JP2017509696A5 - - Google Patents
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- Publication number
- JP2017509696A5 JP2017509696A5 JP2016570929A JP2016570929A JP2017509696A5 JP 2017509696 A5 JP2017509696 A5 JP 2017509696A5 JP 2016570929 A JP2016570929 A JP 2016570929A JP 2016570929 A JP2016570929 A JP 2016570929A JP 2017509696 A5 JP2017509696 A5 JP 2017509696A5
- Authority
- JP
- Japan
- Prior art keywords
- coupling
- formulation
- carboxylic acid
- group
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000008878 coupling Effects 0.000 claims 15
- 238000010168 coupling process Methods 0.000 claims 15
- 238000005859 coupling reaction Methods 0.000 claims 15
- 238000009472 formulation Methods 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 150000001718 carbodiimides Chemical class 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000002843 carboxylic acid group Chemical group 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 241001061127 Thione Species 0.000 claims 2
- 230000005670 electromagnetic radiation Effects 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- RQKQXGMTEDELHW-UHFFFAOYSA-N 1-[3-(diethylamino)propyl]-4-(2-methoxyphenyl)tetrazole-5-thione Chemical group S=C1N(CCCN(CC)CC)N=NN1C1=CC=CC=C1OC RQKQXGMTEDELHW-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461942903P | 2014-02-21 | 2014-02-21 | |
| US61/942,903 | 2014-02-21 | ||
| US201462048689P | 2014-09-10 | 2014-09-10 | |
| US62/048,689 | 2014-09-10 | ||
| PCT/US2015/017173 WO2015127409A1 (en) | 2014-02-21 | 2015-02-23 | Selective photo activation of amino acids for single step peptide coupling |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509696A JP2017509696A (ja) | 2017-04-06 |
| JP2017509696A5 true JP2017509696A5 (enExample) | 2018-04-05 |
| JP6619362B2 JP6619362B2 (ja) | 2019-12-11 |
Family
ID=53879126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570929A Active JP6619362B2 (ja) | 2014-02-21 | 2015-02-23 | 一段階ペプチドカップリングのためのアミノ酸の選択的光活性化 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10040818B2 (enExample) |
| EP (2) | EP3107926B1 (enExample) |
| JP (1) | JP6619362B2 (enExample) |
| AU (3) | AU2015218635B2 (enExample) |
| CA (1) | CA2940177C (enExample) |
| NZ (1) | NZ724210A (enExample) |
| WO (1) | WO2015127409A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3191015A1 (en) | 2012-02-07 | 2013-08-15 | Vibrant Holdings, Llc | Substrates, peptide arrays, and methods |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| EP3107926B1 (en) * | 2014-02-21 | 2020-09-09 | Vibrant Holdings, LLC | Selective photo activation of amino acids for single step peptide coupling |
| ES2798598T3 (es) * | 2015-03-16 | 2020-12-11 | Hoffmann La Roche | Tratamiento combinado con un agonista de TLR7 y un inhibidor de ensamblaje de la cápside del VHB |
| CA3000509C (en) | 2015-10-29 | 2021-07-27 | Vibrant Holdings, Llc | Methods, tools, and tool assemblies for biomolecular analysis using microarrays |
| EP3402897A4 (en) * | 2015-12-28 | 2019-06-19 | Vibrant Holdings, LLC | SUBSTRATES, SYSTEMS AND METHODS FOR NUCLEINE ACIDIFICATION SYNTHESIS |
| WO2018218250A2 (en) | 2017-05-26 | 2018-11-29 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| JP7422087B2 (ja) | 2018-05-09 | 2024-01-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 光活性化された作用物質を使用してポリヌクレオチドアレイを合成する方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5240811A (en) * | 1991-04-15 | 1993-08-31 | Ocg Microelectronic Materials, Inc. | Photogenerated polycarbodiimides from poly(tetrazole-5-thiones) and use in the preparation of coatings and deep-UV photoresists |
| CA2163875A1 (en) | 1993-05-26 | 1994-12-08 | Huig Klinkenberg | Coating composition including a uv-deblockable basic catalyst |
| US6426184B1 (en) * | 1998-02-11 | 2002-07-30 | The Regents Of The University Of Michigan | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
| JP4843955B2 (ja) | 2004-02-16 | 2011-12-21 | 三菱瓦斯化学株式会社 | 光塩基発生剤 |
| US20070122841A1 (en) | 2005-11-30 | 2007-05-31 | Rajasekaran John J | Massively parallel synthesis of proteinaceous biomolecules |
| US20070122842A1 (en) | 2005-11-30 | 2007-05-31 | Rajasekaran John J | Massively parallel synthesis of proteinaceous biomolecules |
| US20070154946A1 (en) | 2005-12-29 | 2007-07-05 | Rajasekaran John J | Massively parallel synthesis of biopolymeric arrays |
| US20070224616A1 (en) * | 2006-03-24 | 2007-09-27 | Erdogan Gulari | Method for forming molecular sequences on surfaces |
| US9096953B2 (en) | 2006-09-29 | 2015-08-04 | Intel Corporation | Method for high throughput, high volume manufacturing of biomolecule micro arrays |
| US20080108149A1 (en) | 2006-10-23 | 2008-05-08 | Narayan Sundararajan | Solid-phase mediated synthesis of molecular microarrays |
| US20090176664A1 (en) | 2007-06-01 | 2009-07-09 | Keting Chu | High density peptide arrays containing kinase or phosphatase substrates |
| GB2511600B (en) | 2011-05-09 | 2019-12-04 | Woodbury Neal | Methods for performing patterned chemistry |
| CA3191015A1 (en) | 2012-02-07 | 2013-08-15 | Vibrant Holdings, Llc | Substrates, peptide arrays, and methods |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| EP2901159B1 (en) | 2012-09-28 | 2020-02-26 | Vibrant Holdings, LLC | Methods, systems, and arrays for biomolecular analysis |
| CA3183995A1 (en) * | 2012-11-14 | 2014-05-22 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| EP3107926B1 (en) * | 2014-02-21 | 2020-09-09 | Vibrant Holdings, LLC | Selective photo activation of amino acids for single step peptide coupling |
-
2015
- 2015-02-23 EP EP15751793.9A patent/EP3107926B1/en active Active
- 2015-02-23 AU AU2015218635A patent/AU2015218635B2/en active Active
- 2015-02-23 WO PCT/US2015/017173 patent/WO2015127409A1/en not_active Ceased
- 2015-02-23 EP EP20191924.8A patent/EP3805207B1/en active Active
- 2015-02-23 JP JP2016570929A patent/JP6619362B2/ja active Active
- 2015-02-23 US US15/120,452 patent/US10040818B2/en active Active
- 2015-02-23 NZ NZ724210A patent/NZ724210A/en unknown
- 2015-02-23 CA CA2940177A patent/CA2940177C/en active Active
-
2017
- 2017-11-28 AU AU2017268546A patent/AU2017268546A1/en not_active Abandoned
-
2018
- 2018-06-26 US US16/019,449 patent/US10577391B2/en active Active
-
2019
- 2019-12-18 AU AU2019283851A patent/AU2019283851A1/en not_active Abandoned
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