 极光激酶b基因k202突变及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012135641A2 (en) * 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center And Research Institute Aurora kinase inhibitors and methods of making and using thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012122629A1 (en) * 2011-03-11 2012-09-20 Mcmaster University A method of vaccination comprising a histone deacetylase inhibitor
US9056133B2 (en) * 2011-05-25 2015-06-16 Cti-S.A. Pharmaceutical kit and method for treating cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012135641A2 (en) * 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center And Research Institute Aurora kinase inhibitors and methods of making and using thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALLEN CORY; IANKOV IANKO; OPYRCHAL MATEUSZ; ET AL: "THE AURORA A KINASE INHIBITOR MLN8237 SIGNIFICANTLY ENHANCES THE ANTITUMOR ACTIVITY OF 以下備考", MOLECULAR THERAPY, vol. VOL:20, NR:SUPPL.1, JPN5017004032, 19 May 2012 (2012-05-19), US, pages 166, ISSN: 0004182333 *
BRAIN AND NERVE, 2009, VOL.61 NO.7 PAGE.815-822, JPN6019017949, ISSN: 0004182335 *
LIBERTINI S; ABAGNALE A; PASSARO C; BOTTA G; ET AL: "AZD1152 NEGATIVELY AFFECTS THE GROWTH OF ANAPLASTIC THYROID CARCINOMA CELLS AND ENHANCES 以下備考", ENDOCRINE RELATED CANCER, vol. VOL:18, NR:1, JPN5017004031, 11 November 2010 (2010-11-11), pages 129 - 141, ISSN: 0004182332 *
QUIGG M; MAIRS R J; BROWN S M; HARLAND J; ET AL: "ASSESSMENT IN VITRO OF A NOVEL THERAPEUTIC STRATEGY FOR GLIOMA, COMBINING HERPES SIMPLEX 以下備考", MEDICINAL CHEMISTRY, vol. VOL:1, NR:5, JPN5017004034, September 2005 (2005-09-01), pages 423 - 429, ISSN: 0004037488 *
TOYOIZUMI T; ET AL: "COMBINES THERAPY WITH CHEMOTHERAPEUTIC AGENTS AND HERPES SIMPLEX VIRUS TYPE 1 ICP34.5 以下備考", HUMAN GENE THERAPY, vol. 10, JPN5017004033, 10 December 1999 (1999-12-10), US, pages 3013 - 3029, ISSN: 0004182334 *

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Publication number Publication date
US20170071991A1 (en) 2017-03-16
EP3142677A1 (en) 2017-03-22
GB201408297D0 (en) 2014-06-25
CN106535940A (zh) 2017-03-22
WO2015173544A1 (en) 2015-11-19

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