JP2017515841A - 腫瘍抗原を発現するポックスウイルス及びtim−3に対するモノクローナル抗体を用いた癌治療のための併用療法 - Google Patents
腫瘍抗原を発現するポックスウイルス及びtim−3に対するモノクローナル抗体を用いた癌治療のための併用療法 Download PDFInfo
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020072789A JP7368305B2 (ja) | 2014-05-13 | 2020-04-15 | 腫瘍抗原を発現するポックスウイルス及びtim-3に対するモノクローナル抗体を用いた癌治療のための併用療法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461992771P | 2014-05-13 | 2014-05-13 | |
| US61/992,771 | 2014-05-13 | ||
| PCT/US2015/029885 WO2015175340A1 (en) | 2014-05-13 | 2015-05-08 | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020072789A Division JP7368305B2 (ja) | 2014-05-13 | 2020-04-15 | 腫瘍抗原を発現するポックスウイルス及びtim-3に対するモノクローナル抗体を用いた癌治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017515841A true JP2017515841A (ja) | 2017-06-15 |
| JP2017515841A5 JP2017515841A5 (enExample) | 2018-06-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2016567413A Pending JP2017515841A (ja) | 2014-05-13 | 2015-05-08 | 腫瘍抗原を発現するポックスウイルス及びtim−3に対するモノクローナル抗体を用いた癌治療のための併用療法 |
| JP2020072789A Active JP7368305B2 (ja) | 2014-05-13 | 2020-04-15 | 腫瘍抗原を発現するポックスウイルス及びtim-3に対するモノクローナル抗体を用いた癌治療のための併用療法 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2020072789A Active JP7368305B2 (ja) | 2014-05-13 | 2020-04-15 | 腫瘍抗原を発現するポックスウイルス及びtim-3に対するモノクローナル抗体を用いた癌治療のための併用療法 |
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| Country | Link |
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| EP (1) | EP3142689B1 (enExample) |
| JP (2) | JP2017515841A (enExample) |
| AU (1) | AU2015259516B2 (enExample) |
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| WO (1) | WO2015175340A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023528984A (ja) * | 2020-06-10 | 2023-07-06 | バヴァリアン・ノルディック・アクティーゼルスカブ | コロナウイルス病に対する組換え修飾ワクシニアウイルスアンカラ(mva)ワクチン |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016115116A1 (en) | 2015-01-12 | 2016-07-21 | Geovax, Inc. | Compositions and methods for generating an immune response to a hemorrhagic fever virus |
| US12030942B2 (en) | 2015-10-02 | 2024-07-09 | Les Laboratoires Servier | Anti-PD-1 antibodies and compositions |
| EP3402802B1 (en) * | 2016-01-08 | 2023-04-12 | Geovax, Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| BR112018015696A2 (pt) | 2016-02-03 | 2018-12-26 | Geovax Inc | composições e métodos para gerar uma resposta imune para um flavivírus |
| CN107281474A (zh) * | 2016-04-11 | 2017-10-24 | 中国科学院上海巴斯德研究所 | 增强抗肿瘤免疫反应的新型免疫策略和免疫组合物 |
| WO2017178493A1 (en) | 2016-04-12 | 2017-10-19 | Symphogen A/S | Anti-tim-3 antibodies and compositions |
| RS65007B1 (sr) | 2016-06-02 | 2024-01-31 | Ultimovacs Asa | Vakcina u kombinaciji sa inhibitorom imunološke kontrolne tačke za primenu u lečenju kancera |
| US20190248893A1 (en) | 2016-07-14 | 2019-08-15 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| WO2018140890A1 (en) * | 2017-01-29 | 2018-08-02 | Zequn Tang | Methods of immune modulation against foreign and/or auto antigens |
| UA129904C2 (uk) * | 2017-04-05 | 2025-09-10 | Ле Лаборатуар Сервьє | Комбінація антитіла до tim-3 й антитіла до pd-1 для лікування раку |
| US11052147B2 (en) | 2017-05-15 | 2021-07-06 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| WO2018210804A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| HUE065242T2 (hu) | 2017-05-30 | 2024-05-28 | Bristol Myers Squibb Co | LAG-3-pozitív tumorok kezelése |
| JP7334124B2 (ja) | 2017-06-21 | 2023-08-28 | トランジェーヌ | 個別化ワクチン |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| CN111918660A (zh) * | 2018-01-24 | 2020-11-10 | 复诺健生物科技加拿大有限公司 | 重组病毒疫苗 |
| CN111253485A (zh) * | 2018-11-30 | 2020-06-09 | 上海开拓者生物医药有限公司 | 抗人tim-3单克隆抗体及其应用 |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| CA3161800A1 (en) | 2019-11-18 | 2021-05-27 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530560A (ja) * | 2004-03-24 | 2007-11-01 | テロス ファーマシューティカルズ, インコーポレイテッド | ワクチンに対する免疫応答を向上させるためのアジュバントおよび使用方法 |
