JP2017513516A - 操作されたキメラpeg化adi及び使用方法 - Google Patents
操作されたキメラpeg化adi及び使用方法 Download PDFInfo
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- JP2017513516A JP2017513516A JP2017501094A JP2017501094A JP2017513516A JP 2017513516 A JP2017513516 A JP 2017513516A JP 2017501094 A JP2017501094 A JP 2017501094A JP 2017501094 A JP2017501094 A JP 2017501094A JP 2017513516 A JP2017513516 A JP 2017513516A
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- microorganism
- mycoplasma
- chimeric adi
- adi
- pneumoniae
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Abstract
Description
本出願は、米国特許法第119条(e)の下で2014年3月18日に出願された米国特許出願第61/954,929号明細書に基づく優先権を主張し、その内容全体が参照によって組み込まれる。
本出願に関連する配列表は、紙コピーの代わりにテキスト形式で提供され、参照によって本明細書に組み込まれる。配列表を含有するテキストファイルの名称は、TDWG_002_02WO_ST25.txtである。テキストファイルは約200KBで、2015年3月11日に作成されたものであり、EFS−Webにより電子的に提出されている。
本発明は一般に、操作されたADI、特に抗原性を減少させるように操作された組換えキメラADIタンパク質に関する。このような操作されたキメラADIタンパク質は、癌などのアルギニン依存性疾患の処置に有用である。
アミノ酸欠乏療法は、一部の癌型の効果的な処置であり得る。今日までに、このアプローチに関する既知の臨床例が1つ存在し、これはアスパラギナーゼを利用してアスパラギンの循環レベルを低下させ、タンパク質合成を阻害するものである。この処置は、急性リンパ芽球性白血病に特に効果的である(Avramis 2005,Viera Pinheiro 2004)。急性リンパ芽球性白血病細胞は、成長及び増殖のためにアミノ酸のアスパラギンを必要とする。対照的に、正常なヒト細胞の多くはアスパラギンを合成することができ、アスパラギン枯渇による影響を受けない。したがって、アスパラギナーゼで血清アスパラギンを減少させることにより、正常な細胞、組織、及び宿主を害することなく癌細胞を選択的に殺傷することができる。アスパラギナーゼのE.coli由来形態は、ヒトへの使用が承認されている。しかしながら、アスパラギナーゼは微生物においてのみ見出され;ヒトでは免疫原性が高く、注射後の血清半減期も短い(Avramis 2005)。アスパラギナーゼをより効果的な薬物にするために、E.coli由来のアスパラギナーゼを、ポリエチレングリコール(PEG)を用いて製剤化し、この酵素の免疫原性及び関連するアレルギー反応を減少させることにより、これらの欠点を最小限に抑えた。加えて、PEGはアスパラギナーゼの循環半減期を大幅に延長するので、処置頻度及び総治療費の両方を減少させる。PEG製剤化アスパラギナーゼの使用は承認されており、Oncaspar(登録商標)の商標名で販売されている(Oncaspar(登録商標)2011,Avramis 2005,Viera Pinheiro 2004,Fu 2007,Zeidan 2008)。
配列番号:1は、野生型M.hominisのADIのアミノ酸配列である。
キメラADI酵素は、活性でありながら、患者の抗ADI−PEG20抗体との交差反応性が低い
本実施例は、(1)アルギニンデイミナーゼ酵素活性を有するタンパク質、(2)抗ADI−PEG20抗体との減少した交差反応性、(3)減少したリジン残基数、及び/または(4)化学的に安定したリンカーによるPEG結合から構成される、人為的に操作されたキメラADI酵素の生成について記載する。
Claims (54)
- 第1微生物に由来するADIタンパク質の触媒ドメイン及び第2微生物に由来するADIタンパク質のαヘリックスドメインを含む、組換えキメラアルギニンデイミナーゼ(ADI)。
- 前記第1微生物が、Mycoplasma属、Clostridium属、Bacillus属、Borrelia属、Enterococcus属、Streptococcus属、Lactobacillus属、及びGiardia属から選択される、請求項1に記載の組換えキメラADI。
- 前記第1微生物が、Mycoplasma pneumonia、Mycoplasma hominis、Mycoplasma arginini、Mycoplasma arthritidis、Streptococcus pyogenes、streptococcus pneumonia、Borrelia burgdorferi、Borrelia afzelii、Giardia intestinalis、Clostridium perfringens、Bacillus licheniformis、及びEnterococcus faecalisから成る群から選択される、請求項1に記載の組換えキメラADI。
- 前記第1微生物が、M.arginini、M.arthritidis、M.hominis、Mycoplasma pneumonia、Mycoplasma phocicerebrale、Mycoplasma orale、Mycoplasma gateae、Mycoplasma phocidae、Mycoplasma columbinum、Mycoplasma iowae、Mycoplasma crocodyli、Mycoplasma fermentans、Mycoplasma penetrans、Mycoplasma gallisepticum、Mycoplasma alligatoris、Mycoplasma mobile、及びMycoplasma capricolumから成る群から選択される、請求項1に記載の組換えキメラADI。
- 前記第2微生物が、場合により前記第1微生物とは異なり、Mycoplasma属、Clostridium属、Bacillus属、Borrelia属、Enterococcus属、Streptococcus属、Lactobacillus属、及びGiardia属から選択される、請求項1に記載の組換えキメラADI。
