CA2943284A1 - Early detection of preeclampsia - Google Patents

Early detection of preeclampsia Download PDF

Info

Publication number
CA2943284A1
CA2943284A1 CA2943284A CA2943284A CA2943284A1 CA 2943284 A1 CA2943284 A1 CA 2943284A1 CA 2943284 A CA2943284 A CA 2943284A CA 2943284 A CA2943284 A CA 2943284A CA 2943284 A1 CA2943284 A1 CA 2943284A1
Authority
CA
Canada
Prior art keywords
anxa2
subject
preeclampsia
level
glycosaminoglycan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2943284A
Other languages
English (en)
French (fr)
Inventor
Carlos Simon
Tamara GARRIDO
Antonio PELLICER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Igenomix SL
Original Assignee
Igenomix SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igenomix SL filed Critical Igenomix SL
Publication of CA2943284A1 publication Critical patent/CA2943284A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/36Gynecology or obstetrics
    • G01N2800/368Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2943284A 2014-03-21 2015-03-19 Early detection of preeclampsia Abandoned CA2943284A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461968728P 2014-03-21 2014-03-21
US61/968,728 2014-03-21
US201461969520P 2014-03-24 2014-03-24
US61/969,520 2014-03-24
PCT/IB2015/001404 WO2015166353A2 (en) 2014-03-21 2015-03-19 Early detection of preeclampsia

Publications (1)

Publication Number Publication Date
CA2943284A1 true CA2943284A1 (en) 2015-11-05

Family

ID=54147245

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2943284A Abandoned CA2943284A1 (en) 2014-03-21 2015-03-19 Early detection of preeclampsia

Country Status (8)

Country Link
US (1) US20170097358A1 (https=)
EP (1) EP3120152A2 (https=)
JP (1) JP6684263B2 (https=)
CN (2) CN110927385A (https=)
BR (1) BR112016021630A2 (https=)
CA (1) CA2943284A1 (https=)
MX (1) MX384485B (https=)
WO (1) WO2015166353A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
US11129851B2 (en) 2014-06-17 2021-09-28 Igenomix S.L. Stem cell therapy in endometrial pathologies
CA3074808A1 (en) * 2017-09-05 2019-03-14 Igenomix S.L. Methods and devices for detecting biomarkers associated with preeclampsia
CA3093206A1 (en) * 2018-03-06 2019-09-12 Christine Metz Methods for detecting and treating endometriosis
CN114990038B (zh) * 2022-05-24 2023-06-27 郑州大学 一种细菌外膜囊泡及其在制备先兆子痫治疗药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712103A (en) * 1995-02-13 1998-01-27 Regents Of The University Of California Diagnostic assay for the prediction of preeclampsia
IL127896A0 (en) * 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
CN101616927A (zh) * 2005-09-15 2009-12-30 迪爱麦有限公司 诊断先兆子痫的方法
CN101680884A (zh) * 2007-05-05 2010-03-24 西安大略大学 检测先兆子痫的方法
EP2019318A1 (en) * 2007-07-27 2009-01-28 Erasmus University Medical Center Rotterdam Protein markers for cardiovascular events
CN105403701B (zh) * 2008-04-11 2017-04-12 中国医学科学院肿瘤医院 膜联蛋白a2的血清检测方法、检测试剂盒及其应用
WO2009143633A1 (en) 2008-05-30 2009-12-03 Institut De Recherches Cliniques De Montreal Pcsk9 inhibitors and methods of use thereof
CN107677828A (zh) * 2008-10-31 2018-02-09 耶鲁大学 子痫前期检测和治疗的方法和组合物
US20120107825A1 (en) * 2010-11-01 2012-05-03 Winger Edward E Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna
EP2678448A4 (en) * 2011-02-22 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L CIRCULATING BIOMARKERS
US9423402B2 (en) * 2011-11-30 2016-08-23 Singapore Health Services Pte. Ltd. GM1 ganglioside to annexin V microparticle polypeptide ratio for biological monitoring
MX356775B (es) * 2012-06-27 2018-06-13 Hoffmann La Roche Medios y metodos que aplican sflt-1/plgf o relacion de endoglina/plgf para descartar el inicio de preeclampsia en un determinado periodo de tiempo.
CN103436552A (zh) * 2013-09-10 2013-12-11 浙江大学 一种人源annexin A2的生产方法及其应用

Also Published As

Publication number Publication date
CN110927385A (zh) 2020-03-27
JP6684263B2 (ja) 2020-04-22
BR112016021630A2 (pt) 2020-02-27
JP2017513021A (ja) 2017-05-25
EP3120152A2 (en) 2017-01-25
US20170097358A1 (en) 2017-04-06
MX384485B (es) 2025-03-14
MX2016012278A (es) 2017-04-27
CN106662589B (zh) 2019-07-30
WO2015166353A3 (en) 2016-01-21
WO2015166353A2 (en) 2015-11-05
CN106662589A (zh) 2017-05-10

Similar Documents

Publication Publication Date Title
Garrido-Gomez et al. Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology
Lala et al. Human placental trophoblast as an in vitro model for tumor progression
Graham et al. Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients
US20170097358A1 (en) Early detection of preeclampsia
Lian et al. Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts
Shokry et al. Expression of matrix metalloproteinases 2 and 9 in human trophoblasts of normal and preeclamptic placentas: preliminary findings
Prithviraj et al. Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion
JP6198868B2 (ja) 炎症および/または心血管疾患における新規診断および治療標的
Wang et al. Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse
Hiden et al. Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth restriction
Chen et al. Silencing of paternally expressed gene 10 inhibits trophoblast proliferation and invasion
El-Sherbiny et al. Metalloprotease (ADAM12-S) as a predictor of preeclampsia: correlation with severity, maternal complications, fetal outcome, and Doppler parameters
Chang et al. PLAC1 is involved in human trophoblast syncytialization
Wölfler et al. A predictive model for endometriosis
Li et al. Role of kisspeptin/GPR54 in the first trimester trophoblast of women with a history of recurrent spontaneous abortion
Motawea et al. Human placenta expresses α2-adrenergic receptors and may be implicated in pathogenesis of preeclampsia and fetal growth restriction
Sahlin et al. Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming
Zhu et al. Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth
Wang et al. Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia
Hambruch et al. Bovine placentomal heparanase and syndecan expression is related to placental maturation
HK40026831A (en) Early detection of preeclampsia
WO2023176923A1 (ja) 着床能の検出方法および着床障害の予測方法
Gerhardt et al. Maternal IVS1-401 T allele of the estrogen receptor α is an independent predictor of late fetal loss
Rajashekhar et al. Expression and secretion of the vascular cell adhesion molecule-1 in human placenta and its decrease in fetal growth restriction
Feng et al. Expression of ADAMTS13 in human endometrium and its potential role in recurrent pregnancy loss

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200318

FZDE Discontinued

Effective date: 20231107