JP2017507142A5 - - Google Patents
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- Publication number
- JP2017507142A5 JP2017507142A5 JP2016553284A JP2016553284A JP2017507142A5 JP 2017507142 A5 JP2017507142 A5 JP 2017507142A5 JP 2016553284 A JP2016553284 A JP 2016553284A JP 2016553284 A JP2016553284 A JP 2016553284A JP 2017507142 A5 JP2017507142 A5 JP 2017507142A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- administered
- fgf
- cartilage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 102000003977 fibroblast growth factor 18 Human genes 0.000 claims 6
- 108090000370 fibroblast growth factor 18 Proteins 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000002260 anti-inflammatory agent Substances 0.000 claims 4
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 4
- 208000015100 cartilage disease Diseases 0.000 claims 3
- 206010061762 Chondropathy Diseases 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 claims 1
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 claims 1
- 229960004238 anakinra Drugs 0.000 claims 1
- 210000001188 articular cartilage Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 1
- 229960001259 diclofenac Drugs 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14000600.8 | 2014-02-20 | ||
| EP14000600 | 2014-02-20 | ||
| PCT/EP2015/053631 WO2015124731A1 (en) | 2014-02-20 | 2015-02-20 | Fgf-18 compound dosing regimen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507142A JP2017507142A (ja) | 2017-03-16 |
| JP2017507142A5 true JP2017507142A5 (Direct) | 2018-03-01 |
| JP6431082B2 JP6431082B2 (ja) | 2018-11-28 |
Family
ID=50151088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553329A Active JP6431083B2 (ja) | 2014-02-20 | 2015-02-20 | Ｆｇｆ−１８化合物の投与計画 |
| JP2016553284A Active JP6431082B2 (ja) | 2014-02-20 | 2015-02-20 | Ｆｇｆ−１８化合物の投与計画 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553329A Active JP6431083B2 (ja) | 2014-02-20 | 2015-02-20 | Ｆｇｆ−１８化合物の投与計画 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9889179B2 (Direct) |
| EP (2) | EP3119417B1 (Direct) |
| JP (2) | JP6431083B2 (Direct) |
| KR (2) | KR102410986B1 (Direct) |
| CN (2) | CN106232622A (Direct) |
| AR (2) | AR099510A1 (Direct) |
| AU (2) | AU2015220777B2 (Direct) |
| BR (2) | BR112016018685A2 (Direct) |
| CA (2) | CA2938791A1 (Direct) |
| DK (2) | DK3107559T3 (Direct) |
| ES (2) | ES2688551T3 (Direct) |
| HR (2) | HRP20181570T1 (Direct) |
| HU (1) | HUE040350T2 (Direct) |
| IL (2) | IL247084B (Direct) |
| LT (2) | LT3107559T (Direct) |
| MX (2) | MX2016010872A (Direct) |
| NZ (1) | NZ723148A (Direct) |
| PL (2) | PL3107559T3 (Direct) |
| PT (2) | PT3107559T (Direct) |
| RS (2) | RS57853B1 (Direct) |
| RU (2) | RU2691946C2 (Direct) |
| SG (2) | SG11201606502YA (Direct) |
| SI (2) | SI3107559T1 (Direct) |
| WO (2) | WO2015124727A1 (Direct) |
| ZA (2) | ZA201605547B (Direct) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10086112B2 (en) | 2014-02-20 | 2018-10-02 | Merck Patent Gmbh | Implant comprising FGF-18 |
| CA2938791A1 (en) | 2014-02-20 | 2015-08-27 | Merck Patent Gmbh | Fgf-18 compound dosing regimen |
| AU2016211950A1 (en) | 2015-01-29 | 2017-07-13 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| RU2743075C2 (ru) | 2016-02-22 | 2021-02-15 | Новартис Аг | Способы применения агонистов fxr |
| HUE058786T2 (hu) | 2017-09-29 | 2022-09-28 | Merck Patent Gmbh | FGF-18 vegyületre vonatkozó válaszkészség elõrejelzésére szolgáló metabolikus biomarkerek |
| DK3688468T3 (da) | 2017-09-29 | 2022-06-20 | Merck Patent Gmbh | Inflammatoriske biomarkører til forudsigelse af modtageligheden for fgf-18 forbindelse |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| CA3127729A1 (en) * | 2019-02-08 | 2020-08-13 | Merck Patent Gmbh | Treatment of patients at risk of rapid progression of osteoarthritis |
| WO2025077768A1 (en) * | 2023-10-11 | 2025-04-17 | Sichuan Real & Best Biotech Co., Ltd. | Compositions and methods for treating arthritis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003279835B2 (en) * | 2002-10-07 | 2009-09-10 | Zymogenetics, Inc. | Methods of administering FGF18 |