- 前記第2微生物が、場合により前記第1微生物とは異なり、Mycoplasma pneumonia、Mycoplasma hominis、Mycoplasma arginini、Mycoplasma arthritidis、Streptococcus pyogenes、streptococcus pneumonia、Borrelia burgdorferi、Borrelia afzelii、Giardia intestinalis、Clostridium perfringens、Bacillus licheniformis、及びEnterococcus faecalisから成る群から選択される、請求項1に記載の組換えキメラADI。
- 前記第2微生物が、場合により前記第1微生物とは異なり、M.arginini、M.arthritidis、M.hominis、Mycoplasma pneumonia、Mycoplasma phocicerebrale、Mycoplasma orale、Mycoplasma gateae、Mycoplasma phocidae、Mycoplasma columbinum、Mycoplasma iowae、Mycoplasma crocodyli、Mycoplasma fermentans、Mycoplasma penetrans、Mycoplasma gallisepticum、Mycoplasma alligatoris、Mycoplasma mobile、及びMycoplasma capricolumから成る群から選択される、請求項1に記載の組換えキメラADI。
- 前記第1微生物が、Mycoplasma gallinarum、Mycoplasma iners、及びMycoplasma columbinumから成る群から選択され、前記第2微生物が、場合により前記第1微生物とは異なり、Mycoplasma gallinarum、Mycoplasma iners、及びMycoplasma columbinumから成る群から選択される、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.argininiであり、前記第2微生物がM.arthritidisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.argininiであり、前記第2微生物がM.hominisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.arthritidisであり、前記第2微生物がM.argininiである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.gateaeであり、前記第2微生物がM.arthritidisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.gateaeであり、前記第2微生物がM.columbinumである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.gateaeであり、前記第2微生物がM.phocicerebraleである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.gateaeであり、前記第2微生物がM.phocidaeである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocicerebraleであり、前記第2微生物がM.alligatorisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocicerebraleであり、前記第2微生物がM.gateaeである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocicerebraleであり、前記第2微生物がM.phocidaeである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocidaeであり、前記第2微生物がM.alligatorisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocidaeであり、前記第2微生物がM.arthritidisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocidaeであり、前記第2微生物がM.columbinumである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocidaeであり、前記第2微生物がM.gateaeである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.phocidaeであり、前記第2微生物がM.phocicerebraleである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.gallinarumであり、前記第2微生物がM.arthritidisである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.gallinarumであり、前記第2微生物がM.inersである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.inersであり、前記第2微生物がM.columbinumである、請求項1に記載の組換えキメラADI。
- 前記第1微生物がM.inersであり、前記第2微生物がM.gallinarumである、請求項1に記載の組換えキメラADI。
- 前記組換えキメラADIが、配列番号:4〜13もしくは22〜59のいずれか1つに示すアミノ酸配列、または配列番号:4〜13もしくは22〜59のいずれか1つと少なくとも90%の配列同一性を有するバリアントを含む、請求項1に記載の組換えキメラADI。
- 前記組換えキメラADIが、少なくとも1つのPEG化部位を除去するように修飾されている、先行請求項のいずれか1項に記載の組換えキメラADI。
- 少なくとも1つのリジン残基が、アミノ酸置換により修飾されている、先行請求項のいずれか1項に記載の組換えキメラADI。
- 少なくとも5つのリジン残基が、アミノ酸置換により修飾されている、請求項30に記載の組換えキメラADI。
- 少なくとも10のリジン残基が、アミノ酸置換により修飾されている、請求項30に記載の組換えキメラADI。
- 少なくとも15のリジン残基が、アミノ酸置換により修飾されている、請求項30に記載の組換えキメラADI。
