JP2017513021A5 - - Google Patents
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- Publication number
- JP2017513021A5 JP2017513021A5 JP2017500456A JP2017500456A JP2017513021A5 JP 2017513021 A5 JP2017513021 A5 JP 2017513021A5 JP 2017500456 A JP2017500456 A JP 2017500456A JP 2017500456 A JP2017500456 A JP 2017500456A JP 2017513021 A5 JP2017513021 A5 JP 2017513021A5
- Authority
- JP
- Japan
- Prior art keywords
- anxa2
- subject
- level
- eclampsia
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004149 Annexin A2 Human genes 0.000 claims description 53
- 108090000668 Annexin A2 Proteins 0.000 claims description 53
- 238000000034 method Methods 0.000 claims description 44
- 201000011461 pre-eclampsia Diseases 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 31
- 239000000523 sample Substances 0.000 claims description 24
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 22
- 229920002971 Heparan sulfate Polymers 0.000 claims description 18
- 230000002357 endometrial effect Effects 0.000 claims description 16
- 238000002965 ELISA Methods 0.000 claims description 11
- 238000003018 immunoassay Methods 0.000 claims description 11
- 238000011532 immunohistochemical staining Methods 0.000 claims description 11
- 238000001262 western blot Methods 0.000 claims description 11
- 229920000045 Dermatan sulfate Polymers 0.000 claims description 9
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 9
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 9
- 229940051593 dermatan sulfate Drugs 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 9
- 239000003055 low molecular weight heparin Substances 0.000 claims description 9
- 229940127215 low-molecular weight heparin Drugs 0.000 claims description 9
- 230000035935 pregnancy Effects 0.000 claims description 8
- 210000002536 stromal cell Anatomy 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 2
- 239000013068 control sample Substances 0.000 claims description 2
- 208000002296 eclampsia Diseases 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461968728P | 2014-03-21 | 2014-03-21 | |
| US61/968,728 | 2014-03-21 | ||
| US201461969520P | 2014-03-24 | 2014-03-24 | |
| US61/969,520 | 2014-03-24 | ||
| PCT/IB2015/001404 WO2015166353A2 (en) | 2014-03-21 | 2015-03-19 | Early detection of preeclampsia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513021A JP2017513021A (ja) | 2017-05-25 |
| JP2017513021A5 true JP2017513021A5 (https=) | 2018-04-26 |
| JP6684263B2 JP6684263B2 (ja) | 2020-04-22 |
Family
ID=54147245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500456A Expired - Fee Related JP6684263B2 (ja) | 2014-03-21 | 2015-03-19 | 子癇前症の早期検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20170097358A1 (https=) |
| EP (1) | EP3120152A2 (https=) |
| JP (1) | JP6684263B2 (https=) |
| CN (2) | CN106662589B (https=) |
| BR (1) | BR112016021630A2 (https=) |
| CA (1) | CA2943284A1 (https=) |
| MX (1) | MX384485B (https=) |
| WO (1) | WO2015166353A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010010201A1 (es) | 2008-07-22 | 2010-01-28 | Equipo Ivi Investigacion Sl | Perfil de expresion genetica como marcador de la receptividad endometrial |
| CN107073040A (zh) | 2014-06-17 | 2017-08-18 | 艾基诺米公司 | 子宫内膜病理状况中的干细胞治疗 |
| CA3074808A1 (en) * | 2017-09-05 | 2019-03-14 | Igenomix S.L. | Methods and devices for detecting biomarkers associated with preeclampsia |
| EP3781144A4 (en) * | 2018-03-06 | 2022-01-12 | The Feinstein Institutes for Medical Research | METHODS TO DETECT AND TREAT ENDOMETRIOSIS |
| CN114990038B (zh) * | 2022-05-24 | 2023-06-27 | 郑州大学 | 一种细菌外膜囊泡及其在制备先兆子痫治疗药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712103A (en) * | 1995-02-13 | 1998-01-27 | Regents Of The University Of California | Diagnostic assay for the prediction of preeclampsia |
| IL127896A0 (en) * | 1998-12-31 | 1999-10-28 | Gail Laster | A novel treatment for preeclampsia and related diseases |
| WO2007030889A1 (en) * | 2005-09-15 | 2007-03-22 | Victor Voroteliak | Method of diagnosing pre-eclampsia |
| WO2008134881A1 (en) * | 2007-05-05 | 2008-11-13 | The University Of Western Ontario | Methods for the detection of preeclampsia |
| EP2019318A1 (en) * | 2007-07-27 | 2009-01-28 | Erasmus University Medical Center Rotterdam | Protein markers for cardiovascular events |
| CN101290321A (zh) * | 2008-04-11 | 2008-10-22 | 中国医学科学院肿瘤研究所 | 膜联蛋白a2的血清检测方法、检测试剂盒及其应用 |
| WO2009143633A1 (en) | 2008-05-30 | 2009-12-03 | Institut De Recherches Cliniques De Montreal | Pcsk9 inhibitors and methods of use thereof |
| CN110208540B (zh) * | 2008-10-31 | 2024-02-09 | 耶鲁大学 | 子痫前期检测和治疗的方法和组合物 |
| US20120107825A1 (en) * | 2010-11-01 | 2012-05-03 | Winger Edward E | Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna |
| WO2012115885A1 (en) * | 2011-02-22 | 2012-08-30 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers |
| US9423402B2 (en) * | 2011-11-30 | 2016-08-23 | Singapore Health Services Pte. Ltd. | GM1 ganglioside to annexin V microparticle polypeptide ratio for biological monitoring |
| WO2014001244A1 (en) * | 2012-06-27 | 2014-01-03 | Roche Diagnostics Gmbh | MEANS AND METHODS APPLYING sFlt-1/PlGF OR ENDOGLIN/PlGF RATIO TO RULE-OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD |
| CN103436552A (zh) * | 2013-09-10 | 2013-12-11 | 浙江大学 | 一种人源annexin A2的生产方法及其应用 |
-
2015
- 2015-03-19 BR BR112016021630-0A patent/BR112016021630A2/pt not_active IP Right Cessation
- 2015-03-19 EP EP15766246.1A patent/EP3120152A2/en not_active Withdrawn
- 2015-03-19 WO PCT/IB2015/001404 patent/WO2015166353A2/en not_active Ceased
- 2015-03-19 JP JP2017500456A patent/JP6684263B2/ja not_active Expired - Fee Related
- 2015-03-19 MX MX2016012278A patent/MX384485B/es unknown
- 2015-03-19 CN CN201580021153.7A patent/CN106662589B/zh not_active Expired - Fee Related
- 2015-03-19 CA CA2943284A patent/CA2943284A1/en not_active Abandoned
- 2015-03-19 US US15/127,901 patent/US20170097358A1/en not_active Abandoned
- 2015-03-19 CN CN201910597754.2A patent/CN110927385A/zh active Pending
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