JP2017512500A5 - - Google Patents
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- JP2017512500A5 JP2017512500A5 JP2017502922A JP2017502922A JP2017512500A5 JP 2017512500 A5 JP2017512500 A5 JP 2017512500A5 JP 2017502922 A JP2017502922 A JP 2017502922A JP 2017502922 A JP2017502922 A JP 2017502922A JP 2017512500 A5 JP2017512500 A5 JP 2017512500A5
- Authority
- JP
- Japan
- Prior art keywords
- lactobacillus
- clostridium
- bacteroides
- composition
- host
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000193464 Clostridium sp. Species 0.000 claims description 26
- 210000004027 cell Anatomy 0.000 claims description 22
- 239000006041 probiotic Substances 0.000 claims description 21
- 235000018291 probiotics Nutrition 0.000 claims description 21
- 101710163270 Nuclease Proteins 0.000 claims description 20
- 230000000529 probiotic effect Effects 0.000 claims description 19
- 241000606125 Bacteroides Species 0.000 claims description 16
- 241000588724 Escherichia coli Species 0.000 claims description 14
- 241000186604 Lactobacillus reuteri Species 0.000 claims description 13
- 230000003115 biocidal effect Effects 0.000 claims description 13
- 229940001882 lactobacillus reuteri Drugs 0.000 claims description 13
- 108020004707 nucleic acids Proteins 0.000 claims description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 13
- 150000007523 nucleic acids Chemical class 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 241000193403 Clostridium Species 0.000 claims description 10
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 9
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 9
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 9
- 241000186605 Lactobacillus paracasei Species 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 241000186660 Lactobacillus Species 0.000 claims description 7
- 230000002068 genetic effect Effects 0.000 claims description 7
- 229940039696 lactobacillus Drugs 0.000 claims description 7
- 241001148536 Bacteroides sp. Species 0.000 claims description 6
- 108091033409 CRISPR Proteins 0.000 claims description 6
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 6
- 108091028113 Trans-activating crRNA Proteins 0.000 claims description 6
- 239000012636 effector Substances 0.000 claims description 6
- 241001468157 Lactobacillus johnsonii Species 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 238000010354 CRISPR gene editing Methods 0.000 claims description 4
- 244000199866 Lactobacillus casei Species 0.000 claims description 4
- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 4
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 4
- 241000191940 Staphylococcus Species 0.000 claims description 4
- 102000008579 Transposases Human genes 0.000 claims description 4
- 108010020764 Transposases Proteins 0.000 claims description 4
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 229940017800 lactobacillus casei Drugs 0.000 claims description 4
- 229940012969 lactobacillus fermentum Drugs 0.000 claims description 4
- 230000001717 pathogenic effect Effects 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 108700012359 toxins Proteins 0.000 claims description 4
- 239000000304 virulence factor Substances 0.000 claims description 4
- 230000007923 virulence factor Effects 0.000 claims description 4
- 241000186394 Eubacterium Species 0.000 claims description 3
- 244000057717 Streptococcus lactis Species 0.000 claims description 3
- 235000014897 Streptococcus lactis Nutrition 0.000 claims description 3
- 238000005202 decontamination Methods 0.000 claims description 3
- 230000003588 decontaminative effect Effects 0.000 claims description 3
- 244000000015 environmental pathogen Species 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 claims description 3
- 241000456624 Actinobacteria bacterium Species 0.000 claims description 2
- 241000544634 Actinomyces graevenitzii Species 0.000 claims description 2
- 241000186066 Actinomyces odontolyticus Species 0.000 claims description 2
- 241000702460 Akkermansia Species 0.000 claims description 2
- 241001580959 Alistipes finegoldii Species 0.000 claims description 2
