JP2017510627A5 - - Google Patents
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- Publication number
- JP2017510627A5 JP2017510627A5 JP2016574516A JP2016574516A JP2017510627A5 JP 2017510627 A5 JP2017510627 A5 JP 2017510627A5 JP 2016574516 A JP2016574516 A JP 2016574516A JP 2016574516 A JP2016574516 A JP 2016574516A JP 2017510627 A5 JP2017510627 A5 JP 2017510627A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antagonist
- mcam
- composition according
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 claims 18
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 18
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 18
- 239000005557 antagonist Substances 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 229940122414 Alpha4 integrin antagonist Drugs 0.000 claims 9
- 108010041012 Integrin alpha4 Proteins 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229960005027 natalizumab Drugs 0.000 claims 2
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952835P | 2014-03-13 | 2014-03-13 | |
| US61/952,835 | 2014-03-13 | ||
| US201462023577P | 2014-07-11 | 2014-07-11 | |
| US62/023,577 | 2014-07-11 | ||
| PCT/IB2015/051785 WO2015136468A1 (en) | 2014-03-13 | 2015-03-12 | Combination treatment for multiple sclerosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020019355A Division JP2020100631A (ja) | 2014-03-13 | 2020-02-07 | 多発性硬化症の併用治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017510627A JP2017510627A (ja) | 2017-04-13 |
| JP2017510627A5 true JP2017510627A5 (cg-RX-API-DMAC7.html) | 2018-04-19 |
Family
ID=52737375
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574516A Pending JP2017510627A (ja) | 2014-03-13 | 2015-03-12 | 多発性硬化症の併用治療 |
| JP2020019355A Pending JP2020100631A (ja) | 2014-03-13 | 2020-02-07 | 多発性硬化症の併用治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020019355A Pending JP2020100631A (ja) | 2014-03-13 | 2020-02-07 | 多発性硬化症の併用治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170002077A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3116910A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2017510627A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170052526A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2938945A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015136468A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI660972B (zh) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
| US10407506B2 (en) | 2014-03-12 | 2019-09-10 | Prothena Biosciences Limited | Anti-MCAM antibodies and associated methods of use |
| JP2017514458A (ja) | 2014-03-12 | 2017-06-08 | プロセナ バイオサイエンシーズ リミテッド | Ｌｇ４−５に対して特異的な抗−ラミニン４抗体 |
| WO2017134178A1 (en) * | 2016-02-05 | 2017-08-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Imaging method for predicting the onset of multiple sclerosis |
| WO2017149513A1 (en) * | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017153955A1 (en) * | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| WO2019093481A1 (ja) * | 2017-11-09 | 2019-05-16 | 北海道公立大学法人札幌医科大学 | 組織再生用医薬及びその製造方法 |
| CA3147044A1 (en) | 2019-07-11 | 2021-01-14 | Tavotek Biotherapeutics (Hong Kong) Limited | Agents that interfere with thymic stromal lymphopoietin (tslp)-receptor signaling |
| TW202504919A (zh) | 2023-05-30 | 2025-02-01 | 美商派拉岡醫療公司 | α4β7整合素抗體組合物及使用方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| ES2257808T3 (es) | 1997-05-29 | 2006-08-01 | MERCK & CO., INC. (A NEW JERSEY CORP.) | Acidos biarilalcanoicos como inhibidores de adhesion celular. |
| JP2001512135A (ja) | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Ｖｌａ−４によって媒介された白血球接着を阻害するジペプチドおよび関連化合物 |
| IL133635A0 (en) | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4 |
| CN1133648C (zh) | 1997-07-31 | 2004-01-07 | 伊兰药品公司 | 抑制vla-4介导的白细胞粘附的取代的苯丙氨酸型化合物 |
| AU739511B2 (en) | 1997-08-22 | 2001-10-11 | F. Hoffmann-La Roche Ag | N-aroylphenylalanine derivatives |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| EP1071680B1 (en) | 1998-04-16 | 2008-07-23 | Encysive Pharmaceuticals, Inc | N,n-disubstituted amides that inhibit the binding of integrins to their receptors |
| GB9811969D0 (en) | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821406D0 (en) | 1998-10-01 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| CA2625839A1 (en) | 1999-02-05 | 2000-08-10 | Samsung Electronics Co., Ltd. | Image texture retrieving method and apparatus thereof |
| TR200201920T2 (tr) | 1999-05-07 | 2002-09-23 | Texas Biotechnology Corporation | İntegrinlerin reseptörlerine bağlanmasını engelleyen karboksilik asit türevleri. |
| AU6909300A (en) | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
| WO2002008206A1 (en) | 2000-07-21 | 2002-01-31 | Elan Pharmaceuticals, Inc. | 3-amino-2-(4-aminocarbonyloxy)phenyl-propionic acid derivatives as alpha-4- integrin inhibitors |
| US7192931B2 (en) * | 2000-10-12 | 2007-03-20 | Neuren Pharmaceuticals Ltd. | Treatment of demyelinating diseases |
| CA2438628A1 (en) * | 2001-02-19 | 2002-08-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Artificial proteins with reduced immunogenicity |
| IL166244A0 (en) | 2001-07-12 | 2006-01-15 | Jefferson Foote | Super humanized antibodies |
| JPWO2003024933A1 (ja) | 2001-09-12 | 2004-12-24 | 科研製薬株式会社 | ２−フェニル−３−ヘテロアリールプロピオン酸誘導体またはその塩、それを用いた医薬 |
| JP2007521249A (ja) * | 2003-01-24 | 2007-08-02 | エラン ファーマシューティカルズ，インコーポレイテッド | 脱髄疾患および麻痺のための組成物ならびに再有髄化剤を投与することによるそれらの治療 |
| JP2010529999A (ja) * | 2007-06-14 | 2010-09-02 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 抗体製剤 |
| EP3202415B1 (en) * | 2010-06-30 | 2021-12-08 | Compugen Ltd. | Fusion protein comprising a c1orf32 polypeptide and one or more domains of an immunoglobulin heavy chain constant region for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders. |
| EP2718327A1 (en) | 2011-06-06 | 2014-04-16 | Neotope Biosciences Limited | Mcam antagonists and methods of treatment |
| TWI660972B (zh) * | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
-
2015
- 2015-03-12 KR KR1020167027876A patent/KR20170052526A/ko not_active Abandoned
- 2015-03-12 WO PCT/IB2015/051785 patent/WO2015136468A1/en not_active Ceased
- 2015-03-12 US US15/125,568 patent/US20170002077A1/en not_active Abandoned
- 2015-03-12 JP JP2016574516A patent/JP2017510627A/ja active Pending
- 2015-03-12 CA CA2938945A patent/CA2938945A1/en active Pending
- 2015-03-12 EP EP15712195.5A patent/EP3116910A1/en not_active Withdrawn
-
2020
- 2020-02-07 JP JP2020019355A patent/JP2020100631A/ja active Pending
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