JP2017508442A5 - - Google Patents
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- JP2017508442A5 JP2017508442A5 JP2016546862A JP2016546862A JP2017508442A5 JP 2017508442 A5 JP2017508442 A5 JP 2017508442A5 JP 2016546862 A JP2016546862 A JP 2016546862A JP 2016546862 A JP2016546862 A JP 2016546862A JP 2017508442 A5 JP2017508442 A5 JP 2017508442A5
- Authority
- JP
- Japan
- Prior art keywords
- genes listed
- derivative
- mdm2i
- salt
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108090000623 proteins and genes Proteins 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 238000000034 method Methods 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 8
- 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 claims 7
- 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 claims 7
- 102100032500 40S ribosomal protein S27-like Human genes 0.000 claims 6
- 102100034150 Apoptosis-enhancing nuclease Human genes 0.000 claims 6
- 101000731896 Homo sapiens 40S ribosomal protein S27-like Proteins 0.000 claims 6
- 101000780559 Homo sapiens Apoptosis-enhancing nuclease Proteins 0.000 claims 6
- 101000928259 Homo sapiens NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 claims 6
- 102100036777 NADPH:adrenodoxin oxidoreductase, mitochondrial Human genes 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- 229940126062 Compound A Drugs 0.000 claims 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000004547 gene signature Effects 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 102100036413 2',5'-phosphodiesterase 12 Human genes 0.000 claims 4
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 4
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 4
- 102100021122 DNA damage-binding protein 2 Human genes 0.000 claims 4
- 102100035481 DNA polymerase eta Human genes 0.000 claims 4
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 4
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims 4
- 102000016251 GREB1 Human genes 0.000 claims 4
- 108050004787 GREB1 Proteins 0.000 claims 4
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 4
- 101001072024 Homo sapiens 2',5'-phosphodiesterase 12 Proteins 0.000 claims 4
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 4
- 101001041466 Homo sapiens DNA damage-binding protein 2 Proteins 0.000 claims 4
- 101001094607 Homo sapiens DNA polymerase eta Proteins 0.000 claims 4
- 101000865085 Homo sapiens DNA polymerase theta Proteins 0.000 claims 4
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 4
- 101001032502 Homo sapiens Iron-sulfur cluster assembly enzyme ISCU, mitochondrial Proteins 0.000 claims 4
- 101001033754 Homo sapiens Mediator of RNA polymerase II transcription subunit 31 Proteins 0.000 claims 4
- 101000574631 Homo sapiens Meteorin Proteins 0.000 claims 4
- 101000645266 Homo sapiens Mitochondrial import inner membrane translocase subunit Tim22 Proteins 0.000 claims 4
- 101000583714 Homo sapiens Pleckstrin homology-like domain family A member 3 Proteins 0.000 claims 4
- 101001105683 Homo sapiens Pre-mRNA-processing-splicing factor 8 Proteins 0.000 claims 4
- 101000842302 Homo sapiens Protein-cysteine N-palmitoyltransferase HHAT Proteins 0.000 claims 4
- 101000717450 Homo sapiens RCC1 and BTB domain-containing protein 1 Proteins 0.000 claims 4
- 101001061669 Homo sapiens Required for excision 1-B domain-containing protein Proteins 0.000 claims 4
- 101000929936 Homo sapiens Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Proteins 0.000 claims 4
- 101000618110 Homo sapiens Sperm-associated antigen 7 Proteins 0.000 claims 4
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 claims 4
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 4
- 102100038096 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial Human genes 0.000 claims 4
- 102100039122 Mediator of RNA polymerase II transcription subunit 31 Human genes 0.000 claims 4
- 102100025695 Meteorin Human genes 0.000 claims 4
- 102100026258 Mitochondrial import inner membrane translocase subunit Tim22 Human genes 0.000 claims 4
