JP2017512774A - 二環式ヌクレオシドの合成 - Google Patents

二環式ヌクレオシドの合成 Download PDF

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Publication number
JP2017512774A
JP2017512774A JP2016557214A JP2016557214A JP2017512774A JP 2017512774 A JP2017512774 A JP 2017512774A JP 2016557214 A JP2016557214 A JP 2016557214A JP 2016557214 A JP2016557214 A JP 2016557214A JP 2017512774 A JP2017512774 A JP 2017512774A
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JP
Japan
Prior art keywords
mmol
methyl
oxy
chlorobenzyl
mixture
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JP2016557214A
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English (en)
Japanese (ja)
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JP2017512774A5 (enExample
Inventor
カート ベーグル，
カート ベーグル，
Original Assignee
ミラゲン セラピューティクス， インコーポレイテッド
ミラゲン セラピューティクス， インコーポレイテッド
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Publication of JP2017512774A publication Critical patent/JP2017512774A/ja
Publication of JP2017512774A5 publication Critical patent/JP2017512774A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
JP2016557214A 2014-03-16 2015-03-16 二環式ヌクレオシドの合成 Pending JP2017512774A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461953889P 2014-03-16 2014-03-16
US61/953,889 2014-03-16
PCT/US2015/020761 WO2015142735A1 (en) 2014-03-16 2015-03-16 Synthesis of bicyclic nucleosides

Publications (2)

Publication Number Publication Date
JP2017512774A true JP2017512774A (ja) 2017-05-25
JP2017512774A5 JP2017512774A5 (enExample) 2018-03-08

Family

ID=54145178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016557214A Pending JP2017512774A (ja) 2014-03-16 2015-03-16 二環式ヌクレオシドの合成

Country Status (6)

Country Link
US (1) US10030042B2 (enExample)
EP (1) EP3119796A4 (enExample)
JP (1) JP2017512774A (enExample)
CN (1) CN106459135A (enExample)
CA (1) CA2940440A1 (enExample)
WO (1) WO2015142735A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518826A (ja) * 2013-03-15 2016-06-30 ミラゲン セラピューティクス， インコーポレイテッド 架橋二環式ヌクレオシド

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11098077B2 (en) 2016-07-05 2021-08-24 Chinook Therapeutics, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
WO2018215049A1 (en) * 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates
JP2022549196A (ja) * 2019-09-23 2022-11-24 ディーエヌエー スクリプト ポリヌクレオチドの鋳型なし酵素的合成における長配列収率の増加
CN114685560B (zh) * 2020-12-31 2024-05-14 沈阳药科大学 含哌啶骨架亚磷酰胺单体及寡聚核苷酸的合成和应用
JP2024534502A (ja) * 2021-09-22 2024-09-20 セーンジーン バイオ ユーエスエー インコーポレイティド オリゴヌクレオチドのインビボ送達に使用するための２’－アルキル又は３’－アルキル修飾リボース誘導体
CN116606338A (zh) * 2023-05-18 2023-08-18 中国人民解放军军事科学院军事医学研究院 6’-氰基修饰的锁核苷、核苷酸和核酸聚合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516256A (ja) * 1998-05-26 2002-06-04 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 二環式糖成分を有する新規ヌクレオシド
WO2013036868A1 (en) * 2011-09-07 2013-03-14 Marina Biotech Inc. Synthesis and uses of nucleic acid compounds with conformationally restricted monomers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833361B2 (en) * 1998-05-26 2004-12-21 Ribapharm, Inc. Nucleosides having bicyclic sugar moiety
WO2011085102A1 (en) * 2010-01-11 2011-07-14 Isis Pharmaceuticals, Inc. Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
EP2970968B1 (en) 2013-03-15 2018-01-10 Miragen Therapeutics, Inc. Bridged bicyclic nucleosides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516256A (ja) * 1998-05-26 2002-06-04 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 二環式糖成分を有する新規ヌクレオシド
WO2013036868A1 (en) * 2011-09-07 2013-03-14 Marina Biotech Inc. Synthesis and uses of nucleic acid compounds with conformationally restricted monomers

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, JPN6019006678, 1999, pages 1147 - 1150, ISSN: 0003986431 *
CHEM. COMMUN., vol. 48, JPN6019006669, 2012, pages 8754 - 8756, ISSN: 0003986427 *
J. ORG. CHEM., vol. 69, JPN6019006665, 2004, pages 4751 - 4759, ISSN: 0004124906 *
NUCLEOSIDES & NUCLEOTIDES, vol. 11(6), JPN6019006673, 1992, pages 1205 - 1218, ISSN: 0003986428 *
NUCLEOSIDES & NUCLEOTIDES, vol. 18(4&5), JPN6019006674, 1999, pages 531 - 536, ISSN: 0003986429 *
SYNTHESIS, vol. 17, JPN6019006666, 2005, pages 2865 - 2870, ISSN: 0003986426 *
TETRAHEDRON, vol. 55, JPN6019006676, 1999, pages 7707 - 7724, ISSN: 0003986430 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518826A (ja) * 2013-03-15 2016-06-30 ミラゲン セラピューティクス， インコーポレイテッド 架橋二環式ヌクレオシド
US10011833B2 (en) 2013-03-15 2018-07-03 MiRagen Therapeutics, Inc. Bridged bicyclic nucleosides

Also Published As

Publication number Publication date
CA2940440A1 (en) 2015-09-24
US20170073368A1 (en) 2017-03-16
CN106459135A (zh) 2017-02-22
US10030042B2 (en) 2018-07-24
WO2015142735A1 (en) 2015-09-24
EP3119796A1 (en) 2017-01-25
EP3119796A4 (en) 2017-08-30

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