JP2017151054A - Automated analyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an automated analyzer of which increase in the size can be prevented.SOLUTION: An automated analyzer comprises: a standby lane 80 that is provided so that a sample rack 12 can be moved onto a dispensation lane 81 where a sample in a sample container held in the sample rack 12 can be dispensed; a first movement mechanism for moving the sample rack 12 on the standby lane 80; and a second movement mechanism for moving the sample rack 12 on one of the standby lane 80 and the dispensation lane 81 to the other. The sample rack 12 placed in a dispensation standby area 801 provided on the standby lane 80 is moved onto the dispensation lane 81, and the sample in the sample container held in the sample rack 12 is dispensed. When analysis data generated by the dispensation of the sample meets a preset re-test condition, the sample rack 12 is moved to a re-dispensation standby area 802 provided on the standby lane 80.SELECTED DRAWING: Figure 3

Description

  Embodiments described herein relate generally to an automatic analyzer that dispenses a sample and a reagent into a reaction container and measures a mixed solution of the sample and the reagent dispensed into the reaction container.

  The automatic analyzer is intended for biochemical test items, immunological test items, etc., and dispenses the sample collected from the subject and the reagent of each test item into the reaction container, and the mixture of the sample and reagent in the reaction container Changes in color tone and turbidity caused by the reaction are optically measured. As a result of this measurement, analytical data represented by the concentration of each test item component contained in the sample, the activity of the enzyme, etc. are obtained.

  Some inspection items require re-examination based on re-examination conditions such as when the analysis data obtained is an abnormal value. For this reason, there is an automatic analyzer equipped with a reinspection function capable of transporting a sample requiring reexamination to a temporary storage location and retransmitting the sample from the temporary storage location to a dispensing position when reexamination is necessary.

Japanese Patent Laid-Open No. 5-72215

  However, since it is necessary to provide a temporary storage place and a transport line for transporting the sample in this place, there is a problem that the automatic analyzer becomes large.

  The embodiment has been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer that can prevent an increase in size.

  In order to achieve the above object, an automatic analyzer according to an embodiment dispenses a sample and a reagent into a reaction container, and in the automatic analyzer that measures a mixed solution of the sample and the reagent in the reaction container, A standby lane provided so that the sample rack can be moved onto a dispensing lane capable of dispensing the sample in the held sample container, and a first moving mechanism for moving the sample rack on the standby lane A second moving mechanism for moving the sample rack on one of the waiting lane or the dispensing lane onto the other lane, and a dispensing waiting area disposed on the waiting lane. When the sample rack to be placed is moved onto the dispensing lane, the sample in the sample container held in the sample rack is dispensed, and an abnormality relating to the dispensing of the sample is detected, or The sample and the test When the analysis data generated by the measurement of the mixed liquid is data that meets the preset re-inspection conditions, the analysis control unit moves the sample rack to the re-dispensing standby area arranged on the standby lane And comprising.

The block diagram which shows the structure of the automatic analyzer which concerns on embodiment. The figure which shows the structure of the analysis part which concerns on embodiment. The top view which showed arrangement | positioning of the sampler part which concerns on embodiment, a sample dispensing probe, a sample dispensing arm, and reaction container. The figure which shows N sample racks mounted in the dispensing standby area on the standby lane which concerns on embodiment. The figure which shows the 1st sample rack moved on the dispensing lane from the waiting lane which concerns on embodiment. The figure which shows the 2nd sample rack moved on the dispensing lane from the waiting lane which concerns on embodiment. The figure which shows the 1st sample rack moved to the dispensing waiting area on a waiting lane from the dispensing lane which concerns on embodiment. The figure which shows the 2nd sample rack moved to the L4 direction at every completion | finish of dispensing of the sample in the 3rd sample rack and sample container which move from the waiting lane which concerns on embodiment. The figure which shows the 2nd sample rack moved to the position mounted on the waiting lane from the dispensing lane which concerns on embodiment. The figure which shows the Nth sample rack moved to the position mounted on the waiting lane from the dispensing lane which concerns on embodiment. The figure which shows the 3rd sample rack moved from the waiting lane to the dispensing lane in order to move to the re-dispensing waiting area according to the embodiment. The third sample rack moved from the dispensing lane according to the embodiment to the re-dispensing waiting area on the waiting lane and moved from the waiting lane to the dispensing lane in order to move to the re-dispensing waiting area 1 The figure which shows the 2nd sample rack. The figure which shows the 1st sample rack moved from the dispensing lane which concerns on embodiment to the re-dispensing waiting area on a waiting lane. The figure which shows the 1st and 3rd sample rack moved to the re-dispensing start position of the waiting lane which concerns on embodiment. The figure which shows the 1st and 3rd sample rack moved to the re-dispensing completion position of the waiting lane which concerns on embodiment.

