JP2017514866A5 - - Google Patents

Info

Publication number

JP2017514866A5

JP2017514866A5 JP2016566754A JP2016566754A JP2017514866A5 JP 2017514866 A5 JP2017514866 A5 JP 2017514866A5 JP 2016566754 A JP2016566754 A JP 2016566754A JP 2016566754 A JP2016566754 A JP 2016566754A JP 2017514866 A5 JP2017514866 A5 JP 2017514866A5

Authority

JP

Japan

Prior art keywords

dressing

dressings

nms

wound

registered trademark

Prior art date

2015-05-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 206010052428 Wound Diseases 0.000 claims 13
• 208000027418 Wounds and injury Diseases 0.000 claims 13
• 229940125431 BRAF inhibitor Drugs 0.000 claims 9
• BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 9
• CMJCXYNUCSMDBY-ZDUSSCGKSA-N lgx818 Chemical compound COC(=O)N[C@@H](C)CNC1=NC=CC(C=2C(=NN(C=2)C(C)C)C=2C(=C(NS(C)(=O)=O)C=C(Cl)C=2)F)=N1 CMJCXYNUCSMDBY-ZDUSSCGKSA-N 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 229960002465 dabrafenib Drugs 0.000 claims 6
• 229950001969 encorafenib Drugs 0.000 claims 6
• GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 4
• MLSAQOINCGAULQ-QFMPWRQOSA-N (E)-SB-590885 Chemical compound C1=CC(OCCN(C)C)=CC=C1C1=NC(C=2C=CN=CC=2)=C(C=2C=C3CCC(/C3=CC=2)=N\O)N1 MLSAQOINCGAULQ-QFMPWRQOSA-N 0.000 claims 3
• DKNUPRMJNUQNHR-UHFFFAOYSA-N 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=NC=1OC(C=1)=CC=CC=1NC(=O)NC=1C=C(C(C)(C)C(F)(F)F)ON=1 DKNUPRMJNUQNHR-UHFFFAOYSA-N 0.000 claims 3
• YABJJWZLRMPFSI-UHFFFAOYSA-N 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine Chemical compound N=1C2=CC(OC=3C=C(N=CC=3)C=3NC(=CN=3)C(F)(F)F)=CC=C2N(C)C=1NC1=CC=C(C(F)(F)F)C=C1 YABJJWZLRMPFSI-UHFFFAOYSA-N 0.000 claims 3
• ZGBGPEDJXCYQPH-UHFFFAOYSA-N 3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide Chemical compound C1=C(NC=2C=C3C(=O)N(C)C=NC3=CC=2)C(C)=CC=C1NC(=O)C1=CC=CC(C(C)(C)C#N)=C1 ZGBGPEDJXCYQPH-UHFFFAOYSA-N 0.000 claims 3
• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 3
• DEZZLWQELQORIU-RELWKKBWSA-N GDC-0879 Chemical compound N=1N(CCO)C=C(C=2C=C3CCC(/C3=CC=2)=N\O)C=1C1=CC=NC=C1 DEZZLWQELQORIU-RELWKKBWSA-N 0.000 claims 3
• 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 3
• UCEQXRCJXIVODC-PMACEKPBSA-N LSM-1131 Chemical compound C1CCC2=CC=CC3=C2N1C=C3[C@@H]1C(=O)NC(=O)[C@H]1C1=CNC2=CC=CC=C12 UCEQXRCJXIVODC-PMACEKPBSA-N 0.000 claims 3
• YZDJQTHVDDOVHR-UHFFFAOYSA-N PLX-4720 Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(Cl)=CN=C3NC=2)=C1F YZDJQTHVDDOVHR-UHFFFAOYSA-N 0.000 claims 3
• -1 RO497655 Chemical compound 0.000 claims 3
• 229930003316 Vitamin D Natural products 0.000 claims 3
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 3
• 229940035676 analgesics Drugs 0.000 claims 3
• 229940069428 antacid Drugs 0.000 claims 3
• 239000003159 antacid agent Substances 0.000 claims 3
• 239000000730 antalgic agent Substances 0.000 claims 3
• 239000000645 desinfectant Substances 0.000 claims 3
