JP2017501848A5 - - Google Patents
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- JP2017501848A5 JP2017501848A5 JP2016553757A JP2016553757A JP2017501848A5 JP 2017501848 A5 JP2017501848 A5 JP 2017501848A5 JP 2016553757 A JP2016553757 A JP 2016553757A JP 2016553757 A JP2016553757 A JP 2016553757A JP 2017501848 A5 JP2017501848 A5 JP 2017501848A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- antibody
- humanized
- synuclein
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000009829 Lewy Body Disease Diseases 0.000 claims 5
- 201000002832 Lewy body dementia Diseases 0.000 claims 5
- 102000003802 alpha-Synuclein Human genes 0.000 claims 5
- 108090000185 alpha-Synuclein Proteins 0.000 claims 5
- 206010010774 Constipation Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 238000009169 immunotherapy Methods 0.000 claims 3
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 108700019146 Transgenes Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000011820 transgenic animal model Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361906372P | 2013-11-19 | 2013-11-19 | |
| US61/906,372 | 2013-11-19 | ||
| PCT/IB2014/066141 WO2015075635A2 (en) | 2013-11-19 | 2014-11-19 | Monitoring immunotherapy of lewy body disease from constipation symptoms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019171039A Division JP2020011978A (ja) | 2013-11-19 | 2019-09-20 | 便秘症状からのレビー小体病の免疫療法のモニター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501848A JP2017501848A (ja) | 2017-01-19 |
| JP2017501848A5 true JP2017501848A5 (OSRAM) | 2017-12-28 |
Family
ID=52000905
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553757A Pending JP2017501848A (ja) | 2013-11-19 | 2014-11-19 | 便秘症状からのレビー小体病の免疫療法のモニター |
| JP2019171039A Pending JP2020011978A (ja) | 2013-11-19 | 2019-09-20 | 便秘症状からのレビー小体病の免疫療法のモニター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019171039A Pending JP2020011978A (ja) | 2013-11-19 | 2019-09-20 | 便秘症状からのレビー小体病の免疫療法のモニター |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11191832B2 (OSRAM) |
| EP (1) | EP3071974A2 (OSRAM) |
| JP (2) | JP2017501848A (OSRAM) |
| WO (1) | WO2015075635A2 (OSRAM) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11191832B2 (en) | 2013-11-19 | 2021-12-07 | Prothena Biosciences Limited | Monitoring immunotherapy of Lewy body disease from constipation symptoms |
| US11073470B2 (en) * | 2014-02-14 | 2021-07-27 | Betasense Gmbh | Attenuated total reflectance-based biosensor for conformation and secondary structure analysis |
| ES2834484T3 (es) | 2016-11-21 | 2021-06-17 | Univ Ruhr Bochum | Método para la preselección de fármacos para enfermedades de plegamiento incorrecto de proteínas |
| MX2019008029A (es) | 2017-01-06 | 2019-12-11 | Abl Bio Inc | Anticuerpo anti-alfa-sinucleina y su uso. |
| KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
| JP7075648B2 (ja) * | 2017-07-05 | 2022-05-26 | ディメンシア・フロント株式会社 | 脳機能疾病鑑別方法及び該方法を含むプログラムを実行するコンピュータプログラムプロダクト |
| JP2021502955A (ja) * | 2017-09-28 | 2021-02-04 | プロセナ・バイオサイエンシズ・リミテッド | シヌクレイン病の治療のための投与レジメン |
| AU2018366644B2 (en) * | 2017-11-14 | 2024-05-02 | Osaka University | Cognitive impairment diagnostic apparatus and cognitive impairment diagnostic program |
| CN116731173A (zh) * | 2017-12-14 | 2023-09-12 | Abl生物公司 | 抗a-syn/igf1r的双特异性抗体及其用途 |
| GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| EA202193058A1 (ru) * | 2019-06-14 | 2022-03-05 | ЭйБиЭл БИО ИНК. | БИСПЕЦИФИЧЕСКОЕ АНТИТЕЛО К -syn/IGF1R И ЕГО ПРИМЕНЕНИЕ |
| US20230265204A1 (en) * | 2020-04-24 | 2023-08-24 | Hoffmann-La Roche Inc. | Enzyme and pathway modulation with sulfhydryl compounds and their derivatives |