| WO2014062778A1 (en) * | 2012-10-19 | 2014-04-24 | Bavarian Nordic, Inc. | Methods and compositions for the treatment of cancer |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
| USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| WO1992020791A1 (en) | 1990-07-10 | 1992-11-26 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
| EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ATE363532T1 (de) | 1991-03-01 | 2007-06-15 | Dyax Corp | Verfahren zur herstellung bindender miniproteine |
| US5766598A (en) | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| JP3926839B2 (ja) | 1993-09-14 | 2007-06-06 | エピミューン,インコーポレイティド | 万能dr−結合性ペプチドを用いる免疫応答の改変 |
| US6165460A (en) | 1995-07-10 | 2000-12-26 | Therion Biologics Corporation | Generation of immune responses to prostate-specific antigen (PSA) |
| JP4475683B2 (ja) | 1996-07-25 | 2010-06-09 | アメリカ合衆国 | 腫瘍関連抗原に対する免疫のための組換えポックス・ウイルス |
| AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
| EP1012276A2 (en) | 1997-02-24 | 2000-06-28 | Therion Biologics Corporation | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
| US6756038B1 (en) | 1997-10-10 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Agonist and antagonist peptides of carcinoembryonic antigen (CEA) |
| CN1325115C (zh) | 1998-10-05 | 2007-07-11 | 法麦克萨有限公司 | Ctl表位和t辅助淋巴细胞表位在免疫接种中的应用 |
| KR100910297B1 (ko) | 2000-11-23 | 2009-08-03 | 버베리안 노딕 에이/에스 | 변형된 백시니아 앙카라 바이러스 변형체 |
| CA2468258C (en) | 2001-11-30 | 2011-10-11 | Jeffrey Schlom | Peptide agonists of prostate-specific antigen, and uses therefor |
| AU2004289368B2 (en) * | 2003-11-12 | 2010-08-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Custom vectors for treating and preventing pancreatic cancer |
| KR101498834B1 (ko) * | 2005-05-09 | 2015-03-05 | 오노 야꾸힝 고교 가부시키가이샤 | 예정 사멸 인자 1(pd-1)에 대한 인간 모노클로날 항체, 및 항-pd-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법 |
| US20110059106A1 (en) * | 2008-01-29 | 2011-03-10 | Brigham And Women's Hospital, Inc. | Methods for modulating a population of myeloid-derived suppressor cells and uses thereof |
| CN104826106B (zh) | 2009-09-30 | 2019-01-11 | 斯隆凯特林防癌纪念中心 | 用于治疗癌症的组合免疫疗法 |
| JP5760796B2 (ja) | 2011-07-22 | 2015-08-12 | 富士通株式会社 | 冷却ユニット |
| US20140294765A1 (en) | 2012-06-21 | 2014-10-02 | Compugen Ltd. | Lsr antibodies, and uses thereof for treatment of cancer |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530560A (ja) * | 2004-03-24 | 2007-11-01 | テロス ファーマシューティカルズ, インコーポレイテッド | ワクチンに対する免疫応答を向上させるためのアジュバントおよび使用方法 |
| WO2014062778A1 (en) * | 2012-10-19 | 2014-04-24 | Bavarian Nordic, Inc. | Methods and compositions for the treatment of cancer |
Non-Patent Citations (1)
| Title |
|---|
| CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 63, no. 4, JPN6019003435, April 2014 (2014-04-01), pages 407 - 418, ISSN: 0004175458 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023528984A (ja) * | 2020-06-10 | 2023-07-06 | バヴァリアン・ノルディック・アクティーゼルスカブ | コロナウイルス病に対する組換え修飾ワクシニアウイルスアンカラ(mva)ワクチン |
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| DK3142689T3 (da) | 2021-02-15 |
| EP3142689B1 (en) | 2020-11-11 |
| NZ725519A (en) | 2023-09-29 |
| CA2946606A1 (en) | 2015-11-19 |
| JP2020125322A (ja) | 2020-08-20 |
| ES2851451T3 (es) | 2021-09-07 |
| EP3142689A1 (en) | 2017-03-22 |
| WO2015175340A1 (en) | 2015-11-19 |
| JP7368305B2 (ja) | 2023-10-24 |
| IL248511A0 (en) | 2016-12-29 |
| AU2015259516A1 (en) | 2016-11-10 |
| AU2015259516B2 (en) | 2020-05-28 |
| CA2946606C (en) | 2023-06-06 |
| IL248511B (en) | 2022-07-01 |
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