JP2017509628A5 - - Google Patents
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- JP2017509628A5 JP2017509628A5 JP2016556898A JP2016556898A JP2017509628A5 JP 2017509628 A5 JP2017509628 A5 JP 2017509628A5 JP 2016556898 A JP2016556898 A JP 2016556898A JP 2016556898 A JP2016556898 A JP 2016556898A JP 2017509628 A5 JP2017509628 A5 JP 2017509628A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461950960P | 2014-03-11 | 2014-03-11 | |
| US61/950,960 | 2014-03-11 | ||
| PCT/US2015/019362 WO2015138278A1 (en) | 2014-03-11 | 2015-03-09 | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020094831A Division JP2020147583A (ja) | 2014-03-11 | 2020-05-29 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017509628A JP2017509628A (ja) | 2017-04-06 |
| JP2017509628A5 true JP2017509628A5 (cg-RX-API-DMAC10.html) | 2018-04-05 |
| JP6712230B2 JP6712230B2 (ja) | 2020-06-17 |
Family
ID=52682963
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556898A Active JP6712230B2 (ja) | 2014-03-11 | 2015-03-09 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
| JP2020094831A Pending JP2020147583A (ja) | 2014-03-11 | 2020-05-29 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020094831A Pending JP2020147583A (ja) | 2014-03-11 | 2020-05-29 | リポジストロフィーおよびインスリン産生の欠損またはインスリンシグナル伝達の欠損と関連する代謝性障害を処置する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20170065678A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3125921B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP6712230B2 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015138278A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3476B1 (ar) | 2011-09-26 | 2020-07-05 | Novartis Ag | بروتينات مندمجة لعلاج الاضطرابات الايضية |
| US9458214B2 (en) | 2011-09-26 | 2016-10-04 | Novartis Ag | Dual function fibroblast growth factor 21 proteins |
| CA3069143A1 (en) * | 2017-07-06 | 2019-01-10 | Yale University | Compositions and methods for treating or preventing endocrine fgf-linked diseases |
| WO2019123427A1 (en) * | 2017-12-22 | 2019-06-27 | Novartis Ag | Methods of treating metabolic disorders with fgf21 variants |
| EP3586860A1 (en) * | 2018-06-22 | 2020-01-01 | Universität Ulm | Complement inhibitors and uses thereof |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| NZ537208A (en) * | 2002-06-27 | 2009-02-28 | Adipogen Pharmaceuticals Pty Ltd | Differentiation modulating agents and uses therefor |
| ATE385806T1 (de) | 2003-06-12 | 2008-03-15 | Lilly Co Eli | Fusionsproteine |
| ES2371072T3 (es) | 2003-06-12 | 2011-12-27 | Eli Lilly And Company | Proteínas de fusión análogas de glp-1. |
| US7504506B2 (en) * | 2003-11-04 | 2009-03-17 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| EP2270163A1 (en) | 2003-12-10 | 2011-01-05 | Eli Lilly and Company | Muteins of fibroblast growth factor 21 |
| EA200601392A1 (ru) * | 2004-01-29 | 2006-12-29 | Апплайд Резеч Системз Арс Холдинг Н. В. | Способы и композиции для лечения липодистрофии |
| PL1751184T3 (pl) | 2004-05-13 | 2010-02-26 | Lilly Co Eli | Białka fuzyjne FGF-21 |
| EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| CA2682147C (en) | 2007-03-30 | 2017-08-08 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| US20110034373A1 (en) | 2007-08-03 | 2011-02-10 | Eli Lilly And Company | Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity |
| WO2009117622A2 (en) | 2008-03-19 | 2009-09-24 | Ambrx, Inc. | Modified fgf-23 polypeptides and their uses |
| SG193860A1 (en) | 2008-06-04 | 2013-10-30 | Amgen Inc | Fgf21 mutants and uses thereof |
| NZ592009A (en) | 2008-10-10 | 2012-11-30 | Amgen Inc | Fgf21 mutants and uses thereof |
| CN102361647B (zh) | 2009-01-23 | 2018-02-16 | 诺沃-诺迪斯克有限公司 | 具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用 |
