JP2017501694A - 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 - Google Patents
診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 Download PDFInfo
- Publication number
- JP2017501694A JP2017501694A JP2016536918A JP2016536918A JP2017501694A JP 2017501694 A JP2017501694 A JP 2017501694A JP 2016536918 A JP2016536918 A JP 2016536918A JP 2016536918 A JP2016536918 A JP 2016536918A JP 2017501694 A JP2017501694 A JP 2017501694A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- exosomes
- exosome
- patient
- gpc1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911863P | 2013-12-04 | 2013-12-04 | |
| US61/911,863 | 2013-12-04 | ||
| PCT/US2014/068630 WO2015085096A1 (en) | 2013-12-04 | 2014-12-04 | Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148579A Division JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501694A true JP2017501694A (ja) | 2017-01-19 |
| JP2017501694A5 JP2017501694A5 (enExample) | 2017-12-21 |
Family
ID=53274132
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536918A Ceased JP2017501694A (ja) | 2013-12-04 | 2014-12-04 | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 |
| JP2019148579A Withdrawn JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 |
| JP2021110830A Active JP7138372B2 (ja) | 2013-12-04 | 2021-07-02 | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148579A Withdrawn JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 |
| JP2021110830A Active JP7138372B2 (ja) | 2013-12-04 | 2021-07-02 | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9921223B2 (enExample) |
| EP (1) | EP3076949B1 (enExample) |
| JP (3) | JP2017501694A (enExample) |
| AU (3) | AU2014360344B2 (enExample) |
| CA (1) | CA2936100A1 (enExample) |
| DK (1) | DK3076949T3 (enExample) |
| HR (1) | HRP20192131T1 (enExample) |
| HU (1) | HUE046489T2 (enExample) |
| LT (1) | LT3076949T (enExample) |
| NZ (1) | NZ721720A (enExample) |
| SI (1) | SI3076949T1 (enExample) |
| WO (1) | WO2015085096A1 (enExample) |
| ZA (1) | ZA201604468B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10959952B2 (en) | 2015-06-10 | 2021-03-30 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
| JP2021519296A (ja) * | 2018-03-28 | 2021-08-10 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 治療用物質を標的送達するためのエキソソームの使用法 |
| JP2022519326A (ja) * | 2019-02-08 | 2022-03-22 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 診断および治療目的のためのエキソソーム関連マイクロバイオームの単離および検出 |
| WO2023210644A1 (ja) * | 2022-04-26 | 2023-11-02 | 国立大学法人東京大学 | がん細胞由来細胞外小胞群の単離濃縮方法、分析方法、薬剤選択方法、キット、及び抗がん剤 |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| WO2006116362A2 (en) | 2005-04-25 | 2006-11-02 | The Trustees Of Boston University | Structured substrates for optical surface profiling |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| US9828603B2 (en) | 2012-08-13 | 2017-11-28 | Cedars Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| WO2014028862A1 (en) | 2012-08-17 | 2014-02-20 | Cornell University | Use of dna in circulating exosomes as a diagnostic marker for metastasic disease |
| EP2971162B1 (en) | 2013-03-15 | 2019-05-08 | Board Of Regents, The University Of Texas System | Mirna biogenesis in exosomes for diagnosis and therapy |
| DK3076949T3 (da) * | 2013-12-04 | 2019-11-25 | Univ Texas | Fremgangsmåde til isolering af kræftcelle-afledte eksosomer |
| WO2015095794A1 (en) | 2013-12-20 | 2015-06-25 | Advanced ReGen Medical Technologies, LLC | Compositions for cellular restoration and methods of making and using same |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| EP3125907A4 (en) * | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| US11357799B2 (en) | 2014-10-03 | 2022-06-14 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016057702A2 (en) | 2014-10-07 | 2016-04-14 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
