JP2017505285A5 - - Google Patents
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- Publication number
- JP2017505285A5 JP2017505285A5 JP2016532631A JP2016532631A JP2017505285A5 JP 2017505285 A5 JP2017505285 A5 JP 2017505285A5 JP 2016532631 A JP2016532631 A JP 2016532631A JP 2016532631 A JP2016532631 A JP 2016532631A JP 2017505285 A5 JP2017505285 A5 JP 2017505285A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- agent according
- salt
- compound
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361906837P | 2013-11-20 | 2013-11-20 | |
| US61/906,837 | 2013-11-20 | ||
| US201461942438P | 2014-02-20 | 2014-02-20 | |
| US61/942,438 | 2014-02-20 | ||
| US201461942941P | 2014-02-21 | 2014-02-21 | |
| US61/942,941 | 2014-02-21 | ||
| US201461974725P | 2014-04-03 | 2014-04-03 | |
| US201461974785P | 2014-04-03 | 2014-04-03 | |
| US201461974816P | 2014-04-03 | 2014-04-03 | |
| US61/974,816 | 2014-04-03 | ||
| US61/974,725 | 2014-04-03 | ||
| US61/974,785 | 2014-04-03 | ||
| PCT/US2014/065742 WO2015077154A1 (en) | 2013-11-20 | 2014-11-14 | Treatment of homozygous familial hypercholesterolemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017505285A JP2017505285A (ja) | 2017-02-16 |
| JP2017505285A5 true JP2017505285A5 (cg-RX-API-DMAC7.html) | 2017-12-21 |
Family
ID=52014370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532631A Withdrawn JP2017505285A (ja) | 2013-11-20 | 2014-11-14 | ホモ接合性家族性高コレステロール血症の治療 |
Country Status (14)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| PT2929031T (pt) | 2012-12-05 | 2018-01-19 | Alnylam Pharmaceuticals Inc | Composições de irna de pcsk9 e métodos de seu uso |
| US9624172B2 (en) | 2014-02-17 | 2017-04-18 | Hetero Research Foundation | Polymorphs of lomitapide and its salts |
| CN106102734B (zh) | 2014-03-20 | 2019-05-14 | 西玛贝医药公司 | 肝内胆汁淤积性疾病的治疗 |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| PL3129018T3 (pl) | 2014-04-11 | 2020-05-18 | Cymabay Therapeutics, Inc. | Leczenie NAFLD i NASH |
| BR102015025502B1 (pt) * | 2015-04-30 | 2022-06-21 | Aegerion Pharmaceuticals, Inc | Composição de lomitapida, tablete, produto de lomitapida, métodos para analisar uma composição de amostra de lomitapida e para determinar uma quantidade de uma impureza em uma amostra da composição |
| KR102793532B1 (ko) * | 2015-08-25 | 2025-04-14 | 알닐람 파마슈티칼스 인코포레이티드 | 전구단백질 컨버타제 서브틸리신 켁신 (pcsk9) 유전자-관련 장애를 치료하기 위한 방법 및 조성물 |
| CN105481758A (zh) * | 2016-01-13 | 2016-04-13 | 天津药物研究院有限公司 | 一种洛美他派晶型ⅰ及其制备方法和用途 |
| JP7541810B2 (ja) | 2016-03-03 | 2024-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ａｎｇｐｔｌ３阻害剤と組み合わせてｐｃｓｋ９阻害剤を投与することにより高脂血症を有する患者を処置するための方法 |
| LT3448426T (lt) * | 2016-04-28 | 2025-07-10 | Regeneron Pharmaceuticals, Inc. | Pacientų, sergančių šeimine hipercholesterolemija, gydymo būdai |
| WO2017200715A1 (en) * | 2016-05-19 | 2017-11-23 | Cymabay Therapeutics, Inc. | Treatment of severe hyperlipidemia |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| WO2019101151A1 (zh) * | 2017-11-23 | 2019-05-31 | 浙江海正药业股份有限公司 | 一种海泽麦布和HMG-CoA还原酶抑制剂的药物组合物 |
| CN113710808A (zh) * | 2018-12-20 | 2021-11-26 | 宾夕法尼亚州大学信托人 | 用于治疗家族性高胆固醇血症的基因疗法 |
| US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
| US20210145774A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of alcoholic liver disease |
| US20210145775A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of intestinal barrier dysfunction and associated diseases |
| CA3186856A1 (en) * | 2020-07-29 | 2022-02-03 | Ruth NALLEN | Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5883109A (en) | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
| US6066653A (en) | 1997-01-17 | 2000-05-23 | Bristol-Myers Squibb Co. | Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs |
| US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| US7301050B2 (en) | 2003-09-19 | 2007-11-27 | Janssen Pharmaceutical N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| KR20060129082A (ko) | 2004-03-05 | 2006-12-14 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과연관된 질환 또는 질병의 치료 방법 |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| ES2712052T3 (es) | 2008-10-17 | 2019-05-09 | Cymabay Therapeutics Inc | Métodos para reducir partículas de LDL pequeñas y densas |
| JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
-
2014
- 2014-11-14 AU AU2014353246A patent/AU2014353246A1/en not_active Abandoned
- 2014-11-14 US US14/541,835 patent/US20150139987A1/en not_active Abandoned
- 2014-11-14 WO PCT/US2014/065742 patent/WO2015077154A1/en not_active Ceased
- 2014-11-14 CA CA2930069A patent/CA2930069A1/en not_active Abandoned
- 2014-11-14 HK HK16112450.0A patent/HK1224186A1/zh unknown
- 2014-11-14 MX MX2016006583A patent/MX2016006583A/es unknown
- 2014-11-14 EA EA201691039A patent/EA201691039A1/ru unknown
- 2014-11-14 JP JP2016532631A patent/JP2017505285A/ja not_active Withdrawn
- 2014-11-14 KR KR1020167016225A patent/KR20160079124A/ko not_active Withdrawn
- 2014-11-14 EP EP14809184.6A patent/EP3071198A1/en not_active Withdrawn
- 2014-11-14 CN CN201480063803.XA patent/CN105764498A/zh active Pending
-
2016
- 2016-05-12 PH PH12016500886A patent/PH12016500886A1/en unknown
- 2016-05-19 IL IL245748A patent/IL245748A0/en unknown
- 2016-05-20 CL CL2016001215A patent/CL2016001215A1/es unknown
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