- 241001135230 Alistipes putredinis Species 0.000 claims description 2
- 241001258698 Allisonella Species 0.000 claims description 2
- 241001464864 Anaerococcus vaginalis Species 0.000 claims description 2
- 241001580965 Anaerofustis stercorihominis Species 0.000 claims description 2
- 241000428313 Anaerotruncus colihominis Species 0.000 claims description 2
- 241000193749 Bacillus coagulans Species 0.000 claims description 2
- 241000217846 Bacteroides caccae Species 0.000 claims description 2
- 241000606124 Bacteroides fragilis Species 0.000 claims description 2
- 241001135228 Bacteroides ovatus Species 0.000 claims description 2
- 241000606219 Bacteroides uniformis Species 0.000 claims description 2
- 241000606215 Bacteroides vulgatus Species 0.000 claims description 2
- 241000605059 Bacteroidetes Species 0.000 claims description 2
- 241000186000 Bifidobacterium Species 0.000 claims description 2
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 2
- 241000483634 Bifidobacterium animalis subsp. lactis BB-12 Species 0.000 claims description 2
- 241001608472 Bifidobacterium longum Species 0.000 claims description 2
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 2
- 241001495171 Bilophila Species 0.000 claims description 2
- 241000186146 Brevibacterium Species 0.000 claims description 2
- 241001262170 Collinsella aerofaciens Species 0.000 claims description 2
- 241000220677 Coprococcus catus Species 0.000 claims description 2
- 241001464949 Coprococcus eutactus Species 0.000 claims description 2
- 241000186216 Corynebacterium Species 0.000 claims description 2
- 241001337994 Cryptococcus <scale insect> Species 0.000 claims description 2
- 241000186427 Cutibacterium acnes Species 0.000 claims description 2
- 241001464974 Cutibacterium avidum Species 0.000 claims description 2
- 241000235035 Debaryomyces Species 0.000 claims description 2
- 241000604463 Desulfovibrio piger Species 0.000 claims description 2
- 241000016537 Dorea longicatena Species 0.000 claims description 2
- 241000312060 Escherichia coli HS Species 0.000 claims description 2
- 241001302654 Escherichia coli Nissle 1917 Species 0.000 claims description 2
- 241000680146 Escherichia coli SE11 Species 0.000 claims description 2
- 241000023505 Escherichia coli SE15 Species 0.000 claims description 2
- 241001531192 Eubacterium ventriosum Species 0.000 claims description 2
- 241001608234 Faecalibacterium Species 0.000 claims description 2
- 241000605909 Fusobacterium Species 0.000 claims description 2
- 241000951752 Fusobacterium sp. oral clone R002 Species 0.000 claims description 2
- 241000193814 Gemella haemolysans Species 0.000 claims description 2
- 108020005004 Guide RNA Proteins 0.000 claims description 2
- 241000606790 Haemophilus Species 0.000 claims description 2
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 2
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 2
- 244000199885 Lactobacillus bulgaricus Species 0.000 claims description 2
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 claims description 2
- 241001147746 Lactobacillus delbrueckii subsp. lactis Species 0.000 claims description 2
- 241001406038 Lactobacillus johnsonii NCC 533 Species 0.000 claims description 2
- 241000194036 Lactococcus Species 0.000 claims description 2
- 241000555676 Malassezia Species 0.000 claims description 2
- 241000192041 Micrococcus Species 0.000 claims description 2
- 241001135232 Odoribacter splanchnicus Species 0.000 claims description 2
- 241000606210 Parabacteroides distasonis Species 0.000 claims description 2
- 241000204306 Parabacteroides merdae Species 0.000 claims description 2
- 241001464887 Parvimonas micra Species 0.000 claims description 2
- 241000951725 Peptostreptococcus sp. oral clone CK035 Species 0.000 claims description 2
- 241000186429 Propionibacterium Species 0.000 claims description 2
- 241000192142 Proteobacteria Species 0.000 claims description 2
- 241001528479 Pseudoflavonifractor capillosus Species 0.000 claims description 2
- 241000872831 Roseburia faecis Species 0.000 claims description 2
- 241000398180 Roseburia intestinalis Species 0.000 claims description 2