| US11971402B2 (en) | 2015-04-24 | 2024-04-30 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| US11339441B2 (en) * | 2015-05-12 | 2022-05-24 | The Research Foundation For The State University Of New York | Profiling chemically modified DNA/RNA units for disease and cancer diagnosis |
| US10345310B2 (en) | 2015-06-09 | 2019-07-09 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| CA2999283A1 (en) | 2015-09-22 | 2017-03-30 | Trustees Of Boston University | Multiplexed phenotyping of nanovesicles |
| GB201518466D0 (en) * | 2015-10-19 | 2015-12-02 | Cizzle Biotechnology Ltd | Use |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| JP7033082B2 (ja) * | 2016-02-05 | 2022-03-09 | ナノビュー バイオサイエンシズ インコーポレイテッド | 表面マーカーを有するエキソソームの検出 |
| SG11201807401RA (en) * | 2016-03-15 | 2018-09-27 | Codiak Biosciences Inc | Therapeutic membrane vesicles |
| WO2017190000A1 (en) | 2016-04-29 | 2017-11-02 | Advanced ReGen Medical Technologies, LLC | Microrna compositions and methods of making and using same |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| EP3472623A4 (en) * | 2016-06-21 | 2020-01-15 | Nant Holdings IP, LLC | TREATMENT OF CANCER GUIDED BY EXOSOME |
| CN106124282B (zh) * | 2016-07-26 | 2019-07-16 | 广州海力特生物科技有限公司 | 一种叠层离心过滤分离提取外泌体的方法 |
| US20180067121A1 (en) * | 2016-09-06 | 2018-03-08 | Nanoco Technologies Ltd. | Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same |
| EP3515459A4 (en) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS |
| IL269483B2 (en) * | 2017-03-21 | 2024-04-01 | Exoprother Medical Ltd | Native cell derived vesicles containing tumor suppressor proteins for therapy |
| GB2560897A (en) * | 2017-03-23 | 2018-10-03 | Lotvall Jan | Tissue-derived extracellular vesicles and their use as diagnostics |
| US11759482B2 (en) | 2017-04-19 | 2023-09-19 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CN107338306A (zh) * | 2017-07-23 | 2017-11-10 | 嘉兴允英医学检验有限公司 | 一种用于GPC1mRNA表达检测的试剂盒 |
| JP2020529477A (ja) * | 2017-08-04 | 2020-10-08 | シーダーズ—シナイ メディカル センター | がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 |
| GB2574785A (en) | 2017-09-15 | 2019-12-25 | Jan Loetvall | Method and system for identifying membrane proteins on extracellular vesicles |
| CN111566484A (zh) * | 2017-11-09 | 2020-08-21 | 宾夕法尼亚大学董事会 | 细胞外囊泡蛋白及其在癌症诊断、预测对疗法的反应和治疗中的用途 |
| US20210285952A1 (en) | 2017-12-01 | 2021-09-16 | Cornell University | Nanoparticles and distinct exosome subsets for detection and treatment of cancer |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| AU2018394238A1 (en) * | 2017-12-28 | 2020-06-18 | Lonza Sales Ag | Exosomes for immuno-oncology and anti-inflammatory therapy |
| EP3740576A4 (en) | 2018-01-18 | 2021-10-20 | Advanced Regen Medical Technologies, LLC | THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| US12241888B2 (en) | 2018-03-14 | 2025-03-04 | Children's Medical Center Corporation | Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof |
| JP7474702B2 (ja) * | 2018-03-28 | 2024-04-25 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法 |
| WO2019199803A1 (en) * | 2018-04-09 | 2019-10-17 | Board Of Regents, The University Of Texas System | Therapeutic targeting of oncogenes using exosomes |
| CN112105736A (zh) * | 2018-05-04 | 2020-12-18 | 西格马-奥尔德里奇有限责任公司 | 生产具有降低宿主细胞蛋白水平的重组蛋白 |
| WO2019232321A1 (en) | 2018-06-01 | 2019-12-05 | NanoView Biosciences, Inc. | Compositions, systems, and methods for enhanced label-free and fluorescence - based detection of nanoparticles |
| US11119798B2 (en) | 2018-11-15 | 2021-09-14 | Sternum Ltd. | Applying control flow integrity verification in intermediate code files |
| US11766484B2 (en) | 2019-01-03 | 2023-09-26 | International Business Machines Corporation | Exosome vessels for delivery of molecular cargo |
