JP2017164562A - 細胞外マトリックス材料から生理活性ゲルを製造する方法 - Google Patents
細胞外マトリックス材料から生理活性ゲルを製造する方法 Download PDFInfo
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Abstract
【解決手段】本発明は、ECM材料から生理活性ゲル、すなわち、生理活性を保ち、かつ前臨床及び臨床組織工学並びに組織再建への再生医療アプローチのための足場として働くことのできるゲルを製造する方法を対象とする。本製造方法は、アルカリ性環境で微粒子化されたECM材料を消化し、中和して生理活性ゲルを得ることにより、ECM材料からの生理活性ゲルを作製できるという新しい認識を利用している。
【選択図】 図1
Description
下記の例証では、例えば分離された膀胱粘膜下組織、小腸粘膜下組織、真皮のうちの1つ又は複数などの、ただしこれらに限定されない任意の数のECM製品を使用できる。下記の例証では、膀胱から分離され、上皮基底膜を有するECMであるUBMが、代表的なECMとして使用される。しかし、本明細書で開示される発明はUBMに限定されず、任意の分離されたECMに適用可能である。
Claims (15)
- 細胞外マトリックス材料から生理活性ゲルを製造する方法であって、
a)哺乳動物組織に由来し、天然型の前記組織で見出される量で配置されている、細胞外マトリックス材料の生理活性成分を含む、細胞外マトリックス材料を用意することと、
b)a)の前記細胞外マトリックス材料を微粒子化することと、
c)b)の前記微粒子化された細胞外マトリックス材料を、アルカリ性溶液中で可溶化することと、
d)酸の添加により、工程c)の前記溶液を中和することと
を含む、方法。 - e)工程d)で調製された、前記可溶化され中和された細胞外マトリックス材料を凍結することと、
f)工程e)で調製された、前記凍結した材料を凍結乾燥することと
を更に含む、請求項1に記載の方法。 - 前記凍結乾燥したゲルを水溶液中で戻すことを更に含む、請求項2に記載の方法。
- 工程d)の後、4℃で最大48時間の滞留時間を更に含む、請求項1に記載の方法。
- 工程c)の時間が、30分〜48時間、及び3〜7日間からなる群から選択される、請求項1に記載の方法。
- 前記細胞外マトリックス材料が、小腸粘膜下組織、膀胱粘膜下組織、上皮基底膜を含む膀胱マトリックス、及び肝臓基底膜からなる群に由来する、請求項1に記載の方法。
- 前記微粒子化された細胞外マトリックス材料の粒子範囲サイズが、1μm〜約1000μmである、請求項1に記載の方法。
- 前記細胞外マトリックス材料が、モル濃度範囲約0.1M〜約1.0MのNaOH中に、微粒子化された細胞外マトリックス材料の濃度約0.5%〜11%w/vで可溶化される、請求項1に記載の方法。
- 前記可溶化された細胞外マトリックス材料が、塩酸中で中和される、請求項1に記載の方法。
- 前記塩酸が、0.1M〜1.0Mの濃度を含む、請求項9に記載の方法。
- 前記生理活性成分が、FGF−2、CTGF及びVEGFからなる群から選択される、請求項1に記載の方法。
- 前記細胞外マトリックスが2時間を超えて可溶化される際、前記可溶化された細胞外マトリックス材料中の前記FGF−2の濃度が、前記細胞外マトリックス材料が1.0MのNaOH中に可溶化される場合、100mMのNaOH中に可溶化される場合よりも高い、請求項11に記載の方法。
- 前記細胞外マトリックス材料が2時間を超えて可溶化される際、前記可溶化された細胞外マトリックス材料中の前記VEGFの濃度が、前記細胞外マトリックス材料が1.0MのNaOH中に可溶化される場合、100mMのNaOH中に可溶化される場合よりも高い、請求項11に記載の方法。
- 前記微粒子化された細胞外マトリックス材料がUBMを含み、前記UBMが、100mMのNaOH中に、微粒子化されたUBMの濃度7%で、4℃で24時間可溶化される、請求項1に記載の方法。
- 工程(b)の前記微粒子化された材料が、200〜700ミクロンの範囲にある、請求項1に記載の方法。
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US8361503B2 (en) | 2007-03-02 | 2013-01-29 | University of Pittsburgh—of the Commonwealth System of Higher Education | Extracellular matrix-derived gels and related methods |
CN106619723A (zh) | 2010-08-24 | 2017-05-10 | 加利福尼亚大学董事会 | 用于心脏治疗的组合物和方法 |
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