| WO2011089170A2 (en) | 2010-01-22 | 2011-07-28 | Novo Nordisk A/S | Process for preparing fgf-21 with low degree of o-glycosylation |
| BRPI1011404B1 (pt) | 2009-05-05 | 2022-05-03 | Amgen Inc | Polipeptídeos mutantes fgf21, polipeptídeo de fusão, multímero, composição farmacêutica, ácido nucleico isolado, vetor e célula hospedeira |
| AU2010246038A1 (en) | 2009-05-05 | 2011-12-01 | Amgen Inc. | FGF21 mutants and uses thereof |
| CA2777717C (en) | 2009-10-15 | 2021-05-25 | Genentech, Inc. | Chimeric fibroblast growth factors with altered receptor specificity |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| EP2460527A1 (en) | 2010-01-21 | 2012-06-06 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| WO2011130417A2 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS |
| JP2013533227A (ja) | 2010-06-08 | 2013-08-22 | ノヴォ ノルディスク アー/エス | Fgf21類似体および誘導体 |
| CN103415300B (zh) | 2010-07-20 | 2018-02-23 | 诺沃—诺迪斯克有限公司 | N‑末端修饰的fgf21化合物 |
| CA2885176C (en) | 2010-09-22 | 2018-10-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| SG190082A1 (en) | 2010-11-05 | 2013-06-28 | Covx Technologies Ireland Ltd | Anti-diabetic compounds |
| US9023791B2 (en) * | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| EP2392927A1 (en) * | 2011-03-11 | 2011-12-07 | F. Hoffmann-La Roche AG | Diagnosis of metabolic disorders in HIV infected patients |
| US20140294820A1 (en) | 2011-06-24 | 2014-10-02 | University Of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
| EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| WO2013033452A2 (en) * | 2011-08-31 | 2013-03-07 | Amgen Inc. | Method of treating or ameliorating type 1 diabetes using fgf21 |
| JO3476B1 (ar) | 2011-09-26 | 2020-07-05 | Novartis Ag | بروتينات مندمجة لعلاج الاضطرابات الايضية |
| US9458214B2 (en) | 2011-09-26 | 2016-10-04 | Novartis Ag | Dual function fibroblast growth factor 21 proteins |
| AR087973A1 (es) * | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
| TWI513705B (zh) | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
| AR092076A1 (es) | 2012-08-22 | 2015-03-18 | Lilly Co Eli | Proteinas homodimericas |
| MX2015002985A (es) | 2012-09-07 | 2015-06-22 | Sanofi Sa | Proteinas de fusion para el tratamiento de un sindrome metabolico. |
| EP3798228A1 (en) | 2012-11-28 | 2021-03-31 | NGM Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| MX383664B (es) | 2012-12-27 | 2025-03-14 | Ngm Biopharmaceuticals Inc | Uso de un péptido para modular la homeostasis de los ácidos biliares o tratamiento de una enfermedad relacionada con los ácidos biliares. |
| WO2014149699A1 (en) | 2013-03-15 | 2014-09-25 | Eli Lilly And Company | Bifunctional protein |
| MX373805B (es) | 2014-03-25 | 2020-03-24 | Regeneron Pharma | Agonistas de receptor fgf21 y usos del mismo. |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016048999A2 (en) | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf21 truncations and mutants and uses thereof |
| MX2017004947A (es) | 2014-10-24 | 2017-06-29 | Bristol Myers Squibb Co | Polipeptidos del factor de crecimiento de fibroblastos 2 (fgf-21) modificados y usos de los mismos. |
-
2015
- 2015-03-09 WO PCT/US2015/019362 patent/WO2015138278A1/en not_active Ceased
- 2015-03-09 US US15/124,877 patent/US20170065678A1/en not_active Abandoned
- 2015-03-09 JP JP2016556898A patent/JP6712230B2/ja active Active
- 2015-03-09 EP EP15710087.6A patent/EP3125921B1/en active Active
-
2019
- 2019-05-09 US US16/407,813 patent/US11963999B2/en active Active
-
2020
- 2020-05-29 JP JP2020094831A patent/JP2020147583A/ja active Pending
-
2024
- 2024-03-19 US US18/609,420 patent/US20240293508A1/en active Pending
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