  Hereinafter, embodiments will be described with reference to the drawings.

  FIG. 1 is a block diagram illustrating a configuration of an automatic analyzer according to the embodiment. This automatic analyzer 100 dispenses a sample such as a standard sample or test sample for each test item and a reagent for each test item, and measures a sample and reagent mixture to generate standard data and test data. The analysis unit 10 is provided. Moreover, the data processing part 40 which processes the standard data and test data produced | generated by the analysis part 10, and produces | generates the calibration data and analysis data of each test | inspection item is provided.

  The automatic analyzer 100 further includes an output unit 50 that outputs calibration data and analysis data generated by the data processing unit 40. Moreover, the drive part 31 which drives the various units of the analysis part 10 and the analysis control part 32 which controls the drive part 31 and operates the various units of the analysis part 10 are provided.

  The automatic analyzer 100 also performs an input for setting analysis parameters for generating analysis data for each inspection item, a sample ID for identifying each sample and an inspection item for each sample, and generating analysis data. Input for making it to be performed, input for setting a re-inspection parameter for determining whether or not to make a second inspection (re-inspection) based on analysis data generated by the first inspection, for each inspection item An operation unit 60 is provided for performing input and the like for setting expiration dates for reagents and calibration data. In addition, a system control unit 70 that controls the analysis control unit 32, the data processing unit 40, and the output unit 50 in an integrated manner is provided.

  FIG. 2 is a diagram illustrating a configuration of the analysis unit 10. The analysis unit 10 includes a sample container 11 for storing a sample such as a standard sample or a test sample for each inspection item, a sample rack 12 capable of holding a plurality of sample containers 11 in which samples are stored, and a sample container. And a sampler unit 13 on which a sample rack 12 holding 11 is placed. In addition, a reagent container 14 containing, for example, a first reagent and a two reagent system, which are reagents that react with components of each test item included in the sample, and a second reagent paired with a two reagent system first reagent. And a reagent container 15 for containing the reagent.

  The sample container 11 is provided with a sample ID such as a barcode for identifying the sample in the sample container 11. The sample rack 12 has a rack ID such as a barcode for identifying the sample rack 12.

  In addition, a reagent rack 16 that holds the reagent container 14 movably and a reagent rack 17 that holds the reagent container 15 movably are provided. In addition, a plurality of reaction vessels 18 arranged on the circumference, and a reaction disk 19 that holds the reaction vessels 18 so as to be rotatable are provided. In addition, a sample dispensing probe 20 is provided for dispensing the sample in the sample container 11 held in the sample rack 12 and discharging the sample into the reaction container 18. Further, a sample dispensing arm 21 that supports the sample dispensing probe 20 so as to be movable is provided.

  In addition, a first reagent dispensing probe 22 is provided for aspirating the first reagent in the reagent container 14 held in the reagent rack 16 and discharging it into the reaction container 18 into which the sample has been dispensed. . In addition, a first reagent dispensing arm 23 that movably supports the first reagent dispensing probe 22 is provided. In addition, a second reagent dispensing probe 24 is provided for aspirating the second reagent in the reagent container 15 held in the reagent rack 17 and discharging it into the reaction container 18 into which the first reagent has been dispensed. ing. In addition, a second reagent dispensing arm 25 that movably supports the second reagent dispensing probe 24 is provided.

  In addition, a stirring unit 26 is provided for stirring the mixed solution of the sample and the first reagent dispensed in the reaction vessel 18 and the mixed solution of the sample, the first reagent, and the second reagent. Further, the reaction container 18 containing the mixed liquid stirred by the stirring unit 26 is irradiated with light, and the light transmitted through the mixed liquid containing the standard sample and the test sample in the reaction container 18 is detected to detect a plurality of light. A measurement unit 27 that generates standard data indicated by absorbance and test data is provided. Further, a cleaning unit 28 for cleaning the inside of the reaction vessel 18 for which the measurement has been completed is provided. The reaction vessel 18 cleaned by the cleaning unit 28 is again used for sample dispensing, reagent dispensing and measurement.

  Although not shown, a pressure detector that detects the pressure in the sample dispensing probe 20 that sucks the sample is provided. When the sample dispensing probe 20 is clogged with, for example, fibrin contained in the sample in the sample container 11, the pressure detector detects an abnormality related to the sample dispensing.