• HXINDCTZKGGRDE-JPKZNVRTSA-L disodium;[3-[5-[2-[[(3r)-1-(1-methylpyrazol-3-yl)sulfonylpiperidin-3-yl]amino]pyrimidin-4-yl]imidazo[2,1-b][1,3]oxazol-6-yl]phenoxy]methyl phosphate Chemical compound [Na+].[Na+].CN1C=CC(S(=O)(=O)N2C[C@@H](CCC2)NC=2N=C(C=CN=2)C=2N3C=COC3=NC=2C=2C=C(OCOP([O-])([O-])=O)C=CC=2)=N1 HXINDCTZKGGRDE-JPKZNVRTSA-L 0.000 claims 3
• 239000003102 growth factor Substances 0.000 claims 3
• 239000000017 hydrogel Substances 0.000 claims 3
• 239000007788 liquid Substances 0.000 claims 3
• MMNNTJYFHUDSKL-UHFFFAOYSA-N methyl n-[6-[2-(5-chloro-2-methylphenyl)-1-hydroxy-3-oxoisoindol-1-yl]-1h-benzimidazol-2-yl]carbamate Chemical compound C=1C=C2NC(NC(=O)OC)=NC2=CC=1C(C1=CC=CC=C1C1=O)(O)N1C1=CC(Cl)=CC=C1C MMNNTJYFHUDSKL-UHFFFAOYSA-N 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 229960003787 sorafenib Drugs 0.000 claims 3
• 229960000487 sorafenib tosylate Drugs 0.000 claims 3
• IVDHYUQIDRJSTI-UHFFFAOYSA-N sorafenib tosylate Chemical compound [H+].CC1=CC=C(S([O-])(=O)=O)C=C1.C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 IVDHYUQIDRJSTI-UHFFFAOYSA-N 0.000 claims 3
• 235000000346 sugar Nutrition 0.000 claims 3
• 150000008163 sugars Chemical class 0.000 claims 3
• 229940081616 tafinlar Drugs 0.000 claims 3
• 229940124597 therapeutic agent Drugs 0.000 claims 3
• 229950005976 tivantinib Drugs 0.000 claims 3
• 229960004066 trametinib Drugs 0.000 claims 3
• LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 3
• 229960003862 vemurafenib Drugs 0.000 claims 3
• 235000019155 vitamin A Nutrition 0.000 claims 3
• 239000011719 vitamin A Substances 0.000 claims 3
• 235000019166 vitamin D Nutrition 0.000 claims 3
• 239000011710 vitamin D Substances 0.000 claims 3
• 150000003710 vitamin D derivatives Chemical class 0.000 claims 3
• 229940046008 vitamin d Drugs 0.000 claims 3
• 229940034727 zelboraf Drugs 0.000 claims 3
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
• 102000008186 Collagen Human genes 0.000 claims 2
• 108010035532 Collagen Proteins 0.000 claims 2
• 230000002745 absorbent Effects 0.000 claims 2
• 239000002250 absorbent Substances 0.000 claims 2
• 229940072056 alginate Drugs 0.000 claims 2
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 230000000844 anti-bacterial effect Effects 0.000 claims 2
• 239000004599 antimicrobial Substances 0.000 claims 2
• 230000001851 biosynthetic effect Effects 0.000 claims 2
• 229920001436 collagen Polymers 0.000 claims 2
• 239000002131 composite material Substances 0.000 claims 2
• 239000000945 filler Substances 0.000 claims 2
• 239000006260 foam Substances 0.000 claims 2
• 239000000416 hydrocolloid Substances 0.000 claims 2
• 239000000565 sealant Substances 0.000 claims 2
• 230000029663 wound healing Effects 0.000 claims 2
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 1
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 1
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 239000006071 cream Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000000499 gel Substances 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 229940045997 vitamin a Drugs 0.000 claims 1