- 102100030925 Pleckstrin homology-like domain family A member 3 Human genes 0.000 claims 4
- 102100021231 Pre-mRNA-processing-splicing factor 8 Human genes 0.000 claims 4
- 102100030616 Protein-cysteine N-palmitoyltransferase HHAT Human genes 0.000 claims 4
- 102100020837 RCC1 and BTB domain-containing protein 1 Human genes 0.000 claims 4
- 102100028426 Required for excision 1-B domain-containing protein Human genes 0.000 claims 4
- 102100035766 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 4
- 102100021912 Sperm-associated antigen 7 Human genes 0.000 claims 4
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 claims 4
- NUKCQDDVORQLDB-OLILMLBXSA-N (3s)-4-[(1r)-1-(2-amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-1-[3-(4-methylpiperazin-1-yl)propyl]-3h-1,4-benzodiazepine-2,5-dione Chemical compound C1([C@@H]2N(C(C3=CC(I)=CC=C3N(CCCN3CCN(C)CC3)C2=O)=O)[C@H](C)C=2C(=CC(Cl)=CC=2)N)=CC=C(Cl)C=C1 NUKCQDDVORQLDB-OLILMLBXSA-N 0.000 claims 3
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical class C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 claims 3
- BDUHCSBCVGXTJM-WUFINQPMSA-N 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone Chemical compound CC(C)OC1=CC(OC)=CC=C1C1=N[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)N1C(=O)N1CC(=O)NCC1 BDUHCSBCVGXTJM-WUFINQPMSA-N 0.000 claims 3
- CLRSLRWKONPSRQ-IIPSPAQQSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 CLRSLRWKONPSRQ-IIPSPAQQSA-N 0.000 claims 3
- 102100022477 DNA repair protein complementing XP-C cells Human genes 0.000 claims 3
- 101000618535 Homo sapiens DNA repair protein complementing XP-C cells Proteins 0.000 claims 3
- 101000836394 Homo sapiens Sestrin-1 Proteins 0.000 claims 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 3
- 102100027288 Sestrin-1 Human genes 0.000 claims 3
- QBGKPEROWUKSBK-QPPIDDCLSA-N [(4s,5r)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone Chemical compound CCOC1=CC(C(C)(C)C)=CC=C1C(N([C@]1(C)C=2C=CC(Cl)=CC=2)C(=O)N2CCN(CCCS(C)(=O)=O)CC2)=N[C@@]1(C)C1=CC=C(Cl)C=C1 QBGKPEROWUKSBK-QPPIDDCLSA-N 0.000 claims 3
- 150000002475 indoles Chemical class 0.000 claims 3
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 claims 3
- 239000002853 nucleic acid probe Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical class NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 claims 3
- 150000004040 pyrrolidinones Chemical class 0.000 claims 3
- XOYCLJDJUKHHHS-LHBOOPKSSA-N (2s,3s,4s,5r,6r)-6-[[(2s,3s,5r)-3-amino-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@H](O2)C(O)=O)O)[C@@H](N)C1 XOYCLJDJUKHHHS-LHBOOPKSSA-N 0.000 claims 2
- 102100027308 Apoptosis regulator BAX Human genes 0.000 claims 2
- 108050006685 Apoptosis regulator BAX Proteins 0.000 claims 2
- 101150060120 C1qbp gene Proteins 0.000 claims 2
- 102100037078 Complement component 1 Q subcomponent-binding protein, mitochondrial Human genes 0.000 claims 2
- 102100022273 Disrupted in schizophrenia 1 protein Human genes 0.000 claims 2
- 101150061947 EIF2D gene Proteins 0.000 claims 2
- 102100021309 Elongation factor Ts, mitochondrial Human genes 0.000 claims 2
- 102100038075 Eukaryotic translation initiation factor 2D Human genes 0.000 claims 2
- 102100027681 Fructose-2,6-bisphosphatase TIGAR Human genes 0.000 claims 2
- 102100033506 G-rich sequence factor 1 Human genes 0.000 claims 2
- 102100040579 Guanidinoacetate N-methyltransferase Human genes 0.000 claims 2
- 101000902072 Homo sapiens Disrupted in schizophrenia 1 protein Proteins 0.000 claims 2
- 101000895350 Homo sapiens Elongation factor Ts, mitochondrial Proteins 0.000 claims 2
- 101000651314 Homo sapiens Fructose-2,6-bisphosphatase TIGAR Proteins 0.000 claims 2
- 101000870806 Homo sapiens G-rich sequence factor 1 Proteins 0.000 claims 2
- 101000893897 Homo sapiens Guanidinoacetate N-methyltransferase Proteins 0.000 claims 2
- 101000576989 Homo sapiens Mannose-P-dolichol utilization defect 1 protein Proteins 0.000 claims 2