| US12084491B2 (en) | 2020-09-10 | 2024-09-10 | Prothena Biosciences Limited | Treatment of Parkinson's disease |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3521994A1 (de) | 1985-06-20 | 1987-01-02 | Bayer Ag | N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| EP0735893B1 (en) | 1993-09-14 | 2008-11-26 | Pharmexa Inc. | Pan dr-binding peptides for enhancement of the immune response |
| US5786464C1 (en) | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| DE19539493A1 (de) | 1995-10-24 | 1997-04-30 | Thomae Gmbh Dr K | Starker homologer Promotor aus Hamster |
| EP1281718A3 (en) | 1995-11-10 | 2005-01-19 | ELAN CORPORATION, Plc | Peptides which enhance transport across tissues |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
| AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
| EP1005368B1 (en) | 1997-03-10 | 2009-09-02 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| CA2361492A1 (en) | 1999-02-05 | 2000-08-10 | Samsung Electronics Co., Ltd. | Image texture retrieving method and apparatus thereof |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| MXPA05005481A (es) | 2002-11-29 | 2005-07-25 | Boehringer Ingelheim Pharma | Nuevos genes de la fosfotransferasa de neomicina y procedimiento para la seleccion de celulas recombinantes de produccion elevada. |
| DK1633189T3 (en) | 2003-05-19 | 2017-08-21 | Prothena Biosciences Ltd | TRUNCTED FRAGMENTS OF ALFA SYNUCLEIN IN LEWY BODY DISEASE |
| US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| AU2003253286A1 (en) * | 2003-07-29 | 2005-02-15 | Fra Production S.P.A. | Machine for automatically presenting poultry to an operator entrusted with their tying |
| DE10338531A1 (de) | 2003-08-19 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Reklonierung von Produktionszellen |
| WO2005047860A2 (en) * | 2003-11-08 | 2005-05-26 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| PT1820022E (pt) | 2004-11-10 | 2009-08-05 | Boehringer Ingelheim Pharma | Utilização de análise por citometria de fluxo para optimizar estratégias de conservação de bancos de células cho |
| US8502016B1 (en) | 2005-02-11 | 2013-08-06 | Elan Pharmaceuticals, Inc. | Genomic alpha synuclein transgenic animal |
| US20080124760A1 (en) | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
| DK3067066T3 (da) * | 2007-02-23 | 2019-05-20 | Prothena Biosciences Ltd | Forebyggelse og behandling af synukleinopatisk og amyloidogenisk sygdom |
| US20120142902A1 (en) * | 2007-02-23 | 2012-06-07 | The Regents Of The University Of California | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| WO2008107388A1 (en) | 2007-03-02 | 2008-09-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Improvement of protein production |
| EP2031064A1 (de) | 2007-08-29 | 2009-03-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Steigerung von Proteintitern |
| LT2771031T (lt) * | 2011-10-28 | 2018-08-27 | Prothena Biosciences Limited | Humanizuoti antikūnai, kurie atpažįsta alfa sinukleiną |
| US11191832B2 (en) | 2013-11-19 | 2021-12-07 | Prothena Biosciences Limited | Monitoring immunotherapy of Lewy body disease from constipation symptoms |
-
2014
- 2014-11-19 US US15/037,978 patent/US11191832B2/en active Active
- 2014-11-19 EP EP14805676.5A patent/EP3071974A2/en not_active Ceased
- 2014-11-19 WO PCT/IB2014/066141 patent/WO2015075635A2/en not_active Ceased
- 2014-11-19 JP JP2016553757A patent/JP2017501848A/ja active Pending
-
2019
- 2019-09-20 JP JP2019171039A patent/JP2020011978A/ja active Pending
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