- 241000192031 Ruminococcus Species 0.000 claims description 2
- 241000123753 Ruminococcus bromii Species 0.000 claims description 2
- 241000123754 Ruminococcus callidus Species 0.000 claims description 2
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims description 2
- 241000194017 Streptococcus Species 0.000 claims description 2
- 241001134658 Streptococcus mitis Species 0.000 claims description 2
- 241000193991 Streptococcus parasanguinis Species 0.000 claims description 2
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 2
- 241000187747 Streptomyces Species 0.000 claims description 2
- 241001261005 Verrucomicrobia Species 0.000 claims description 2
- 241000186569 [Clostridium] leptum Species 0.000 claims description 2
- 241001147801 [Clostridium] scindens Species 0.000 claims description 2
- 241000193450 [Clostridium] symbiosum Species 0.000 claims description 2
- 241001531273 [Eubacterium] eligens Species 0.000 claims description 2
- 241001531197 [Eubacterium] hallii Species 0.000 claims description 2
- 241001531189 [Eubacterium] siraeum Species 0.000 claims description 2
- 241001464867 [Ruminococcus] gnavus Species 0.000 claims description 2
- 229940054340 bacillus coagulans Drugs 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 229940009291 bifidobacterium longum Drugs 0.000 claims description 2
- 210000002615 epidermis Anatomy 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 2
- 229940004208 lactobacillus bulgaricus Drugs 0.000 claims description 2
- PSBAIJVSCTZDDB-UHFFFAOYSA-N phenyl acetylsalicylate Chemical compound CC(=O)OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 PSBAIJVSCTZDDB-UHFFFAOYSA-N 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 229940055019 propionibacterium acne Drugs 0.000 claims description 2
- 229940055009 propionibacterium avidum Drugs 0.000 claims description 2
- 229960002181 saccharomyces boulardii Drugs 0.000 claims description 2
- 125000006850 spacer group Chemical group 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 230000002103 transcriptional effect Effects 0.000 claims description 2
- 241001515965 unidentified phage Species 0.000 claims description 2
- 210000001635 urinary tract Anatomy 0.000 claims description 2
- 210000005253 yeast cell Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 22
- 241001134569 Flavonifractor plautii Species 0.000 claims 1
- 241001531188 [Eubacterium] rectale Species 0.000 claims 1
- 208000012931 Urologic disease Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461970024P | 2014-03-25 | 2014-03-25 | |
| US61/970,024 | 2014-03-25 | ||
| PCT/US2015/022508 WO2015148680A1 (en) | 2014-03-25 | 2015-03-25 | Methods and genetic systems for cell engineering |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020132873A Division JP2021000092A (ja) | 2014-03-25 | 2020-08-05 | 細胞工学のための方法および遺伝システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017512500A JP2017512500A (ja) | 2017-05-25 |
| JP2017512500A5 true JP2017512500A5 (enExample) | 2018-04-19 |
Family
ID=54196352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502922A Pending JP2017512500A (ja) | 2014-03-25 | 2015-03-25 | 細胞工学のための方法および遺伝システム |
| JP2020132873A Pending JP2021000092A (ja) | 2014-03-25 | 2020-08-05 | 細胞工学のための方法および遺伝システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020132873A Pending JP2021000092A (ja) | 2014-03-25 | 2020-08-05 | 細胞工学のための方法および遺伝システム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20170173086A1 (enExample) |
| EP (1) | EP3122870B1 (enExample) |
| JP (2) | JP2017512500A (enExample) |
| AU (1) | AU2015236045B2 (enExample) |
| CA (1) | CA2943775A1 (enExample) |
| DK (1) | DK3122870T3 (enExample) |
| WO (1) | WO2015148680A1 (enExample) |
Families Citing this family (74)
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| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| WO2014160059A1 (en) | 2013-03-13 | 2014-10-02 | Gen9, Inc. | Compositions and methods for synthesis of high fidelity oligonucleotides |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| WO2015066119A1 (en) | 2013-10-30 | 2015-05-07 | North Carolina State University | Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri |
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| JP2017512481A (ja) | 2014-04-08 | 2017-05-25 | ノースカロライナ ステート ユニバーシティーＮｏｒｔｈ Ｃａｒｏｌｉｎａ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ | Ｃｒｉｓｐｒ関連遺伝子を用いた、ｒｎａ依存性の転写抑制のための方法および組成物 |
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| EP4302824A3 (en) | 2016-04-20 | 2024-03-20 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for nucleic acid expression and protein secretion in bacteroides |
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| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018071841A1 (en) * | 2016-10-14 | 2018-04-19 | The Forsyth Institute | Compositions and methods for evading bacterial defense mechanisms |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US11566238B2 (en) | 2016-12-15 | 2023-01-31 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating growth of a genetically modified gut bacterial cell |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US11224624B2 (en) * | 2017-02-14 | 2022-01-18 | California Institute Of Technology | Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease |
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| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
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| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
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| WO2021119594A1 (en) * | 2019-12-13 | 2021-06-17 | The Regents Of The University Of California | Reducing antibiotic resistance in bacteria using pro-active genetics |
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| CN112029699B (zh) * | 2020-11-04 | 2021-06-08 | 中国农业科学院北京畜牧兽医研究所 | 一种基于内源CRISPR-Cas系统的丁酸梭菌基因编辑系统及其应用 |
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Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0487159A1 (en) * | 1990-11-23 | 1992-05-27 | Unilever N.V. | A food-grade vector suitable for transforming a food-grade host cell, use of said vector for transforming food-grade host cells, and use of said transformed cells in biotransformation processes |
| US7005561B2 (en) | 2000-03-08 | 2006-02-28 | University Of Georgia Research Foundation, Inc. | Arabitol or ribitol as positive selectable markers |
| US20050019335A1 (en) * | 2001-11-12 | 2005-01-27 | Lowery David E | Salmonella vaccine |
| ES2593811T3 (es) * | 2003-08-14 | 2016-12-13 | Dsm Ip Assets B.V. | Producción microbiana de ácido L-ascórbico |
| FI116068B (fi) | 2003-09-15 | 2005-09-15 | Fit Biotech Oyj Plc | Uusi selektiojärjestelmä, siinä käyttökelpoinen vektori, bakteerisolukantoja sekä menetelmä solujen valikoimiseksi |
| EP2211879B1 (en) * | 2007-10-26 | 2014-05-07 | Brenda E. Moore | Probiotic compositions and methods for inducing and supporting weight loss |
| JP5783503B2 (ja) * | 2008-09-03 | 2015-09-24 | 国立研究開発法人農業・食品産業技術総合研究機構 | 外来遺伝子を導入しない、非遺伝子組換えの遺伝子欠損株とその作製および選抜方法 |
| JP5940977B2 (ja) * | 2009-08-11 | 2016-06-29 | サンガモ バイオサイエンシーズ， インコーポレイテッド | 標的改変によるホモ接合生物 |
| WO2011101696A1 (en) * | 2010-02-18 | 2011-08-25 | Cellectis | Improved meganuclease recombination system |
| CN103261213A (zh) | 2010-10-20 | 2013-08-21 | 杜邦营养生物科学有限公司 | 乳球菌CRISPR-Cas序列 |
| AU2013266968B2 (en) * | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| EP4074330A1 (en) | 2013-09-05 | 2022-10-19 | Massachusetts Institute of Technology | Tuning microbial populations with programmable nucleases |
| WO2015148680A1 (en) | 2014-03-25 | 2015-10-01 | Ginkgo Bioworks, Inc. | Methods and genetic systems for cell engineering |
-
2015
- 2015-03-25 WO PCT/US2015/022508 patent/WO2015148680A1/en not_active Ceased
- 2015-03-25 EP EP15768011.7A patent/EP3122870B1/en not_active Revoked
- 2015-03-25 AU AU2015236045A patent/AU2015236045B2/en not_active Ceased
- 2015-03-25 DK DK15768011.7T patent/DK3122870T3/da active
- 2015-03-25 JP JP2017502922A patent/JP2017512500A/ja active Pending
- 2015-03-25 CA CA2943775A patent/CA2943775A1/en not_active Abandoned
- 2015-03-25 US US15/127,498 patent/US20170173086A1/en not_active Abandoned
-
2020
- 2020-08-05 JP JP2020132873A patent/JP2021000092A/ja active Pending
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