- 少なくとも20のリジン残基が、アミノ酸置換により修飾されている、請求項30に記載の組換えキメラADI。
- 前記組換えキメラADIが、配列番号:10〜13のいずれか1つに示す前記アミノ酸配列を含む、請求項30に記載の組換えキメラADI。
- 生体適合性リンカーによりポリエチレングリコールに共有結合する、先行請求項のいずれか1項に記載の組換えキメラADI。
- 前記アルギニンデイミナーゼが、2つ以上のポリエチレングリコール分子に共有結合する、請求項30に記載の組換えキメラADI。
- 前記アルギニンデイミナーゼが、約1〜約10のポリエチレングリコール分子に共有結合する、請求項30に記載の組換えキメラADI。
- 前記アルギニンデイミナーゼが、5±3のPEG分子に共有結合する、請求項30に記載の組換えキメラADI。
- 前記PEG分子が、直鎖または分岐鎖PEG分子である、請求項30に記載の組換えキメラADI。
- 前記ポリエチレングリコールが、約1,000〜約40,000の総重量平均分子量を有する、請求項30に記載の組換えキメラADI。
- 前記ポリエチレングリコールが、約10,000〜約30,000の総重量平均分子量を有する、請求項30に記載の組換えキメラADI。
- 前記生体適合性リンカーが、スクシニル基、アミド基、イミド基、カルバメート基、エステル基、エポキシ基、カルボキシル基、ヒドロキシル基、炭水化物、チロシン基、システイン基、ヒスチジン基、メチレン基、またはこれらの組み合わせを含む、請求項30に記載の組換えキメラADI。
- 前記スクシニル基の供給源が、スクシンイミジルスクシネートである、請求項30に記載の組換えキメラADI。
- 先行請求項のいずれか1項に記載の前記組換えキメラADIをコードするポリヌクレオチド。
- 請求項45に記載の前記ポリヌクレオチドを含むベクター。
- 請求項46に記載の前記ベクターを含む単離宿主細胞。
- 先行請求項のいずれか1項に記載の前記組換えキメラADI及び生理学的に許容される担体を含む組成物。
- オートファジー調節剤をさらに含む、請求項48に記載の組成物。
- 前記オートファジー調節剤が、クロロキン、3−メチルアデニン、ヒドロキシクロロキン、バフィロマイシンA1、5−アミノ−4−イミダゾールカルボキサミドリボシド(AICAR)、オカダ酸、N6−メルカプトプリンリボシド、ビンブラスチン、ワートマニン、ラパマイシン、エベロリムス、メトホルミン、ペリホシン、レスベラトロール、及びタモキシフェンから成る群から選択される、請求項49に記載の組成物。
- 化学療法剤をさらに含む、請求項48に記載の組成物。
- 前記化学療法剤が、ドセタキセル、カルボプラチン、シクロホスファミド、ゲムシタビン、シスプラチン、ソラフェニブ、スニチニブ及びエベロリムスから成る群から選択される、請求項51に記載の組成物。
- 癌の処置方法、その症状の改善方法、またはその進行の阻害方法であって、それを必要とする患者に、治療有効量の請求項48に記載の前記組成物を投与し、それによって前記癌を処置する、その前記症状を改善させる、またはその前記進行を阻害することを含む、前記方法。
- 前記癌が、黒色腫、膵臓癌、前立腺癌、小細胞肺癌、中皮腫、リンパ性白血病、慢性骨髄性白血病、リンパ腫、肝細胞癌、肉腫、白血病、急性骨髄性白血病、再発性急性骨髄性白血病、乳癌、卵巣癌、結腸直腸癌、胃の癌、神経膠腫、多形性膠芽腫、非小細胞肺癌(NSCLC)、腎臓癌、膀胱癌、子宮癌、食道癌、脳癌、頭頸部癌、子宮頸癌、精巣癌、及び胃癌から成る群から選択される、請求項53に記載の方法。
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WO2022063178A1 (en) * | 2020-09-23 | 2022-03-31 | The Hong Kong Polytechnic University | Fluorescent biosensor for rapid determination of l-arginine |
KR102640230B1 (ko) * | 2021-09-24 | 2024-02-22 | 가천대학교 산학협력단 | C-peptide를 처리한 자궁내막 기질세포의 이동성 변화 기작을 이용한 자궁내막 관련질환의 진단 방법 및 자궁내막 관련질환 치료제의 스크리닝 방법 |
US20240084282A1 (en) * | 2022-09-02 | 2024-03-14 | Polaris Group | Modified arginine deiminases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001524836A (ja) * | 1997-05-12 | 2001-12-04 | フエニツクス・フアーマコロジクス・インコーポレーテツド | 修飾されたアルギニンデイミナーゼ |
JP2003533186A (ja) * | 2000-05-04 | 2003-11-11 | フエニツクス・フアーマコロジクス・インコーポレーテツド | アルギニンデイミナーゼの新規突然変異体 |
JP2006515281A (ja) * | 2002-11-18 | 2006-05-25 | フエニツクス・フアーマコロジクス・インコーポレーテツド | インビボでウイルス複製を阻害する方法 |
WO2014151982A2 (en) * | 2013-03-15 | 2014-09-25 | Polaris Group | Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2900279B2 (ja) | 1989-08-02 | 1999-06-02 | 株式会社ジャパンエナジー | 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤 |
US5372942A (en) | 1992-02-10 | 1994-12-13 | Coriell Institute For Medical Research | Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent |
US5804183A (en) | 1997-01-31 | 1998-09-08 | Enzon, Inc. | Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same |
US6180387B1 (en) | 1997-08-11 | 2001-01-30 | Smithkline Beecham Corporation | Arginine deiminase |
IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
WO2002009741A1 (en) | 2000-07-27 | 2002-02-07 | Angiolab, Inc. | The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis |
CN1518595A (zh) * | 2000-11-28 | 2004-08-04 | 凤凰药理学公司 | 修饰的精氨酸脱亚胺酶 |
US20050202451A1 (en) | 2003-04-29 | 2005-09-15 | Burczynski Michael E. | Methods and apparatuses for diagnosing AML and MDS |
WO2005052145A2 (en) * | 2003-10-07 | 2005-06-09 | University Of Florida | Recombinant alkaliizing bacteria |
CN101002945B (zh) | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
WO2009006590A2 (en) | 2007-07-04 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Docetaxel process and polymorphs |
US20090238813A1 (en) | 2007-12-28 | 2009-09-24 | Board Of Regents, The University Of Texas System | Compositions And Methods For Engineered Human Arginine Deiminases |
WO2010083312A2 (en) | 2009-01-14 | 2010-07-22 | The Trustees Of The University Of Pennsylvania | Micro-rna biomarker in cancer |
WO2011053871A2 (en) | 2009-10-30 | 2011-05-05 | Life Technologies Corporation | Multi-primer assay for mycoplasma detection |
AU2011260016B2 (en) | 2010-06-02 | 2013-08-22 | Fresenius Kabi Oncology Ltd. | Stable pharmaceutical compositions of Rapamycin esters |
US20120148559A1 (en) | 2010-12-01 | 2012-06-14 | Board Of Regents The University Of Texas System | Compositions and method for deimmunization of proteins |
US8663967B2 (en) | 2011-08-22 | 2014-03-04 | Jiangsu T-Mab Biopharma Co., Ltd. | Arginine deiminase mutant and preparation and application thereof |
JP2014521602A (ja) | 2012-04-04 | 2014-08-28 | ポラリス グループ | アルギニンデイミナーゼを用いる処置方法 |
WO2015143006A1 (en) | 2014-03-18 | 2015-09-24 | Tdw Group | Engineered chimeric pegylated adi and methods of use |
SG11201702103XA (en) | 2014-09-16 | 2017-04-27 | Polaris Group | Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001524836A (ja) * | 1997-05-12 | 2001-12-04 | フエニツクス・フアーマコロジクス・インコーポレーテツド | 修飾されたアルギニンデイミナーゼ |
JP2003533186A (ja) * | 2000-05-04 | 2003-11-11 | フエニツクス・フアーマコロジクス・インコーポレーテツド | アルギニンデイミナーゼの新規突然変異体 |
JP2006515281A (ja) * | 2002-11-18 | 2006-05-25 | フエニツクス・フアーマコロジクス・インコーポレーテツド | インビボでウイルス複製を阻害する方法 |
WO2014151982A2 (en) * | 2013-03-15 | 2014-09-25 | Polaris Group | Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment |
Non-Patent Citations (1)
Title |
---|
ARGININE DEIMINASE [MYCOPLASMA COLUMBINUM SF7] [08-AUG-2011] RETRIEVED FROM GENBANK [ONLINE] ACCES, JPN6019002810 * |
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KR20160134789A (ko) | 2016-11-23 |
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CN106794229B (zh) | 2020-12-18 |
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JP6612316B2 (ja) | 2019-11-27 |
US20170000862A1 (en) | 2017-01-05 |
CN106794229A (zh) | 2017-05-31 |
US10463721B2 (en) | 2019-11-05 |
EP3119421A1 (en) | 2017-01-25 |
WO2015143006A1 (en) | 2015-09-24 |
KR102523031B1 (ko) | 2023-04-19 |
EP3119421A4 (en) | 2017-11-29 |
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