| WO2020146390A1 (en) | 2019-01-09 | 2020-07-16 | Exocure Biosciences, Inc. | Bacteria-derived vesicles and uses thereof |
| WO2020160402A1 (en) * | 2019-02-01 | 2020-08-06 | NanoView Biosciences, Inc. | Systems and methods for vesicle cargo labeling and detection |
| WO2020219699A1 (en) * | 2019-04-23 | 2020-10-29 | Children's Medical Center Corporation | Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb) |
| JP7462452B2 (ja) * | 2020-03-27 | 2024-04-05 | 株式会社日立製作所 | 培養細胞の分化レベルを評価するための評価装置および評価方法、並びに自動細胞培養システム |
| CN112698033A (zh) * | 2020-12-09 | 2021-04-23 | 复旦大学附属中山医院 | 一种血源性外泌体her2的检测方法及其应用 |
| US20230340606A1 (en) * | 2021-09-09 | 2023-10-26 | The Regents Of The University Of California | Extracellular repetitive rna biomarkers of mutant kras cancers |
| US20250011876A1 (en) * | 2021-11-02 | 2025-01-09 | The Regents Of The University Of California | Extracellular rna signatures of mutant kras(g12c) cancers |
| US20250290919A1 (en) * | 2022-05-06 | 2025-09-18 | The Trustees Of The University Of Pennsylvania | Ultrasensitive single extracellular vesicle detection using high throughput droplet digital enzyme-linked immunosorbent assay |
| WO2024047441A1 (en) * | 2022-09-01 | 2024-03-07 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud | Method for monitoring tumor burden in subjects during therapeutic intervention |
| WO2024073671A1 (en) * | 2022-09-30 | 2024-04-04 | Foundation Medicine, Inc. | Systems and methods for processing clinico-genomic data |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011510663A (ja) * | 2008-02-01 | 2011-04-07 | ザ ジェネラル ホスピタル コーポレイション | 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US20030064949A1 (en) | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| FR2766205B1 (fr) * | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| KR100519384B1 (ko) * | 2002-08-13 | 2005-10-06 | (주)누백스 | 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도 |
| US20120196285A1 (en) * | 2011-01-31 | 2012-08-02 | Esoterix Genetic Laboratories, Llc | Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules |
| US9777042B2 (en) | 2011-12-15 | 2017-10-03 | Morehouse School Of Medicine | Method of purifying HIV/SIV Nef from exosomal fusion proteins |
| US9309559B2 (en) * | 2013-04-15 | 2016-04-12 | Albert Einstein College Of Medicine, Inc. | Simultaneous extraction of DNA and RNA from FFPE tissues |
| DK3076949T3 (da) * | 2013-12-04 | 2019-11-25 | Univ Texas | Fremgangsmåde til isolering af kræftcelle-afledte eksosomer |
-
2014
- 2014-12-04 DK DK14867768T patent/DK3076949T3/da active
- 2014-12-04 EP EP14867768.5A patent/EP3076949B1/en active Active
- 2014-12-04 SI SI201431412T patent/SI3076949T1/sl unknown
- 2014-12-04 JP JP2016536918A patent/JP2017501694A/ja not_active Ceased
- 2014-12-04 WO PCT/US2014/068630 patent/WO2015085096A1/en not_active Ceased
- 2014-12-04 US US15/101,857 patent/US9921223B2/en active Active
- 2014-12-04 CA CA2936100A patent/CA2936100A1/en active Pending
- 2014-12-04 NZ NZ721720A patent/NZ721720A/en not_active IP Right Cessation
- 2014-12-04 HU HUE14867768A patent/HUE046489T2/hu unknown
- 2014-12-04 HR HRP20192131TT patent/HRP20192131T1/hr unknown
- 2014-12-04 LT LT14867768T patent/LT3076949T/lt unknown
- 2014-12-04 AU AU2014360344A patent/AU2014360344B2/en not_active Ceased
-
2016
- 2016-06-30 ZA ZA2016/04468A patent/ZA201604468B/en unknown
-
2017
- 2017-11-01 US US15/801,269 patent/US10598665B2/en active Active
-
2019
- 2019-01-30 AU AU2019200573A patent/AU2019200573A1/en not_active Abandoned
- 2019-02-25 AU AU2019201290A patent/AU2019201290A1/en not_active Withdrawn
- 2019-08-13 JP JP2019148579A patent/JP2019198327A/ja not_active Withdrawn
-
2020
- 2020-03-04 US US16/809,300 patent/US20200200755A1/en not_active Abandoned