  In addition, a cleaning tank in which the cleaning liquid is supplied and the sample dispensing probe 20 is cleaned, and the liquid level of the sample and the cleaning liquid by contact between the sample dispensing probe 20 and the sample in the sample container 11 and the cleaning liquid in the cleaning tank. A liquid level detector is provided. When the cleaning liquid in the cleaning tank or the sample in the sample container 11 is insufficient, the liquid level detector detects an abnormality related to the dispensing of the sample.

  In addition, a cleaning tank in which the cleaning liquid is supplied and the first reagent dispensing probe 22 is cleaned, and the first reagent dispensing probe 22 is contacted with the first reagent in the reagent container 14 and the cleaning liquid in the cleaning tank. A liquid level detector for detecting the liquid level of one reagent or cleaning liquid is provided. The liquid level detector detects an abnormality related to the dispensing of the first reagent when the cleaning liquid in the cleaning tank or the first reagent sample in the reagent container 14 is insufficient.

  In addition, the cleaning tank in which the cleaning liquid is supplied and the second reagent dispensing probe 24 is cleaned, and the second reagent dispensing probe 24 is brought into contact with the second reagent in the reagent container 15 and the cleaning liquid in the cleaning tank. 2 A liquid level detector for detecting the liquid level of the reagent and the cleaning liquid is provided. When the cleaning liquid in the cleaning tank or the second reagent sample in the reagent container 15 is insufficient, the liquid level detector detects an abnormality related to the dispensing of the second reagent.

  In addition, the reaction vessel 18 is disposed, and includes a thermostatic chamber that holds a heat medium such as water for keeping the reaction vessel 18 at a predetermined temperature, and a temperature adjusting unit that adjusts the temperature of the heat medium in the thermostatic bath. Yes. And a temperature regulator part detects the abnormality which concerns on the measurement of the liquid mixture in the reaction container 18, when the heat medium in a thermostat does not enter into the preset allowable range. Further, the measurement unit 27 detects an abnormality related to the measurement of the mixed liquid in the reaction vessel 18 when a plurality of standard data and a plurality of test data include data that is out of a preset allowable range.

  The data processing unit 40 illustrated in FIG. 1 includes a calculation unit 41 and a data storage unit 42. And the calculating part 41 produces | generates calibration data from the standard data of each test | inspection item produced | generated by the analysis part 10, The analysis data is produced | generated for the test data produced | generated by the analysis part 10 using the calibration data of this test | inspection item. Generate. Measurement of mixed liquids including analysis data exceeding the threshold set as retest parameters, analysis data generated using expired reagents and calibration data, and reagents with dispensing errors detected An error flag is added to the analysis data generated by the above and the analysis data generated by the measurement of the mixed liquid in which the abnormality relating to the measurement is detected. The data storage unit 42 stores the calibration data generated by the calculation unit 41 for each inspection item, and stores the analysis data of each inspection item generated by the calculation unit 41 for each test sample.

  The output unit 50 includes a printing unit 51 that prints out the standard data and analysis data generated by the data processing unit 40, and a display unit 52 that displays the data. The printing unit 51 includes a printer or the like, and prints out calibration data and analysis data on printer paper or the like according to a preset format.

  The display unit 52 includes a monitor such as a CRT or a liquid crystal panel. Then, an analysis parameter setting screen for setting analysis parameters for each inspection item is displayed. In addition, a reinspection parameter setting screen for setting reinspection parameters such as a threshold value for each inspection item is displayed. Further, an inspection item setting screen for setting the sample ID and the inspection item for each sample is displayed.

  The drive unit 31 includes first and second moving mechanisms 311 and 312 that are disposed below the sampler unit 13 of the analysis unit 10 and move the sample rack 12 of the sampler unit 13. Further, various units other than the sample rack 12 of the analysis unit 10 and a mechanism for driving the units are provided. Then, the reagent racks 16 and 17 are respectively driven to rotate the reagent containers 14 and 15. Further, the reaction disk 19 is driven to rotate and move the reaction vessel 18.

  The drive unit 31 drives the sample dispensing arm 21, the first reagent dispensing arm 23, and the second reagent dispensing arm 25, respectively, so that the sample dispensing probe 20, the first reagent dispensing probe 22, and the first reagent dispensing arm 25 are driven. 2 Reagent dispensing probe 24 is rotated and moved up and down. Further, the stirring unit 26 and the cleaning unit 28 are moved up and down, respectively.

