JP2017501848A5 - - Google Patents
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- JP2017501848A5 JP2017501848A5 JP2016553757A JP2016553757A JP2017501848A5 JP 2017501848 A5 JP2017501848 A5 JP 2017501848A5 JP 2016553757 A JP2016553757 A JP 2016553757A JP 2016553757 A JP2016553757 A JP 2016553757A JP 2017501848 A5 JP2017501848 A5 JP 2017501848A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antibody
- humanized
- synuclein
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000009829 Lewy Body Disease Diseases 0.000 claims 5
- 201000002832 Lewy body dementia Diseases 0.000 claims 5
- 102000003802 alpha-Synuclein Human genes 0.000 claims 5
- 108090000185 alpha-Synuclein Proteins 0.000 claims 5
- 206010010774 Constipation Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 238000009169 immunotherapy Methods 0.000 claims 3
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000011820 transgenic animal model Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361906372P | 2013-11-19 | 2013-11-19 | |
| US61/906,372 | 2013-11-19 | ||
| PCT/IB2014/066141 WO2015075635A2 (en) | 2013-11-19 | 2014-11-19 | Monitoring immunotherapy of lewy body disease from constipation symptoms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019171039A Division JP2020011978A (ja) | 2013-11-19 | 2019-09-20 | 便秘症状からのレビー小体病の免疫療法のモニター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501848A JP2017501848A (ja) | 2017-01-19 |
| JP2017501848A5 true JP2017501848A5 (cg-RX-API-DMAC7.html) | 2017-12-28 |
Family
ID=52000905
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553757A Pending JP2017501848A (ja) | 2013-11-19 | 2014-11-19 | 便秘症状からのレビー小体病の免疫療法のモニター |
| JP2019171039A Pending JP2020011978A (ja) | 2013-11-19 | 2019-09-20 | 便秘症状からのレビー小体病の免疫療法のモニター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019171039A Pending JP2020011978A (ja) | 2013-11-19 | 2019-09-20 | 便秘症状からのレビー小体病の免疫療法のモニター |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11191832B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3071974A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2017501848A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015075635A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015075635A2 (en) | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
| US11073470B2 (en) * | 2014-02-14 | 2021-07-27 | Betasense Gmbh | Attenuated total reflectance-based biosensor for conformation and secondary structure analysis |
| ES2834484T3 (es) | 2016-11-21 | 2021-06-17 | Univ Ruhr Bochum | Método para la preselección de fármacos para enfermedades de plegamiento incorrecto de proteínas |
| MX2019008029A (es) | 2017-01-06 | 2019-12-11 | Abl Bio Inc | Anticuerpo anti-alfa-sinucleina y su uso. |
| EP3583124A1 (en) | 2017-02-17 | 2019-12-25 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| JP7075648B2 (ja) * | 2017-07-05 | 2022-05-26 | ディメンシア・フロント株式会社 | 脳機能疾病鑑別方法及び該方法を含むプログラムを実行するコンピュータプログラムプロダクト |
| CA3076313A1 (en) * | 2017-09-28 | 2019-04-04 | Prothena Biosciences Limited | Dosing regimes for treatment of synucleinopathies |
| SG11202004441XA (en) * | 2017-11-14 | 2020-06-29 | Univ Osaka | Cognitive impairment diagnostic apparatus and cognitive impairment diagnostic program |
| JP7212391B2 (ja) * | 2017-12-14 | 2023-01-25 | エービーエル バイオ インコーポレイテッド | ａ－ｓｙｎ／ＩＧＦ１Ｒに対する二重特異抗体およびその用途 |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| EP3985022A4 (en) * | 2019-06-14 | 2023-08-02 | ABL Bio, Inc. | BISPECIFIC ANTIBODIES AGAINST A-SYN/IGF1R AND ITS USE |
| JP2023522417A (ja) * | 2020-04-24 | 2023-05-30 | エフ． ホフマン－ラ ロシュ アーゲー | スルフヒドリル化合物およびその誘導体を用いた酵素および経路調節 |
| MX2023002851A (es) | 2020-09-10 | 2023-03-22 | Prothena Biosciences Ltd | Tratamiento de la enfermedad de parkinson. |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3521994A1 (de) | 1985-06-20 | 1987-01-02 | Bayer Ag | N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| ATE415173T1 (de) | 1993-09-14 | 2008-12-15 | Pharmexa Inc | Pan dr-bindeproteinen zur erhöhung der immunantwort |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
| EP0859959B1 (en) | 1995-11-10 | 2003-08-06 | ELAN CORPORATION, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
| AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
| WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| CA2625839A1 (en) | 1999-02-05 | 2000-08-10 | Samsung Electronics Co., Ltd. | Image texture retrieving method and apparatus thereof |
| IL166244A0 (en) | 2001-07-12 | 2006-01-15 | Jefferson Foote | Super humanized antibodies |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| EP1567652B1 (de) | 2002-11-29 | 2007-08-22 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Neue neomycin-phosphotransferase-gene und verfahren zur selektion von hochproduzierenden rekombinanten zellen |
| DK2361928T3 (en) | 2003-05-19 | 2017-07-03 | Prothena Biosciences Ltd | Truncated fragments of alpha synuclein in Lewy body disease |
| US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| AU2003253286A1 (en) * | 2003-07-29 | 2005-02-15 | Fra Production S.P.A. | Machine for automatically presenting poultry to an operator entrusted with their tying |
| DE10338531A1 (de) | 2003-08-19 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Reklonierung von Produktionszellen |
| WO2005047860A2 (en) * | 2003-11-08 | 2005-05-26 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| ATE433110T1 (de) | 2004-11-10 | 2009-06-15 | Boehringer Ingelheim Pharma | Verwendung von durchflusszytometrischer analyse zur optimierung von zellbankingstrategien für cho-zellen |
| US8502016B1 (en) | 2005-02-11 | 2013-08-06 | Elan Pharmaceuticals, Inc. | Genomic alpha synuclein transgenic animal |
| US20080124760A1 (en) | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
| PL2583978T3 (pl) * | 2007-02-23 | 2016-07-29 | Prothena Biosciences Ltd Co | Profilaktyka i leczenie chorób synukleinopatycznych i amyloidogennych |
| US20120142902A1 (en) * | 2007-02-23 | 2012-06-07 | The Regents Of The University Of California | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| DK2126093T3 (da) | 2007-03-02 | 2013-01-07 | Boehringer Ingelheim Pharma | Forbedring af proteinfremstilling |
| EP2031064A1 (de) | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| PT3378535T (pt) * | 2011-10-28 | 2023-02-06 | Prothena Biosciences Ltd | Anticorpos humanizados que reconhecem a alfa-sinucleína |
| WO2015075635A2 (en) | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
-
2014
- 2014-11-19 WO PCT/IB2014/066141 patent/WO2015075635A2/en not_active Ceased
- 2014-11-19 US US15/037,978 patent/US11191832B2/en active Active
- 2014-11-19 EP EP14805676.5A patent/EP3071974A2/en not_active Ceased
- 2014-11-19 JP JP2016553757A patent/JP2017501848A/ja active Pending
-
2019
- 2019-09-20 JP JP2019171039A patent/JP2020011978A/ja active Pending