JP2017506738A - 適合したエテンデュを有する分光計 - Google Patents
適合したエテンデュを有する分光計 Download PDFInfo
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Abstract
Description
ここで、jは導波路を特定する添え字(番号)、Sは入射スペクトル、Tjは導波路jの透過率である。本発明の実施形態では、入射スペクトルは、測定結果に基づいて再構築されてもよい。スペクトルは、最小二乗法によるフィッティングを用いて再構築されてもよい。再構築されたスペクトルを図18に示している。図18は、入力スペクトル1910と、再構築されたスペクトル1920とを示している。スペクトルは、図17に示す測定結果に基づいて再構築されている。本発明の実施形態では、入力スペクトルの完全な再構築は要求されない(例えば、グルコース濃度の評価(推定、見積もり)のためには)。図19は、二重ピークを有する入力スペクトルを示す。ピークの1つは885nmであり、他方は875nmである。図20は、入力スペクトル2110と、再構築されたスペクトル2120とを示している。
‐SNRpeak, glucose:脱イオン水中のグルコースについて、強いグルコースラマンピークの位置で測定されたラマンスペクトル信号の信号対雑音比。例えば、1126cm−1のピークが、最も強い信号を与えるグルコースピークである。この例では、強い蛍光またはラマンバックグラウンドは存在しない。
‐SNRpeak, skin:強いグルコースラマンピークの位置で測定される皮膚中のグルコースについてのラマンスペクトル信号の信号対雑音比。この例では、強いバックグラウンド蛍光と他のラマン信号が大きいショットノイズにつながる。
−SNRsystem:スペクトル分析後のグルコース濃度測定の信号対雑音比。この値は、複数のピークに由来する情報が結びついているので、SNRpeak,skinよりも大きくなる。
ここで、Pglucose はグルコーススペクトル、ηic は入射結合効率(光学システム全体の入射結合効率)、ηdet は検出器の効率、tは積分時間(または積算時間)である。グルコーススペクトルと検出器の効率との積の例を図4に示している。
Claims (14)
- 放射線ビームの特徴を明らかにするための光学システム(100)であって、
光放射線ガイドシステムと、
分光計チップ(130)とを備え、
前記光放射線ガイドシステムは、
前記放射線ビームを平行化して平行放射線ビームを形成するためのコリメータ(110)と、
前記平行放射線ビームのパワーを、孤立した複数のライン状領域にわたって分布させるためのビーム成形器(120)であって、前記ビーム成形器に入射する、前記平行放射線ビームのスペクトルは、前記孤立した複数のライン状領域のそれぞれに分配されるようにしたビーム成形器(120)と、
前記分光計チップ(130)は、前記ビーム成形器(120)から到来する、孤立した複数のライン状放射線を処理するように構成されている、
光学システム(100)。 - 前記ビーム成形器(120)は、楔形状を有する、
請求項1に記載の光学システム(100)。 - 前記コリメータと前記ビーム成形器は、該ビーム成形器が、前記楔の短い側である楔入口領域(122)を介して放射線を受信可能であるように配置されている、
請求項2に記載の光学システム(100)。 - 前記ビーム成形器は、楔入口領域に垂直入射する放射線が、前記楔の他の面で最初に反射されることなく楔出口領域に直接に誘導されるように形成されている、
請求項2または3に記載の光学システム(100)。 - 前記コリメータ(110)は、少なくとも部分的に、3D放物線形状を有する、
請求項1から4のいずれか1項に記載の光学システム(100)。 - 前記コリメータ(110)は、入射点を有し、該入射点と前記コリメータの出力部との間で放射ビームを折り曲げるように形成されている、
請求項1から5のいずれか1項に記載の光学システム(100)。 - 前記ビーム成形器は、前記孤立した複数のライン状領域に前記放射線ビームを向けるための出口領域を有し、
前記出口領域は、波状パターンまたは階段状パターンを有する、
請求項1から6のいずれか1項に記載の光学システム(100)。 - 前記波状パターンまたは階段状パターンは、複数の第1部分(310)と複数の第2部分(320)とを有し、
前記第2部分は、前記第1部分どうしを相互に接続し、
隣接する第1部分どうしは、前記第1部分の長さよりも短い間隔を開けて配置され、かつ、前記ビーム成形器の入口領域に対して垂直な方向に実質的に平行な方向を向いている、
請求項7に記載の光学システム(100)。 - 前記第2部分(320)は、屈曲している、
請求項8に記載の光学システム(100)。 - 前記分光計チップ(130)は、複数の検出チャネル(210)を有し、
各検出チャネルは、入射結合グレーティング(220)と、出射結合グレーティング(230)と、スペクトル依存型透過システム(240)とを有し、
前記入射結合グレーティング(220)は、前記スペクトル依存型透過システム(240)を通じて前記出射結合グレーティング(230)に結合され、
前記入射結合グレーティング(220)は、孤立した複数のラインの上に配置されている、
請求項1から9のいずれか1項に記載の光学システム(100)。 - 前記スペクトル依存型透過システム(240)は、ファブリペローシステムである、
請求項10に記載の光学システム(100)。 - 前記コリメータ(110)と前記ビーム成形器(120)との間には、励起放射線を阻止するための第1阻止フィルタ(140)が配置されている、
請求項1から11のいずれか1項に記載の光学システム(100)。 - リストバンドに一体化されている、
請求項1から12のいずれか1項に記載の光学システム(100)。 - グルコースセンサとしての、請求項1から13のいずれか1項に記載の光学システム(100)の使用。
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