  The analysis control unit 32 controls the driving unit 31 based on the analysis parameters, the input information such as the sample ID set for each sample and the inspection item, and operates the various units of the analysis unit 10. Then, sample dispensing, reagent dispensing, mixing liquid stirring, measurement, and the like are executed. In addition, abnormality detection by each unit such as the measurement unit 27, the pressure detector, each liquid level detector, and the temperature adjustment unit of the analysis unit 10, exceeding the threshold value of the set reexamination parameter, expiration date, etc. If the re-inspection condition is met in the first inspection, the re-inspection is executed.

  Measurement of mixed liquids including analysis data that is outside the threshold set as retest parameters, analysis data generated using expired reagents and calibration data, and reagents in which dispensing abnormalities are detected An error flag is added to the analysis data generated by the measurement and the analysis data generated by the measurement of the mixed liquid in which the abnormality relating to the measurement is detected, and the data satisfies the reinspection condition. Therefore, in the retest, the same sample and reagent as in the first test are dispensed, and a retest is performed to generate retest data that is the second analysis data.

  In addition, when an abnormality relating to the dispensing of the sample is detected, the sample cannot be dispensed, so that the examination of the sample for which dispensing has been interrupted becomes a reinspection target. In the re-inspection, among the inspection items set for the suspended sample, the inspection item when the dispensing of the sample is interrupted in the first inspection and the inspection item where the sample is not dispensed are re-displayed. Subject to inspection.

  In the embodiment of the present application, various abnormalities can be detected by various units of the analysis unit 10 other than the above-described units, and any abnormality detection may be used as the reinspection condition.

  The operation unit 60 includes input devices such as a keyboard, a mouse, a button, and a touch key panel. Then, an input for setting an analysis parameter, an input for setting a reinspection parameter, an input for setting a sample ID and an inspection item, and the like are performed.

  The system control unit 70 includes a CPU and a storage circuit. And after memorize | stored input information, such as each analysis parameter, each reexamination parameter, each sample ID, and test | inspection item which are input from the operation part 60, based on these input information, the analysis control part 32 and the data processing part 40 are stored. The output unit 50 is controlled in an integrated manner.

  Next, details of the configuration of the sampler unit 13 in the analysis unit 10 will be described.

  FIG. 3 is a plan view showing the arrangement of the sampler unit 13, the sample dispensing probe 20, the sample dispensing arm 21, and the reaction vessel 18. The sampler unit 13 includes a standby lane 80 and a dispensing lane 81 arranged so that the longitudinal direction is perpendicular to the longitudinal direction of the standby lane 80.

  The standby lane 80 is provided so that the sample rack 12 can be moved onto a dispensing lane 81 where the sample in the sample container 11 held in the sample rack 12 can be dispensed. In the standby lane 80, the dispensing standby area 801 on the same plane and the re-dispensing standby area 802 adjacent to the dispensing standby area 801 adjacent to the arrow L 1 that is one of the longitudinal directions of the standby lane 80. Is arranged.

  In the dispensing standby area 801, the sample rack 12 to be inspected that holds the sample container 11 containing the sample to be dispensed the first time for each inspection item, the short direction of the sample rack 12 is the standby lane. It is mounted so as to be parallel to the longitudinal direction of 80. Further, in the re-dispensing standby area 802, for the re-examination after the first dispensing of the sample in the sample container 11 among the sample racks 12 placed in the dispensing standby area 801 is performed. A sample rack 12 to be re-inspected for holding a sample container 11 containing a sample to be dispensed a second time is stored.

  The sampler unit 13 also includes a position detector 82 that detects the position of each sample rack 12 placed in the dispensing standby area 801 on the standby lane 80, and each sample at the rack ID reading position P 1 on the standby lane 80. A rack ID reader 83 that reads a rack ID written on the rack 12 is provided. Further, a sample ID reader 84 for reading the sample ID written on the sample container 11 at the sample ID reading position P3 held in the sample rack 12 on the dispensing lane 81 is provided. Moreover, it has LED85 arrange | positioned on the waiting lane 80 which lights so that the re-dispensing waiting area 802 can be identified. And among LED85, the range 85a of the waiting lane 80 longitudinal direction in the re-dispensing waiting area 802 lights so that a movement is possible.

  The re-dispensing standby area 802 is arranged so that the range 85a can be changed by an input from the operation unit 60 according to the number of sample racks 12 to be stored.

  Then, all the sample racks 12 on the standby lane 80 are simultaneously moved at the same speed by the first moving mechanism 311 of the driving unit 31 in the L1 direction in the same direction and the arrow L2 direction opposite to the L1 direction. The The sample rack 12 at the pull-in position P2 on the standby lane 80 is dispensed in the direction of the arrow L3 perpendicular to the L1 and L2 directions from the standby lane 80 by the second moving mechanism 312 of the drive unit 31. Moved up. Further, the sample rack 12 moved onto the dispensing lane 81 is moved in the L1 direction on the dispensing lane 81 by the second moving mechanism 312. Further, the sample rack 12 moved in the L1 direction on the dispensing lane 81 is moved by the second moving mechanism 312 onto the standby lane 80 in the direction of the arrow L4 opposite to the L3 direction.