-
2021
- 2021-07-02 JP JP2021110830A patent/JP7138372B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011510663A (ja) * | 2008-02-01 | 2011-04-07 | ザ ジェネラル ホスピタル コーポレイション | 医学的疾患および医学的状態の診断、予後および治療におけるマイクロベシクルの使用 |
Non-Patent Citations (2)
| Title |
|---|
| J. MOL. CELL BIOL., vol. 5, JPN6018040506, 11 April 2013 (2013-04-11), pages 227 - 238, ISSN: 0003899126 * |
| THE PROSTATE, vol. 72, JPN6018040507, 2012, pages 1736 - 1745, ISSN: 0003899127 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10959952B2 (en) | 2015-06-10 | 2021-03-30 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
| JP2021519296A (ja) * | 2018-03-28 | 2021-08-10 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 治療用物質を標的送達するためのエキソソームの使用法 |
| JP2022519326A (ja) * | 2019-02-08 | 2022-03-22 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 診断および治療目的のためのエキソソーム関連マイクロバイオームの単離および検出 |
| WO2023210644A1 (ja) * | 2022-04-26 | 2023-11-02 | 国立大学法人東京大学 | がん細胞由来細胞外小胞群の単離濃縮方法、分析方法、薬剤選択方法、キット、及び抗がん剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180045728A1 (en) | 2018-02-15 |
| AU2019200573A1 (en) | 2019-02-21 |
| US10598665B2 (en) | 2020-03-24 |
| WO2015085096A1 (en) | 2015-06-11 |
| EP3076949A1 (en) | 2016-10-12 |
| SI3076949T1 (sl) | 2020-01-31 |
| EP3076949A4 (en) | 2017-11-22 |
| HRP20192131T1 (hr) | 2020-02-21 |
| NZ721720A (en) | 2022-04-29 |
| ZA201604468B (en) | 2024-01-31 |
| US20200200755A1 (en) | 2020-06-25 |
| US9921223B2 (en) | 2018-03-20 |
| EP3076949B1 (en) | 2019-09-04 |
| US20170059572A1 (en) | 2017-03-02 |
| AU2019201290A1 (en) | 2019-03-14 |
| CA2936100A1 (en) | 2015-06-11 |
| LT3076949T (lt) | 2019-12-10 |
| JP7138372B2 (ja) | 2022-09-16 |
| HUE046489T2 (hu) | 2020-03-30 |
| JP2019198327A (ja) | 2019-11-21 |
| JP2021177760A (ja) | 2021-11-18 |
| DK3076949T3 (da) | 2019-11-25 |
| AU2014360344B2 (en) | 2018-11-29 |
| AU2014360344A1 (en) | 2016-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7138372B2 (ja) | 診断および療法のためのエキソソーム中のゲノムdna、rnaおよびタンパク質の分析 | |
| EP3833760B1 (en) | Microrna-based therapy targeted against lcp-1 positive cancers | |
| CN113694075A (zh) | 用于医治疾病的外泌体的用途 | |
| CN104080461A (zh) | 靶向微小rna mir-409-5p、mir-379和mir-154*来治疗前列腺癌骨转移和耐药性肺癌 | |
| SG188666A1 (en) | Methods and reagents for detection and treatment of esophageal metaplasia | |
| AU2018386215B2 (en) | Methods and compositions for treating cancer using exosomes-associated gene editing | |
| US20210369858A1 (en) | Use of exosomes for targeted delivery of therapeutic agents | |
| JP7602246B2 (ja) | エキソソームを用いる腫瘍抑制因子の治療的調整法 | |
| CA3095136A1 (en) | Use of exosomes for targeted delivery of therapeutic agents | |
| WO2019191429A2 (en) | Identification of epigenetic alterations in dna isolated from exosomes | |
| US20220163532A1 (en) | Nuclear-derived exosomes and methods of use thereof | |
| HK1227707A1 (en) | Method for isolating cancer cell-derived exoxomes | |
| HK1227707B (en) | Method for isolating cancer cell-derived exoxomes | |
| Liang et al. | Circ847 upregulation via CAFs suppresses salivary adenoid cystic carcinoma progression through VIM-EMT |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160816 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171107 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171107 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20181017 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190117 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190206 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190613 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190710 |
|
| A045 | Written measure of dismissal of application [lapsed due to lack of payment] |
Free format text: JAPANESE INTERMEDIATE CODE: A045 Effective date: 20191023 |