JP6619362B2 - 一段階ペプチドカップリングのためのアミノ酸の選択的光活性化 - Google Patents

一段階ペプチドカップリングのためのアミノ酸の選択的光活性化 Download PDF

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JP6619362B2
JP6619362B2 JP2016570929A JP2016570929A JP6619362B2 JP 6619362 B2 JP6619362 B2 JP 6619362B2 JP 2016570929 A JP2016570929 A JP 2016570929A JP 2016570929 A JP2016570929 A JP 2016570929A JP 6619362 B2 JP6619362 B2 JP 6619362B2
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amino acids
coupling
carboxylic acid
molecule
support
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JP2017509696A (ja
JP2017509696A5 (enExample
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ヴァサンス ジャヤラマン
ヴァサンス ジャヤラマン
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ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー
ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/086—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2016570929A 2014-02-21 2015-02-23 一段階ペプチドカップリングのためのアミノ酸の選択的光活性化 Active JP6619362B2 (ja)

Applications Claiming Priority (5)

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US201461942903P 2014-02-21 2014-02-21
US61/942,903 2014-02-21
US201462048689P 2014-09-10 2014-09-10
US62/048,689 2014-09-10
PCT/US2015/017173 WO2015127409A1 (en) 2014-02-21 2015-02-23 Selective photo activation of amino acids for single step peptide coupling

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JP2017509696A JP2017509696A (ja) 2017-04-06
JP2017509696A5 JP2017509696A5 (enExample) 2018-04-05
JP6619362B2 true JP6619362B2 (ja) 2019-12-11

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US (2) US10040818B2 (enExample)
EP (2) EP3107926B1 (enExample)
JP (1) JP6619362B2 (enExample)
AU (3) AU2015218635B2 (enExample)
CA (1) CA2940177C (enExample)
NZ (1) NZ724210A (enExample)
WO (1) WO2015127409A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3191015A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
EP3107926B1 (en) * 2014-02-21 2020-09-09 Vibrant Holdings, LLC Selective photo activation of amino acids for single step peptide coupling
ES2798598T3 (es) * 2015-03-16 2020-12-11 Hoffmann La Roche Tratamiento combinado con un agonista de TLR7 y un inhibidor de ensamblaje de la cápside del VHB
CA3000509C (en) 2015-10-29 2021-07-27 Vibrant Holdings, Llc Methods, tools, and tool assemblies for biomolecular analysis using microarrays
EP3402897A4 (en) * 2015-12-28 2019-06-19 Vibrant Holdings, LLC SUBSTRATES, SYSTEMS AND METHODS FOR NUCLEINE ACIDIFICATION SYNTHESIS
WO2018218250A2 (en) 2017-05-26 2018-11-29 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
JP7422087B2 (ja) 2018-05-09 2024-01-25 ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー 光活性化された作用物質を使用してポリヌクレオチドアレイを合成する方法

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5240811A (en) * 1991-04-15 1993-08-31 Ocg Microelectronic Materials, Inc. Photogenerated polycarbodiimides from poly(tetrazole-5-thiones) and use in the preparation of coatings and deep-UV photoresists
CA2163875A1 (en) 1993-05-26 1994-12-08 Huig Klinkenberg Coating composition including a uv-deblockable basic catalyst
US6426184B1 (en) * 1998-02-11 2002-07-30 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
JP4843955B2 (ja) 2004-02-16 2011-12-21 三菱瓦斯化学株式会社 光塩基発生剤
US20070122841A1 (en) 2005-11-30 2007-05-31 Rajasekaran John J Massively parallel synthesis of proteinaceous biomolecules
US20070122842A1 (en) 2005-11-30 2007-05-31 Rajasekaran John J Massively parallel synthesis of proteinaceous biomolecules
US20070154946A1 (en) 2005-12-29 2007-07-05 Rajasekaran John J Massively parallel synthesis of biopolymeric arrays
US20070224616A1 (en) * 2006-03-24 2007-09-27 Erdogan Gulari Method for forming molecular sequences on surfaces
US9096953B2 (en) 2006-09-29 2015-08-04 Intel Corporation Method for high throughput, high volume manufacturing of biomolecule micro arrays
US20080108149A1 (en) 2006-10-23 2008-05-08 Narayan Sundararajan Solid-phase mediated synthesis of molecular microarrays
US20090176664A1 (en) 2007-06-01 2009-07-09 Keting Chu High density peptide arrays containing kinase or phosphatase substrates
GB2511600B (en) 2011-05-09 2019-12-04 Woodbury Neal Methods for performing patterned chemistry
CA3191015A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
EP2901159B1 (en) 2012-09-28 2020-02-26 Vibrant Holdings, LLC Methods, systems, and arrays for biomolecular analysis
CA3183995A1 (en) * 2012-11-14 2014-05-22 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
EP3107926B1 (en) * 2014-02-21 2020-09-09 Vibrant Holdings, LLC Selective photo activation of amino acids for single step peptide coupling

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Publication number Publication date
EP3107926B1 (en) 2020-09-09
AU2015218635B2 (en) 2017-08-31
EP3805207A1 (en) 2021-04-14
US10040818B2 (en) 2018-08-07
EP3107926A1 (en) 2016-12-28
US10577391B2 (en) 2020-03-03
AU2015218635A1 (en) 2016-10-06
AU2019283851A1 (en) 2020-01-23
AU2017268546A1 (en) 2017-12-21
AU2015218635A2 (en) 2017-03-16
WO2015127409A1 (en) 2015-08-27
EP3107926A4 (en) 2017-10-04
EP3805207B1 (en) 2023-04-05
US20170129918A1 (en) 2017-05-11
US20190023734A1 (en) 2019-01-24
JP2017509696A (ja) 2017-04-06
NZ724210A (en) 2017-10-27
CA2940177A1 (en) 2015-08-27
CA2940177C (en) 2020-02-25

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