  The analysis control unit 32 includes a re-inspection condition set in advance, a sample ID, an inspection item set for the sample identified by the sample ID, position information of each sample rack 12 detected by the position detector 82, and a rack ID. Based on the rack ID read by the reader 83, the sample ID read by the sample ID reader 84, the analysis data generated by the data processing unit 40, etc., all the sample racks 12 on the standby lane 80 and the dispensing lane 81 are displayed. Control movement.

  Then, the sample rack 12 placed in the dispensing standby area 801 on the standby lane 80 is moved onto the dispensing lane 81 to dispense the sample in the sample container 11 held in the sample rack 12, When dispensing of the sample in the sample container 11 held in the sample rack 12 is completed, the sample is moved to the dispensing standby area 801, and analysis data generated by measuring the mixed solution of the sample and the reagent in the sample container 11 is obtained. Is the data that satisfies the preset re-inspection conditions, the sample rack 12 is moved from the dispensing standby area 801 to the re-dispensing standby area 802 on the standby lane 80 via the dispensing lane 81.

  Further, the sample rack 12 placed in the dispensing standby area 801 on the standby lane 80 is moved onto the dispensing lane 81 so that the sample in the sample container 11 held by the sample rack 12 is dispensed. When an abnormality relating to the dispensing of the sample is detected, the sample rack 12 is moved from the dispensing lane 81 to the re-dispensing waiting area 802 on the waiting lane 80.

  Hereinafter, an example of the operation of the automatic analyzer 100 will be described with reference to FIGS. 1 to 15.

  After inputting the sample ID and setting the inspection item for each sample to be inspected from the operation unit 60, the system control unit 70, the analysis control unit 32, the data The processing unit 40 and the output unit 50 are instructed to start inspection. The analysis control unit 32 controls the drive unit 31 to operate various units of the analysis unit 10.

  As shown in FIG. 4, the LED 85 of the sampler unit 13 in the analysis unit 10 includes a range 85 a of a re-dispensing standby area 802 adjacent to the dispensing standby area 801 with, for example, a rack ID reading position P1 on the standby lane 80 as an end. Lights up. Then, the N sample racks 12 to be inspected that hold the sample container 11 in which the sample of the input sample ID is stored are placed in the dispensing standby area 801 on the standby lane 80.

  The position detector 82 detects the position of the dispensing standby area 801 where the N sample racks 12 are placed. As shown in FIG. 4, the first moving mechanism 311 of the drive unit 31 moves the N sample racks 12 whose positions are detected in the L1 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  The rack ID reader 83 reads the rack ID of the first sample rack 12 that reaches the rack ID reading position P1 by moving in the L1 direction. The first moving mechanism 311 moves each sample rack 12 in the dispensing standby area 801 in the L1 direction until the first sample rack 12 whose rack ID has been read reaches the pull-in position P2. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  As shown in FIG. 5, the second moving mechanism 312 moves the first sample rack 12 at the drawing position P <b> 2 from the standby lane 80 to the dispensing lane 81. The sample ID reader 84 reads the sample ID of each sample container 11 at the sample ID reading position P3 held in the first sample rack 12 moved from the standby lane 80 to the dispensing lane 81. The rack ID reader 83 reads the rack ID of the second sample rack 12 at the rack ID reading position P1.

  The second moving mechanism 312 moves one first sample rack 12 on the dispensing lane 81 from which the sample ID has been read, on the dispensing lane 81 in the L1 direction. The first moving mechanism 311 moves (N−1) sample racks 12 in the dispensing standby area 801 by one sample rack 12 in the L1 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  As shown in FIG. 6, the second moving mechanism 312 moves the second sample rack 12 at the pull-in position P <b> 2 from the standby lane 80 to the dispensing lane 81. The sample ID reader 84 reads the sample ID of each sample container 11 at the sample ID reading position P3 held in the second sample rack 12 moved from the standby lane 80 to the dispensing lane 81. The rack ID reader 83 reads the rack ID of the third sample rack 12 at the rack ID reading position P1.

  The sample dispensing probe 20 dispenses the sample in the sample container 11 at the suction position P4 held by the first sample rack 12 on the dispensing lane 81. The second moving mechanism 312 moves the first sample rack 12 by one sample container 11 in the L4 direction every time the dispensing of the sample in the sample container 11 at the suction position P4 is completed.