- 101000701936 Homo sapiens Signal peptidase complex subunit 1 Proteins 0.000 claims 2
- 101000648224 Homo sapiens Syntaxin-8 Proteins 0.000 claims 2
- 101000795222 Homo sapiens TP53-regulated inhibitor of apoptosis 1 Proteins 0.000 claims 2
- 101000723893 Homo sapiens Zinc finger matrin-type protein 3 Proteins 0.000 claims 2
- 102100025297 Mannose-P-dolichol utilization defect 1 protein Human genes 0.000 claims 2
- 102100021769 Mitochondrial 2-oxoglutarate/malate carrier protein Human genes 0.000 claims 2
- 108091006417 SLC25A11 Proteins 0.000 claims 2
- 102100030313 Signal peptidase complex subunit 1 Human genes 0.000 claims 2
- 102100028808 Syntaxin-8 Human genes 0.000 claims 2
- 102100029669 TP53-regulated inhibitor of apoptosis 1 Human genes 0.000 claims 2
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 2
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 claims 2
- 102100028482 Zinc finger matrin-type protein 3 Human genes 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 102100032857 Cyclin-dependent kinase 1 Human genes 0.000 claims 1
- 101710106279 Cyclin-dependent kinase 1 Proteins 0.000 claims 1
- 101150080074 TP53 gene Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 108700025694 p53 Genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461927310P | 2014-01-14 | 2014-01-14 | |
| US61/927,310 | 2014-01-14 | ||
| PCT/JP2015/051157 WO2015108175A1 (en) | 2014-01-14 | 2015-01-13 | Gene signatures associated with sensitivity to mdm2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017508442A JP2017508442A (ja) | 2017-03-30 |
| JP2017508442A5 true JP2017508442A5 (enExample) | 2018-02-08 |
Family
ID=52432889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546862A Pending JP2017508442A (ja) | 2014-01-14 | 2015-01-13 | Ｍｄｍ２阻害剤に対する感受性と関連する遺伝子シグネチャー |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20160333419A1 (enExample) |
| EP (1) | EP3094746A1 (enExample) |
| JP (1) | JP2017508442A (enExample) |
| WO (1) | WO2015108175A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2508531B1 (en) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Stitched polypeptides |
| TR201807311T4 (tr) | 2011-03-10 | 2018-06-21 | Daiichi Sankyo Co Ltd | Dispiropirolidin derivesi. |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| BR112017005598A2 (pt) | 2014-09-24 | 2017-12-12 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
| JP2018503595A (ja) | 2014-09-24 | 2018-02-08 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその製剤 |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| TWI750129B (zh) * | 2015-08-03 | 2021-12-21 | 瑞士商諾華公司 | 作為血液學毒性生物標記之ｇｄｆ-１５ |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| EP3364972A1 (en) * | 2015-10-23 | 2018-08-29 | Daiichi Sankyo Company, Limited | Dosage regimen of mdm2 inhibitor for treating cancers |
| EP3364966A1 (en) * | 2015-10-23 | 2018-08-29 | Daiichi Sankyo Company, Limited | Pharmaceutical composition for use in treating aml and method of treating aml in a subject in need thereof |
| CN106512009B (zh) * | 2016-10-28 | 2019-10-11 | 武汉大学 | Ph同源域家族a成员3（phlda3）在治疗心肌肥厚中的应用 |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| US20220249538A1 (en) * | 2019-05-23 | 2022-08-11 | Osaka University | Treatment agent for sex hormone-insensitive greb1-positive tumors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014020502A2 (en) * | 2012-07-31 | 2014-02-06 | Novartis Ag | Markers associated with human double minute 2 inhibitors |
| AU2014286237B2 (en) * | 2013-07-03 | 2020-08-20 | F. Hoffmann-La Roche Ag | mRNA-based gene expression for personalizing patient cancer therapy with an MDM2 antagonist |
-
2015
- 2015-01-13 US US15/111,358 patent/US20160333419A1/en not_active Abandoned
- 2015-01-13 WO PCT/JP2015/051157 patent/WO2015108175A1/en not_active Ceased
- 2015-01-13 EP EP15701594.2A patent/EP3094746A1/en not_active Withdrawn
- 2015-01-13 JP JP2016546862A patent/JP2017508442A/ja active Pending
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