| US20060009389A1 (en) * | 2004-07-06 | 2006-01-12 | Moore Emma E | Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use |
| US20070243132A1 (en) * | 2005-12-22 | 2007-10-18 | Apollo Life Sciences Limited | Transdermal delivery of pharmaceutical agents |
| KR101419961B1 (ko) * | 2006-08-25 | 2014-07-30 | 아레스 트레이딩 에스.에이. | Ｆｇｆ-18 로 연골 질환의 치료 |
| CN101505787B (zh) * | 2006-08-25 | 2013-09-04 | 阿雷斯贸易股份有限公司 | 软骨障碍的治疗 |
| DE102006043260A1 (de) * | 2006-09-11 | 2008-03-27 | Krones Ag | Etikettieranlage |
| CA2830882C (en) * | 2011-03-22 | 2021-03-16 | Dinesh Barawkar | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| EP3107591B1 (en) | 2014-02-20 | 2018-04-18 | Merck Patent GmbH | Fgf-18 in graft transplantation and tissue engineering procedures |
| US10086112B2 (en) | 2014-02-20 | 2018-10-02 | Merck Patent Gmbh | Implant comprising FGF-18 |
| CA2938791A1 (en) | 2014-02-20 | 2015-08-27 | Merck Patent Gmbh | Fgf-18 compound dosing regimen |
-
2015
- 2015-02-20 CA CA2938791A patent/CA2938791A1/en not_active Abandoned
- 2015-02-20 HR HRP20181570TT patent/HRP20181570T1/hr unknown
- 2015-02-20 LT LTEP15706006.2T patent/LT3107559T/lt unknown
- 2015-02-20 CA CA2938793A patent/CA2938793A1/en active Pending
- 2015-02-20 SG SG11201606502YA patent/SG11201606502YA/en unknown
- 2015-02-20 PL PL15706006T patent/PL3107559T3/pl unknown
- 2015-02-20 CN CN201580020536.2A patent/CN106232622A/zh active Pending
- 2015-02-20 BR BR112016018685A patent/BR112016018685A2/pt not_active Application Discontinuation
- 2015-02-20 DK DK15706006.2T patent/DK3107559T3/en active
- 2015-02-20 JP JP2016553329A patent/JP6431083B2/ja active Active
- 2015-02-20 LT LTEP15707076.4T patent/LT3119417T/lt unknown
- 2015-02-20 ES ES15707076.4T patent/ES2688551T3/es active Active
- 2015-02-20 MX MX2016010872A patent/MX2016010872A/es active IP Right Grant
- 2015-02-20 HR HRP20181572TT patent/HRP20181572T1/hr unknown
- 2015-02-20 AU AU2015220777A patent/AU2015220777B2/en active Active
- 2015-02-20 AU AU2015220773A patent/AU2015220773B2/en active Active
- 2015-02-20 SG SG11201606505UA patent/SG11201606505UA/en unknown
- 2015-02-20 CN CN201580020532.4A patent/CN106456713A/zh active Pending
- 2015-02-20 ES ES15706006.2T patent/ES2689071T3/es active Active
- 2015-02-20 SI SI201530428T patent/SI3107559T1/sl unknown
- 2015-02-20 JP JP2016553284A patent/JP6431082B2/ja active Active
- 2015-02-20 AR ARP150100508A patent/AR099510A1/es unknown
- 2015-02-20 DK DK15707076.4T patent/DK3119417T3/en active
- 2015-02-20 SI SI201530410T patent/SI3119417T1/sl unknown
- 2015-02-20 HU HUE15706006A patent/HUE040350T2/hu unknown
- 2015-02-20 AR ARP150100507A patent/AR099558A1/es unknown
- 2015-02-20 EP EP15707076.4A patent/EP3119417B1/en active Active
- 2015-02-20 PL PL15707076T patent/PL3119417T3/pl unknown
- 2015-02-20 BR BR112016018696A patent/BR112016018696A2/pt not_active Application Discontinuation
- 2015-02-20 PT PT15706006T patent/PT3107559T/pt unknown
- 2015-02-20 WO PCT/EP2015/053624 patent/WO2015124727A1/en not_active Ceased
- 2015-02-20 NZ NZ723148A patent/NZ723148A/en unknown
- 2015-02-20 PT PT15707076T patent/PT3119417T/pt unknown
- 2015-02-20 MX MX2016010871A patent/MX2016010871A/es active IP Right Grant
- 2015-02-20 KR KR1020167025246A patent/KR102410986B1/ko active Active
- 2015-02-20 RS RS20181167A patent/RS57853B1/sr unknown
- 2015-02-20 RU RU2016137289A patent/RU2691946C2/ru active
- 2015-02-20 RS RS20181168A patent/RS57709B1/sr unknown
- 2015-02-20 EP EP15706006.2A patent/EP3107559B1/en active Active
- 2015-02-20 KR KR1020167025245A patent/KR102410988B1/ko active Active
- 2015-02-20 WO PCT/EP2015/053631 patent/WO2015124731A1/en not_active Ceased
- 2015-02-20 RU RU2016137292A patent/RU2700582C2/ru active
- 2015-02-20 US US15/120,131 patent/US9889179B2/en active Active
- 2015-02-20 US US15/120,134 patent/US9724388B2/en active Active
-
2016
- 2016-08-03 IL IL247084A patent/IL247084B/en active IP Right Grant
- 2016-08-03 IL IL247083A patent/IL247083B/en active IP Right Grant
- 2016-08-10 ZA ZA2016/05547A patent/ZA201605547B/en unknown
- 2016-08-10 ZA ZA2016/05548A patent/ZA201605548B/en unknown
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