  When the dispensing of the samples in all the sample containers 11 held in the first sample rack 12 is completed, the second moving mechanism 312 moves the first sample rack 12 into the dispensing lane as shown in FIG. Move from 81 to the position where the first sample rack 12 is placed in the dispensing standby area 801 on the standby lane 80.

  The second moving mechanism 312 moves the second sample rack 12 from which the sample ID has been read by one sample rack 12 on the dispensing lane 81 in the L1 direction. The first moving mechanism 311 moves (N−1) sample racks 12 on the standby lane 80 by one sample rack 12 in the L1 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  As shown in FIG. 8, the second moving mechanism 312 moves the third sample rack 12 at the pull-in position P <b> 2 from the standby lane 80 to the dispensing lane 81. The sample ID reader 84 reads the sample ID of each sample container 11 at the sample ID reading position P3 held in the third sample rack 12 moved from the standby lane 80 to the dispensing lane 81. The rack ID reader 83 reads the rack ID of the fourth sample rack 12 at the rack ID reading position P1.

  The sample dispensing probe 20 dispenses the sample in the sample container 11 at the suction position P4 held by the second sample rack 12 on the dispensing lane 81. The second moving mechanism 312 moves the second sample rack 12 in the L4 direction by one sample container 11 each time the dispensing of the sample in the sample container 11 at the suction position P4 is completed.

  When the dispensing of the samples in all the sample containers 11 held by the second sample rack 12 is completed, the second moving mechanism 312 dispenses the second sample rack 12 as shown in FIG. It moves from the lane 81 to the placed position on the standby lane 80.

  The second moving mechanism 312 moves one third sample rack 12 from which the sample ID has been read on the dispensing lane 81 in the L1 direction. The first moving mechanism 311 moves one sample rack 12 on the standby lane 80 by one in the L1 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  The sample dispensing probe 20 dispenses the sample in the sample container 11 at the suction position P4 held by the third sample rack 12 on the dispensing lane 81. The second moving mechanism 312 moves the third sample rack 12 by one sample container 11 in the L4 direction every time the dispensing of the sample in the sample container 11 at the suction position P4 is completed.

  When the dispensing of the samples in all the sample containers 11 held in the third sample rack 12 is completed, the second moving mechanism 312 moves the third sample rack 12 to the dispensing standby area 801 on the standby lane 80. To the position where the third sample rack 12 is placed.

  The first and second moving mechanisms 311 and 312 move the fourth and subsequent (N−3) sample racks 12 in the same manner as the first to third sample racks 12. The rack ID reader 83 reads the rack IDs of the fourth and subsequent (N-3) sample racks 12 in the same manner as the first to third sample racks 12. The sample ID reader 84 reads the sample IDs of the sample containers 11 held in the fourth and subsequent (N-3) sample racks 12 in the same manner as the first to third sample racks 12. The sample dispensing probe 20 dispenses the sample in the sample container 11 held in the fourth and subsequent (N-3) sample racks 12 in the same manner as in the first to third sample racks 12. Do.

  When the dispensing of the samples in all the sample containers 11 held in the Nth sample rack 12 is completed, the second moving mechanism 312, as shown in FIG. 10, the Nth sample on the dispensing lane 81. The rack 12 is moved to the position where the Nth sample rack 12 is placed in the dispensing standby area 801 on the standby lane 80.

  After all the analysis data is generated by the data processing unit 40 by dispensing the samples in the sample containers 11 held in the N sample racks 12, the analysis control unit 32 is generated by the data processing unit 40. If the analysis data does not include analysis data that meets the reinspection conditions, the operation of all the units of the analysis unit 10 is terminated. In addition, when the analysis data generated by the data processing unit 40 includes analysis data that meets the reinspection conditions, the sample container 11 that holds the sample in which the analysis data that meets the reinspection conditions is generated is held. The sample rack 12 to be re-inspected is moved from the dispensing standby area 801 on the standby lane 80 to the re-dispensing standby area 802.

  Here, for example, the first and third sample racks 12 holding the sample containers 11 that store the samples for which the analysis data that deviates from the threshold value set as the reinspection parameter are redistributed from the dispensing standby area 801. Note An example of moving to the standby area 802 will be described.

