JP2017503639A - 分離液を用いたサンプル濃縮及び検出のためのシステム及び方法 - Google Patents
分離液を用いたサンプル濃縮及び検出のためのシステム及び方法 Download PDFInfo
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| US10870087B2 (en) | 2015-11-27 | 2020-12-22 | Merck Patent Gmbh | Membrane support and membrane filtration device |
| AU2017269412B2 (en) * | 2016-05-27 | 2022-01-20 | Biomerieux, Inc. | Method and apparatus for detection of foam in specimen containers |
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| CN112570154B (zh) * | 2021-02-24 | 2024-03-19 | 英诺维尔智能科技(苏州)有限公司 | 一种离心换液装置 |
| EP4166247A1 (en) * | 2021-10-12 | 2023-04-19 | Getinge Lancer SAS | Industrial washer with exhaust system |
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| US7781159B2 (en) | 2002-05-09 | 2010-08-24 | Nanologix, Inc. | Micromethod and device for rapid detection, enumeration and identification of entities |
| US8361783B2 (en) | 2002-05-09 | 2013-01-29 | Nanologix, Inc. | Micromethod and device for the rapid detection, enumeration and identification of microorganisms |
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| US20030235677A1 (en) | 2002-06-25 | 2003-12-25 | 3M Innovative Properties Company | Complex microstructure film |
| CA2521999A1 (en) | 2002-12-20 | 2004-09-02 | Biotrove, Inc. | Assay apparatus and method using microfluidic arrays |
| US7524623B2 (en) | 2003-07-28 | 2009-04-28 | Nanologix, Inc. | Method and device for rapid detection of microorganisms by changing the shape of micro-colonies |
| US7582472B2 (en) | 2003-08-26 | 2009-09-01 | Smith Kenneth E | Apparatus and method for liquid sample testing |
| US20070134784A1 (en) | 2005-12-09 | 2007-06-14 | Halverson Kurt J | Microreplicated microarrays |
| DE102006022877B4 (de) | 2006-05-15 | 2009-01-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Bestimmung der Viabilität von Zellen in Zellkulturen |
| US20080000892A1 (en) * | 2006-06-26 | 2008-01-03 | Applera Corporation | Heated cover methods and technology |
| CN101566389A (zh) | 2008-04-24 | 2009-10-28 | 沈阳东方钢铁有限公司 | 卧式高温热风炉 |
| US20100015690A1 (en) | 2008-07-16 | 2010-01-21 | Ortho-Clinical Diagnostics, Inc. | Use of fluid aspiration/dispensing tip as a microcentrifuge tube |
| KR20110091719A (ko) * | 2008-10-31 | 2011-08-12 | 바이오메리욱스, 인코포레이티드. | 식별제를 사용한 미생물의 분리 및 특성규명 방법 |
| CN102317754B (zh) | 2008-12-19 | 2015-09-30 | 3M创新有限公司 | 用于处理样品的系统和方法 |
| CN102317370B (zh) | 2008-12-19 | 2014-05-07 | 3M创新有限公司 | 由乙烯-三氟氯乙烯共聚物所得的微孔材料及其制备方法 |
| WO2010080232A1 (en) | 2008-12-19 | 2010-07-15 | 3M Innovative Properties Company | System and method for concentrating samples |
| KR20110112825A (ko) | 2008-12-31 | 2011-10-13 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 상이한 기공 크기를 갖는 다중 구역을 갖는 다공성 멤브레인 |
| US9592341B2 (en) | 2009-10-16 | 2017-03-14 | Sanofi-Aventis Deutschland Gmbh | Arrangement for use in a drug delivery device |
| WO2011063332A2 (en) | 2009-11-23 | 2011-05-26 | 3M Innovative Properties Company | Microwell array articles and methods of use |
| US8585905B2 (en) | 2010-02-26 | 2013-11-19 | Waters Technologies Corporation | Devices, kits and methods for performing chemical processing |
| WO2011152967A2 (en) | 2010-06-01 | 2011-12-08 | 3M Innovative Properties Company | Coated porous materials |
| WO2011153085A2 (en) | 2010-06-01 | 2011-12-08 | 3M Innovative Properties Company | Process for making coated porous materials |
| CA2801894A1 (en) | 2010-06-07 | 2011-12-15 | 3M Innovative Properties Company | Filtration methods and devices |
| EP2940147B1 (en) | 2010-06-07 | 2018-03-21 | 3M Innovative Properties Company | Filtration methods and devices |
| CN103620373B (zh) * | 2011-06-30 | 2017-07-07 | 3M创新有限公司 | 利用过滤器和微结构化表面检测样品中所关注分析物的方法 |
| JP2014518394A (ja) | 2011-06-30 | 2014-07-28 | スリーエム イノベイティブ プロパティズ カンパニー | 微細構造化表面を使用して、サンプル内の目的の検体を検出するためのシステム及び方法 |
| EP3083054A2 (en) | 2013-12-20 | 2016-10-26 | 3M Innovative Properties Company | Systems and methods for sample concentration and detection |
-
2014
- 2014-12-16 CN CN201480068898.4A patent/CN105828948A/zh active Pending
- 2014-12-16 EP EP14825030.1A patent/EP3083055A1/en active Pending
- 2014-12-16 US US15/105,063 patent/US10639629B2/en active Active
- 2014-12-16 JP JP2016541084A patent/JP2017503639A/ja not_active Withdrawn
- 2014-12-16 WO PCT/US2014/070523 patent/WO2015095145A1/en not_active Ceased
- 2014-12-16 CN CN202010346415.XA patent/CN111514950A/zh active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020521122A (ja) * | 2017-05-17 | 2020-07-16 | ラジオメーター・メディカル・アー・ペー・エス | 流体中の検体を検出するための多孔質光ファイバ |
| JP6991436B2 (ja) | 2017-05-17 | 2022-01-12 | ラジオメーター・メディカル・アー・ペー・エス | 流体中の検体を検出するための多孔質光ファイバ |
Also Published As
| Publication number | Publication date |
|---|---|
| US10639629B2 (en) | 2020-05-05 |
| CN105828948A (zh) | 2016-08-03 |
| US20160310941A1 (en) | 2016-10-27 |
| WO2015095145A1 (en) | 2015-06-25 |
| CN111514950A (zh) | 2020-08-11 |
| EP3083055A1 (en) | 2016-10-26 |
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