  After the N-th sample rack 12 is moved to the dispensing standby area 801, the first moving mechanism 311 moves the N number of samples in the dispensing standby area 801 until, for example, the third sample rack 12 reaches the drawing position P2. The sample rack 12 is moved in the L2 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  The second moving mechanism 312 moves the third sample rack 12 moved to the pull-in position P2 from the standby lane 80 to the dispensing lane 81 as shown in FIG. Next, the sample rack 12 that has moved onto the dispensing lane 81 moves on the dispensing lane 81 in the L1 direction. After the third sample rack 12 has been moved onto the dispensing lane 81, the first moving mechanism 311 has (N−1) in the dispensing standby area 801 until the first sample rack 12 reaches the drawing position P2. ) Move the sample racks 12 in the L2 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  The second moving mechanism 312 moves the third sample rack 12 moved in the L1 direction on the dispensing lane 81 from the dispensing lane 81 to the re-dispensing waiting area on the waiting lane 80 as shown in FIG. Move to 802. Further, the first sample rack 12 at the pull-in position P2 is moved from the waiting lane 80 to the dispensing lane 81. Subsequently, it moves in the L1 direction on the dispensing lane 81.

  The third sample rack 12 is stopped at the position where the sample container 11 containing the sample to be reinspected on the dispensing lane 81 reaches the suction position P4, and the sample to be reinspected is inspected by the sample dispensing probe 20. You may carry out so that the sample of an item may be dispensed.

  The second moving mechanism 312 moves the first sample rack 12 moved onto the dispensing lane 81 in the L1 direction on the dispensing lane 81. The first moving mechanism 311 moves (N−1) sample racks 12 on the standby lane 80 by one in the L2 direction. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80.

  The second moving mechanism 312 moves the first sample rack 12 moved in the L1 direction on the dispensing lane 81 from the dispensing lane 81 to the re-dispensing waiting area on the waiting lane 80 as shown in FIG. Move to 802.

  The first sample rack 12 is stopped at the position where the sample container 11 containing the sample to be reinspected on the dispensing lane 81 reaches the suction position P4, and the sample to be reinspected is inspected by the sample dispensing probe 20. You may carry out so that the sample of an item may be dispensed.

  The first moving mechanism 311 stores the first and third sample racks 12 stored in the re-dispensing standby area 802 on the standby lane 80 and the (N-2) sample racks 12 in the dispensing standby area 801. As shown in FIG. 14, the sample is moved in the L2 direction and stopped at a position where the re-dispensing start position, for example, the first sample rack 12 reaches the rack ID reading position P1. The analysis control unit 32 moves the range 85 a in which the LED 85 is lit in the same direction at the same speed as each sample rack 12 on the standby lane 80. The analysis control unit 32 moves the range 85a in which the LED 85 is lit in the same direction as each sample rack 12 on the standby lane 80 in the same direction, and stops when each sample rack 12 on the standby lane 80 stops. Let

  In this way, the sample rack 12 to be re-inspected can be moved from the dispensing standby area 801 on the standby lane 80 where the sample rack 12 is placed to the re-dispensing standby area 802 on the standby lane 80. it can. In addition, by lighting the range 85a of the re-dispensing standby area 802, the sample rack 12 to be re-inspected that has been moved to the re-dispensing standby area 802 can be easily identified.

  Here, when the retest start is input from the operation unit 60, the first moving mechanism 311 moves on the standby lane 80 from the redispensing start position to the position where the first sample rack 12 reaches the drawing position P2. The N sample racks 12 are moved in the L1 direction. The second moving mechanism 312 moves the first sample rack 12 from the standby lane 80 to a position where the sample container 11 containing the sample to be retested on the dispensing lane 81 reaches the suction position P4. The sample dispensing probe 20 dispenses the sample of the inspection item to be reinspected in the sample container 11 at the suction position P4. When dispensing of the sample for reinspection is completed, the first sample rack 12 is moved from the dispensing lane 81 to the first moved position in the redispensing waiting area 802 on the waiting lane 80.

  The first moving mechanism 311 moves the N sample racks 12 on the standby lane 80 in the L1 direction to a position where the third sample rack 12 reaches the pull-in position P2. The second moving mechanism 312 moves the third sample rack 12 from the standby lane 80 to a position where the sample container 11 containing the sample to be retested on the dispensing lane 81 reaches the suction position P4. The sample dispensing probe 20 dispenses the sample of the inspection item to be reinspected in the sample container 11 at the suction position P4.

  When the dispensing of the sample to be retested is completed, the third sample rack 12 is moved from the dispensing lane 81 to the first moved position in the redispensing waiting area 802 on the waiting lane 80. The first moving mechanism 311 moves the first and third sample racks 12 returned to the re-dispensing waiting area 802 on the waiting lane 80 and the (N−2) sample racks 12 in the dispensing waiting area 801. Stop at the re-dispensing end position moved by one in the L1 direction. The analysis control unit 32 moves the range 85a in which the LED 85 is lit in the same direction as each sample rack 12 on the standby lane 80 in the same direction, and stops when each sample rack 12 on the standby lane 80 stops. Let

  Then, when the retest data is generated by the data processing unit 40 and output from the output unit 50 by the second sample dispensing, the system control unit 70 sends the analysis control unit 32, the data processing unit 40, and the output unit 50. By instructing the end of the inspection, the automatic analyzer 100 ends the operation.

  According to the embodiment described above, the redispensing standby area in which the sample rack 12 to be retested can be stored on the standby lane 80 provided so that the sample rack 12 to be tested can be moved to the dispensing lane 81. By providing 802, it is not necessary to provide a storage place for temporarily storing the sample rack 12 that may be re-inspected after the first sample is dispensed. Can do. Moreover, since the conveyance line which conveys to a temporary storage place is not required, the enlargement of the analysis part 10 can be prevented.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These novel embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalents thereof.

11 Sample container 12 Sample rack 13 Sampler unit 18 Reaction vessel 20 Sample dispensing probe 32 Analysis control unit 80 Standby lane 81 Dispensing lane 311 First moving mechanism 312 Second moving mechanism 801 Dispensing standby area 802 Redispensing standby area

Claims (10)

In an automatic analyzer that dispenses a sample and a reagent into a reaction container and measures a mixed solution of the sample and the reagent in the reaction container,
A standby lane provided so that the sample rack can be moved onto a dispensing lane capable of dispensing the sample in the sample container held in the sample rack;
A first moving mechanism for moving the sample rack on the waiting lane;
A second moving mechanism for moving the sample rack on one of the waiting lane or the dispensing lane onto the other lane;
The sample rack placed in the dispensing standby area arranged on the waiting lane is moved onto the dispensing lane, and the sample in the sample container held in the sample rack is dispensed, and the When abnormality relating to the dispensing of the sample is detected, or when the analysis data generated by the measurement of the mixed solution of the sample and the reagent is data that meets preset retest conditions, the sample rack is An analysis control unit that moves to a re-dispensing waiting area arranged on the waiting lane;
An automatic analyzer comprising: The re-dispensing standby area is disposed in one direction in the longitudinal direction of the standby lane with respect to the dispensing standby area,
The automatic analyzer according to claim 1, wherein the first moving mechanism moves the sample rack on the waiting lane in the longitudinal direction.   The automatic analyzer according to claim 1, wherein the first moving mechanism moves all the sample racks on the waiting lane in the same direction at the same speed.   The automatic analyzer according to any one of claims 1 to 3, wherein the re-dispensing standby area and the dispensing standby area are disposed on the same surface of the standby lane.   The automatic analyzer according to any one of claims 1 to 4, wherein the re-dispensing standby area is disposed so that a range in a longitudinal direction of the standby lane can be identified.   The automatic analyzer according to any one of claims 1 to 5, wherein the re-dispensing standby area is arranged such that a range in a longitudinal direction of the standby lane can be changed.   The analysis control unit moves the sample rack placed in the dispensing standby area onto the dispensing lane, and finishes dispensing the sample in the sample container held in the sample rack. When the analysis data generated by measuring the sample in the sample container and the mixed solution of the reagent is the data that meets the preset re-inspection conditions, move the sample rack to the dispensing standby area. The automatic analyzer according to any one of claims 1 to 6, wherein the sample rack moved from an area onto the dispensing lane and moved onto the dispensing lane is moved to the re-dispensing standby area.   The analysis control unit moves the sample rack placed in the dispensing standby area onto the dispensing lane, dispenses the sample in the sample container held in the sample rack, 8. The sample rack is moved to the re-dispensing standby area when analysis data generated by measurement of the reagent mixture exceeds a preset threshold value. 9. Automatic analyzer.   The analysis control unit moves the sample rack placed in the dispensing standby area onto the dispensing lane, and finishes dispensing the sample in the sample container held in the sample rack. When the analysis data generated by moving the sample to the injection standby area and measuring the mixed solution of the sample and the reagent exceeds a preset threshold, the sample rack is moved from the dispensing standby area to the re-dispense standby. The automatic analyzer according to claim 8, which is moved to an area.   The analysis control unit moves the sample rack placed in the dispensing standby area onto the dispensing lane, causes the sample in the sample container held in the sample rack to be dispensed, and The automatic analyzer according to claim 1, wherein when an abnormality related to dispensing is detected, the sample rack is moved from the dispensing lane to the re-dispensing standby area.

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